LOCUS       NM_177450               2829 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus carnosine dipeptidase 1 (Cndp1), mRNA.
ACCESSION   NM_177450
VERSION     NM_177450.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2829)
  AUTHORS   Pfeffer,T., Wetzel,C., Kirschner,P., Bartosova,M., Poth,T.,
            Schwab,C., Poschet,G., Zemva,J., Bulkescher,R., Damgov,I.,
            Thiel,C., Garbade,S.F., Klingbeil,K., Peters,V. and Schmitt,C.P.
  TITLE     Carnosinase-1 Knock-Out Reduces Kidney Fibrosis in Type-1 Diabetic
            Mice on High Fat Diet
  JOURNAL   Antioxidants (Basel) 12 (6), 1270 (2023)
   PUBMED   37372000
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2829)
  AUTHORS   Wetzel,C., Pfeffer,T., Bulkescher,R., Zemva,J., Modafferi,S.,
            Polimeni,A., Salinaro,A.T., Calabrese,V., Schmitt,C.P. and
            Peters,V.
  TITLE     Anserine and Carnosine Induce HSP70-Dependent H2S Formation in
            Endothelial Cells and Murine Kidney
  JOURNAL   Antioxidants (Basel) 12 (1), 66 (2022)
   PUBMED   36670928
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2829)
  AUTHORS   Weigand,T., Colbatzky,F., Pfeffer,T., Garbade,S.F., Klingbeil,K.,
            Colbatzky,F., Becker,M., Zemva,J., Bulkescher,R., Schurfeld,R.,
            Thiel,C., Volk,N., Reuss,D., Hoffmann,G.F., Freichel,M., Hecker,M.,
            Poth,T., Fleming,T., Poschet,G., Schmitt,C.P. and Peters,V.
  TITLE     A Global Cndp1-Knock-Out Selectively Increases Renal Carnosine and
            Anserine Concentrations in an Age- and Gender-Specific Manner in
            Mice
  JOURNAL   Int J Mol Sci 21 (14), 4887 (2020)
   PUBMED   32664451
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2829)
  AUTHORS   Veiga-da-Cunha,M., Chevalier,N., Stroobant,V., Vertommen,D. and Van
            Schaftingen,E.
  TITLE     Metabolite proofreading in carnosine and homocarnosine synthesis:
            molecular identification of PM20D2 as beta-alanyl-lysine
            dipeptidase
  JOURNAL   J Biol Chem 289 (28), 19726-19736 (2014)
   PUBMED   24891507
REFERENCE   5  (bases 1 to 2829)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   6  (bases 1 to 2829)
  AUTHORS   Franco-Pons,N., Virgos,C., Vogel,W.F., Urena,J.M., Soriano,E., del
            Rio,J.A. and Vilella,E.
  TITLE     Expression of discoidin domain receptor 1 during mouse brain
            development follows the progress of myelination
  JOURNAL   Neuroscience 140 (2), 463-475 (2006)
   PUBMED   16603319
REFERENCE   7  (bases 1 to 2829)
  AUTHORS   Teufel,M., Saudek,V., Ledig,J.P., Bernhardt,A., Boularand,S.,
            Carreau,A., Cairns,N.J., Carter,C., Cowley,D.J., Duverger,D.,
            Ganzhorn,A.J., Guenet,C., Heintzelmann,B., Laucher,V., Sauvage,C.
            and Smirnova,T.
  TITLE     Sequence identification and characterization of human carnosinase
            and a closely related non-specific dipeptidase
  JOURNAL   J Biol Chem 278 (8), 6521-6531 (2003)
   PUBMED   12473676
REFERENCE   8  (bases 1 to 2829)
  AUTHORS   Tarozzo,G., Cappello,P., De Andrea,M., Walters,E., Margolis,F.L.,
            Oestreicher,B. and Fasolo,A.
  TITLE     Prenatal differentiation of mouse vomeronasal neurones
  JOURNAL   Eur J Neurosci 10 (1), 392-396 (1998)
   PUBMED   9753148
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY006586.1, AK085308.1, AK165706.1, AK162089.1 and BB499598.1.
