LOCUS       NM_001033317            2480 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Mus musculus cyclic nucleotide gated channel alpha 4 (Cnga4), mRNA.
ACCESSION   NM_001033317 XM_145875 XM_908656
VERSION     NM_001033317.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2480)
  AUTHORS   Cisneros-Mejorado,A. and Sanchez Herrera,D.P.
  TITLE     cGMP and cyclic nucleotide-gated channels participate in mouse
            sperm capacitation
  JOURNAL   FEBS Lett 586 (2), 149-153 (2012)
   PUBMED   22192355
REFERENCE   2  (bases 1 to 2480)
  AUTHORS   Michalakis,S., Reisert,J., Geiger,H., Wetzel,C., Zong,X.,
            Bradley,J., Spehr,M., Huttl,S., Gerstner,A., Pfeifer,A., Hatt,H.,
            Yau,K.W. and Biel,M.
  TITLE     Loss of CNGB1 protein leads to olfactory dysfunction and subciliary
            cyclic nucleotide-gated channel trapping
  JOURNAL   J Biol Chem 281 (46), 35156-35166 (2006)
   PUBMED   16980309
REFERENCE   3  (bases 1 to 2480)
  AUTHORS   Kelliher,K.R., Ziesmann,J., Munger,S.D., Reed,R.R. and Zufall,F.
  TITLE     Importance of the CNGA4 channel gene for odor discrimination and
            adaptation in behaving mice
  JOURNAL   Proc Natl Acad Sci U S A 100 (7), 4299-4304 (2003)
   PUBMED   12649326
REFERENCE   4  (bases 1 to 2480)
  AUTHORS   Zhong,H., Molday,L.L., Molday,R.S. and Yau,K.W.
  TITLE     The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B
            stoichiometry
  JOURNAL   Nature 420 (6912), 193-198 (2002)
   PUBMED   12432397
REFERENCE   5  (bases 1 to 2480)
  AUTHORS   Bradley,J., Frings,S., Yau,K.W. and Reed,R.
  TITLE     Nomenclature for ion channel subunits
  JOURNAL   Science 294 (5549), 2095-2096 (2001)
   PUBMED   11764791
REFERENCE   6  (bases 1 to 2480)
  AUTHORS   Munger,S.D., Lane,A.P., Zhong,H., Leinders-Zufall,T., Yau,K.W.,
            Zufall,F. and Reed,R.R.
  TITLE     Central role of the CNGA4 channel subunit in
            Ca2+-calmodulin-dependent odor adaptation
  JOURNAL   Science 294 (5549), 2172-2175 (2001)
   PUBMED   11739959
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC125055.3.
            
            On May 2, 2007 this sequence version replaced NM_001033317.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136723.1, BC107347.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               AC125055.3         124937-125122       c
            187-288             AC125055.3         124700-124801       c
            289-395             AC125055.3         124414-124520       c
            396-1041            AC125055.3         123563-124208       c
            1042-1391           AC125055.3         122540-122889       c
            1392-2480           AC125055.3         120952-122040       c
FEATURES             Location/Qualifiers
     source          1..2480
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 55.85 cM"
     gene            1..2480
                     /gene="Cnga4"
                     /gene_synonym="OCNC2"
                     /note="cyclic nucleotide gated channel alpha 4"
                     /db_xref="GeneID:233649"
                     /db_xref="MGI:MGI:2664099"
     exon            1..186
                     /gene="Cnga4"
                     /gene_synonym="OCNC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1852
                     /gene="Cnga4"
                     /gene_synonym="OCNC2"
                     /note="olfactory cyclic nucleotide-gated channel; cyclic
                     nucleotide-gated cation channel alpha-4; CNG4; CNG-4; CNG
                     channel alpha-4; cyclic nucleotide gated cation channel;
                     olfactory cyclic nucleotide-gated channel subunit 2"
                     /codon_start=1
                     /product="cyclic nucleotide-gated channel alpha-4"
                     /protein_id="NP_001028489.1"
                     /db_xref="CCDS:CCDS21650.1"
                     /db_xref="GeneID:233649"
                     /db_xref="MGI:MGI:2664099"
                     /translation="MSQDSKVKTTESTPPAPTKARKWLPVLDPSGDYYYWWLNTMVFP
                     IMYNLIIVVCRACFPDLQHSYLVAWFVLDYTSDLLYLLDIGVRFHTGFLEQGILVVDK
                     SMIASRYVRTWSFLLDLASLVPTDAAYVQLGPHIPTLRLNRFLRVPRLFEAFDRTETR
                     TAYPNAFRIAKLMIYIFVVIHWNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQY
                     LYSFYFSTLILTTVGDTPLPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTAD
                     AAFYPDHALVKKYMKLQHVNRRLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEV
                     AVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGREMYIIREGQ
                     LAVVADDGVTQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDL
                     REVLSEYPQAQAVMEEKGREILLKMNKLDVNAEAAEIALQEATESRLKGLDQQLDDLQ
                     TKFARLLAELESSALKIAYRIERLEWQTREWPMPDDMGEADDEAEPGEGTSKDGEEKA
                     GQEGPSGLE"
     exon            187..288
                     /gene="Cnga4"
                     /gene_synonym="OCNC2"
                     /inference="alignment:Splign:2.1.0"
     exon            289..395
                     /gene="Cnga4"
                     /gene_synonym="OCNC2"
                     /inference="alignment:Splign:2.1.0"
     exon            396..1041
                     /gene="Cnga4"
                     /gene_synonym="OCNC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1391
                     /gene="Cnga4"
                     /gene_synonym="OCNC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..2480
                     /gene="Cnga4"
                     /gene_synonym="OCNC2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagacagaa agacgcagct ggagccccag ggcagcttct tccaggaagc caggcacttt
       61 ctcaagccac ctctaattgg cgaagtcctg gatatcctac aggctaggac cacactacag
      121 aaacatgagc caggacagca aagtgaagac aacagagtcc acgcccccag ccccaaccaa
      181 agccaggaag tggctgccag tcctagaccc atctggggat tattactact ggtggctgaa
      241 cacgatggtc ttcccaatca tgtataatct catcatcgtt gtatgcaggg cctgctttcc
      301 tgacttgcaa cacagttacc tggtggcctg gtttgtgctg gactacacga gtgacctgct
      361 gtacctacta gatattgggg tacgcttcca cacaggattc ctagaacagg gcatcctggt
      421 ggtagacaaa agcatgatcg ccagtcgcta tgtacgcacc tggagcttcc tgttggacct
      481 ggcttccctg gtccccacag atgcagccta cgtgcagcta ggcccccaca tccctacact
      541 ccggctaaac cgctttctcc gagtgcctcg cctctttgag gctttcgacc gtacagagac
      601 ccgcacagct tacccaaatg ccttccgcat agccaagctg atgatctaca tttttgtcgt
      661 catccattgg aacagctgct tatacttcgc cctgtccagg tacctgggct tcggacggga
      721 tgcatgggta tacccagacc ctgcgcagcc tggctttgag cgcttgcggc gccagtatct
      781 ctacagcttc tacttctcca ctctgatcct gaccactgtg ggtgacacac cgctgccagc
      841 ccgagaggaa gagtacctct tcatggtggg tgacttcctg ctggccgtca tgggtttcgc
      901 caccatcatg ggtagcatga gctctgtcat ttacaacatg aacacggcag atgcagcctt
      961 ctacccagac catgctctgg taaagaaata catgaagcta cagcacgtca accgaaggct
     1021 ggagcggcgc gttattgact ggtaccagca tctgcagatc aacaagaaga tgaccaatga
     1081 ggtagccatc ttgcagcact tgcctgagcg gctgcgggca gaggtcgctg tatccgtaca
     1141 cctgtctacc ctgagccgag tacagatctt ccagaactgt gaagccagcc tgctggaaga
     1201 gctggtgcta aagctccagc cccagaccta ctcaccaggc gaatacgtat gccgcaaagg
     1261 ggacattggc cgagagatgt acatcatccg cgagggccag ctggctgtgg tggcagatga
     1321 cggtgtcaca cagtatgctg tgcttggtgc agggctctac tttggggaga ttagcatcat
     1381 caacatcaaa gggaacatgt ctggaaaccg acgaacagct aacatcaaga gcctgggcta
     1441 ttcagacctc ttctgcctca gcaaggagga tctacgggag gtgctgagtg agtacccaca
     1501 ggcccaggca gtcatggagg agaagggccg tgaaatcttg ctcaaaatga ataaattgga
     1561 tgtgaatgct gaggcagctg agatcgccct ccaggaggcc acagagtctc ggctgaaagg
     1621 cctcgaccag cagcttgatg acctacagac caagtttgct cgcctcctgg ctgagctgga
     1681 gtccagcgca ctgaagatag cttaccgcat tgaaaggctg gagtggcaga ctcgagagtg
     1741 gccgatgcca gacgacatgg gtgaggctga tgatgaggct gagcctggag aaggaacgtc
     1801 caaggatgga gaggaaaaag ctggccagga gggaccctca ggcctagaat gaccccattc
     1861 tcaccctagg actcccagct caagtaattc cagagtggta ggaaagtctg cctgcaggaa
     1921 ttgtcatcct atttgctagg tcacagaaac ttaggtaaat tggcctagag atgcctagct
     1981 atggatgtgg gtcatagcat acatgtccca tactcaccag cagcacacac acatgcacac
     2041 actcaggctc aggcgcaaga ctgagttcca cataaaatgt tcctgtcttc tgctcccagt
     2101 gcatcctcat aaacatacct atgacttatg ctcaccctgt gatcacagag aacaatttaa
     2161 tgcactggga ctgctggggt gacctttgta catttaaagg aggtcgctgg tataggagga
     2221 caaggacagt gtgaagctac agggaaagaa ggcagttaaa atttctaaac tactagatca
     2281 ctgcttcagc tgcttccagg catggccaga cttcaggtct gagctgggcc aggtagtatt
     2341 ttaaaatgaa cgtgatgtgt aacttagagt tcagctagat aatacacatc attattggga
     2401 gagattaaga gagttattac cctttaaaac attttaaaat atgtaattat tttgtgactt
     2461 attaataaaa tgtaaggttc
//
