LOCUS       NM_023821              11850 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus cardiomyopathy associated 5 (Cmya5), mRNA.
ACCESSION   NM_023821
VERSION     NM_023821.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11850)
  AUTHORS   Lu,F., Liou,C., Ma,Q., Wu,Z., Xue,B., Xia,Y., Xia,S.,
            Trembley,M.A., Ponek,A., Xie,W., Shani,K., Bortolin,R.H.,
            Prondzynski,M., Berkson,P., Zhang,X., Naya,F.J., Bedi,K.C.,
            Margulies,K.B., Zhang,D., Parker,K.K. and Pu,W.T.
  TITLE     Virally delivered CMYA5 enhances the assembly of cardiac dyads
  JOURNAL   Nat Biomed Eng (2024) In press
   PUBMED   39237710
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 11850)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 11850)
  AUTHORS   Stathopoulou,K., Schnittger,J., Raabe,J., Fleischer,F., Mangels,N.,
            Piasecki,A., Findlay,J., Hartmann,K., Krasemann,S., Schlossarek,S.,
            Uebeler,J., Wixler,V., Blake,D.J., Baillie,G.S., Carrier,L.,
            Ehler,E. and Cuello,F.
  TITLE     CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes
  JOURNAL   FEBS J 289 (15), 4622-4645 (2022)
   PUBMED   35176204
  REMARK    GeneRIF: CMYA5 is a novel interaction partner of FHL2 in cardiac
            myocytes.
REFERENCE   4  (bases 1 to 11850)
  AUTHORS   Lu,F., Ma,Q., Xie,W., Liou,C.L., Zhang,D., Sweat,M.E., Jardin,B.D.,
            Naya,F.J., Guo,Y., Cheng,H. and Pu,W.T.
  TITLE     CMYA5 establishes cardiac dyad architecture and positioning
  JOURNAL   Nat Commun 13 (1), 2185 (2022)
   PUBMED   35449169
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11850)
  AUTHORS   Tsoupri,E., Kostavasili,I., Kloukina,I., Tsikitis,M., Miliou,D.,
            Vasilaki,E., Varela,A., Nakos-Bimpos,M., Davos,C., Mavroidis,M.,
            Polissidis,A. and Capetanaki,Y.
  TITLE     Myospryn deficiency leads to impaired cardiac structure and
            function and schizophrenia-associated symptoms
  JOURNAL   Cell Tissue Res 385 (3), 675-696 (2021)
   PUBMED   34037836
REFERENCE   6  (bases 1 to 11850)
  AUTHORS   Reynolds,J.G., McCalmon,S.A., Donaghey,J.A. and Naya,F.J.
  TITLE     Deregulated protein kinase A signaling and myospryn expression in
            muscular dystrophy
  JOURNAL   J Biol Chem 283 (13), 8070-8074 (2008)
   PUBMED   18252718
  REMARK    GeneRIF: reveal for the first time abnormalities in the protein
            kinase A signal transduction pathway and myospryn regulation in
            dystrophin deficiency
REFERENCE   7  (bases 1 to 11850)
  AUTHORS   Kouloumenta,A., Mavroidis,M. and Capetanaki,Y.
  TITLE     Proper perinuclear localization of the TRIM-like protein myospryn
            requires its binding partner desmin
  JOURNAL   J Biol Chem 282 (48), 35211-35221 (2007)
   PUBMED   17872945
  REMARK    GeneRIF: perinuclear localization of the TRIM-like protein myospryn
            requires its binding partner desmin
REFERENCE   8  (bases 1 to 11850)
  AUTHORS   Hamstra,D.A., Bhojani,M.S., Griffin,L.B., Laxman,B., Ross,B.D. and
            Rehemtulla,A.
  TITLE     Real-time evaluation of p53 oscillatory behavior in vivo using
            bioluminescent imaging
  JOURNAL   Cancer Res 66 (15), 7482-7489 (2006)
   PUBMED   16885345
REFERENCE   9  (bases 1 to 11850)
  AUTHORS   Durham,J.T., Brand,O.M., Arnold,M., Reynolds,J.G., Muthukumar,L.,
            Weiler,H., Richardson,J.A. and Naya,F.J.
  TITLE     Myospryn is a direct transcriptional target for MEF2A that encodes
            a striated muscle, alpha-actinin-interacting, costamere-localized
            protein
  JOURNAL   J Biol Chem 281 (10), 6841-6849 (2006)
   PUBMED   16407236
  REMARK    GeneRIF: Functions directly downstream of MEF2A at the costamere in
            striated muscle potentially playing a role in myofibrillogenesis.
REFERENCE   10 (bases 1 to 11850)
  AUTHORS   Benson,M.A., Tinsley,C.L. and Blake,D.J.
  TITLE     Myospryn is a novel binding partner for dysbindin in muscle
  JOURNAL   J Biol Chem 279 (11), 10450-10458 (2004)
   PUBMED   14688250
  REMARK    GeneRIF: Myospryn is a novel binding partner for dysbindin in
            muscle
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130217.4 and AC132463.3.
