LOCUS       NM_001289531            2169 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus CNDP dipeptidase 2 (Cndp2), transcript variant 1,
            mRNA.
ACCESSION   NM_001289531
VERSION     NM_001289531.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2169)
  AUTHORS   Moya-Garzon,M.D., Wang,M., Li,V.L., Lyu,X., Wei,W., Tung,A.S.,
            Raun,S.H., Zhao,M., Coassolo,L., Islam,H., Oliveira,B., Dai,Y.,
            Spaas,J., Delgado-Gonzalez,A., Donoso,K., Alvarez-Buylla,A.,
            Franco-Montalban,F., Letian,A., Ward,C.P., Liu,L., Svensson,K.J.,
            Goldberg,E.L., Gardner,C.D., Little,J.P., Banik,S.M., Xu,Y. and
            Long,J.Z.
  TITLE     A beta-hydroxybutyrate shunt pathway generates anti-obesity ketone
            metabolites
  JOURNAL   Cell 188 (1), 175-186 (2025)
   PUBMED   39536746
REFERENCE   2  (bases 1 to 2169)
  AUTHORS   Xiao,S., Li,V.L., Lyu,X., Chen,X., Wei,W., Abbasi,F., Knowles,J.W.,
            Tung,A.S., Deng,S., Tiwari,G., Shi,X., Zheng,S., Farrell,L.,
            Chen,Z.Z., Taylor,K.D., Guo,X., Goodarzi,M.O., Wood,A.C.,
            Chen,Y.I., Lange,L.A., Rich,S.S., Rotter,J.I., Clish,C.B.,
            Tahir,U.A., Gerszten,R.E., Benson,M.D. and Long,J.Z.
  TITLE     Lac-Phe mediates the effects of metformin on food intake and body
            weight
  JOURNAL   Nat Metab 6 (4), 659-669 (2024)
   PUBMED   38499766
REFERENCE   3  (bases 1 to 2169)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2169)
  AUTHORS   Li,V.L., He,Y., Contrepois,K., Liu,H., Kim,J.T., Wiggenhorn,A.L.,
            Tanzo,J.T., Tung,A.S., Lyu,X., Zushin,P.H., Jansen,R.S.,
            Michael,B., Loh,K.Y., Yang,A.C., Carl,C.S., Voldstedlund,C.T.,
            Wei,W., Terrell,S.M., Moeller,B.C., Arthur,R.M., Wallis,G.A., van
            de Wetering,K., Stahl,A., Kiens,B., Richter,E.A., Banik,S.M.,
            Snyder,M.P., Xu,Y. and Long,J.Z.
  TITLE     An exercise-inducible metabolite that suppresses feeding and
            obesity
  JOURNAL   Nature 606 (7915), 785-790 (2022)
   PUBMED   35705806
REFERENCE   5  (bases 1 to 2169)
  AUTHORS   Kobayashi,S., Homma,T., Okumura,N., Han,J., Nagaoka,K., Sato,H.,
            Konno,H., Yamada,S., Takao,T. and Fujii,J.
  TITLE     Carnosine dipeptidase II (CNDP2) protects cells under cysteine
            insufficiency by hydrolyzing glutathione-related peptides
  JOURNAL   Free Radic Biol Med 174, 12-27 (2021)
   PUBMED   34324979
REFERENCE   6  (bases 1 to 2169)
  AUTHORS   Leinwand,L.A. and Ruddle,F.H.
  TITLE     Assignment of the gene for dipeptidase 2 to Mus musculus chromosome
            18 by somatic cell hybridization
  JOURNAL   Biochem Genet 16 (5-6), 477-484 (1978)
   PUBMED   736882
REFERENCE   7  (bases 1 to 2169)
  AUTHORS   Kozak,C.A. and Ruddle,F.H.
  TITLE     Assignment of the genes for thymidine kinase and galactokinase to
            Mus musculus chromosome 11 and the preferential segregation of this
            chromosome in Chinese hamster/mouse somatic cell hybrids
  JOURNAL   Somatic Cell Genet 3 (2), 121-133 (1977)
   PUBMED   204065
REFERENCE   8  (bases 1 to 2169)
  AUTHORS   Francke,U., Lalley,P.A., Moss,W., Ivy,J. and Minna,J.D.
  TITLE     Gene mapping in Mus musculus by interspecific cell hybridization:
            assignment of the genes for tripeptidase-1 to chromosome 10,
            dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome
            12, and adenylate kinase-1 to chromosome 2
  JOURNAL   Cytogenet Cell Genet 19 (2-3), 57-84 (1977)
   PUBMED   198184
REFERENCE   9  (bases 1 to 2169)
  AUTHORS   Kozak,C., Nichols,E. and Ruddle,F.H.
