LOCUS       NM_013927               4708 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus cyclic nucleotide gated channel beta 3 (Cngb3), mRNA.
ACCESSION   NM_013927
VERSION     NM_013927.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4708)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4708)
  AUTHORS   Yamada,R., Oguri,A., Fujiki,K., Shirahige,K., Hirate,Y.,
            Kanai-Azuma,M., Takezoe,H., Akimoto,Y., Takahashi,N. and Kanai,Y.
  TITLE     MAB21L1 modulates gene expression and DNA metabolic processes in
            the lens placode
  JOURNAL   Dis Model Mech 14 (12) (2021)
   PUBMED   34779479
REFERENCE   3  (bases 1 to 4708)
  AUTHORS   Jinda,W., Tuekprakhon,A., Thongnoppakhun,W., Limwongse,C.,
            Trinavarat,A. and Atchaneeyasakul,L.O.
  TITLE     Molecular and clinical characterization of Thai patients with
            achromatopsia: identification of three novel disease-associated
            variants in the CNGA3 and CNGB3 genes
  JOURNAL   Int Ophthalmol 41 (1), 121-134 (2021)
   PUBMED   32869108
  REMARK    GeneRIF: Molecular and clinical characterization of Thai patients
            with achromatopsia: identification of three novel
            disease-associated variants in the CNGA3 and CNGB3 genes.
REFERENCE   4  (bases 1 to 4708)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4708)
  AUTHORS   Hassall,M.M., Barnard,A.R., Orlans,H.O., McClements,M.E., Charbel
            Issa,P., Aslam,S.A. and MacLaren,R.E.
  TITLE     A Novel Achromatopsia Mouse Model Resulting From a Naturally
            Occurring Missense Change in Cngb3
  JOURNAL   Invest Ophthalmol Vis Sci 59 (15), 6102-6110 (2018)
   PUBMED   30592498
  REMARK    GeneRIF: We identified the spontaneous occurrence of a 10th model
            of cone photoreceptor function loss (cpfl10) in an isolated line of
            inbred mice. Our results indicate that this is caused by a novel
            missense mutation in the Cngb3 gene, with a fully recessive
            inheritance pattern.
REFERENCE   6  (bases 1 to 4708)
  AUTHORS   Huttl,S., Michalakis,S., Seeliger,M., Luo,D.G., Acar,N., Geiger,H.,
            Hudl,K., Mader,R., Haverkamp,S., Moser,M., Pfeifer,A., Gerstner,A.,
            Yau,K.W. and Biel,M.
  TITLE     Impaired channel targeting and retinal degeneration in mice lacking
            the cyclic nucleotide-gated channel subunit CNGB1
  JOURNAL   J Neurosci 25 (1), 130-138 (2005)
   PUBMED   15634774
REFERENCE   7  (bases 1 to 4708)
  AUTHORS   Zhong,H., Molday,L.L., Molday,R.S. and Yau,K.W.
  TITLE     The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B
            stoichiometry
  JOURNAL   Nature 420 (6912), 193-198 (2002)
   PUBMED   12432397
  REMARK    GeneRIF: The heteromeric cyclic nucleotide-gated channel adopts a
            3A:1B stoichiometry
REFERENCE   8  (bases 1 to 4708)
  AUTHORS   Bareil,C., Hamel,C.P., Delague,V., Arnaud,B., Demaille,J. and
            Claustres,M.
  TITLE     Segregation of a mutation in CNGB1 encoding the beta-subunit of the
            rod cGMP-gated channel in a family with autosomal recessive
            retinitis pigmentosa
  JOURNAL   Hum Genet 108 (4), 328-334 (2001)
   PUBMED   11379879
REFERENCE   9  (bases 1 to 4708)
  AUTHORS   Kohl,S., Baumann,B., Broghammer,M., Jagle,H., Sieving,P.,
            Kellner,U., Spegal,R., Anastasi,M., Zrenner,E., Sharpe,L.T. and
            Wissinger,B.
  TITLE     Mutations in the CNGB3 gene encoding the beta-subunit of the cone
            photoreceptor cGMP-gated channel are responsible for achromatopsia
            (ACHM3) linked to chromosome 8q21
  JOURNAL   Hum Mol Genet 9 (14), 2107-2116 (2000)
   PUBMED   10958649
REFERENCE   10 (bases 1 to 4708)
  AUTHORS   Gerstner,A., Zong,X., Hofmann,F. and Biel,M.