            
            On Aug 28, 2009 this sequence version replaced NM_023821.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-367               AC130217.4         182380-182746       c
            368-9677            AC130217.4         127142-136451       c
            9678-9773           AC130217.4         122567-122662       c
            9774-10007          AC130217.4         121173-121406       c
            10008-10030         AC130217.4         119206-119228       c
            10031-10149         AC130217.4         112375-112493       c
            10150-10299         AC130217.4         107301-107450       c
            10300-10446         AC130217.4         103247-103393       c
            10447-10594         AC130217.4         101465-101612       c
            10595-10728         AC130217.4         88159-88292         c
            10729-10828         AC130217.4         86898-86997         c
            10829-11002         AC130217.4         83889-84062         c
            11003-11850         AC132463.3         2842-3689
FEATURES             Location/Qualifiers
     source          1..11850
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 47.81 cM"
     gene            1..11850
                     /gene="Cmya5"
                     /gene_synonym="2310076E16Rik; 2310076E21Rik; sr553; Srfsd;
                     Tims"
                     /note="cardiomyopathy associated 5"
                     /db_xref="GeneID:76469"
                     /db_xref="MGI:MGI:1923719"
     exon            1..367
                     /gene="Cmya5"
                     /gene_synonym="2310076E16Rik; 2310076E21Rik; sr553; Srfsd;
                     Tims"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..11249
                     /gene="Cmya5"
                     /gene_synonym="2310076E16Rik; 2310076E21Rik; sr553; Srfsd;
                     Tims"
                     /note="myospryn; stretch response protein 553;
                     stretch-responsive fibronectin protein type 3; TRIM-like
                     protein; heart and skeletal muscle-specific and sprouty
                     domain-containing"
                     /codon_start=1
                     /product="cardiomyopathy-associated protein 5"
                     /protein_id="NP_076310.2"
                     /db_xref="CCDS:CCDS49329.1"
                     /db_xref="GeneID:76469"
                     /db_xref="MGI:MGI:1923719"
                     /translation="MESGDSGLAAQGFLGWGADEEVAQELETEEESEGEGEETAAESE
                     EEPDARLSDEDEEGKTKQECIVSDPSFSMVAVQREDSGITWETNSSRSSTPWASGESQ
                     TSGICSLEGSALTSPPGSVSFIMDEVKRTRKRTQKSKRGSPSLRRKGSKKRNSLESQD
                     VLTNQEDGPSISESPVLNIENEKSSIGTYDKTRRKKTASNTPPITGAIYKEHKPLVLK
                     PVYIGTVQYKIKMFNSVKEELIPLQFYGTLPKGYVIKEIHYRRGKDSSISLEPDLSNG
                     GSNIVPQRKLAQSPEEDKVRELAPPWRGALSKGSRTSLFSHEEQKKTYADSNLNVPSS
                     TEHAFPSSARNDTADQEENLSLPQMMPQQPADESKTHRMEPPSIPATMVLERAKEELE
                     QNAQGKESSEDDASVLTGSADDVQQEGLVSVNHSMPWEAEKESLETGPPRPAPAIQEK
                     FEPDMEGLEPISTEKTEQASEYVTSSEPIVHREEEHAPEPIVHREEEHAPEPIVHREE
                     EHAPEPIVHREEEHAPESIVHREEEHAPESIVQREEEHAPEPESIVHREEEHAPGPVP
                     IVHREEEHVPELESIVHRGEEHAPEPIVHRDEGHAPEPIVHREEEHVPEPIVHRDEGH
                     APEPIVHREEEHVPEPESIVHREEEHAPEPMVLRKAQLERGVETSTPITDTTEPEDSS
                     LEEEIIELDYPESPLASKETSPSPLSPEVEHRKEPILPTQMTFTPERITLSEEEREEN
                     ESVSTDSAFVSEYSVLQDLNHTPEKLEVEAVSVSDVKSSNEPAVFSEDDEERESYSPA
                     MTSVSEQSLSPSTTEKTSAIQSPLFSTVSPVLSGDEASESVCHSPESESAAEYSVPAH
                     AQELLLKTGDHKLPLKSQRVSEPIIQAEDEKEDIGLLPPAALSQAVLSEDESLGSGSF
