LOCUS       NM_001410247            3262 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cyclic nucleotide gated channel alpha 2 (Cnga2),
            transcript variant 2, mRNA.
ACCESSION   NM_001410247 XM_036161804
VERSION     NM_001410247.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3262)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3262)
  AUTHORS   Fujimoto,S., Leiwe,M.N., Aihara,S., Sakaguchi,R., Muroyama,Y.,
            Kobayakawa,R., Kobayakawa,K., Saito,T. and Imai,T.
  TITLE     Activity-dependent local protection and lateral inhibition control
            synaptic competition in developing mitral cells in mice
  JOURNAL   Dev Cell 58 (14), 1221-1236 (2023)
   PUBMED   37290446
REFERENCE   3  (bases 1 to 3262)
  AUTHORS   Koike,K., Yoo,S.J., Bleymehl,K., Omura,M., Zapiec,B., Pyrski,M.,
            Blum,T., Khan,M., Bai,Z., Leinders-Zufall,T., Mombaerts,P. and
            Zufall,F.
  TITLE     Danger perception and stress response through an olfactory sensor
            for the bacterial metabolite hydrogen sulfide
  JOURNAL   Neuron 109 (15), 2469-2484 (2021)
   PUBMED   34186026
REFERENCE   4  (bases 1 to 3262)
  AUTHORS   Nakashima,A., Ihara,N., Shigeta,M., Kiyonari,H., Ikegaya,Y. and
            Takeuchi,H.
  TITLE     Structured spike series specify gene expression patterns for
            olfactory circuit formation
  JOURNAL   Science 365 (6448) (2019)
   PUBMED   31171707
REFERENCE   5  (bases 1 to 3262)
  AUTHORS   Lin,D.M., Wang,F., Lowe,G., Gold,G.H., Axel,R., Ngai,J. and
            Brunet,L.
  TITLE     Formation of precise connections in the olfactory bulb occurs in
            the absence of odorant-evoked neuronal activity
  JOURNAL   Neuron 26 (1), 69-80 (2000)
   PUBMED   10798393
REFERENCE   6  (bases 1 to 3262)
  AUTHORS   Baker,H., Cummings,D.M., Munger,S.D., Margolis,J.W., Franzen,L.,
            Reed,R.R. and Margolis,F.L.
  TITLE     Targeted deletion of a cyclic nucleotide-gated channel subunit
            (OCNC1): biochemical and morphological consequences in adult mice
  JOURNAL   J Neurosci 19 (21), 9313-9321 (1999)
   PUBMED   10531436
REFERENCE   7  (bases 1 to 3262)
  AUTHORS   Parent,A., Schrader,K., Munger,S.D., Reed,R.R., Linden,D.J. and
            Ronnett,G.V.
  TITLE     Synaptic transmission and hippocampal long-term potentiation in
            olfactory cyclic nucleotide-gated channel type 1 null mouse
  JOURNAL   J Neurophysiol 79 (6), 3295-3301 (1998)
   PUBMED   9636130
REFERENCE   8  (bases 1 to 3262)
  AUTHORS   Brunet,L.J., Gold,G.H. and Ngai,J.
  TITLE     General anosmia caused by a targeted disruption of the mouse
            olfactory cyclic nucleotide-gated cation channel
  JOURNAL   Neuron 17 (4), 681-693 (1996)
   PUBMED   8893025
REFERENCE   9  (bases 1 to 3262)
  AUTHORS   Ruiz,M.L., London,B. and Nadal-Ginard,B.
  TITLE     Cloning and characterization of an olfactory cyclic
            nucleotide-gated channel expressed in mouse heart
  JOURNAL   J Mol Cell Cardiol 28 (7), 1453-1461 (1996)
   PUBMED   8841933
REFERENCE   10 (bases 1 to 3262)
  AUTHORS   Miyawaki,A., Homma,H., Tamura,H., Matsui,M. and Mikoshiba,K.
  TITLE     Zonal distribution of sulfotransferase for phenol in olfactory
            sustentacular cells
  JOURNAL   EMBO J 15 (9), 2050-2055 (1996)
   PUBMED   8641270
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL731693.9.
            
            [WARNING] On May 7, 2024 this sequence was replaced by
            NM_001410247.2.
            
            On Aug 1, 2022 this sequence version replaced XM_036161804.1.
            
            Summary: This gene encodes a transmembrane protein that is the main
            subunit of the nucleotide-gated olfactory ion channel, which plays
            a key role in transducing chemosensory signal resulting from
            hydrogen sulphide exposure. Signaling pathways mediated by this
            gene operate in the cilia of type B cells. Knock out of this gene
            affects development of the olfactory epithelium and olfactory bulb.
