LOCUS       NM_001195413            6201 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus cyclic nucleotide gated channel beta 1 (Cngb1),
            transcript variant 1, mRNA.
ACCESSION   NM_001195413
VERSION     NM_001195413.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6201)
  AUTHORS   Scalabrino,M.L., Thapa,M., Wang,T., Sampath,A.P., Chen,J. and
            Field,G.D.
  TITLE     Late gene therapy limits the restoration of retinal function in a
            mouse model of retinitis pigmentosa
  JOURNAL   Nat Commun 14 (1), 8256 (2023)
   PUBMED   38086857
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6201)
  AUTHORS   Scalabrino,M.L., Thapa,M., Chew,L.A., Zhang,E., Xu,J.,
            Sampath,A.P., Chen,J. and Field,G.D.
  TITLE     Robust cone-mediated signaling persists late into rod photoreceptor
            degeneration
  JOURNAL   Elife 11, e80271 (2022)
   PUBMED   36040015
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6201)
  AUTHORS   Yan,J., Gunter,A., Das,S., Muhlfriedel,R., Michalakis,S., Jiao,K.,
            Seeliger,M.W. and Paquet-Durand,F.
  TITLE     Inherited Retinal Degeneration: PARP-Dependent Activation of
            Calpain Requires CNG Channel Activity
  JOURNAL   Biomolecules 12 (3), 455 (2022)
   PUBMED   35327647
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6201)
  AUTHORS   Pearring,J.N., Martinez-Marquez,J., Willer,J.R., Lieu,E.C.,
            Salinas,R.Y. and Arshavsky,V.Y.
  TITLE     The GARP Domain of the Rod CNG Channel's beta1-Subunit Contains
            Distinct Sites for Outer Segment Targeting and Connecting to the
            Photoreceptor Disk Rim
  JOURNAL   J Neurosci 41 (14), 3094-3104 (2021)
   PUBMED   33637563
  REMARK    GeneRIF: The GARP Domain of the Rod CNG Channel's beta1-Subunit
            Contains Distinct Sites for Outer Segment Targeting and Connecting
            to the Photoreceptor Disk Rim.
REFERENCE   5  (bases 1 to 6201)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6201)
  AUTHORS   Corbo,J.C. and Cepko,C.L.
  TITLE     A hybrid photoreceptor expressing both rod and cone genes in a
            mouse model of enhanced S-cone syndrome
  JOURNAL   PLoS Genet 1 (2), e11 (2005)
   PUBMED   16110338
  REMARK    Erratum:[PLoS Genet. 2008 Jan;4(1):e18]
REFERENCE   7  (bases 1 to 6201)
  AUTHORS   Huttl,S., Michalakis,S., Seeliger,M., Luo,D.G., Acar,N., Geiger,H.,
            Hudl,K., Mader,R., Haverkamp,S., Moser,M., Pfeifer,A., Gerstner,A.,
            Yau,K.W. and Biel,M.
  TITLE     Impaired channel targeting and retinal degeneration in mice lacking
            the cyclic nucleotide-gated channel subunit CNGB1
  JOURNAL   J Neurosci 25 (1), 130-138 (2005)
   PUBMED   15634774
  REMARK    GeneRIF: Our results show that CNGB1 is a crucial determinant of
            native cyclic nucleotide-gated channel targeting.
REFERENCE   8  (bases 1 to 6201)
  AUTHORS   Schmucker,C., Seeliger,M., Humphries,P., Biel,M. and Schaeffel,F.
  TITLE     Grating acuity at different luminances in wild-type mice and in
            mice lacking rod or cone function
  JOURNAL   Invest Ophthalmol Vis Sci 46 (1), 398-407 (2005)
   PUBMED   15623801
REFERENCE   9  (bases 1 to 6201)
  AUTHORS   Zhong,H., Molday,L.L., Molday,R.S. and Yau,K.W.
  TITLE     The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B
            stoichiometry
  JOURNAL   Nature 420 (6912), 193-198 (2002)
   PUBMED   12432397
REFERENCE   10 (bases 1 to 6201)
  AUTHORS   Bradley,J., Frings,S., Yau,K.W. and Reed,R.