                     ASDSKLPFKPSVSQNATRESPQKTIDDMPQFKPRGLSDPATLLEEEKEAIGVGLSSSN
                     EVSAVECALPPQTTELLSESHAPPPWAISSEQVVQSEEGSRDQQRGSFSSTPELGHTS
                     PLLLKGASSPTGLSEQGQEEDNIGPLSPDSAFASEFSFSPYPTQELEKRELGRDSPLC
                     LTSPSEQTVLSDEDTEEADLFSPDSASQVSIPPYRIAETEQNKVEPDELLPRRSAPDY
                     PYFSEADEEEAGSSVVTPVPEHSEPSQEREESSPCRPVFEDLSLLPSADKTGQAETMS
                     DVPTISTSVSEYLILAQQEKTQASLEPEAEDLVPPPTSGWEKRDAKSSLPAVTIAASS
                     SALSSVVKEETTSVLPTSQPSVSPESTCVLKPEQEPTAPLTLTSADEQMALPRVGREK
                     AVLDSQEATAHKSQDQTPEPRLPNVPGSGMKYSVLSDLGDEPKADVKLNLAPTVTSEL
                     EQRMLSKNEPEVAKPHSPPEETSISGPKVLSAVKTEVKQESKITRELPAASSGRERGA
                     EHSPPAPPALPALMEEMGKDTEASSSATTVPVTKLDSNSTKLGRDEVLTDPSLASPVE
                     HPGLKGVGKSELGSGLPLPSMSTSEVLRPEPKLPVNSGVEVEREDNEPPPLQVSPTSK
                     PTVPNDKHEEITRSPDSENVVSDDLAPTLLALRHEMNRQAEETSSPVPGSFLSGEQEL
                     IKLPPEPEKHKQLSEVPTAGSELIDSRDRDRSLGIEPVKPIGTEPGPSILEKGPAELQ
                     RRGKEQEENRKLPVPASAPLETASFDLPIEQKEPKRTLHEGQAVEVPDESSSSADKPE
                     LGVKQLAEKKENLEQPKPFVTTERASVTGSKVKESLISPKDNTWMLEKPDGLVNQHED
                     RKPGTGQLESSESTDLMSEKLGAAPLDTDHTSETRNQETSKAPVSGEKLSQEPRRVQS
                     KAVDDSEEGRKLASGNVEVLTQSKSVPAVKAKATPQPPETPEVTQKPSEKSLVTEQGL
                     PAEKGKKGISSFKSWMSSLLFGSSIPDSKVSDNEDLETRPGPSVEKAVPAIEPKGTVP
                     AEVNIAEKPAVHSLPEVTVKLAEEPKGVSVKSSISQDLKEKLTFLSNEDVLKQPKSNS
                     ENYGQKELPGFSEGMGESLATSVGDKHPGIHPCSPMGEKVGMEEAQNMAPLHITESQR
                     RQKPEVSSPSMWNISARKEEPSSDHKETWLSSSDVVDRMPQKPKSAQSAFTRMNSEEP
                     ASMILPVESKGSLSDLGEDRLRQEMPKPTSLEHCEEEVERPTEEKDGWETRSFSLAGK
                     RGLAEKQEIMAPLELRENEAVGELQRMPESRPFKLEESKAAERLEQRISPTEKLMEKP
                     SKTLALDRREKEVQEWVFSEGEKQEYPPAAMPVPGASAVSLDKAQPHLLAKPTPVVEK
                     PEHIVTEVYPEIRERKAAETQPHPQEEGKTLVEKTKVSRVESPHGEETDGHSLTQEGN
                     LELEKSGESRVDLKEERRRFVMPELSLGASVAAEDGSVQPRPLSKDAARVSDMTDETK
                     HLGTPPTQPSAVEPQTLVLGTSVEHTVKKQETWSDRPTVHTFQTSKDYTEEMLKQSVL
                     ISKHHLEAVEDVHRNEPPSSAASNYTQFMLSASEISADGVPPMGGTAQEPEGTSVKDE
                     EFSVTSKPAGLSEDQKSAFSIISEGCEILNIHAPAFIPSVDQEESEQMQDKLQYLEEK
                     ASFKSISVHDEKKAAASHKTQKSKLEVPDRKITSLKENETKETHKTKEEIATDSGMGD
                     FTPIQPTVSGEEDYFEKYTLIDYNLSPGSGKQKSTVEESSEEATKTLTSFPESSAEQA
                     LDHEYNLVKLDESFYGPEKDDSKLSHAEMQKSLAIQKPDDRNAPKGISRDVDSRSPGM
                     PLFDVEEGVLSKRQIFPTTPKAVNPELLEEPPALSFFYKDLYEGAGGEKNEGETASEG
                     DSVDSETSFPRRHSDTDDGPGMYFEKYILKDDILHDETVTQEDQGQGLEEKPVGEEDS
                     QQLRVAEREIRRKPETSFWEKNLEEQHKVVGREGEPTGHMETLDEAAMQQKAPITEQV
                     RAVTQKMSYAVPFQDTRCVLESEPSSQGNEAGNASPDVNLNVPVQESFPEEESAAGAT
                     YAPEVLQERLVPSVSREERLHNTPVQDEYDFVGSLNQEAASQAILPEEPGSESSPKEV
                     LSQGSESFEHIREQELTSEGEPRMSASQEVWDRTEDQSARESVTAKTQKEPKKTQAES
                     YCYTCKSLVSEMDKALDIHKDHEVSALDTAISAVKVQLGEFLENLQEKSLRIEAFVSE
                     IESFFNTIEEKCSKNEKRLEMQNEEMMKRVLAQYDEKAQSFEEVKKKKMEFLHDQMVH
                     FLQSMDTAKDTLETIVREAEELDETVFLASFEEINERLLSAMESTASLENMPAAFSLF
                     EHYDDSSARSDQMLKQVAVPQPPRLEPQEPSSATSTTIAVYWSVNKEDVVDSFQVYCV
                     EEPQDDQEINELVEEYRLTVKESCCIFEDLEPDRCYQVWVMAVNFTGCSLPSERAIFR
                     TAPSTAVIHVEDCTVCWNTATVRWRPANPEATETYTLEYCRQHSPEGEGLRSFSGIKG
                     LQLKVNLPPNDNYFFYVRATNASGTSEQSEAALISTRGTRFLLLRETAHPALQISANG
                     TVISFSERRRLTEIPSVLGEELPACGQHYWETTVADSPAYRLGICTSSAVRAGALGQG