            
            On Oct 6, 2007 this sequence version replaced NM_177450.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085308.1, BC043305.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BY006586.1         2-12
            12-49               AK085308.1         2-39
            50-773              AK165706.1         2-725
            774-2116            AK085308.1         764-2106
            2117-2450           AK162089.1         893-1226
            2451-2823           AK085308.1         2442-2814
            2824-2829           BB499598.1         183-188
FEATURES             Location/Qualifiers
     source          1..2829
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 57.53 cM"
     gene            1..2829
                     /gene="Cndp1"
                     /gene_synonym="Cn1"
                     /note="carnosine dipeptidase 1"
                     /db_xref="GeneID:338403"
                     /db_xref="MGI:MGI:2451097"
     exon            1..194
                     /gene="Cndp1"
                     /gene_synonym="Cn1"
                     /inference="alignment:Splign:2.1.0"
     exon            195..349
                     /gene="Cndp1"
                     /gene_synonym="Cn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..1750
                     /gene="Cndp1"
                     /gene_synonym="Cn1"
                     /EC_number="3.4.13.20"
                     /note="carnosinase 1; CNDP dipeptidase 1; carnosine
                     dipeptidase 1 (metallopeptidase M20 family)"
                     /codon_start=1
                     /product="beta-Ala-His dipeptidase"
                     /protein_id="NP_803233.2"
                     /db_xref="CCDS:CCDS29382.1"
                     /db_xref="GeneID:338403"
                     /db_xref="MGI:MGI:2451097"
                     /translation="MFSSAHSGLLEKLFHYIDLHQDEFVQTLKEWVAIESDSVQPVPR
                     LRQKLFQMMALAADKLRNLGAGVESIDLGSQQMPDGQSLPIPPILLAELGSDPEKPTV
                     CFYGHLDVQPAQKDDGWLTDPYTLTEVDGKLYGRGATDNKGPVLAWINAVSTFRALQQ
                     DLPVNIKLILEGMEEAGSIALEELVMREKDHFFSSVDYIVISDNLWLSQRKPALTYGT
                     RGNCYFTVEVKCRDQDFHSGTFGGILNEPMADLVALLGSLVDSSGHILIPGIYDQMAP
                     ITEGEKTMYKNIDMDLEEYQNINQVEKFLFDTKEELLMHLWRYPSLSIHGIEGAFDEP
                     GTKTVIPGRVLGKFSIRLVPTMSPSVVEKQVTQHLEAVFSKRNSFNKMAVSMVLGLHP
                     WTANVNDTQYLAAQRTIKTVFGVNPDMIRDGSTIPIAKIFQAITQKSVMMLPLGAVDD
                     GEHSQNEKINRWNYIQGSKLFAAFFLELSKQHSGHQMPSSVY"
     exon            350..499
                     /gene="Cndp1"
                     /gene_synonym="Cn1"
                     /inference="alignment:Splign:2.1.0"
     exon            500..662
                     /gene="Cndp1"
                     /gene_synonym="Cn1"
                     /inference="alignment:Splign:2.1.0"
     exon            663..751
                     /gene="Cndp1"
                     /gene_synonym="Cn1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..952
                     /gene="Cndp1"
                     /gene_synonym="Cn1"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1037
                     /gene="Cndp1"
                     /gene_synonym="Cn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1198
                     /gene="Cndp1"
                     /gene_synonym="Cn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1363
                     /gene="Cndp1"
                     /gene_synonym="Cn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1505
                     /gene="Cndp1"
                     /gene_synonym="Cn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1653
                     /gene="Cndp1"
                     /gene_synonym="Cn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..2829
                     /gene="Cndp1"