  TITLE     Nomenclature for ion channel subunits
  JOURNAL   Science 294 (5549), 2095-2096 (2001)
   PUBMED   11764791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC016201.1, AC102518.11, BC045114.1 and BC046523.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HQ116386.1, SRR9219382.175516.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1017              BC016201.1         1-1017
            1018-1177           AC102518.11        37003-37162
            1178-1438           AC102518.11        39323-39583
            1439-6189           BC045114.1         1-4751
            6190-6201           BC046523.1         3084-3095
FEATURES             Location/Qualifiers
     source          1..6201
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 47.12 cM"
     gene            1..6201
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /note="cyclic nucleotide gated channel beta 1"
                     /db_xref="GeneID:333329"
                     /db_xref="MGI:MGI:2664102"
     exon            1..54
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            55..323
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..4040
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclic nucleotide-gated channel beta subunit 1; CNG
                     channel 4; cyclic nucleotide-gated cation channel 4;
                     cyclic nucleotide-gated cation channel beta-1"
                     /codon_start=1
                     /product="cyclic nucleotide-gated channel beta-1 isoform
                     1"
                     /protein_id="NP_001182342.1"
                     /db_xref="CCDS:CCDS72151.1"
                     /db_xref="GeneID:333329"
                     /db_xref="MGI:MGI:2664102"
                     /translation="MLGWVQRVLPQPPGTPQKTVETAGPQPETESKPEANPQPEPEPQ
                     QEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPVPEEAPPEVQALPPEEPMEGEGEAEAG
                     PSLQETQVADPAQPTSQAQVAVAKVNRPSSWMLSWFWRGMQKVVPQPVCSNGGQNLAA
                     GERDPDQGGAQIPEPCGTGDPGSAEASGTQDTEPSLWLLRWLEQNLEKVLPQPPPPSL
                     AWKVEPEAAVLDPDPPGTPMQMEPTESPSQPNPGPLEPEEEPAAEPQPGFQSSSLPPP
                     GDPVRLIEWLLHRLEMALPQPVLHGKAAEQEPGCPGMCDVQTISILPVEQVEHDLVLE
                     EVDSCWEDAQQEDGASPQETEVAPAHEEESEAIVEIPRELTKIQEEREDEQEEDEEEK
                     EEEKKKGEEEKEKEEEEKEKEKEKEEEKEEEEKEEEEEEEKEEEEEEKEEEEKEEEEK
                     EEEEEEEEEEEEPIVLLDSCLVVQADVDECQLERTPSELASIQELPEEKEEKEEEKEE
                     EKEEEEEKKEEEVEKKEEGEATNSTVPATKEHPELQVEDTDADSGPLIPEETLPPPER
                     PPPSPVKSDTLTVPGAAAAGHRKKLPSQDDEAEELKALSPAESPVVAWSDPTTPQEAD
                     GQDRAASTASQNSAIINDRLQELVKMFKERTEKVKEKLIDPDVTSDEESPKPSPAKKA
                     PEPDPAQKPAEAEVAEEEHYCDMLCCKFKRRPLKMYRFPQSIDPLTNLMYILWLFFVV
                     LAWNWNCWLIPVRWAFPYQRADNIHFWLLMDYLCDFIYLLDITVFQMRLQFVKGGDII
                     TDKKEMRNNYLKSRRFKMDLLCLLPLDFLYLKLGINPLLRLPRCLKYMAFFEFNNRLE
                     AILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAFQGIGSTHWVYDGVGNSYIRCYYW
                     AVKTLITIGGLPDPQTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSC
                     MDSTVKYMNFYKIPRSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNY
                     SIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGG
                     PDGKAVLVTLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYP
                     ESQKLLRKKARRMLRNNNKPKEEKSVLILPPRAGTPKLFNAALAAAGKMGPRGAKGGK