                     ETSWYMHCSEPQRYTFFYSGIVSEVHATERPARVGILLDYTNQRLLFINAESGQLLFI
                     VRHRFNEGVHPAFALEKPGRCTLHLGLEPPDSVRHK"
     exon            368..9677
                     /gene="Cmya5"
                     /gene_synonym="2310076E16Rik; 2310076E21Rik; sr553; Srfsd;
                     Tims"
                     /inference="alignment:Splign:2.1.0"
     exon            9678..9773
                     /gene="Cmya5"
                     /gene_synonym="2310076E16Rik; 2310076E21Rik; sr553; Srfsd;
                     Tims"
                     /inference="alignment:Splign:2.1.0"
     exon            9774..10007
                     /gene="Cmya5"
                     /gene_synonym="2310076E16Rik; 2310076E21Rik; sr553; Srfsd;
                     Tims"
                     /inference="alignment:Splign:2.1.0"
     exon            10008..10030
                     /gene="Cmya5"
                     /gene_synonym="2310076E16Rik; 2310076E21Rik; sr553; Srfsd;
                     Tims"
                     /inference="alignment:Splign:2.1.0"
     exon            10031..10149
                     /gene="Cmya5"
                     /gene_synonym="2310076E16Rik; 2310076E21Rik; sr553; Srfsd;
                     Tims"
                     /inference="alignment:Splign:2.1.0"
     exon            10150..10299
                     /gene="Cmya5"
                     /gene_synonym="2310076E16Rik; 2310076E21Rik; sr553; Srfsd;
                     Tims"
                     /inference="alignment:Splign:2.1.0"
     exon            10300..10446
                     /gene="Cmya5"
                     /gene_synonym="2310076E16Rik; 2310076E21Rik; sr553; Srfsd;
                     Tims"
                     /inference="alignment:Splign:2.1.0"
     exon            10447..10594
                     /gene="Cmya5"
                     /gene_synonym="2310076E16Rik; 2310076E21Rik; sr553; Srfsd;
                     Tims"
                     /inference="alignment:Splign:2.1.0"
     exon            10595..10728
                     /gene="Cmya5"
                     /gene_synonym="2310076E16Rik; 2310076E21Rik; sr553; Srfsd;
                     Tims"
                     /inference="alignment:Splign:2.1.0"
     exon            10729..10828
                     /gene="Cmya5"
                     /gene_synonym="2310076E16Rik; 2310076E21Rik; sr553; Srfsd;
                     Tims"
                     /inference="alignment:Splign:2.1.0"
     exon            10829..11002
                     /gene="Cmya5"
                     /gene_synonym="2310076E16Rik; 2310076E21Rik; sr553; Srfsd;
                     Tims"
                     /inference="alignment:Splign:2.1.0"
     exon            11003..11850
                     /gene="Cmya5"
                     /gene_synonym="2310076E16Rik; 2310076E21Rik; sr553; Srfsd;
                     Tims"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11821..11826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cmya5"
                     /gene_synonym="2310076E16Rik; 2310076E21Rik; sr553; Srfsd;
                     Tims"
                     /note="hexamer: AATAAA"
     polyA_site      11850
                     /gene="Cmya5"
                     /gene_synonym="2310076E16Rik; 2310076E21Rik; sr553; Srfsd;
                     Tims"
                     /note="major polyA site"
ORIGIN      
        1 gcggggaagt tggcagggac tggaaccaga ggaagctgag ccagggccgc agaagctccg
       61 tggcgaaact ttcttgacgc cttctattta aaggcttggg gcgaccccgc cccgcgcgcc
      121 gggaacccaa gcagccccgc gggccctggc aaagtgcagt cagacggaga acaccgggcg
      181 aggcgtgggc agctccgact ccggccagga caggcgcgat ggagagcggc gacagcggac
