LOCUS       NM_001282010            3623 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus cyclic nucleotide gated channel alpha 3 (Cnga3),
            transcript variant 1, mRNA.
ACCESSION   NM_001282010
VERSION     NM_001282010.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3623)
  AUTHORS   Dai X, Jin X, Ye Q, Huang H, Duo L, Lu C, Bao J and Chen H.
  TITLE     Intraperitoneal chromophore injections delay early-onset and rapid
            retinal cone degeneration in a mouse model of Leber congenital
            amaurosis
  JOURNAL   Exp Eye Res 212, 108776 (2021)
   PUBMED   34582935
REFERENCE   2  (bases 1 to 3623)
  AUTHORS   Javed A, Mattar P, Lu S, Kruczek K, Kloc M, Gonzalez-Cordero A,
            Bremner R, Ali RR and Cayouette M.
  TITLE     Pou2f1 and Pou2f2 cooperate to control the timing of cone
            photoreceptor production in the developing mouse retina
  JOURNAL   Development 147 (18) (2020)
   PUBMED   32878923
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3623)
  AUTHORS   Yang F, Ma H, Butler MR and Ding XQ.
  TITLE     Potential contribution of ryanodine receptor 2 upregulation to
            cGMP/PKG signaling-induced cone degeneration in cyclic
            nucleotide-gated channel deficiency
  JOURNAL   FASEB J 34 (5), 6335-6350 (2020)
   PUBMED   32173907
REFERENCE   4  (bases 1 to 3623)
  AUTHORS   Collin GB, Gogna N, Chang B, Damkham N, Pinkney J, Hyde LF, Stone
            L, Naggert JK, Nishina PM and Krebs MP.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3623)
  AUTHORS   Feketa VV, Nikolaev YA, Merriman DK, Bagriantsev SN and Gracheva
            EO.
  TITLE     CNGA3 acts as a cold sensor in hypothalamic neurons
  JOURNAL   Elife 9, e55370 (2020)
   PUBMED   32270761
  REMARK    GeneRIF: CNGA3 acts as a cold sensor in hypothalamic neurons.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3623)
  AUTHORS   Wissinger B, Gamer D, Jagle H, Giorda R, Marx T, Mayer S, Tippmann
            S, Broghammer M, Jurklies B, Rosenberg T, Jacobson SG, Sener EC,
            Tatlipinar S, Hoyng CB, Castellan C, Bitoun P, Andreasson S,
            Rudolph G, Kellner U, Lorenz B, Wolff G, Verellen-Dumoulin C,
            Schwartz M, Cremers FP, Apfelstedt-Sylla E, Zrenner E, Salati R,
            Sharpe LT and Kohl S.
  TITLE     CNGA3 mutations in hereditary cone photoreceptor disorders
  JOURNAL   Am J Hum Genet 69 (4), 722-737 (2001)
   PUBMED   11536077
REFERENCE   7  (bases 1 to 3623)
  AUTHORS   Seeliger MW, Grimm C, Stahlberg F, Friedburg C, Jaissle G, Zrenner
            E, Guo H, Reme CE, Humphries P, Hofmann F, Biel M, Fariss RN,
            Redmond TM and Wenzel A.
  TITLE     New views on RPE65 deficiency: the rod system is the source of
            vision in a mouse model of Leber congenital amaurosis
  JOURNAL   Nat Genet 29 (1), 70-74 (2001)
   PUBMED   11528395
REFERENCE   8  (bases 1 to 3623)
  AUTHORS   Hirano AA, Hack I, Wassle H and Duvoisin RM.
  TITLE     Cloning and immunocytochemical localization of a cyclic
            nucleotide-gated channel alpha-subunit to all cone photoreceptors
            in the mouse retina
  JOURNAL   J Comp Neurol 421 (1), 80-94 (2000)
   PUBMED   10813773
REFERENCE   9  (bases 1 to 3623)
  AUTHORS   Gerstner A, Zong X, Hofmann F and Biel M.
  TITLE     Molecular cloning and functional characterization of a new
            modulatory cyclic nucleotide-gated channel subunit from mouse
            retina
  JOURNAL   J Neurosci 20 (4), 1324-1332 (2000)
   PUBMED   10662822
REFERENCE   10 (bases 1 to 3623)
  AUTHORS   Biel M, Seeliger M, Pfeifer A, Kohler K, Gerstner A, Ludwig A,
            Jaissle G, Fauser S, Zrenner E and Hofmann F.
  TITLE     Selective loss of cone function in mice lacking the cyclic
            nucleotide-gated channel CNG3
  JOURNAL   Proc Natl Acad Sci U S A 96 (13), 7553-7557 (1999)
   PUBMED   10377453
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133096.3, CJ167467.1 and BC035272.1.