                     LAHLRARLKELAALEAAARQQQLLEQAKSSQEAGGEEGSGATDQPAPQEPPEPKDPPK
                     PPGPPEPSAQSSPPPASAKPEESTGEAAGPPEPSVRIRVSPGPDPGEQTLSVEVLEEK
                     KEGAE"
     exon            324..381
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            382..448
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            449..563
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            564..606
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            607..640
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            641..716
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            717..756
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            757..904
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            905..980
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1017
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1177
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1453
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1541
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1662
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1825
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1933
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2091
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2247
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2456
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2507
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2594
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2659
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2782
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2924
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..3084
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3182
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            3183..3266
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            3267..3385
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            3386..3532
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            3533..3752
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     exon            3753..6191
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6171..6176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /note="hexamer: ATTAAA"
     polyA_site      6191
                     /gene="Cngb1"
                     /gene_synonym="CNG-4; CNG4; Cngb1b; Garp2; Gm1959"
                     /note="major polyA site"
ORIGIN      
        1 agctgctggg gcactgagaa ggcaattcct ggctagccgc tgacatctga acaggtgtca
       61 ggatgttggg ctgggtccaa agggtgctgc ctcagcctcc ggggacccct cagaagaccg
      121 tggagacagc aggaccacag ccagaaacag agtcgaaacc agaggccaac ccacaaccgg
      181 agccagaacc tcagcaggaa ccagagccag agccagagcc agagccagag ccagagccag
      241 agccagagcc agagccagag ccagagccag aacctgaacc tgaaccagta cctgaagagg
      301 ctccacctga ggtccaggcc ctgccaccag aggagccaat ggaaggagag ggagaggctg
      361 aggctggtcc cagccttcaa gagacccagg tagctgaccc tgctcagccc acctcccagg
      421 cccaggttgc tgttgccaag gtgaacaggc ccagctcctg gatgttgagc tggttctgga
      481 gaggcatgca gaaggtcgtg ccacagcctg tctgcagcaa tgggggccag aacctggctg
      541 ccggagagcg agacccagat cagggtggag cacagatccc agaaccttgt ggcactgggg
      601 acccaggatc tgcagaagct tccgggactc aggacactga gcccagcctt tggctgctca
      661 ggtggcttga gcagaatctg gaaaaagtgc tgccccagcc ccctccgcct tccctggcct
