LOCUS       NM_146215               3577 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus cap methyltransferase 2 (Cmtr2), mRNA.
ACCESSION   NM_146215
VERSION     NM_146215.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3577)
  AUTHORS   Yermalovich,A.V., Mohsenin,Z., Cowdin,M., Giotti,B., Gupta,A.,
            Feng,A., Golomb,L., Wheeler,D.B., Xu,K., Tsankov,A., Cleaver,O. and
            Meyerson,M.
  TITLE     An essential role for Cmtr2 in mammalian embryonic development
  JOURNAL   Dev Biol 516, 47-58 (2024)
   PUBMED   39094818
  REMARK    GeneRIF: An essential role for Cmtr2 in mammalian embryonic
            development.
REFERENCE   2  (bases 1 to 3577)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3577)
  AUTHORS   Dohnalkova,M., Krasnykov,K., Mendel,M., Li,L., Panasenko,O.,
            Fleury-Olela,F., Vagbo,C.B., Homolka,D. and Pillai,R.S.
  TITLE     Essential roles of RNA cap-proximal ribose methylation in mammalian
            embryonic development and fertility
  JOURNAL   Cell Rep 42 (7), 112786 (2023)
   PUBMED   37436893
REFERENCE   4  (bases 1 to 3577)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163615.5.
            
            On Jul 31, 2009 this sequence version replaced NM_146215.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025546.1, AK050315.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               AC163615.5         123368-123494       c
            128-3577            AC163615.5         116965-120414       c
FEATURES             Location/Qualifiers
     source          1..3577
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.48 cM"
     gene            1..3577
                     /gene="Cmtr2"
                     /gene_synonym="C730036L12Rik; Ftsjd1; MTr2"
                     /note="cap methyltransferase 2"
                     /db_xref="GeneID:234728"
                     /db_xref="MGI:MGI:2384580"
     exon            1..127
                     /gene="Cmtr2"
                     /gene_synonym="C730036L12Rik; Ftsjd1; MTr2"
                     /inference="alignment:Splign:2.1.0"
     exon            128..3577
                     /gene="Cmtr2"
                     /gene_synonym="C730036L12Rik; Ftsjd1; MTr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..2451
                     /gene="Cmtr2"
                     /gene_synonym="C730036L12Rik; Ftsjd1; MTr2"
                     /EC_number="2.1.1.296"
                     /note="ftsJ methyltransferase domain-containing protein 1;
                     FtsJ methyltransferase domain containing 1; cap2
                     2'O-ribose methyltransferase 2"
                     /codon_start=1
                     /product="cap-specific mRNA
                     (nucleoside-2'-O-)-methyltransferase 2"
                     /protein_id="NP_666327.2"
                     /db_xref="CCDS:CCDS22662.1"
                     /db_xref="GeneID:234728"
                     /db_xref="MGI:MGI:2384580"
                     /translation="MSKRRKLPARQPACLETFSPDVLNDVSELFAKSFSYRKPLDNEW
                     QLPAPTESFSCGHLEFRALLDLKNSLNEVKNLLSDKKLDEWHRHTAFTNKAGKIISHV
                     KKAVNAELCTQAWCKFQEILCSFPLIPQEAFQSGRLNSLHLCEAPGAFIASLNHYLKS