            
            [WARNING] On Apr 25, 2023 this sequence was replaced by
            NM_001282010.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849375, SAMN00849377
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AC133096.3         129412-129469       c
            59-479              CJ167467.1         1-421
            480-526             AC133096.3         105807-105853       c
            527-3623            BC035272.1         416-3512
FEATURES             Location/Qualifiers
     source          1..3623
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..3623
                     /gene="Cnga3"
                     /gene_synonym="CNG3"
                     /note="cyclic nucleotide gated channel alpha 3"
                     /db_xref="GeneID:12790"
                     /db_xref="MGI:MGI:1341818"
     exon            1..164
                     /gene="Cnga3"
                     /gene_synonym="CNG3"
                     /inference="alignment:Splign:2.1.0"
     exon            165..275
                     /gene="Cnga3"
                     /gene_synonym="CNG3"
                     /inference="alignment:Splign:2.1.0"
     exon            276..412
                     /gene="Cnga3"
                     /gene_synonym="CNG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..2321
                     /gene="Cnga3"
                     /gene_synonym="CNG3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclic nucleotide-gated cation channel alpha-3; CNG-3; CNG
                     channel alpha-3; cone photoreceptor cGMP-gated channel
                     subunit alpha; cyclic nucleotide-gated channel subunit
                     alpha 3"
                     /codon_start=1
                     /product="cyclic nucleotide-gated cation channel alpha-3
                     isoform 1"
                     /protein_id="NP_001268939.1"
                     /db_xref="CCDS:CCDS78566.1"
                     /db_xref="GeneID:12790"
                     /db_xref="MGI:MGI:1341818"
                     /translation="MAKVNTQCSQPSPTQLSIKNADRDLDHVENGLGRSHSPCEETSS
                     TLQQGIAMETRGLAGSARSVVTSQGPARVSRLIISIRAWASRHLHDEDQTPDSFLDRF
                     HGSELKEVSTRESNAQPNPGEQKPPDGGEGRKEEPIVVDPSSNIYYRWLTAIALPVFY
                     NWCLLVCRACFDELQSEHLTLWLVLDYSADVLYVLDMLVRARTGFLEQGLMVRDTKRL
                     WKHYTKTLHFKLDILSLIPTDLAYLKLGVNYPELRFNRLLKFSRLFEFFDRTETRTNY
                     PNVFRIGNLVLYTLIIIHWNACIYFAISKFIGFGTDSWVYPNTSKPEYARLSRKYIYS
                     LYWSTLTLTTIGETPPPVKDEEYLFVVIDFLVGILIFATIVGNVGSMISNMNAPRVEF
                     QAKIDSVKQYMQFRKVTKDLETRVIRWFDYLWANRKTVDEKEVLKNLPDKLKAEIAIN
                     VHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGREMYIIKEGKLAV
                     VADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEA
                     LTEYPDAKRALEEKGRQILMKDNLIDEDLVAARVDTRDVEEKVEYLESSLDILQTRFA
                     RLLAEYSASQMKLKQRLTRLESQMNRRCCGFSPDRENSEDASKTD"
     exon            413..526
                     /gene="Cnga3"
                     /gene_synonym="CNG3"
                     /inference="alignment:Splign:2.1.0"
     exon            527..706
                     /gene="Cnga3"
                     /gene_synonym="CNG3"
                     /inference="alignment:Splign:2.1.0"
     exon            707..814
                     /gene="Cnga3"
                     /gene_synonym="CNG3"
                     /inference="alignment:Splign:2.1.0"
     exon            815..921
                     /gene="Cnga3"
                     /gene_synonym="CNG3"
                     /inference="alignment:Splign:2.1.0"
     exon            922..3609
                     /gene="Cnga3"
                     /gene_synonym="CNG3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagttactc cgcctgctgg acccagaaga ccatgccgga gacagggagc tgaagagcag
       61 gagaaagaag tccgggctgt tgcccagaac agagagagag agagagagag gaaggagtcg
      121 ctctcccaga tccaggcgca ccaagaagcc caaactttga caggaagcaa gcgtcttcct
      181 aggcacggct tgcctccttc aagaaggaga cttaagcaga gcggtgtgga gtctgcagcc
      241 ttcgataagc aggcattggt gaaacagcct cacagcaggc caccccgggg ctgaatgtga