                     /gene_synonym="Cn1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2808..2813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cndp1"
                     /gene_synonym="Cn1"
                     /note="putative"
     polyA_site      2823
                     /gene="Cndp1"
                     /gene_synonym="Cn1"
                     /note="putative"
ORIGIN      
        1 ggtctgggat taacacaacc aggaaaaacc tgagagtttt gttttcttcc tttgtatttt
       61 gttttaaacc agtcaccgtg aaaaaccaag ttaataaaac acaattttcc cccctgtcat
      121 aataaattca ttgaagcaga aacaggacag agcagccttc accacacaag aacattagga
      181 cggcgtgaga cttggcttcg tctctctcgg cactgctgct gtgggccaat cacaggcttc
      241 gtctctctcg gcactacagc tggagcaggc aatgttctct tcggcacact ctgggctgtt
      301 ggagaagctc ttccactaca tagacctcca ccaggatgag ttcgtgcaga cactgaagga
      361 gtgggtggcc attgagagtg attctgtgca gcctgtgcct cgtctcagac agaagctctt
      421 ccagatgatg gccttggctg cagacaaact ccggaacctg ggagctgggg tggagtccat
      481 agacttgggt tctcagcaga tgcctgatgg tcagagtctc cccatacctc ctatcctatt
      541 ggctgagctg ggaagtgatc ccgagaagcc aactgtatgc ttctatgggc acctggacgt
      601 gcagccagct cagaaggacg acgggtggct cacggacccc tacacactga cagaggtgga
      661 tgggaaactg tatggacggg gagcaacaga caacaagggc cccgtcttgg cttggatcaa
      721 tgccgtgagc accttcagag ctctgcagca ggatcttccc gtgaacatca aactcatcct
      781 ggagggaatg gaagaagccg gttccatcgc cctggaggaa ctcgtcatga gagaaaagga
      841 ccacttcttc tccagtgtgg actacattgt gatttcagac aacctgtggc tcagccagag
      901 gaaacctgca ctcacttatg gaacccgggg gaactgctac ttcacggtgg aggtgaagtg
      961 tagagatcaa gatttccact caggaacctt tggtggcatc ctcaacgaac caatggctga
     1021 cttggttgct cttctaggta gcctggtgga ttcatcaggc cacatcctaa ttcctggaat
     1081 ctatgatcaa atggcaccta ttacagaggg agaaaagaca atgtataaaa acattgatat
     1141 ggacctagaa gaataccaga acatcaacca agttgagaaa tttctgtttg ataccaagga
     1201 ggaacttctg atgcacctgt ggaggtatcc gtctctctcc atccatggca tcgagggtgc
     1261 ctttgatgag cctggaacta aaacagtcat tcccggccga gtcctaggga aattttcaat
     1321 ccgtctagtc cctaccatgt ctccgtctgt ggtggagaaa caggtaactc agcatctcga
     1381 agctgtcttc tctaaaagga atagtttcaa caagatggcc gtttctatgg tcctaggact
     1441 ccacccatgg actgcaaacg tcaatgatac tcagtacctt gcagcacaga gaaccatcaa
     1501 aacagtgttt ggagttaatc ctgacatgat ccgggatggg tcaaccattc caattgccaa
     1561 aatattccag gctatcacac aaaagagtgt gatgatgctc ccactgggag ctgtggacga
     1621 tggagagcac tctcagaatg agaagatcaa caggtggaac tacatacagg ggtcgaaatt
     1681 attcgctgcc tttttcctgg agttgtcaaa acagcattca ggacaccaga tgccttccag
     1741 tgtctactga tccacgggca gcactcccac ctcagacgct ggacaaagca ggagttggga
     1801 aaattcagga aatatggaaa atgaaaggtt tcgaaggcac agacagatat tggagatgtt
     1861 ttaacagtcc ctccgtcact taacttccac aagtcacagc taccgagacc gttagttcct
     1921 gaatctactg caacaggctg gggtaacctt ctaatacagg tggggtgtct ctttagtcaa
     1981 ttagattctc actttcaatt ccattggctt aacactccag ttcactttcc agtcccaaga
     2041 actgtggttc ccaatcatcg gacccagggt ctcaggaccc gagtcatctt cacctctgtt
     2101 ctcttaataa tggaagtgtg gcttcaacaa ccggctacag tgatttcctt gtggattcac
     2161 ttttagaaga gttactaggg catgtctctg taataacttc ttgcctctcc ttcatttgtt
     2221 ccccgacaca cacccccccc ccggattcct gaacactctg aagctaaatg atcaatattc
     2281 atagcctcac accatttgga atccttgtgc aaagatgatt tttttcttta attccaaaca
     2341 tcttcagctt tgccgtgatc gatgccacct gctcagcccc tctgactctc attcttccac
     2401 cccatcagga aagccccctt cctgcaaact tgtgcacccg ccactctacc agaaaaaatg
     2461 caccctcatg gaatttctct cacccctttg gaattttgct caatgagttt atctgaattg
     2521 cttaaggctt ttaacagcgc cagcatcaga tggagagcta atcaaccctg acatcagcaa
     2581 gacattcttg atttaaagct ctcagctaaa tctgcatcca ttaatcattt tagttaacta
     2641 tcttgtttgg cttgattgag cttgatggtg tgaacattac aaagaggtat tttgtttttt
     2701 acagtcaagt gtatataaat aatccaattc ttataaattg gttactcaaa tcatgctaat
     2761 agaaaagact ttgaaggttt attttaaatg cttctcttat ggttccaaat aaaaacattc
     2821 cataacttg
//