      241 tcgcagccca gggcttccta ggatggggtg cagacgagga ggtggcccag gagctggaga
      301 cggaggagga gtcggagggc gagggggagg agacggcggc cgagtcggag gaggagcccg
      361 acgccaggtt atcagatgag gatgaggagg gcaagaccaa gcaggagtgt atcgtctctg
      421 acccttcctt ttccatggtg gcagttcaac gtgaagacag tgggataacc tgggagacca
      481 actcaagcag atcttccact ccttgggctt caggagaaag tcagacctcg ggaatatgta
      541 gtttggaagg gtcagctctg acttctcctc caggaagtgt ttcctttatt atggatgaag
      601 ttaaaaggac acggaaaaga actcagaagt ccaagcgtgg ctcaccgtca ctgcgtcgga
      661 aaggcagcaa aaaaaggaat tctctggaat cacaagatgt tctgacaaac caagaagatg
      721 gtccttcaat ttcagaaagc cctgtgctca atattgagaa tgaaaagtca tctattggca
      781 cttatgataa aacaagaagg aagaagactg catcaaatac gcctcccatc actggggcta
      841 tctacaaaga gcacaaacca ttagtgttga agccagtcta cataggaacg gtacaataca
      901 aaataaagat gttcaattca gttaaagaag agttaattcc tctacaattt tatgggacgt
      961 tgccaaaagg ttatgtaatt aaggaaatac attacaggag aggaaaagat tcatctatta
     1021 gtctagagcc ggatttgagc aatggtggtt ctaatatagt tccccaaagg aaattagccc
     1081 agagcccaga agaagacaaa gtaagagagc ttgctccacc ctggagaggt gccctctcca
     1141 aagggtccag gacctcattg tttagtcacg aagagcaaaa gaaaacgtat gccgattcca
     1201 atttaaatgt tccatcttca acagaacacg catttccctc cagtgccaga aatgatacag
     1261 ctgatcaaga agaaaatctc agccttccac aaatgatgcc acaacagcca gctgatgaat
     1321 caaagaccca cagaatggag ccaccaagca ttccagcaac catggtcctt gaaagagcaa
     1381 aggaagaact ggaacagaat gcacaaggaa aggaaagttc agaggatgat gcttcagtct
     1441 tgacaggctc agccgatgat gtgcaacagg aaggcttggt ttctgtcaac cattccatgc
     1501 catgggaggc agagaaggag tctttagaga caggaccacc aagaccagcg ccagccatcc
     1561 aagaaaagtt tgagccagac atggaagggc tagagccgat ttcaacagaa aaaacagaac
     1621 aagcgtctga atacgtgacc tcatctgagc ccatagtcca cagagaggag gagcatgcgc
     1681 ctgagcccat agtccacaga gaggaggagc atgcgcctga gcccatagtc cacagagagg
     1741 aggagcatgc gcctgagccc atagtccaca gagaggagga gcatgcgcct gaatccatag
     1801 tccacagaga ggaggagcat gcgcctgagt ccatagttca aagagaggag gagcatgcgc
     1861 ctgagcctga gtccatagtc cacagagagg aggagcatgc gcctgggcct gtgcccatag
     1921 tccacagaga ggaggagcat gtgcctgagc ttgagtccat agtccacaga ggggaggagc
     1981 atgcgcctga gcccatagtc cacagagatg aggggcatgc accggagccc atagtccaca
     2041 gagaggagga gcatgtgcct gagcccatag tccacagaga tgaggggcat gcacctgagc
     2101 ccatagttca cagagaggag gagcatgtgc ctgagcctga gtccatagtc cacagagagg
     2161 aggagcatgc gcctgaaccc atggttctta gaaaggcaca actagagagg ggagtggaaa
     2221 cttctacgcc aatcacggat accactgaac ccgaagattc tagtctagaa gaagagatca
     2281 tagaacttga ttacccggaa agtcctttag cttctaagga gacttcccca tcgcctttgt
     2341 cccctgaagt agagcacaga aaagagccca ttctaccaac acagatgaca ttcacacctg
     2401 aacgtatcac tttgtccgag gaagaaagag aagaaaacga gtctgtttct accgattctg
     2461 cttttgtatc tgagtattca gtcctacagg atttgaacca tacaccagag aagctggaag
     2521 tagaggcagt ttctgtatct gatgtgaaat ctagcaatga acctgcagtc ttttcagagg
     2581 acgacgagga acgtgagtct tattccccag ctatgacctc tgtatctgag cagtctcttt
     2641 ctccatccac cactgagaag acatctgcca tccagtcccc actcttttca acagtttcac
     2701 cagtcctgtc tggagatgag gcctcagaga gcgtgtgtca ctcaccagaa tctgaatctg
     2761 cggctgagta ttctgttcca gcacatgcgc aagagttgct gttgaaaaca ggtgaccaca
     2821 agctcccatt aaagtcccaa cgtgtttctg agcccatcat tcaggcagaa gatgagaaag
     2881 aagatattgg gctacttccc ccagcagcac tgagccaggc agttctatcg gaagatgaga
     2941 gtctaggaag tggaagtttc gcatcagatt caaagctgcc atttaaaccc tcggtttcac
     3001 aaaatgcaac acgggaatcc ccccaaaaaa caatagatga catgccccaa ttcaaaccaa
     3061 gaggcctttc tgatcctgca accctgttag aagaagaaaa ggaagccatt ggagttgggc