      721 ggaaagttga acctgaggct gctgtcttgg atccagatcc tccaggaacc cctatgcaga
      781 tggagcccac agagagcccc tcccagccta atcctggacc cctggagcct gaggaagagc
      841 cagctgcaga gccccagcct ggcttccaat cctcttccct gccaccaccc ggggaccccg
      901 tcaggctgat tgagtggctc ctacacagac tggagatggc cctgcctcag cccgtgctcc
      961 atgggaaggc tgcagagcaa gagcctggct gccctgggat gtgtgacgta cagaccatca
     1021 gcatcctccc cgtggaacag gtggaacatg atcttgtcct ggaggaggtg gactcttgct
     1081 gggaggatgc tcagcaggaa gatggcgcca gcccgcagga gacagaggtg gctccagctc
     1141 atgaagaaga gagtgaggcc atagtggaga tacccaggga gctgacgaag attcaagaag
     1201 aaagagaaga tgagcaggaa gaggatgagg aagagaagga ggaagagaag aagaaggggg
     1261 aggaagagaa ggagaaggag gaggaagaga aagagaaaga gaaggagaag gaggaggaga
     1321 aggaagagga agagaaggag gaggaggagg aggaagaaaa ggaagaggaa gaggaggaaa
     1381 aggaagaaga ggagaaggaa gaggaggaga aggaagagga ggaagaagaa gaggaggagg
     1441 aagaagagcc tattgtcctg ctggatagct gtttggtggt gcaggctgat gtggacgagt
     1501 gccagctaga aaggacaccg tcagagctag catcgatcca ggagctgcca gaagagaaag
     1561 aggagaagga agaggagaag gaggaggaga aagaggagga ggaggaaaag aaggaggaag
     1621 aagtggagaa gaaggaggaa ggggaggcca caaactcaac agtaccagcc acaaaggagc
     1681 acccggagct ccaggtagaa gacacggatg ctgatagtgg ccccctcatc ccagaggaga
     1741 cactccctcc acctgagaga ccaccaccgt ctcctgtcaa gtcggacacc ctcacagttc
     1801 ccggcgccgc tgcagcaggc cacaggaaga agctaccttc tcaggatgat gaggccgaag
     1861 agctcaaggc cctgtcacca gctgagtccc cagtggttgc ctggtcggac cccaccaccc
     1921 cacaggaggc tgatggccag gaccgagcag cctccaccgc cagccagaac agtgccatca
     1981 tcaatgaccg gctccaggag ctggtgaaga tgttcaagga gcggacggag aaggtgaagg
     2041 agaagctcat tgaccctgac gtcacctctg atgaggagag ccccaagccc tccccggcca
     2101 agaaggcccc agaaccagac ccagcccaga agccagcgga ggcagaggtg gcagaggagg
     2161 aacactactg cgacatgctc tgctgcaagt tcaagcgcag gcccttgaag atgtaccggt
     2221 tcccccagag tatcgaccca ctgaccaacc tcatgtacat cttgtggctg ttctttgtgg
     2281 tgctggcctg gaactggaac tgctggctga tccctgtgcg ctgggccttc ccgtaccagc
     2341 gggcagacaa catccacttc tggctcctca tggattactt gtgcgacttc atctacctcc
     2401 tggacatcac cgtgttccag atgcgcctgc agtttgtcaa aggcggggac atcattacag
     2461 acaagaagga gatgcgtaat aactacctga agtctcgccg gtttaagatg gacctgctct
     2521 gcctcctgcc cttggacttt ctctacttga aacttggcat caaccctctc cttcgcctgc
     2581 cccgctgcct gaagtacatg gccttctttg agtttaataa ccgcctggaa gccatcctca
     2641 gcaaagccta cgtttacaga gtcatcagga ccacggccta cctgctgtac agcctgcacc
     2701 tcaactcctg cctttactac tgggcatcag ccttccaggg catcggctcc actcactggg
     2761 tttacgacgg agtggggaac agttatattc gatgctacta ctgggctgtg aaaaccctca
     2821 tcaccatcgg aggactgccc gacccccaga cgctctttga gattgtcttc cagctgctga
     2881 actattttac cggggtcttt gctttctctg tgatgattgg acagatgaga gatgtggtgg
     2941 gggccgccac agcggggcag acctactacc gcagctgcat ggacagcaca gtgaagtaca
     3001 tgaacttcta caagatcccc aggtctgtgc agaaccgtgt caagacctgg tatgagtaca
     3061 cctggcattc gcaaggcatg ctggatgagt cagagctgat ggtacaactt ccggacaaga
     3121 tgcgactgga cctggccatt gatgtgaact acagtattgt cagcaaagtg gccctctttc
     3181 agggctgtga ccggcagatg atcttcgaca tgctcaagcg gcttcgttct gttgtctacc
     3241 tacccaatga ctatgtgtgc aagaaggggg agattggccg agagatgtac attatccagg
     3301 cggggcaggt gcaggtgctg ggcggcccag atgggaaggc tgtactggtg acactcaaag
     3361 ccggatcggt gtttggagaa ataagcttgc tggctgtcgg gggtggcaac cggcgcacag
     3421 ccaacgtggt ggcccatggc ttcaccaacc tcttcatact ggacaagaag gacttgaatg
