LOCUS       NM_009920               1361 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus cornichon family AMPA receptor auxiliary protein 2
            (Cnih2), transcript variant 1, mRNA.
ACCESSION   NM_009920 XM_905737
VERSION     NM_009920.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1361)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1361)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1361)
  AUTHORS   Zhang,D., Watson,J.F., Matthews,P.M., Cais,O. and Greger,I.H.
  TITLE     Gating and modulation of a hetero-octameric AMPA glutamate receptor
  JOURNAL   Nature 594 (7863), 454-458 (2021)
   PUBMED   34079129
  REMARK    GeneRIF: Gating and modulation of a hetero-octameric AMPA glutamate
            receptor.
REFERENCE   4  (bases 1 to 1361)
  AUTHORS   Yu,J., Rao,P., Clark,S., Mitra,J., Ha,T. and Gouaux,E.
  TITLE     Hippocampal AMPA receptor assemblies and mechanism of allosteric
            inhibition
  JOURNAL   Nature 594 (7863), 448-453 (2021)
   PUBMED   33981040
REFERENCE   5  (bases 1 to 1361)
  AUTHORS   Sultana,A., Nakaya,N., Dong,L., Abu-Asab,M., Qian,H. and
            Tomarev,S.I.
  TITLE     Deletion of olfactomedin 2 induces changes in the AMPA receptor
            complex and impairs visual, olfactory, and motor functions in mice
  JOURNAL   Exp Neurol 261, 802-811 (2014)
   PUBMED   25218043
REFERENCE   6  (bases 1 to 1361)
  AUTHORS   Gill,M.B., Kato,A.S., Roberts,M.F., Yu,H., Wang,H., Tomita,S. and
            Bredt,D.S.
  TITLE     Cornichon-2 modulates AMPA receptor-transmembrane AMPA receptor
            regulatory protein assembly to dictate gating and pharmacology
  JOURNAL   J Neurosci 31 (18), 6928-6938 (2011)
   PUBMED   21543622
REFERENCE   7  (bases 1 to 1361)
  AUTHORS   Schober,D.A., Gill,M.B., Yu,H., Gernert,D.L., Jeffries,M.W.,
            Ornstein,P.L., Kato,A.S., Felder,C.C. and Bredt,D.S.
  TITLE     Transmembrane AMPA receptor regulatory proteins and cornichon-2
            allosterically regulate AMPA receptor antagonists and potentiators
  JOURNAL   J Biol Chem 286 (15), 13134-13142 (2011)
   PUBMED   21343286
  REMARK    GeneRIF: Transmembrane AMPA receptor regulatory proteins and
            cornichon-2 allosterically regulate AMPA receptor antagonists and
            potentiators.
REFERENCE   8  (bases 1 to 1361)
  AUTHORS   Kato,A.S., Gill,M.B., Ho,M.T., Yu,H., Tu,Y., Siuda,E.R., Wang,H.,
            Qian,Y.W., Nisenbaum,E.S., Tomita,S. and Bredt,D.S.
  TITLE     Hippocampal AMPA receptor gating controlled by both TARP and
            cornichon proteins
  JOURNAL   Neuron 68 (6), 1082-1096 (2010)
   PUBMED   21172611
  REMARK    GeneRIF: Cornichon homolog 2 (CNIH-2) associates with TARP gamma-8
            in hippocampus postsynaptic densities; CNIH-2 protein levels are
            diminished in transmembrane AMPA receptor regulatory protein (TARP)
            gamma-8 knockout mice.
REFERENCE   9  (bases 1 to 1361)
  AUTHORS   Shi,Y., Suh,Y.H., Milstein,A.D., Isozaki,K., Schmid,S.M.,
            Roche,K.W. and Nicoll,R.A.
  TITLE     Functional comparison of the effects of TARPs and cornichons on
            AMPA receptor trafficking and gating
  JOURNAL   Proc Natl Acad Sci U S A 107 (37), 16315-16319 (2010)
   PUBMED   20805473
REFERENCE   10 (bases 1 to 1361)
  AUTHORS   Hwang,S.Y., Oh,B., Zhang,Z., Miller,W., Solter,D. and Knowles,B.B.
  TITLE     The mouse cornichon gene family
  JOURNAL   Dev Genes Evol 209 (2), 120-125 (1999)
   PUBMED   10022955
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK141483.1 and CX243776.1.
            
            On Oct 11, 2014 this sequence version replaced NM_009920.3.