     3121 tatcttcatc caatgaggtc tctgcagtgg aatgcgctct ccccccacaa accactgagc
     3181 tgctttctga aagccatgcc ccacctccct gggccatctc atccgaacaa gtggtccaat
     3241 cagaagaagg gagcagagac cagcagcggg gctcattctc ttccacacca gagcttggcc
     3301 acacatctcc tctgcttcta aagggtgcct cctcacccac aggtctatca gagcaagggc
     3361 aggaagagga caatattggg cccctttccc ctgattctgc atttgcgtca gaattctcat
     3421 tctcacccta tccgactcag gaactagaga agagagagct ggggcgggat tctccactgt
     3481 gcttaacgtc cccctctgag cagactgttc tgtctgatga ggacacggaa gaggctgacc
     3541 tcttttctcc ggattcagca tcacaggtgt caatcccacc ataccgaatc gcagaaacag
     3601 agcaaaacaa ggtcgagcca gacgaattac tacctaggag gtctgctcca gactatccct
     3661 acttctcaga ggcagatgaa gaagaggcgg ggtcctcagt ggtcacgcct gtgcctgagc
     3721 attctgagcc atcgcaggag cgggaggagt cttccccttg taggcctgtg ttcgaagatc
     3781 tgagcctgct accttcggca gataagaccg gccaagcaga aactatgtca gatgttccaa
     3841 caatttcaac ctctgtgtct gaatatctca tcctggcaca gcaggagaaa actcaggcat
     3901 ctttggagcc tgaggctgaa gatttggtac caccaccaac cagtggatgg gagaagagag
     3961 atgcaaagag tagtctgcca gcagttacaa tagcagcttc ctcttctgca ctctcatcag
     4021 tggtaaagga agaaaccaca tccgttttgc ccacctctca gccctcagtt tcacccgagt
     4081 caacctgtgt gcttaagcca gagcaggagc ccacagcacc tctcactcta acaagtgcag
     4141 atgaacagat ggctttgccc agagtcggaa gggaaaaagc tgtgctggat tctcaagaag
     4201 cgacagcaca caaatcgcag gatcagacac cagagcctcg gctcccaaat gttccagggt
     4261 ctgggatgaa atattcagtt ttgtctgact tgggagatga gccaaaggcg gatgtcaaac
     4321 tcaatttagc tccaactgtg acttctgaac tagaacagag aatgttgtca aagaatgagc
     4381 ctgaagtggc aaaaccacac tcacctccag aggaaacatc tatttctgga cctaaggttt
     4441 tatctgcagt gaaaacggaa gtgaaacagg agtccaaaat aaccagggaa cttcctgcgg
     4501 cttcatcggg gagagagagg ggagcagaac acagtccacc tgcaccacct gcacttccag
     4561 cattgatgga agagatgggg aaagacacag aagccagctc ttctgccacc acagtgccag
     4621 taactaagct tgattcaaat tcaactaaat taggcaggga tgaagtcctg acagatccat
     4681 ctcttgccag ccctgtggaa cacccaggct taaagggagt agggaagagc gagttaggca
     4741 gtggtttgcc tttgcccagc atgtctacct cagaggtgtt aaggcctgaa cccaaacttc
     4801 ctgtcaactc aggggttgag gtagagagag aagacaacga gccacctcca ttgcaagtgt
     4861 cacccacatc caaacccacg gtgccaaatg acaaacacga ggagataaca aggtctcctg
     4921 attctgaaaa tgtagtttca gatgatttag ctccaacatt actggccctc agacatgaga
     4981 tgaacaggca agcagaggag acatcttctc cagtgccggg gagtttcctg tcaggagagc
     5041 aagagcttat aaagctcccc ccagagcctg agaagcacaa acagttatca gaagtaccaa
     5101 ctgctgggtc agaactcatt gatagtagag atagagatag atccttaggt atagaaccag
     5161 taaaacccat cggaacggaa ccagggcctt ctatcttaga aaagggcccc gctgagcttc
     5221 agagaagagg aaaagaacaa gaagaaaaca ggaagcttcc tgtgcctgcc tcagctccat
     5281 tagagactgc ttcttttgac ctccccattg agcaaaaaga gcctaaacgg acccttcatg
     5341 agggccaagc tgttgaggtg cctgatgaga gcagctcttc tgcagataag ccagagctgg
     5401 gtgttaaaca attggcagag aagaaggaga atttggagca acccaagcca tttgtgacaa
     5461 ctgagcgtgc cagtgttaca ggatcaaaag tgaaagagag tctcatttct ccaaaggaca
     5521 acacctggat gctggaaaag ccagatggct tagtcaatca gcatgaagat agaaaaccag
     5581 gaactgggca gctggagtcc tctgagagca ctgatctgat gtcagagaaa cttggggctg
     5641 ctccactgga tacagatcac acatctgaaa ccagaaacca agaaacaagc aaagcaccag
     5701 tgtctggtga gaagctatct caggaaccca gaagggttca gtcaaaggct gtagatgatt
     5761 ctgaggaagg gagaaagcta gcctctggca acgtggaagt actcacccaa agtaaatctg
     5821 tccctgctgt gaaagcaaaa gccacacctc aacctccaga gaccccagag gtgacacaaa
     5881 agccatctga gaagtcactc gtcactgagc aaggtcttcc tgcagagaag ggaaagaaag
     5941 gcatttcatc ttttaaatca tggatgtcta gtttattgtt tggatcaagc attccagata
     6001 gtaaggtctc tgacaacgaa gatctagaaa ctcgtccagg tccctctgta gagaaagcag