     3481 aaattttagt gcattacccg gaatctcaga agttacttcg gaagaaggcc aggcgcatgc
     3541 taagaaataa caacaaaccc aaggaggaaa agagtgtgct catcctgccc ccgcgtgcgg
     3601 gcaccccgaa gctcttcaat gctgccctgg ctgctgcagg aaagatgggc cccaggggag
     3661 ccaagggcgg caagctcgcc cacctgagag ccaggctcaa ggaactggct gcactggagg
     3721 cagccgcgcg acagcaacag ctgctggaac aggccaagag ctcgcaagaa gctgggggag
     3781 aggagggctc tggggccaca gaccaacctg caccccagga gccaccagag cccaaggacc
     3841 ctccgaagcc accagggcca ccagagccct cagcccagag ctctccacct ccagcctcag
     3901 caaagcccga ggaaagcacg ggggaggcag cagggccccc ggagccctcg gtgaggatcc
     3961 gtgtgagtcc aggccctgat cccggggagc agacactgtc ggtggaggtg ctggaggaga
     4021 agaaagaggg ggcggagtga ggtgcatgaa gcgcccagat cccatcccca ggtctttgaa
     4081 ccacccgcct cgccaagcgt cccagcctaa gggcgccttc tcacaggctt gtagaaacgc
     4141 tcaaatttca ccaggtggta gtgatgccct cgagctcctg ccattccctg agcaccctgc
     4201 tcccttcctg aggttgctat tttcaagaag aaaaccgcct tgtacttctc aaagatttga
     4261 ggagagacta gaagagggct ccaacatcaa ggagaactct actagacaaa tcaagggttg
     4321 atgacttggt agggtcccca ccagaagcca ccctctgttt aaatggtgaa gagctggagt
     4381 cccactgagc acctgcaaac ccaggactgg ggagaccaag atagtccttg gttcaagggc
     4441 agccagggct acatagtgag actctgcctc aaaagaaaac agtagcaaaa ttgcttgagg
     4501 agttcccagg cacctcgtga cccctttggg gtccaaagac cctttgatgg gggggagggt
     4561 cgcctaagac tattgtaaag atcagatatt tacattatga ttcacaacag tagcaaaata
     4621 acagtaataa agtagcattg gaaataatgg ttaggggtca ccacaacaca aggaactgtg
     4681 ttaaagggtc acagtgtgag aaaggttgag aatcaccgag ctaagctcat ccacatccca
     4741 gcagtaaaca cagttgtcta gctgatggca gggcaggtga tcccggtatt ccttgctcca
     4801 ggtagtgatg gctgcattat catcttagcg cccttgaaag tattgcttat cttagtaggt
     4861 aacgatatca agagctctcc atgctactct ggtcctagca tttagagagt atgcttgtag
     4921 ctgggtgtca tggaggcagg gggatcagcc tgggctagat agcaatatcc catcttaaaa
     4981 aggaaagggg gaagtgtatt ggttcattgg tgatgacagc acagtccatg tttaaatgcg
     5041 tggtgacatc tcagccactg ctcatcagtg agcctttgga ttgttttctg atctcactct
     5101 atcaagaata acatggcagg gccattgaga gagctcagtg ggcagaggcc cttgccaccc
     5161 taccatgcaa acgtgatgac ctaagttata tctctgaaac ccatgtgaag ctgcaaagtc
     5221 gactccacga gctcgcagta ataaactcat ctcctacaca tggggtggct cactaggaag
     5281 catttacctg gcctgtgtga cttcctgggt ttgatcctca ataccaaaag aaagaacctc
     5341 acacagagct aatctctcac tagcacactt tattttttta agcgatgtgg ggtggggtct
     5401 gggagtctag tcagttttgt ttttgttgtt gtttgttttt ttaaccctaa catccttaaa
     5461 cagcatcctc agagctgcat cctatgttct aaagcccggg ccctgagaat gctacccgct
     5521 tgtggccagt attccggatg ctcctacaga gtaaacatgc cacccttcag taaacggtgg
     5581 catgtgtccc tggcgcctcc acgtgagagc ctgcttcatg cggaatctgt tttctgtgaa
     5641 tgcacctact tttagatgct agcccttgaa aatatattgc ttattatatg aagcaagagg
     5701 ttcccgtggt tcctgggaag aacgttaatt tcgaaatgag atcggcagtg tcttaatttc
     5761 actgagctat ctcatttacg gtgagactca cagaaacaag atgttaggta aactgagttg
     5821 gagaccggca ctaatctcct gtctgaattg gactggctgg ccactgatat agtccagaga
     5881 ttgctgtaat cctgaagcct gaagagaaca cgcatgtgtg cccattgatt ctctcctctt
     5941 ttaatctcct tgttgggtct tgcattgata atttgattga taatgaacag cataccactt
     6001 tttttaaaaa aaccatataa atattctaaa tagaactaaa accaagaagc tgcttaaaaa
     6061 cttcattatc aaaatatgct cagccatcgg aactagtcta agctgtttcc acagcacaca
     6121 agaatacttt ctgtacacgc cggctttcac agtacagctc attttaatta attaaagagt
     6181 ttagacaaac aaaaaaaaaa a
//