            
            Summary: This gene encodes a protein that is an auxiliary subunit
            of the ionotropic glutamate receptor of the AMPA subtype. This
            protein is similar to a Drosophila protein involved in
            anterior-posterior and dorsal-ventral patterning. Cnih2 conditional
            knockout mice exhibit reduced AMPA receptor synaptic transmission
            in the hippocampus. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141483.1, BC059922.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1332              AK141483.1         1-1332
            1333-1361           CX243776.1         601-629
FEATURES             Location/Qualifiers
     source          1..1361
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.24 cM"
     gene            1..1361
                     /gene="Cnih2"
                     /gene_synonym="CNIH-2; Cnil"
                     /note="cornichon family AMPA receptor auxiliary protein 2"
                     /db_xref="GeneID:12794"
                     /db_xref="MGI:MGI:1277225"
     exon            1..339
                     /gene="Cnih2"
                     /gene_synonym="CNIH-2; Cnil"
                     /inference="alignment:Splign:2.1.0"
     exon            340..408
                     /gene="Cnih2"
                     /gene_synonym="CNIH-2; Cnil"
                     /inference="alignment:Splign:2.1.0"
     exon            409..456
                     /gene="Cnih2"
                     /gene_synonym="CNIH-2; Cnil"
                     /inference="alignment:Splign:2.1.0"
     exon            457..569
                     /gene="Cnih2"
                     /gene_synonym="CNIH-2; Cnil"
                     /inference="alignment:Splign:2.1.0"
     exon            570..713
                     /gene="Cnih2"
                     /gene_synonym="CNIH-2; Cnil"
                     /inference="alignment:Splign:2.1.0"
     exon            714..1343
                     /gene="Cnih2"
                     /gene_synonym="CNIH-2; Cnil"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1321..1326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnih2"
                     /gene_synonym="CNIH-2; Cnil"
                     /note="hexamer: AATAAA"
     polyA_site      1343
                     /gene="Cnih2"
                     /gene_synonym="CNIH-2; Cnil"
                     /note="major polyA site"
ORIGIN      
        1 gagcgaggga gccgcgggcg agggatcgca ggatgagcga tcggggcccg ggcagccggc
       61 agcggacgcg ccccccgagc cccacggccc gcgccccgcg tcccccacgg cctcgtggcc
      121 ctggtcccgg acgcgctgtc cgtgtcccta gagtccggtg ggccatgccc gtccggccct
      181 aagtgtgggc cggggggcgt ccccttgcgc ccagaccccg cgctggcgcc ccccgggcca
      241 ccgcccggcg cgggggccat ggcgttcacc ttcgcagcat tctgctacat gctcaccctg
      301 gtgctgtgcg cctccctcat cttctttgtc atctggcaca tcatagcctt tgatgagctg
      361 cggactgact tcaagaaccc catcgaccag gggaacccag cgcgggcacg cgagcgtttg
      421 aaaaacatcg aacgcatctg ctgcctcctg aggaagctgg tggtcccgga atattccatc
      481 cacggcctct tctgtctgat gtttctgtgt gcagcagagt gggtgaccct gggcctcaac
      541 atccccctcc tcttctacca cctctggagg tacttccacc gtcctgcgga tggctctgag
      601 gtcatgtatg atgcggtctc tatcatgaat gctgacatcc tcaactactg ccagaaggag
      661 tcctggtgca aactcgcctt ctacctgctg tccttcttct attacctgta cagtatggtt
      721 tatacgttgg tgagcttcta agggggaagc cggccaggga gcaagcccag aacggaccgg
      781 acgcctgtgc acccccagcc ctgcccctct ggccacagag gcctcagccc tggggaggga
      841 ggaggcactg gtgcctccag cctctccacc ccccaaactg ctgctgcggg gacccccgcc
      901 ttcagagctc tccccttctg actagggcca ggcaaagctc taaacgggtg ggggcttctc
      961 tgctagcctg cagctaggca tggcagttgt cctggaaggg gtaggacttc cggttttgtc
     1021 cgctccaggg gaatttgggc cctgccaaca ggcagacctt gatcctggaa atactgggca
     1081 gcccaccttg gccctcaccc tgaagctccc cgtgcaggtg ggggggcacc tacaccagga
     1141 atgagcaggc tcaacatggg ggcagcccca tccctagtct gccctccccc ctccccaggc
     1201 tctctctcca acccagtctc tacttatccc aaatccaacc taccctgtcc cttggaccta
     1261 ttttctatgt tgcctggagg agtccagcac cccatcccct gacatttgtg acaaaatatg
     1321 aataaactac tgaaaacaca caaaaaaaaa aaaaaaaaaa a
//