  TITLE     Gene linkage analysis in the mouse by somatic cell hybridization:
            assignment of adenine phosphoribosyltransferase to chromosome 8 and
            alpha-galactosidase to the X chromosome
  JOURNAL   Somatic Cell Genet 1 (4), 371-382 (1975)
   PUBMED   1235912
REFERENCE   10 (bases 1 to 2169)
  AUTHORS   Lewis,W.H. and Truslove,G.M.
  TITLE     Electrophoretic heterogeneity of mouse erythrocyte peptidases
  JOURNAL   Biochem Genet 3 (5), 493-498 (1969)
   PUBMED   4187938
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN721222.1, AK152442.1, AK003779.1 and CJ306472.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159129.1, AK152442.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               CN721222.1         1-206
            207-409             AK152442.1         173-375
            410-2150            AK003779.1         299-2039
            2151-2169           CJ306472.1         411-429
FEATURES             Location/Qualifiers
     source          1..2169
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 57.53 cM"
     gene            1..2169
                     /gene="Cndp2"
                     /gene_synonym="0610010E05Rik; Cn2; Dip-2; Pep-1; Pep1"
                     /note="CNDP dipeptidase 2"
                     /db_xref="GeneID:66054"
                     /db_xref="MGI:MGI:1913304"
     exon            1..222
                     /gene="Cndp2"
                     /gene_synonym="0610010E05Rik; Cn2; Dip-2; Pep-1; Pep1"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..1590
                     /gene="Cndp2"
                     /gene_synonym="0610010E05Rik; Cn2; Dip-2; Pep-1; Pep1"
                     /EC_number="3.4.13.18"
                     /note="cytosolic nonspecific dipeptidase; peptidase 1;
                     glutamate carboxypeptidase-like protein 1; peptidase A;
                     threonyl dipeptidase; CNDP dipeptidase 2 (metallopeptidase
                     M20 family)"
                     /codon_start=1
                     /product="cytosolic non-specific dipeptidase"
                     /protein_id="NP_001276460.1"
                     /db_xref="CCDS:CCDS29383.1"
                     /db_xref="GeneID:66054"
                     /db_xref="MGI:MGI:1913304"
                     /translation="MSALKAVFQYIDENQDRYVKKLAEWVAIQSVSAWPEKRGEIRRM
                     MEVAAADVQRLGGSVELVDIGKQKLPDGSEIPLPPILLGKLGSDPQKKTVCIYGHLDV
                     QPAALEDGWDSEPFTLVEREGKLYGRGSTDDKGPVAGWMNALEAYQKTGQEIPVNLRF
                     CLEGMEESGSEGLDELIFAQKDKFFKDVDYVCISDNYWLGKNKPCITYGLRGICYFFI
                     EVECSDKDLHSGVYGGSVHEAMTDLISLMGCLVDKKGKILIPGINDAVAPVTDEEHAL
                     YDHIDFDMEEFAKDVGAETLLHSCKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPR
                     KVVGKFSIRLVPDMIPEVVSEQVSSYLSKKFAELQSPNKFKVYMGHGGKPWVSDFNHP
                     HYQAGRRALKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEK
                     LNRLNYIEGTKMLAAYLYEVSQLKN"
     exon            223..366
                     /gene="Cndp2"
                     /gene_synonym="0610010E05Rik; Cn2; Dip-2; Pep-1; Pep1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..529
                     /gene="Cndp2"
                     /gene_synonym="0610010E05Rik; Cn2; Dip-2; Pep-1; Pep1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..618
                     /gene="Cndp2"
                     /gene_synonym="0610010E05Rik; Cn2; Dip-2; Pep-1; Pep1"
                     /inference="alignment:Splign:2.1.0"
     exon            619..819
                     /gene="Cndp2"
                     /gene_synonym="0610010E05Rik; Cn2; Dip-2; Pep-1; Pep1"
                     /inference="alignment:Splign:2.1.0"
     exon            820..904
                     /gene="Cndp2"
                     /gene_synonym="0610010E05Rik; Cn2; Dip-2; Pep-1; Pep1"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1065
                     /gene="Cndp2"