                     HRFPCEWSWVANSLNPYHEANDNLRMITDDRLMANTLHCWYFGPDNTGDIMTLKYLTG
                     LQDFLSGMSPIHLVTADGSFDCQGNPGEQEALVSSLHYCEAVTALITLGDGGSFVLKM
                     FTLFEHCSVNLMYLLNCSFDQVHVFKPATSKAGNSEVYVVCLRYKGREAVQPLLSRMV
                     LNFGTEMTRKALFPHHVIPKSFLERHEECCTFFHRYQLETISENIRLFESMGTGEQER
                     LNNLRDCAVQYFMQKFQLKPLSRNHWLVKKSNIGCSMNTKWFGQRNKYFKTYNERKMM
                     ETLSWKDKVAKGYFNSWAEEHTVYHPGQNSLLEGTASSLEYQSWQVLEGKKLPKVKCS
                     PFCDGEILKTLNEAIEKSLGEALSVDAKVSSKQQYRCCPVFSEESVLSELLRLTKCLP
                     DEQGAEPSGPVKCLLVGSPAVCDLQMPAPLEIQLVESVELTAFSCSLLHDGDPAYQHL
                     FLDCLLHSLRRLHRGDVMVLPILSCFTRFMAGLTFVLHGCFRFITFSCPTSLEPLRTC
                     AVLLCIGYQNLPDAVFQFLQNVHDLLSKLLHPSAPRQILQFLPMEALLQGTLLDFLWD
                     LNAAIAKRHLHLIIQGERDQAIGSLEL"
     regulatory      3363..3368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cmtr2"
                     /gene_synonym="C730036L12Rik; Ftsjd1; MTr2"
                     /note="hexamer: AATAAA"
     regulatory      3370..3375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cmtr2"
                     /gene_synonym="C730036L12Rik; Ftsjd1; MTr2"
                     /note="hexamer: AATGAA"
     polyA_site      3383
                     /gene="Cmtr2"
                     /gene_synonym="C730036L12Rik; Ftsjd1; MTr2"
                     /note="major polyA site"
     polyA_site      3387
                     /gene="Cmtr2"
                     /gene_synonym="C730036L12Rik; Ftsjd1; MTr2"
                     /note="major polyA site"
     regulatory      3557..3562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cmtr2"
                     /gene_synonym="C730036L12Rik; Ftsjd1; MTr2"
                     /note="hexamer: AATAAA"
     polyA_site      3576
                     /gene="Cmtr2"
                     /gene_synonym="C730036L12Rik; Ftsjd1; MTr2"
                     /note="major polyA site"
ORIGIN      
        1 agctgttccc gggagcggaa gtggcaggtg gctcgttaga gtgaggaccg cgtgtgcggt
       61 gctactctgc tcctgctcga ggggctctgg tgggcgtggg ctgaaggaat gcggacccgg
      121 cttctcgatt tttaactcag tttgacaatg agcaagcgca gaaagcttcc ggctcggcag
      181 ccagcttgct tggagacctt cagcccagac gtcctcaatg acgtgtctga gctctttgcc
      241 aagagctttt cctaccgtaa gccactcgat aatgagtggc agttaccagc tcccacggag
      301 agcttctcct gtgggcacct cgagttcagg gctcttctag acttgaagaa ctccctgaac
      361 gaagtgaaga acctcctgag cgataagaag ctggacgagt ggcacaggca cacggccttc
      421 accaacaagg caggcaaaat catctctcat gtcaaaaagg ccgtgaacgc ggaactctgc
      481 actcaggcct ggtgcaaatt ccaggagatc ctgtgcagtt tccccctcat tccgcaggaa
      541 gcttttcaga gtggaagact gaattctctg cacctgtgtg aagctccggg cgccttcatc
      601 gctagcctca accattactt aaaatctcac cggttcccct gtgaatggag ctgggtggcg
      661 aacagcctga atccatacca cgaggcaaac gacaatctta ggatgattac ggatgaccgg
      721 ctgatggcaa ataccttgca ctgctggtac ttcggcccag ataataccgg tgatatcatg
      781 accctgaaat atctgaccgg gcttcaggac ttcctcagcg gcatgtctcc cattcacttg
      841 gtcacggctg atggcagctt cgattgccaa ggaaacccag gtgaacagga agccttagtg
      901 tcgtctttgc attactgcga agctgtcact gctctgatca ctcttggaga cggcggctct
      961 tttgttctaa agatgtttac gttgtttgaa cactgttctg tgaacctcat gtacctgcta