  TITLE     Molecular cloning and functional characterization of a new
            modulatory cyclic nucleotide-gated channel subunit from mouse
            retina
  JOURNAL   J Neurosci 20 (4), 1324-1332 (2000)
   PUBMED   10662822
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX001053.7, AL772281.7, BX640400.4 and AL683894.6.
            
            On Nov 17, 2006 this sequence version replaced NM_013927.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ243572.1, SRR17784643.604576.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164138,
                                           SAMN01164141 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               BX001053.7         29014-29207
            195-270             BX001053.7         31670-31745
            271-397             BX001053.7         57695-57821
            398-555             AL772281.7         2499-2656
            556-702             AL772281.7         4800-4946
            703-911             AL772281.7         6099-6307
            912-962             AL772281.7         13587-13637
            963-1049            AL772281.7         17613-17699
            1050-1114           AL772281.7         34313-34377
            1115-1237           AL772281.7         35067-35189
            1238-1379           AL772281.7         54033-54174
            1380-1539           BX640400.4         7468-7627
            1540-1637           BX640400.4         10446-10543
            1638-1721           BX640400.4         43653-43736
            1722-1840           BX640400.4         63809-63927
            1841-1987           AL683894.6         5272-5418
            1988-2162           AL683894.6         6003-6177
            2163-4708           AL683894.6         8908-11453
FEATURES             Location/Qualifiers
     source          1..4708
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 7.42 cM"
     gene            1..4708
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /note="cyclic nucleotide gated channel beta 3"
                     /db_xref="GeneID:30952"
                     /db_xref="MGI:MGI:1353562"
     exon            1..194
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..2168
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /note="cyclic nucleotide-gated cation channel beta-3; CNG
                     channel beta-3; cyclic nucleotide-gated channel subunit
                     CNG6; cone photoreceptor cGMP-gated channel subunit beta;
                     cyclic nucleotide-gated cation channel modulatory subunit;
                     cyclic nucleotide gated channel beta 6"
                     /codon_start=1
                     /product="cyclic nucleotide-gated channel beta-3"
                     /protein_id="NP_038955.1"
                     /db_xref="CCDS:CCDS17990.1"
                     /db_xref="GeneID:30952"
                     /db_xref="MGI:MGI:1353562"
                     /translation="MLKSLTVKFNKVNPMEGRMEKKLCPNLSSLSQPTIAQGDNQSEK
                     EPLRSRTPITFEKSHSKEDNSTGENSLRDFTPNPDPECRAELTRTMAEMEKTRTGKER
                     PVSFKTKVLETSIINEYTDAHLHNLVERMRERTALYKKTLTEEENFPEVEASSQTAMS
                     TNISPKQENNSKLKEHQDTFSFKPQRVPVKEHLRRMILPRSIDSYTDRVYLLWLLLVT
                     IAYNWNCWLLPVRLVFPCQTPDNKNYWIITDIVCDIIYLCDILLIQPRLQFVRGGEII
                     VDSNELKRNYRSSTKFRMDVASLLPFEVLYIFFGVNPIFRANRILKYTSFFEFNHHLE
                     SIMDKAYVYRVIRTTGYLLFLLHINACVYYWASDYEGIGSTKWVYNGEGNKYLRCFYW
                     AVRTLITIGGLPEPQTSFEIVFQFLNFFSGVFVFSSLIGQMRDVIGAATANQNYFQAC
                     MDHIIAYMNKYSIPQSVQYRVRTWLEYTWNSQRILDESNLLENLPTAMQLSIALDINF
                     SIIDKVELFKGCDTQMIYDLLLRLKSTIYLPGDFVCKKGEIGKEMYIIKHGEVQVLGG
                     PDGAQVLVTLKAGSVFGEISLLAKGGGNRRTADVVAHGFANLLTLDKKTLQEILLHYP
                     TSKKLLMKKAKILLSQKGKTTQAIPARPGPAFLFPPKEETPRMLKVLLGNTGKVDLGR