     6061 tacctgccat agagcctaaa ggtacagttc ctgctgaggt taatatagcc gagaagccag
     6121 cggttcattc attacctgag gtcacagtta aactggccga ggagcccaaa ggcgtttcag
     6181 ttaaatccag cataagtcaa gaccttaaag aaaaactcac atttttatca aacgaagacg
     6241 ttttaaagca acctaagtct aactctgaaa actatgggca gaaggaactg ccaggcttct
     6301 cagaaggaat gggcgaaagc ttagctactt cagttggtga caaacatcct ggaattcatc
     6361 cttgttcccc tatgggtgag aaagtgggta tggaagaagc ccaaaacatg gctcctcttc
     6421 atattactga gagccaaaga cgccagaagc cagaggtctc ttctccgtct atgtggaata
     6481 tttctgcacg taaggaagag ccaagcagtg atcacaagga aacatggctc tcgtcatctg
     6541 acgtagtaga tagaatgcca cagaagccca aatcagccca gtccgccttc acaaggatga
     6601 actcagagga accagcatca atgattctgc cagtggaatc aaaaggcagt ttaagtgatc
     6661 ttggtgaaga cagacttaga caagaaatgc caaaacccac ttctttggaa cattgtgaag
     6721 aggaagtgga acgtccaaca gaggagaagg atggctggga aactagatca ttttccttgg
     6781 cagggaagag gggcctggca gagaagcaag aaatcatggc tcccttggaa ctcagggaaa
     6841 atgaagcagt aggagagttg caaaggatgc cggaatctcg acctttcaaa ttggaagaat
     6901 caaaagctgc tgagaggctt gaacagcgca tctctccaac tgaaaagctc atggaaaaac
     6961 ccagcaagac tcttgctttg gataggagag aaaaggaagt gcaggaatgg gtattttcag
     7021 aaggagagaa gcaagaatac ccccctgcag ccatgcctgt gcctggagca tcagctgttt
     7081 ctttggataa ggctcaacca catttgctgg ctaaaccaac accagttgtt gaaaaaccag
     7141 aacatatagt cacagaggta tacccagaaa ttagggagag aaaggcagca gaaacccaac
     7201 cacatcccca ggaagaaggt aaaactttag tagagaaaac caaggtttcc cgtgtggagt
     7261 ctccccatgg agaggaaacg gatggccatt ctcttactca ggaaggaaat ctggagttgg
     7321 aaaagtcagg tgagagtaga gtggatctca aagaggaaag gaggcggttc gtgatgcccg
     7381 agttgtccct tggtgcttca gtggctgcgg aagatggaag tgtgcagcca agacccctat
     7441 ctaaggatgc tgctagggta tcagacatga ctgatgaaac aaagcattta ggaacgccgc
     7501 caactcagcc gtcagctgta gaaccacaaa ctcttgtttt aggaacttct gtagaacata
     7561 cagtgaagaa acaagaaaca tggtcagaca ggcccacagt ccacactttc cagacatcta
     7621 aagactacac ggaagagatg ctgaaacagt ctgttcttat ttcaaagcat cacttggaag
     7681 ctgtggaaga tgtgcacaga aacgaaccgc cctcttcagc agcaagtaac tatactcagt
     7741 ttatgcttag tgcatcagag atcagtgctg atggagttcc tcctatggga ggcacagccc
     7801 aggagcctga aggcacctct gtgaaagatg aagaattttc agtaaccagc aagccagctg
     7861 gcctttcaga agatcagaag agtgccttta gcatcatttc tgaaggctgc gagatattga
     7921 atatccatgc ccctgccttc atcccttcag tggatcagga agaaagtgaa caaatgcaag
     7981 ataagttaca gtatttggaa gagaaagctt catttaaaag catatctgtt catgatgaga
     8041 agaaggcagc tgcttcccat aaaacgcaga agagcaagtt agaagttcct gataggaaaa
     8101 ttacatcact gaaggaaaat gagacaaagg aaactcataa gacaaaggag gagatagcca
     8161 cagactcagg aatgggtgat ttcacaccta tccaacccac agtttctggt gaagaggatt
     8221 attttgaaaa atatactttg attgattata acctctcccc aggctcagga aaacagaaat
     8281 caactgttga ggaatcttca gaggaagcca ccaaaacact gacttctttc ccagaaagtt
     8341 cagctgaaca ggccctagac catgaatata acttagtaaa gttagacgag agcttttatg
     8401 ggccagaaaa ggatgatagc aaattatctc atgcagagat gcaaaagtct ttggctatcc
     8461 aaaaaccaga tgacagaaat gctccaaagg gtatcagtag agatgtggac tccaggtctc
     8521 ctgggatgcc tttatttgat gtggaggaag gagttctatc aaaaagacaa atatttccca
     8581 ccacccccaa ggctgtcaac cctgagctgc tagaggagcc cccagcactt tccttcttct
     8641 ataaggatct gtatgaaggg gcgggtgggg agaaaaatga aggcgaaaca gcttcagaag
     8701 gtgacagtgt ggactctgag acatcattcc caaggcgaca ttctgacact gatgatggac
     8761 caggtatgta ttttgagaag tacatactca aagacgacat tcttcatgac gaaactgtaa
     8821 ctcaagaaga tcaaggccaa ggcctggaag aaaagccagt tggtgaagag gattcacagc
     8881 aactgagagt tgcagaaaga gagatcagga gaaagcctga aactagtttt tgggagaaaa