            [provided by RefSeq, Aug 2022].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363660.2964678.1,
                                           SRR1660811.252332.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-541               AL731693.9         129355-129895
            542-677             AL731693.9         131578-131713
            678-773             AL731693.9         132247-132342
            774-944             AL731693.9         133181-133351
            945-1052            AL731693.9         134419-134526
            1053-1159           AL731693.9         136040-136146
            1160-3262           AL731693.9         136424-138526
FEATURES             Location/Qualifiers
     source          1..3262
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.15 cM"
     gene            1..3262
                     /gene="Cnga2"
                     /gene_synonym="Cnca; Cncg4; CNG2; OCNC1"
                     /note="cyclic nucleotide gated channel alpha 2"
                     /db_xref="GeneID:12789"
                     /db_xref="MGI:MGI:108040"
     exon            1..541
                     /gene="Cnga2"
                     /gene_synonym="Cnca; Cncg4; CNG2; OCNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            542..677
                     /gene="Cnga2"
                     /gene_synonym="Cnca; Cncg4; CNG2; OCNC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             565..2559
                     /gene="Cnga2"
                     /gene_synonym="Cnca; Cncg4; CNG2; OCNC1"
                     /note="CNG channel alpha-2; cyclic nucleotide-gated cation
                     channel 2; cyclic nucleotide gated channel 4"
                     /codon_start=1
                     /product="cyclic nucleotide-gated olfactory channel"
                     /protein_id="NP_001397176.1"
                     /db_xref="GeneID:12789"
                     /db_xref="MGI:MGI:108040"
                     /translation="MMTEKSNGVKSSPANNHNHHPPPSIKANGKDDHRAGSRPQSVAA
                     DDDTSSELQRLAEMDTPRRGRGGFRRIVRLVGIIRDWANKNFREEEPRPDSFLERFRG
                     PELQTVTTHQGDGKGDKDGEGKGTKKKFELFVLDPAGDWYYRWLFVIAMPVLYNWCLL
                     VARACFSDLQRNYFVVWLVLDYFSDTVYIADLIIRLRTGFLEQGLLVKDPKKLRDNYI
                     HTLQFKLDVASIIPTDLIYFAVGIHSPEVRFNRLLHFARMFEFFDRTETRTSYPNIFR
                     ISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWST
                     LTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKID
                     AVKHYMQFRKVSKDMEAKVIKWFDYLWTNKKTVDEREVLKNLPAKLRAEIAINVHLST
                     LKKVRIFQDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDG
                     VTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYP
                     DAKKVLEERGREILMKEGLLDENEVAASMEVDVQEKLEQLETNMETLYTRFARLLAEY
                     TGAQQKLKQRITVLETKMKQNHEDDYLSDGINTPEPAVAE"
     exon            678..773
                     /gene="Cnga2"
                     /gene_synonym="Cnca; Cncg4; CNG2; OCNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            774..944
                     /gene="Cnga2"
                     /gene_synonym="Cnca; Cncg4; CNG2; OCNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1052
                     /gene="Cnga2"
                     /gene_synonym="Cnca; Cncg4; CNG2; OCNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1159
                     /gene="Cnga2"
                     /gene_synonym="Cnca; Cncg4; CNG2; OCNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..3262
                     /gene="Cnga2"
                     /gene_synonym="Cnca; Cncg4; CNG2; OCNC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3244..3249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnga2"
                     /gene_synonym="Cnca; Cncg4; CNG2; OCNC1"
                     /note="hexamer: AATAAA"
     polyA_site      3262
                     /gene="Cnga2"
                     /gene_synonym="Cnca; Cncg4; CNG2; OCNC1"
                     /note="major polyA site"
ORIGIN      
        1 tttttttttt gcagagtgtg ccattgagaa cctgcgtaac tgtgtgagct gagacaatgt