                     LLKGKRKTTTQK"
     exon            195..270
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            271..397
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            398..555
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            556..702
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            703..911
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            912..962
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1049
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1114
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1237
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1379
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1539
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1637
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1721
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1840
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1987
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2162
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..4708
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2595..2600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /note="hexamer: ATTAAA"
     polyA_site      2623
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
     regulatory      2876..2881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /note="hexamer: AATAAA"
     polyA_site      2897
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
     regulatory      4683..4688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /note="hexamer: AATAAA"
     polyA_site      4708
                     /gene="Cngb3"
                     /gene_synonym="CCNC2; CNG6; Cngbeta2"
                     /note="major polyA site"
ORIGIN      
        1 tggaaagaaa aacaaagcac atctctcctc ttcgagatac agggtcatat aatcggaggt
       61 ctttcagacc tgcctcagag aagatgttaa aatcactgac agtaaaattc aacaaagtga
      121 atcccatgga agggagaatg gagaagaaac tctgccccaa cctgagcagt ctttctcagc
      181 caaccatagc acagggagac aaccaaagtg aaaaagaacc tctgaggagc aggacaccaa
      241 tcacatttga aaagtcacac agcaaagaag acaacagcac tggggaaaac tctctcagag
      301 atttcacccc aaatcctgac cctgaatgtc gagcagaact caccagaaca atggcagaga
      361 tggagaaaac taggactggg aaagaaaggc cagtcagctt taagaccaaa gtgcttgaaa
      421 cctcaattat aaatgaatat actgatgccc acctacacaa cctagtggaa agaatgcgtg
      481 aaaggactgc tctctacaag aaaacattga cagaggaaga aaatttccca gaagtggaag
      541 ccagctctca gactgcaatg tctacaaata tatcaccaaa acaagagaac aattccaagc
      601 taaaagaaca ccaagacacg ttttctttca aaccccagag agtcccagta aaagagcacc
      661 tacgaagaat gatacttccc agaagcatag actcctacac agatcgggtc tatctcttgt
      721 ggctcctgct tgtcaccatt gcgtataact ggaactgttg gctgctacca gtgcgcctcg
      781 tctttccatg ccaaacacca gataacaaga actactggat tattactgac atcgtatgtg
      841 atatcatcta cctttgtgat atactattga tccagccaag actccaattt gtaagaggag
      901 gagaaattat tgtagattca aatgagctga agaggaacta ccggagttct acaaagtttc
      961 ggatggatgt ggcatctcta ctgccattcg aagttctcta catcttcttt ggagttaatc
     1021 caatattcag agcaaatcgg atattaaagt atacttcatt ctttgagttt aaccatcacc
     1081 tggagtctat aatggacaaa gcatatgtct acagagtcat ccgaacaact ggctacttgc
     1141 tgtttctcct gcacattaac gcctgtgttt attactgggc ttcagactat gaaggaattg
     1201 gctcaactaa atgggtctat aatggtgaag gcaacaagta tctgcgatgc ttttattggg
     1261 cagttcgaac tttaattact atcgggggcc ttccagagcc acagacttca tttgaaattg
     1321 tttttcaatt cttgaatttt ttctctgggg tttttgtttt ctccagctta attggtcaga
     1381 tgcgtgatgt gattggggca gcaacagcca atcagaacta cttccaagcc tgcatggacc
     1441 atatcattgc ctacatgaac aaatactcta ttcctcagag tgtgcagtat cgagttcgga
     1501 cttggctgga atatacatgg aactcacaaa gaatcctaga tgagtccaac ttgcttgaga
     1561 acctcccgac agcaatgcag ttgtctattg cccttgacat aaacttcagt atcatcgaca
     1621 aggtggagtt attcaagggc tgtgacacac agatgattta tgacctgctg ctaagattga