      301 cctgtgcaga gatggcaaag gtgaacaccc agtgttcaca gccctccccg acccaacttt
      361 caataaagaa tgcggacaga gatctcgacc acgtagagaa cggcctgggc aggtctcact
      421 caccatgtga ggagacatct tccacactgc agcaagggat cgccatggag acccgaggac
      481 tggctggatc cgcacggagc gtagtcacaa gccagggacc agccagggtg tcacgcctca
      541 tcatctcgat tcgtgcgtgg gcctccaggc acttacacga tgaagaccag acacctgact
      601 cctttttgga tcgatttcat ggatctgagc ttaaggaagt ctccacccgg gaaagcaatg
      661 cccagcccaa cccaggagaa cagaagccac cagacggagg ggaaggcagg aaggaggagc
      721 ccattgtggt ggacccctcc agcaacatct actaccgctg gctgactgcc atcgcgctcc
      781 cagtcttcta taactggtgt ctacttgtat gcagggcctg ttttgatgag ctacaatcag
      841 agcacctgac gctgtggctg gtcttggact actctgcaga tgtcctttat gttttagaca
      901 tgctggttcg agcccggaca ggtttccttg agcaaggcct aatggtcaga gataccaaga
      961 ggctgtggaa acattacaca aagaccttgc acttcaagct ggacatcctg tctctcatcc
     1021 ccacagacct ggcttattta aagttgggcg tgaactaccc agaactgagg ttcaaccgcc
     1081 tcctgaagtt ctctcggctc tttgaattct ttgaccgcac agagacaagg accaactacc
     1141 ccaacgtgtt caggataggg aacttggtcc tttacacact catcatcatc cactggaatg
     1201 cctgcatcta ctttgccatt tccaagttca ttggttttgg gacagactcc tgggtctatc
     1261 caaacacctc caagccggag tatgcacgac tctcccggaa gtacatttac agtctctact
     1321 ggtccaccct gaccctgacc accattggtg agaccccacc ccccgtgaaa gatgaagagt
     1381 atctctttgt ggtcatcgac ttcctggtgg gtatcctgat ctttgccacc atagtgggca
     1441 acgtaggctc catgatttcc aacatgaacg ctccccgggt agagttccag gctaagatcg
     1501 actccgtcaa gcagtacatg cagttccgga aggtaaccaa ggacttggag actcgggtta
     1561 tccggtggtt tgactatctg tgggccaaca ggaagacggt ggatgaaaag gaagtgctca
     1621 aaaacctccc ggacaagctg aaggctgaga tcgccatcaa cgtgcacctg gacacgctga
     1681 agaaggtccg aatcttccag gactgcgagg cggggctgct ggtggagctg gtgctgaagc
     1741 tccgccccac tgtgttcagc cccggggact acatatgcaa aaagggggac attggaagag
     1801 agatgtacat catcaaggag ggcaagctgg ctgtggtggc tgatgacggg gtcacccagt
     1861 ttgtggtcct cagtgacggc agttactttg gggagattag catcttaaac attaagggga
     1921 gcaagtctgg gaaccgcagg acggccaaca tcaggagtat cggctactca gacctgttct
     1981 gcctctccaa ggatgaccta atggaagccc tcaccgagta cccagacgct aagagggctc
     2041 tggaggaaaa gggccgtcag attctgatga aggacaacct aattgatgag gacctagtcg
     2101 cggccagggt agataccagg gacgttgagg agaaggtgga gtacctggag tcgtccctgg
     2161 acatcctgca gacgaggttt gcccgactcc tggctgagta cagtgcctcc cagatgaagc
     2221 tgaaacagcg gctcactcgg ctggagagcc agatgaacag gaggtgttgt ggcttctcac
     2281 ctgacaggga gaattccgag gatgcttcaa agactgactg aaaatgcagg tggctctgcc
     2341 tcctgctccc cccccccccc cccggggcca gctctctggg cgacactata tagcctcggg
     2401 gtaaagggtt tggctgtggt ttcgcctcag tgctactcat cctttgggag tggtgtgaca
     2461 gcaaggaaga gccttagttt cctctcctat gaaatgggac tcatggctgt cggccccaga
     2521 agttccagac tatcatgagg tggcgaaggt tgtggctttg gaaagcgtga agagttccca
     2581 acccagtgta taagcatatg tgcacatgat tctaatgttg ttagttatgt tggcatatgg
     2641 gtatgttcag ttgtcggcgg aggtcaggag agggcgttgc atcccctggg ctggagttac
     2701 ctgctgttgt aagctaccca gcatgggtgc tgggatcctg tcttcattag ggttactatt
     2761 gctgtgatga aatatcataa ccaatgcaag ttaggaagaa aaggtttttt tttcggctta
     2821 cactccacat catagtccat cattgaagga agtcagggca ggaactcaaa ctgggcagga
     2881 agctggaggc aggagctgat gcagaggcca taaaggggag ctgcttactg gtttgctctt
     2941 cttagcttgc taagcctgct ttcttataga acccagaacc accagcccgg gagtagtcct
     3001 acttgcaatg ggctaggccc tccttcatct atcattagtt aaggaaatgc tccacggact
     3061 tgcctacagc tggatcttag ggaggcattt tctcagtcat cctctcagat gactctaact
     3121 tgtgtcaagt tgacataaaa atccgaccag cacaaatcca aacgtgtagt ccttcccata
     3181 tttattgagg tgaaggtcct gctctgttac ccagtccagc cttcaactcc catgcccaag
     3241 tgttgtcccc tcgccagcct tccaagtagc tgggaccaca ggcacactcc actgtttcca
     3301 acccagataa gttttgtttt gttttgtttt gttttgtttt gttttgtttt aatgaaatcc
     3361 atgggaatgt ttaagcccct tatcctagct atgttataaa tggatgtctt acggggctgg
     3421 tgagataact cagtggttaa gagcactagc tgctcttcca gaggtcatga gttcaattcc
     3481 cagcaaccac aaggtggctc acaaccatct atagggggat ctgatgccct cttcgggcag
     3541 gtggatatat gtgcaaaaga gcactcatac attaaataat aaatacaatt aaagatatat
     3601 ataaatggaa aaaaaaaaaa aaa
//
