LOCUS       NM_027585               2106 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cyclic nucleotide binding domain containing 2 (Cnbd2),
            transcript variant 1, mRNA.
ACCESSION   NM_027585
VERSION     NM_027585.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2106)
  AUTHORS   Krahling,A.M., Alvarez,L., Debowski,K., Van,Q., Gunkel,M.,
            Irsen,S., Al-Amoudi,A., Strunker,T., Kremmer,E., Krause,E.,
            Voigt,I., Wortge,S., Waisman,A., Weyand,I., Seifert,R., Kaupp,U.B.
            and Wachten,D.
  TITLE     CRIS-a novel cAMP-binding protein controlling spermiogenesis and
            the development of flagellar bending
  JOURNAL   PLoS Genet 9 (12), e1003960 (2013)
   PUBMED   24339785
  REMARK    GeneRIF: Our results suggest that CRIS interacts during
            spermiogenesis with Ca(2+)-regulated proteins that in mature sperm
            are involved in flagellar bending.
REFERENCE   2  (bases 1 to 2106)
  AUTHORS   Tkatchenko,T.V., Moreno-Rodriguez,R.A., Conway,S.J.,
            Molkentin,J.D., Markwald,R.R. and Tkatchenko,A.V.
  TITLE     Lack of periostin leads to suppression of Notch1 signaling and
            calcific aortic valve disease
  JOURNAL   Physiol Genomics 39 (3), 160-168 (2009)
   PUBMED   19723774
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY097898.1, AK014912.1 and BX637137.1.
            
            On Feb 2, 2008 this sequence version replaced NM_027585.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014912.1, BC140978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-310               BY097898.1         2-311
            311-2030            AK014912.1         334-2053
            2031-2106           BX637137.1         6-81                c
FEATURES             Location/Qualifiers
     source          1..2106
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 77.39 cM"
     gene            1..2106
                     /gene="Cnbd2"
                     /gene_synonym="4921517L17Rik; 5430421B09Rik; Cris"
                     /note="cyclic nucleotide binding domain containing 2"
                     /db_xref="GeneID:70873"
                     /db_xref="MGI:MGI:1918123"
     exon            1..327
                     /gene="Cnbd2"
                     /gene_synonym="4921517L17Rik; 5430421B09Rik; Cris"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..2082
                     /gene="Cnbd2"
                     /gene_synonym="4921517L17Rik; 5430421B09Rik; Cris"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclic nucleotide-binding domain-containing protein 2;
                     cyclic nucleotide-receptor involved in sperm function"
                     /codon_start=1
                     /product="cyclic nucleotide-binding domain-containing
                     protein 2 isoform 1"
                     /protein_id="NP_081861.2"
                     /db_xref="CCDS:CCDS50778.1"
                     /db_xref="GeneID:70873"
                     /db_xref="MGI:MGI:1918123"
                     /translation="MNRSANPEAASSTSHVKFDLGKSVDISSTDTKDGGTARSPLEPA
                     DKSDTTESKSESGSDSRSEEDKESPASIKEIKAETPQPKDRPGVQIKLSWSQKIKSWT
                     AKKKRKLYQLVIDIIMMNRVCKMFRQGLRGFREYQIIEPVHKKHPDFSFWDKKKQGRI
                     SFVTEDFAAQEGHFPPRAISITQKKPSWRTHQEIQDLCNILQALDCYRSYTESLQLLL
                     AKVIRFERFGRRRVIVKKGQMGNSFYFIYLGTVAITEDEDGSSAFLDPHPTLLHRGGS
                     FGEMGLLSTTVRSATVVCMEETEFLVVDREDFVANKLGDEVQKETQYRYNFFRNLDIF
                     QSWSEEKLWKLVALGRIERFSYGQMVSKDFMNSAFITFICQGNCEILRLVALGDCSAY
                     YKWVWQQLELLDHKPLRIHDNEISPKERFKELQIKSYPLQDFTYLKLLRLQKAREQQG
                     IDFHGKINKVENTLPKLLGPKIKSRFGHLVKCSMVNTKFGELPKEAIVGVYMKIHKTE
                     EGEIVGLHQAFVPEIQRDCRPFILLSLGSELIQVRKEKFYDMVDEETRAKIIKMDVDY
                     PSDEDLCQSFLKENDYIVFRKDLLRLLVEPLNKSPFIPVQTKKKEIYNHKSLFLDLCS
                     LEKKVKQHYPIFLAPQKYLPPLRVVQAISAPRHKIQELLPQYKNAGVLI"
     exon            328..381
                     /gene="Cnbd2"
                     /gene_synonym="4921517L17Rik; 5430421B09Rik; Cris"
                     /inference="alignment:Splign:2.1.0"
     exon            382..519
                     /gene="Cnbd2"
                     /gene_synonym="4921517L17Rik; 5430421B09Rik; Cris"
                     /inference="alignment:Splign:2.1.0"
     exon            520..573
                     /gene="Cnbd2"
                     /gene_synonym="4921517L17Rik; 5430421B09Rik; Cris"
                     /inference="alignment:Splign:2.1.0"
     exon            574..737
