LOCUS       NM_029074               1832 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus CTD nuclear envelope phosphatase 1 regulatory subunit
            1 (Cnep1r1), mRNA.
ACCESSION   NM_029074 XM_356102
VERSION     NM_029074.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1832)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1832)
  AUTHORS   Horiuchi,K., Perez-Cerezales,S., Papasaikas,P., Ramos-Ibeas,P.,
            Lopez-Cardona,A.P., Laguna-Barraza,R., Fonseca Balvis,N.,
            Pericuesta,E., Fernandez-Gonzalez,R., Planells,B., Viera,A.,
            Suja,J.A., Ross,P.J., Alen,F., Orio,L., Rodriguez de Fonseca,F.,
            Pintado,B., Valcarcel,J. and Gutierrez-Adan,A.
  TITLE     Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12
            Intron Splicing-Defective Zrsr1 Mutant Mice
  JOURNAL   Cell Rep 23 (1), 143-155 (2018)
   PUBMED   29617656
REFERENCE   3  (bases 1 to 1832)
  AUTHORS   Xia,P., Wang,S., Xiong,Z., Zhu,X., Ye,B., Du,Y., Meng,S., Qu,Y.,
            Liu,J., Gao,G., Tian,Y. and Fan,Z.
  TITLE     The ER membrane adaptor ERAdP senses the bacterial second messenger
            c-di-AMP and initiates anti-bacterial immunity
  JOURNAL   Nat Immunol 19 (2), 141-150 (2018)
   PUBMED   29292386
REFERENCE   4  (bases 1 to 1832)
  AUTHORS   Han,S., Bahmanyar,S., Zhang,P., Grishin,N., Oegema,K., Crooke,R.,
            Graham,M., Reue,K., Dixon,J.E. and Goodman,J.M.
  TITLE     Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly
            TMEM188) is the metazoan Spo7p ortholog and functions in the lipin
            activation pathway
  JOURNAL   J Biol Chem 287 (5), 3123-3137 (2012)
   PUBMED   22134922
  REMARK    GeneRIF: Nuclear envelope phosphatase 1-regulatory subunit 1
            (formerly TMEM188) is the metazoan Spo7p ortholog and functions in
            the lipin activation pathway.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY124150.1, AK146578.1 and AC126034.4.
            
            On Nov 15, 2007 this sequence version replaced NM_029074.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.162823.1, AK146578.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BY124150.1         1-10
            11-677              AK146578.1         2-668
            678-1832            AC126034.4         79849-81003         c
FEATURES             Location/Qualifiers
     source          1..1832
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 43.06 cM"
     gene            1..1832
                     /gene="Cnep1r1"
                     /gene_synonym="5033428A16Rik; NEP1-R1; Tmem188"
                     /note="CTD nuclear envelope phosphatase 1 regulatory
                     subunit 1"
                     /db_xref="GeneID:382030"
                     /db_xref="MGI:MGI:1921981"
     exon            1..111
                     /gene="Cnep1r1"
                     /gene_synonym="5033428A16Rik; NEP1-R1; Tmem188"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..464
                     /gene="Cnep1r1"
                     /gene_synonym="5033428A16Rik; NEP1-R1; Tmem188"
                     /note="transmembrane protein 188"
                     /codon_start=1
                     /product="nuclear envelope phosphatase-regulatory subunit
                     1"
                     /protein_id="NP_083350.2"
                     /db_xref="CCDS:CCDS52628.1"
                     /db_xref="GeneID:382030"
                     /db_xref="MGI:MGI:1921981"
                     /translation="MNSLEQAEDLKAFERRLTEYIHCLQPATGRWRMLLIVVSVCTAT
                     GAWNWLIDPETQKVSFFTSLWNHPFFTISCITLIGLFFAGIHKRVVAPSIIAARCRTV
                     LAEYNMSCDDTGKLILKPRPHVQ"
     exon            112..183
                     /gene="Cnep1r1"
                     /gene_synonym="5033428A16Rik; NEP1-R1; Tmem188"