     8941 atctggaaga acagcacaaa gttgttggcc gggaaggaga acccacaggc cacatggaga
     9001 cccttgatga ggcggcaatg cagcagaaag ctcccattac agagcaagtc agagcagtca
     9061 cccagaagat gagctatgca gttccattcc aggacacccg ctgtgttctg gagagtgagc
     9121 caagcagcca gggtaatgag gcaggaaatg caagtccaga tgtcaatctg aatgtccccg
     9181 tacaagagtc tttcccagaa gaagaatctg cagcaggtgc cacctatgct cctgaagtat
     9241 tgcaagagag gctggtccca tctgtgtccc gggaagagag gctccacaat acccctgtgc
     9301 aggatgagta tgactttgtt ggctctctga atcaggaagc agccagtcaa gccatcttac
     9361 cagaagagcc aggttcagaa tcctcaccca aagaagtgtt atctcaagga tcagaatcct
     9421 ttgagcacat cagggaacag gagctcacga gtgaggggga accaagaatg tctgcttcac
     9481 aggaagtgtg ggacaggaca gaagaccaat cagcaagaga atcagtgacc gctaagacac
     9541 aaaaggaacc gaaaaagact caggctgaat cttactgcta cacctgcaaa agcctggtct
     9601 ctgaaatgga caaggcactg gacattcaca aagaccacga ggtttcagca ctcgacacgg
     9661 ctataagtgc tgttaaggtt caattaggag aatttcttga gaacctacaa gaaaaatcct
     9721 tgaggattga agcttttgtt agtgagattg aatccttttt taataccatt gaggaaaagt
     9781 gtagcaaaaa tgagaaacga ctggaaatgc agaacgagga aatgatgaag agggttttgg
     9841 cgcagtatga tgagaaagca cagagcttcg aggaagtgaa gaagaagaag atggagttcc
     9901 tgcatgacca gatggtccac ttcctgcaga gcatggacac ggctaaggac accctagaga
     9961 ctattgtgag agaggcggag gagcttgacg agacagtttt cctggcttcc tttgaggaaa
    10021 tcaatgaaag gctgctgtct gccatggaga gcacagcttc cttagagaac atgcctgccg
    10081 cgttctcact tttcgaacac tacgatgaca gctcggcgcg aagtgaccag atgttgaaac
    10141 aagtggctgt tccacagcct cccagactag aaccccagga accaagctct gctaccagca
    10201 caacaattgc agtgtactgg agcgtgaaca aggaggatgt tgtggactca ttccaggtat
    10261 actgtgtaga ggagcctcag gatgatcaag aaataaatga actggtagaa gaatatagat
    10321 taacagtgaa ggaaagttgc tgcatatttg aagacttaga acccgatcga tgttaccaag
    10381 tgtgggtgat ggctgtcaac ttcaccggat gtagcctgcc cagtgaaaga gcaattttta
    10441 gaacagcacc gtccacagct gtgattcatg tagaagactg tactgtgtgt tggaacactg
    10501 ccactgtcag atggcggcct gccaacccgg aggccaccga gacctacact ctggagtact
    10561 gcagacagca ctctcctgag ggcgagggcc tgagatcttt ctctggaatt aaaggactcc
    10621 agctcaaggt taacctccct cccaacgaca attacttctt ctatgtgaga gccaccaatg
    10681 cctctgggac gagtgaacag agtgaagctg ccctcatctc caccagagga actagattcc
    10741 tcttattgag agaaacagct cacccagctc tccagatctc cgcgaacggg acggtgatca
    10801 gcttctctga gaggagacgg ctgacggaga tcccctcagt gctgggtgag gagctgcctg
    10861 cctgcggcca gcattactgg gaaaccaccg tcgcagacag tccagcctat cgactcggca
    10921 tctgcaccag ctcagctgtg agggctggtg ccctgggaca aggggagacc tcatggtaca
    10981 tgcactgctc tgagccacag agatacacat ttttctacag tggcattgtg agtgaggtgc
    11041 acgcaaccga gcgtccagcc agagtgggca ttctgctgga ctataccaac cagagacttc
    11101 tgtttataaa cgccgagagt ggacagctgc tcttcatcgt gaggcacagg ttcaacgagg
    11161 gcgtgcatcc cgcctttgcc ttggagaagc ctgggagatg tactctgcac ctgggcttag
    11221 agcccccaga ctctgtcagg cacaagtgat cctgggcatt cagagtttat cagaatatga
    11281 gcaagagttg ggggtcagac ctatcattct gtctctcagg caatgtgcat tatttagata
    11341 gtctcccaca cacctgcact gacgggagct ccgggtgccg cagtcagcat gagagcagag
    11401 ccagggaccc cgtgcctcat ggagcagtgt gtgagtggag gggcggaaac acagccttca
    11461 cccttggttc acagttggag ttgtttccta aagtcaaagg atttatactt gacctgaacc
    11521 aaaccccgag aaaaggactg tgtctgctct gttggtcgaa ttccccagtg gctaagtcag
    11581 agggggggga gatgtgtccc tggcacacct cttactaagg gacgtcgact tttttcacaa
    11641 gaaaatgtca ccttacttca ctagaggata atgaacccta gtcattagag gaaatgtttt
    11701 agctgatcta aatttacaat gaattctttt attatcacat gtgctgtaga atgtaagcct
    11761 ctcttctctg aaagtttaaa tgtagaaaag taatagatat cagagatttc cattttgtta
    11821 aataaatggc tagcatctta taaaataaaa
//