                     /gene_synonym="0610010E05Rik; Cn2; Dip-2; Pep-1; Pep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1230
                     /gene="Cndp2"
                     /gene_synonym="0610010E05Rik; Cn2; Dip-2; Pep-1; Pep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1372
                     /gene="Cndp2"
                     /gene_synonym="0610010E05Rik; Cn2; Dip-2; Pep-1; Pep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1520
                     /gene="Cndp2"
                     /gene_synonym="0610010E05Rik; Cn2; Dip-2; Pep-1; Pep1"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..2156
                     /gene="Cndp2"
                     /gene_synonym="0610010E05Rik; Cn2; Dip-2; Pep-1; Pep1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2127..2132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cndp2"
                     /gene_synonym="0610010E05Rik; Cn2; Dip-2; Pep-1; Pep1"
                     /note="hexamer: AATAAA"
     polyA_site      2152
                     /gene="Cndp2"
                     /gene_synonym="0610010E05Rik; Cn2; Dip-2; Pep-1; Pep1"
                     /note="major polyA site"
ORIGIN      
        1 cctgtgataa gtgtgtgtcg caatgctctg ctgacagggt ggagtccttc tcagtcctca
       61 cacagtgcct ctggccacag cccttcagtc ccagctgcaa gcaggtctga ccccattgct
      121 ctctctactc agagtttccc cggtctgaag tcagcctgaa agatgtcagc cctcaaagct
      181 gtcttccagt atatcgatga aaaccaggac cgctacgtca agaaacttgc agaatgggtg
      241 gccatccaga gcgtgtccgc atggccggag aagagaggag agatcagaag gatgatggag
      301 gtggcagctg ccgatgtcca gaggctgggg ggctccgtgg aactggtgga tattgggaag
      361 cagaagctcc cagatggctc ggagatacca cttcctccca ttctgctggg caagctaggc
      421 agcgaccccc agaagaaaac cgtgtgcatt tacgggcacc tggacgtgca gcctgcggcc
      481 ctggaggacg ggtgggacag cgagcccttc accttggtgg agcgggaagg caagctgtat
      541 gggagaggct ccacggacga taaggggcca gtggccgggt ggatgaatgc cctggaagcc
      601 tatcagaaga ctggtcagga gatcccagtc aacctgcggt tctgcctgga aggcatggag
      661 gagtctggct ccgaaggcct ggatgagctc atttttgccc agaaagacaa gttcttcaaa
      721 gatgtggact atgtgtgcat ttcagacaat tactggctgg ggaagaataa gccgtgtatc
      781 acgtacggcc tcagaggcat ctgttacttc ttcatcgagg tggaatgcag tgacaaagac
      841 ctccattctg gggtatatgg aggctcagtg cacgaggcca tgacggatct catttcactg
      901 atgggctgcc tggtagacaa gaaggggaag atcctcatcc cgggcatcaa cgatgccgtg
      961 gcgcctgtga cggatgagga gcatgcgctc tacgaccaca ttgacttcga tatggaagag
     1021 ttcgccaagg acgtgggggc tgagaccctt ctgcacagct gcaagaaaga catcctgatg
     1081 cacagatggc gatacccgtc cctctccctg catgggatcg aaggggcctt ctccggttca
     1141 ggggccaaga ctgtgatccc cagaaaggtg gtcggcaagt tctccatcag gctcgtgcca
     1201 gacatgatac cggaagttgt tagcgagcaa gtttcaagct acttgtcaaa aaaatttgct
     1261 gaactgcaga gccccaacaa gttcaaggtg tacatgggcc acggcgggaa gccctgggtg
     1321 tctgacttca accatcctca ttaccaggcg gggagaagag ccctgaagac agtgtttggt
     1381 gttgagcctg acttgaccag agaaggtggc agtattcctg tgaccttgac ctttcaagag
     1441 gccacaggca aaaatgtcat gctattgcca gtggggtcag cagatgacgg tgcccactcg
     1501 cagaatgaga agctcaacag gctcaactac atagaaggaa ccaaaatgct ggctgcatat
     1561 ctgtatgagg tgtctcagct gaagaactga gaagtctcag tttcctcgga gtgctgttcc
     1621 tacccagaaa caatctgccc tctctctctt ccagctttct cgggaaagtg gaagtttctt
     1681 ttccctatct ctttctcagg tcacaggcag acaggcaaga atggagacat tgcctccagc
     1741 tgtcacctgt cagctgtgtc aggcagttgg acgtggtcag tcctgagact tactggggac
     1801 aactgactgg ccatgattgg gggtaggagg gtgtctcaga tgtggtcagt gtgacttcac
     1861 ctccaggaag tagccagagt ccaaaagctc caagtctgtg ggaggtactg cccaccatgg
     1921 actgaggctc agggaatatc caggaaggaa atgagagcat ccattagctc cttgtgctgt
     1981 gacagcacca tggtgacccg tcactgtgct ctgtatccca tcttaagacc ctagctgacc
     2041 atcactggtg tcccctcctg ttgctgtccc cttgaactta tcccaacagt ccccatggaa
     2101 gcaccagtcc agttgcagct actactaata aatgtgacaa tgagcctctg gaggaaaaaa
     2161 aaaaaaaaa
//