     1681 aatccactat ttatttacct ggtgactttg tctgcaaaaa gggagaaatt ggaaaagaaa
     1741 tgtacatcat caaacacgga gaagtccaag tccttggagg ccctgatggt gctcaagttc
     1801 tggttactct gaaagctggg tcagtgtttg gagaaataag ccttctggca aaaggaggag
     1861 gaaatcgccg gacagctgat gttgtggccc acggatttgc caatctttta actctggaca
     1921 aaaagactct ccaagaaatt ctgctgcatt atccaacttc taaaaagctc ctcatgaaga
     1981 aagccaaaat tcttttaagc cagaagggaa agaccactca ggcaatccct gcaagaccag
     2041 gacctgcctt tcttttccca ccaaaagaag agacaccccg aatgcttaaa gttctcctag
     2101 gaaacacagg aaaggtggac cttggaagac tccttaaagg aaagagaaaa acaaccactc
     2161 agaaataaag gtgaaagttc caaaggaaga agaagaagag gaaaagaata tgaagacaaa
     2221 ggaacagagc tagcagaaaa agaagaaaaa aaacccactg gataggttca aaggcacact
     2281 aagttctatt acagtggagg aaatgtccca atcaattaaa taggcagttt tccccaaagg
     2341 acatgcctat caattgatca tcagcaacat ggtcctgcta ctgagactgg agaagagatt
     2401 ctgactatca aagtcaagaa aagggctaag caataagtgc ttgattatct ttaaatgtaa
     2461 tctagctaat tcccaaagag attcctggaa attgtagctt aaattaatga gggaaactaa
     2521 cctcactggg accctgggaa actgcaggca aatccttagc ttcatttcca ggagttggat
     2581 tcatcaataa gactattaaa aacaatcctc ttatccactg tcagtagatt tgagcaattg
     2641 atatttcttt taaatgtctg cagtagataa tttatcttct ttcttgatga aatatccttg
     2701 ttccactttg gtagacttga tttttatgct actgtgattt actgtccttc ctgcttacat
     2761 ttttgtggta tataatttct ggcaaagcac tttgttcaaa tgtccaaagt agactcttct
     2821 gtccaaggta gactcatctt acttcttatg aatagtgaaa gggtgtgaaa tttttaataa
     2881 aataggtcat aaatcaagtg gtttctattt aaataagggt gttgagtcac taaatctagc
     2941 acctgacgtt gacacaggct gacgtcatgg aaccttctga atgagaactc tgattttcac
     3001 tcgaagtcaa tgtcagttag caaaaatagc aagcttatag acaaaagacc aaatcaaaag
     3061 caaagttccc tcactaacaa ctgtaccccg gcctcttaga gcctcacccc tgtgacgtgc
     3121 aacatctcac aggaatattt gaagcttcac tctgctgacg gatgatatcc ttttcaacca
     3181 gaccattgca agaaaaaaga aaaaaaaaac ttgattcaaa acacattgca atttaacaaa
     3241 atagtggggc tttcaccttt ttatccagaa taataagata gcacacgagg taagatataa
     3301 gtccccttta attattataa aaagtctccc tccctcatag agtcacagtc cctttgcatt
     3361 gtaagaaact gtcacgtgga tgttatgttc ccagattatt tgtatttgcc tatgtcccta
     3421 gccttgcaga tgctacttca catggcaaaa ccagttggca gcatcccact atggcaaaat
     3481 cagattgcag caacatgctg gaggaagtgg atcattttcc aaataaaatt tactgttttt
     3541 ccttatacca acttaaagga catcagacta gctctgctgg cccaacagat gcagagtaga
     3601 gtcagactgt ctccatttta atacaggcta acgtgacatt ttccagaacc ttccttaaac
     3661 attagcttcc ttcaaaaggt gccagatagg aattctagtg ttgcttaaag ccttaggata
     3721 aagtgataag attaggaatg catattatat acatcagttt gacagatcct cacagttatt
     3781 gggactacat gtacagcagt ttataaaacc ttcaagttag ttaagtccac ttgaggaagc
     3841 tctcctgaga cttcacttag cacggagaca attaccaaag ttacatgctg ggaagaggcc
     3901 aaaactgcta gactggtatt gaaagtgatc atatacacta aatctccttc taatgaatgc
     3961 cattaggatg gaatgttgaa ttccatgtaa gatggctgtt tccaagtccc agaagaaggc
     4021 tatcataata gcacattgtg aggaggattt taaccaatta catttactca aaactgtaca
     4081 acatggatgc atctgtcatg ctttgtggaa atcagaaatt gatttttaaa gggtagtgtc
     4141 tgatagagtt gtcctttaag tttttacaaa ggctggttga tagttttcag aattggaagg
     4201 aatatgaaca aaatttaaat agcagttact atcatgaaca aaaggtcctg gaaagaagct
     4261 gtgcctataa aagctaaatg actggttagc aatccaataa ttgtgaagtg gttggctctg
     4321 cacatccaga tcgcaattac aaactttcta gcttaccctc cttggtactc attcattacc
     4381 cacctctgtg tctgacctaa tatccttgtg agtagtaggt taaattcctt tgggatgtat
     4441 gaaaaggttc atttgcttcc acaagcccca cagccaagaa tgtcatttgg taggaacttc
     4501 aacagagatt tttccacttc tgttataatc aatgtatgtt acgtgttcag taatatatgt
     4561 gaaaagcatg ttgatttaca actttctttt ttctgtcact ataaaaactt cataaacttc
     4621 agccaccttg gaaaatagaa tttgaggtga cccatatcat gggacctcat atttctcccc
     4681 agaataaatc catctcttac acttttaa
//