     1021 aattgttctt ttgaccaagt tcatgttttc aaacctgcga ctagcaaggc aggaaactca
     1081 gaagtctatg tggtgtgtct tcgctataag ggaagagagg ccgttcagcc tctgctatct
     1141 aggatggtgt tgaacttcgg cactgagatg accaggaagg cgctctttcc tcatcatgtg
     1201 atccccaaat ccttccttga gcgacacgaa gagtgttgta cgttctttca tagataccag
     1261 ttagagacta tatctgagaa cattcgtctt tttgagagca tgggaacggg ggagcaagag
     1321 agactcaata atctaaggga ttgcgctgta caatatttta tgcaaaaatt tcaactgaag
     1381 cctctttcaa gaaatcactg gctcgttaaa aagtccaata ttggttgtag tatgaacacg
     1441 aaatggtttg gacagagaaa caagtatttt aaaacctata atgaacggaa gatgatggaa
     1501 accctttcat ggaaggataa agtagccaaa ggatacttca atagttgggc agaggaacac
     1561 accgtctatc atcccgggca gaattccctc cttgaaggga ctgcttccag tcttgagtac
     1621 cagtcgtggc aagtcttaga aggaaagaaa ctgccgaagg taaagtgttc ccctttctgt
     1681 gatggtgaaa ttttaaagac tctcaatgaa gccatcgaga agtccttagg agaagctttg
     1741 agcgtggatg ccaaggtcag ttccaagcag caataccgct gttgtcccgt cttttcagaa
     1801 gagtcagtat tatccgagtt gttgaggctt accaagtgcc ttccggacga acagggtgcg
     1861 gaacccagcg gcccagtcaa gtgcctgctg gtgggctcac cggccgtctg tgatctccag
     1921 atgcccgcgc cactggaaat ccagcttgtg gagtccgtgg agctcacagc cttcagctgt
     1981 tccctgcttc acgatggtga cccagcctac cagcatttgt tcttggactg cctgctgcac
     2041 tcactgaggc ggcttcacag gggagatgtg atggtcttgc ccatcctttc ttgcttcacg
     2101 aggtttatgg ctggcctgac cttcgtcctc cacggctgtt ttagatttat cacgttctct
     2161 tgtcccacgt ccctggagcc cctcaggacc tgtgccgtct tgctgtgcat tggttatcag
     2221 aaccttccag atgcagtttt ccagtttcta cagaatgttc atgacctctt gagcaagctg
     2281 ctgcacccca gtgcccctcg gcagatttta cagttcctac caatggaggc gctccttcag
     2341 gggacgctgc ttgacttttt gtgggatttg aacgctgcca ttgctaaaag gcatctgcat
     2401 ttgattattc aaggagagcg agaccaagcc atcggcagcc ttgagttata aaattgagca
     2461 cggcattgat gacgtgcagc cgttttgtga cttacagttt ccgatttcat tttacctgcc
     2521 ctatttattt aatacttttc attttggaga gacaccaatt tgtgtattaa aggacattaa
     2581 ttgtggaaag ttgtggcttg ttctgatgtg aaggatatat gactcatagg cacagagttt
     2641 ttgtggtagg agccgtgtac tgatggtatt tagcccctaa tcatgtgaca tctgtatgtg
     2701 ttcgagtggc tacacgcttg cttgcatata cagttgagtc agtcttatct gctgcagact
     2761 tacaccctgt gccttcattc agactttttc cccaactgat tcctctctta ggctgatgct
     2821 tttaatgatt gttagaggtt atttattcat gacaggaagt gagtcactct ctggcttcac
     2881 tatttacctg gaagcacttg gcatgtctgt ggacttcagg gatctttatt ccagattgtt
     2941 tgatatgtgc cattgccttt tgattggtgg cttcattttc tttgaattga aatgaaatac
     3001 agattttttt tttgtatgac ttttgctagc tataactact tcaactaata agaaagaaca
     3061 gctttaagcc aaaaccaaag gtcatttttg tacagtgaaa aactgtgtct agtactcctt
     3121 tgtcacgaaa cacttccttc agcaatgttg gcatttttaa ggaaagatgg ttttaaggct
     3181 tggtgtgcag tctcctgtgg gttacaccgg agtgtgatgg ttgtggcgaa atgtaaccca
     3241 gaatgatggc taaacaaact ttgtatcttt attggttttg ttttttagta tgaaaatagc
     3301 accttactga gattatccat gagatagaca tttttatcaa tttcattgag aaatatgtat
     3361 ttaataaata atgaactttt ctaccaaggt gttaatttgt cattattttg aaattttata
     3421 aggtacataa ttagacctca tataaatttt taggtatttc tttgttactt aaaaaaaaaa
     3481 atagaagtat tctatcatgt atccaattaa caaatagttc atgctctgct atttctgagt
     3541 tccattacaa gccacaaata aagtcttcag caggtgt
//