                     /gene="Cnbd2"
                     /gene_synonym="4921517L17Rik; 5430421B09Rik; Cris"
                     /inference="alignment:Splign:2.1.0"
     exon            738..894
                     /gene="Cnbd2"
                     /gene_synonym="4921517L17Rik; 5430421B09Rik; Cris"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1046
                     /gene="Cnbd2"
                     /gene_synonym="4921517L17Rik; 5430421B09Rik; Cris"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1185
                     /gene="Cnbd2"
                     /gene_synonym="4921517L17Rik; 5430421B09Rik; Cris"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1300
                     /gene="Cnbd2"
                     /gene_synonym="4921517L17Rik; 5430421B09Rik; Cris"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1478
                     /gene="Cnbd2"
                     /gene_synonym="4921517L17Rik; 5430421B09Rik; Cris"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1599
                     /gene="Cnbd2"
                     /gene_synonym="4921517L17Rik; 5430421B09Rik; Cris"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1763
                     /gene="Cnbd2"
                     /gene_synonym="4921517L17Rik; 5430421B09Rik; Cris"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..2106
                     /gene="Cnbd2"
                     /gene_synonym="4921517L17Rik; 5430421B09Rik; Cris"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2087..2092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cnbd2"
                     /gene_synonym="4921517L17Rik; 5430421B09Rik; Cris"
                     /note="hexamer: AATAAA"
     polyA_site      2106
                     /gene="Cnbd2"
                     /gene_synonym="4921517L17Rik; 5430421B09Rik; Cris"
                     /note="major polyA site"
ORIGIN      
        1 aggacaggct gcgggcaagc ccagcttacc tcgacccgcg aagctcctcg gtggccggaa
       61 atgaaccgat ccgcgaatcc ggaagccgcc tcctctacca gtcacgtgaa gtttgatctg
      121 gggaagtccg tagacatcag ctctactgac actaaggatg gcggcactgc aaggtcccca
      181 ttggagccgg cggacaagtc ggacacgaca gagtcgaaat ctgagtcggg atcggattcc
      241 agatcagagg aagacaagga gagtccggcc tcgattaagg agataaaggc ggagacaccc
      301 caaccgaagg accgccctgg cgtgcagatt aagctctcat ggtcacagaa gataaagagc
      361 tggacagcaa aaaagaaaag aaaactgtac cagctcgtca tagacatcat catgatgaac
      421 cgagtgtgta agatgttccg tcaaggcctc aggggatttc gggaatatca gatcattgag
      481 cctgttcaca agaagcatcc tgacttctcc ttctgggata aaaagaagca aggccgtatc
      541 tcgtttgtta ccgaggactt tgctgcacag gagggtcact tccctccgag ggccatttct
      601 atcacacaga agaagccatc ctggaggacc caccaggaga tccaagacct ctgcaatatt
      661 cttcaggctc tagattgcta ccgcagctac acagagtctc tacagctgct cctggccaag
      721 gtcatacgct ttgaaaggtt cggtcgccgg cgcgtcatcg tcaagaaggg gcagatgggc
      781 aatagctttt atttcatcta cctgggcaca gtggccataa ctgaggacga ggatgggagc
      841 agtgctttcc tggaccctca cccaacactg ctgcacaggg gtggctcctt cggggaaatg
      901 ggccttctaa gcaccacagt aaggagtgcc acggtggtct gcatggagga gacagagttc
      961 ctggtggtcg acagagagga tttcgttgca aataagctgg gtgacgaagt tcagaaggaa
     1021 actcagtatc ggtacaactt ttttaggaac ttggacatat tccagtcttg gtctgaagag
     1081 aagctctgga agctggtggc cttggggagg atagagaggt tctcatacgg acagatggtg
     1141 tctaaagact ttatgaattc ggcattcatc acatttatct gccagggcaa ctgtgaaatc
     1201 ctgcgattgg tagccctggg cgactgcagt gcctattaca agtgggtctg gcagcaactg
     1261 gagctgctgg atcacaaacc tctgagaatt catgacaatg aaatatctcc aaaggagaga
     1321 tttaaggaac tccagatcaa atcctatcct ctgcaggatt tcacgtattt gaaacttctg
     1381 cgtctccaga aagccagaga gcaacaggga atagacttcc acggcaagat caacaaagta
     1441 gaaaacactc tccccaagtt gctgggccca aagatcaaat ccaggttcgg tcatctagtc
     1501 aaatgttcca tggtcaacac caagtttggt gaactcccca aggaggccat agtgggggtc
     1561 tacatgaaga tccacaagac agaggaagga gagattgtgg gccttcacca ggcctttgtc
     1621 ccggaaatcc agcgagattg ccggcccttc atccttctga gtttgggatc agagttgata
     1681 caagtaagaa aagagaagtt ttatgacatg gttgacgagg agacaagagc aaagataata
     1741 aagatggatg tggactatcc cagcgatgaa gacctgtgcc agagtttcct gaaggaaaac
     1801 gactatattg tctttcggaa ggatttgctg cggttactgg tggagcccct caataagtca
     1861 ccattcatcc cagtccagac caagaagaaa gagatctaca accacaagtc tttgttcctg
     1921 gatctgtgca gccttgaaaa gaaggtgaag cagcactatc ccatttttct ggcgccccag
     1981 aaatacctgc cccccttgag ggttgtccaa gccatctcag caccccggca caaaatccaa
     2041 gaactcctgc ctcaatataa gaatgcaggg gtccttattt agaacaaata aagtaggttc
     2101 ggatta
//