       61 ttagctggct gttctgattc ccctaaatgg acagttctga tgaaggccat gtgtggttgg
      121 gtgatgtcac aagggagtca gaaaaatagg aggcctgttt ctgttagaga aactgtagag
      181 agtcacagag gaggaatatt ttttaatgcc aaaagcatag agagagaaaa tatgtgttgt
      241 agtgtcctct gatctgcaag cttgcacttc aacacaacca gtcctgaaat tgatcagtgt
      301 gagtggccct ggatttgttt ccattgcctg ggacatcttt gtctccatgg tctgctgcct
      361 ccagggtcca agcaagtact tgtggatgct ggtttctttc cctcaggtat cctcattagc
      421 atcctgatgc catagtccca cagagagcac caggaaagca tctctgaggc tgcttgacgt
      481 gactgccgtc accatggtga ctgcttcgga tgctggaaga agtgaaagag gctggaaaga
      541 ggtgagagcc ctggatgtac atggatgatg accgaaaaat ccaacggtgt gaagagctct
      601 ccagctaata accataacca tcatcctcct ccttctatca aggccaatgg caaagatgac
      661 cacagggcag gtagcagacc acagtctgtg gcagctgatg atgacacttc ctcagaactg
      721 caaaggttgg cagagatgga tactccacgc aggggaaggg gtggcttccg aaggattgtc
      781 cgcctggtgg ggatcatcag agactgggcc aacaaaaatt tccgtgagga ggaaccaaga
      841 cctgactcct tcctagagcg tttccgtggg cctgagctcc agactgtgac aacccatcag
      901 ggggatggca aaggcgacaa ggacggcgag ggaaagggca ccaaaaagaa atttgaactg
      961 tttgttttgg acccagctgg agactggtat taccgttggt tgtttgtcat tgccatgcct
     1021 gttctttaca actggtgtct gttggtagcc agagcctgct tcagtgatct acagagaaac
     1081 tattttgtgg tatggctggt gctggattac ttctcagaca ctgtttatat tgcagacctc
     1141 atcattcggc tgcgcacagg cttcctagaa caagggctcc tggtcaaaga ccccaagaaa
     1201 ttgcgagaca actatatcca cactttgcag ttcaaattgg atgtggcttc tatcatcccc
     1261 actgacctca tttattttgc tgtgggtatc cacagccctg aggtacgctt taatcgtctg
     1321 ttacactttg cccgtatgtt tgagttcttt gaccgcactg agacacgtac aagctacccc
     1381 aacatcttcc gaatcagcaa cctggtcctc tacatcttgg tcatcatcca ctggaatgct
     1441 tgtatttact atgctatctc taagtccatt ggctttgggg ttgacacctg ggtttacccc
     1501 aacattactg accctgaata tggctacctg gctagggagt acatttactg cctttactgg
     1561 tccacactga ccctcaccac cattggagag acaccacccc ctgtaaagga tgaggagtac
     1621 ctatttgtca tctttgactt cctgattggt gtcctcatct ttgccactat tgtgggaaat
     1681 gtgggctcca tgatctccaa catgaatgcc acacgagcag agttccaggc caagattgat
     1741 gctgtcaaac actacatgca gttccgaaag gtcagtaaag acatggaagc caaggtcatc
     1801 aaatggtttg actacttgtg gaccaataag aagacagtag atgaacgaga agtcctaaag
     1861 aacctgcctg caaagcttag ggcagagata gccattaatg ttcatttgtc cactctgaag
     1921 aaagtgcgca tattccagga ttgtgaagct ggcctgctgg tggaactggt actgaagctt
     1981 cgtcctcagg tctttagtcc tggagattat atttgccgta agggggacat tggcaaggaa
     2041 atgtacatca tcaaggaggg caaattggca gtggtagctg atgatggtgt gactcagtat
     2101 gccttgctgt cagctgggag ctgctttggt gagattagta tccttaacat taagggtagc
     2161 aaaatgggca atcggcgcac tgccaatatc cgtagtctgg gctactcaga tctcttctgc
     2221 ttgtccaagg atgatcttat ggaagctgtg actgagtatc ctgatgccaa gaaagtcctg
     2281 gaagaacggg gtagggagat cctgatgaag gaaggtctac tggatgagaa tgaagtggca
     2341 gctagtatgg aggtagatgt tcaggagaag ctggagcagc tggagacaaa catggagacc
     2401 ttgtacactc gttttgcccg cctgctggct gagtacactg gagcccagca gaagctcaaa
     2461 cagcgcatca cagtgctgga gaccaagatg aaacagaacc atgaggatga ttacctatca
     2521 gatgggataa acacccctga gccagctgtt gctgaatagc cataggtgcc tgtccagcct
     2581 tgctttgacc ccaggagtta gaagtgctgt atagaacttt acatttacac acattatgct
     2641 catgtccctc cgaactccca aagccttgct gaggcttaag gttttggcta catcttggag
     2701 tccccttcca agtccagcta acagccaagc ttgtggataa tggagatcat gtgggttgaa
     2761 tttctaagag cgtgacctcc taagtctcac aaggaatcag agaatagcta aattgtcctt
     2821 cctgaggctt ttctgggact agataactag acagtgttct ctgaagaaca ctgtgcacca
     2881 caatgcctgc ctgactcctt ttagcttctt tatatcgagt cactccctac tgcattctgc
     2941 cccaaatacc tttttaatgt gttctctgaa cagcctgttt ccatgcactt gtacacattt
     3001 aagaattggc tgcagacact gggcccccta ccctgcctcc caaggcatgc aaggtctgtg
     3061 aggggagtgg gaaggtgggt ttgagtgttg gtgctcaggg tcatacttcc ttgtcagaca
     3121 atgtcactct gagaaggagg tggctggcag ctttggccat cacaccttat gcacacaagt
     3181 tctgaagagt ttgtgaaggc tactgctgca tgagatactg tgaattagag gcacttaaaa
     3241 gttaataaat tcctttcagc ta
//