                     /inference="alignment:Splign:2.1.0"
     exon            184..257
                     /gene="Cnep1r1"
                     /gene_synonym="5033428A16Rik; NEP1-R1; Tmem188"
                     /inference="alignment:Splign:2.1.0"
     exon            258..367
                     /gene="Cnep1r1"
                     /gene_synonym="5033428A16Rik; NEP1-R1; Tmem188"
                     /inference="alignment:Splign:2.1.0"
     exon            368..422
                     /gene="Cnep1r1"
                     /gene_synonym="5033428A16Rik; NEP1-R1; Tmem188"
                     /inference="alignment:Splign:2.1.0"
     exon            423..1832
                     /gene="Cnep1r1"
                     /gene_synonym="5033428A16Rik; NEP1-R1; Tmem188"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1726..1731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnep1r1"
                     /gene_synonym="5033428A16Rik; NEP1-R1; Tmem188"
                     /note="hexamer: AATAAA"
     polyA_site      1745
                     /gene="Cnep1r1"
                     /gene_synonym="5033428A16Rik; NEP1-R1; Tmem188"
                     /note="major polyA site"
     regulatory      1795..1800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnep1r1"
                     /gene_synonym="5033428A16Rik; NEP1-R1; Tmem188"
                     /note="hexamer: AATAAA"
     polyA_site      1828
                     /gene="Cnep1r1"
                     /gene_synonym="5033428A16Rik; NEP1-R1; Tmem188"
ORIGIN      
        1 ggtgggagtt ggcgctgtcg gcggggcggg gagggcgggc tgcgatgagg accgggccgt
       61 ggcggtgacc ggagctgccg cccgacatga actcgctgga acaagcggaa gatctcaagg
      121 ctttcgaaag aagacttact gaatatattc attgcttgca acctgccact ggacgttgga
      181 gaatgcttct tatagtggtg tctgtctgta cagctactgg tgcctggaac tggctaatag
      241 atcctgagac acaaaaggtg tccttcttca cgtcattatg gaaccatccg tttttcacta
      301 ttagctgtat aactctaata ggcttgttct ttgctggaat acacaaaaga gtagtcgcac
      361 catcaattat agctgctcga tgtcgaacgg tattagcaga atacaatatg tcctgtgatg
      421 atacaggaaa gctaattttg aaacctagac ctcatgttca atgacagtcc gcactgttgc
      481 tagagaacct aaaccagtct tttctcaagt gagtgataca gcaaaatgcc atagaggatt
      541 ccttttggag tcggacatgt gacggtttag cagcaactga caagaagtgt gcaatattgg
      601 cccagatgat gttgatgatg ctggctgagc tcgcagcgcc tcagtacctt tgattacctg
      661 tgttcagtat tagtgtcact tcagcacttc agcccctgca cagaactctg cggatgaagt
      721 atgtgggtat tactaagtta aacttagaaa ccaaacctcc ttcagttttt ataatgtatt
      781 tttgcaaact attgtaaata gcaaatcaat gccaatgtta aaccaagagg aaaatgtttg
      841 gactttgttc tcctgcacca gtatttgagg aaccatctgc ttgacatctc cacagctcct
      901 taaactggct attacgtgtg cctttcattc ataatgcctc ttcccattgc actgcaggaa
      961 caacatcaaa ttccacttag actgagcaaa tctcatctcc attatgttga aaaatttata
     1021 gatgttttga caatttttgt taagcctgat actagattct ggcaactatt atacttttca
     1081 gtaaattgtt ttcatttaac actaaattac tttttaaaaa aaaaaaattt aaaaacaccc
     1141 caaactcttc tgaatgtaca agttaaaaaa ttatgtatta tctgggaatt tgacagtcct
     1201 tatttcaggt gactggattt tatgctgtgg tagacgtgtt acactaatac cgtcctggtg
     1261 tagctgatgg gccccgtcca tcactagtaa cacagaacca cactacaaac cagagcctgc
     1321 agctctctct gctggagagt gttgatggca tactgtgtat gcgcaacagc cacgtgtact
     1381 acagtagccc ttaaaataaa actgtcggaa ttgctgtaaa tgcttaaagt actagaggtg
     1441 ccttttacct gtttattaga agattttgag aaagttaaat tatttcatga gcaatatgtt
     1501 aaatttcatc caacattaaa ctaaatttga ataacaggac aaaatcgttt aacaaagctg
     1561 ccatttaact tacatgtatt catctctact ttcctgggta taaaatcaca ttctttgaat
     1621 tgcagcaata aaaccctctg cttctaagaa ctctctaaga gggtattcta tgtgttttgc
     1681 attgtttcat tttctgtaaa ttttgtaggt aaatatgtgt ataaaaataa atactttata
     1741 tataactagt ggttagagat tttctttggt ttattgtgtc tgcaactata aaaaaataaa
     1801 catattctaa gtatcagata caagctaact cc
//
