LOCUS       NM_133978               1158 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus CKLF-like MARVEL transmembrane domain containing 7
            (Cmtm7), transcript variant 1, mRNA.
ACCESSION   NM_133978
VERSION     NM_133978.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1158)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1158)
  AUTHORS   Liu,Z., Liu,Y., Li,T., Wang,P., Mo,X., Lv,P., Ma,D. and Han,W.
  TITLE     Essential role for Cmtm7 in cell-surface phenotype, BCR signaling,
            survival and Igmu repertoire of splenic B-1a cells
  JOURNAL   Cell Immunol 352, 104100 (2020)
   PUBMED   32305130
  REMARK    GeneRIF: Essential role for Cmtm7 in cell-surface phenotype, BCR
            signaling, survival and Igmu repertoire of splenic B-1a cells.
REFERENCE   3  (bases 1 to 1158)
  AUTHORS   Liu,Z., Liu,Y., Li,T., Wang,P., Mo,X., Lv,P., Ma,D. and Han,W.
  TITLE     CMTM7 plays key roles in TLR-induced plasma cell differentiation
            and p38 activation in murine B-1 B cells
  JOURNAL   Eur J Immunol 50 (6), 809-821 (2020)
   PUBMED   32022930
  REMARK    GeneRIF: CMTM7 plays key roles in TLR-induced plasma cell
            differentiation and p38 activation in murine B-1 B cells.
REFERENCE   4  (bases 1 to 1158)
  AUTHORS   Liu,Z., Liu,Y., Li,T., Wang,P., Mo,X., Lv,P., Ge,Q., Ma,D. and
            Han,W.
  TITLE     Cmtm7 knockout inhibits B-1a cell development at the transitional
            (TrB-1a) stage
  JOURNAL   Int Immunol 31 (11), 715-728 (2019)
   PUBMED   31081901
  REMARK    GeneRIF: The Cmtm7 deficiency resulted in a slow proliferation and
            high cell death rate of TrB-1a cells. Thus, Cmtm7 controls B-1a
            cell development at the transitional stage.
REFERENCE   5  (bases 1 to 1158)
  AUTHORS   Zhang,Y., Wang,J.Y. and Han,W.
  TITLE     A role for CMTM7 in BCR expression and survival in B-1a but not B-2
            cells
  JOURNAL   Int Immunol 26 (1), 47-57 (2014)
   PUBMED   24080084
  REMARK    GeneRIF: The reduction of B-1a cells in Cmtm7(flox/) mice was
            associated with reduced BCR expression.
REFERENCE   6  (bases 1 to 1158)
  AUTHORS   Miyazaki,A., Yogosawa,S., Murakami,A. and Kitamura,D.
  TITLE     Identification of CMTM7 as a transmembrane linker of BLNK and the
            B-cell receptor
  JOURNAL   PLoS One 7 (2), e31829 (2012)
   PUBMED   22363743
  REMARK    GeneRIF: CMTM7 functions to link sIgM and BLNK in the plasma
            membrane.
REFERENCE   7  (bases 1 to 1158)
  AUTHORS   Han,W., Ding,P., Xu,M., Wang,L., Rui,M., Shi,S., Liu,Y., Zheng,Y.,
            Chen,Y., Yang,T. and Ma,D.
  TITLE     Identification of eight genes encoding chemokine-like factor
            superfamily members 1-8 (CKLFSF1-8) by in silico cloning and
            experimental validation
  JOURNAL   Genomics 81 (6), 609-617 (2003)
   PUBMED   12782130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163344.2 and AF188504.1.
            
            On Nov 16, 2011 this sequence version replaced NM_133978.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF188504.1, AY241869.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               AC163344.2         62538-62701
            165-1158            AF188504.1         1-994
FEATURES             Location/Qualifiers
     source          1..1158
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 65.13 cM"
     gene            1..1158
                     /gene="Cmtm7"
                     /gene_synonym="Cklfsf7; LNV"
                     /note="CKLF-like MARVEL transmembrane domain containing 7"
                     /db_xref="GeneID:102545"
                     /db_xref="MGI:MGI:2447166"
     exon            1..326
                     /gene="Cmtm7"
                     /gene_synonym="Cklfsf7; LNV"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..695
                     /gene="Cmtm7"
                     /gene_synonym="Cklfsf7; LNV"
                     /note="isoform 1 is encoded by transcript variant 1;
                     chemokine-like factor super family 7; CKLF-like MARVEL
                     transmembrane domain-containing protein 7; chemokine-like
                     factor superfamily member 7"
                     /codon_start=1
                     /product="CKLF-like MARVEL transmembrane domain-containing
                     protein 7 isoform 1"
                     /protein_id="NP_598739.1"
                     /db_xref="CCDS:CCDS57710.1"
                     /db_xref="GeneID:102545"
                     /db_xref="MGI:MGI:2447166"
                     /translation="MSHGSGLVRTTCSSGGALGPGQPSEGLLDRVYPLTHGALFKVAQ
                     MVTLLIAFICVRSSVPIDYGAHSFFEVVTMCDLIMILIFYLVHLFRFYRVLTCISWPL
                     SELLHYLIGTLLLLIASIVIASKSYNQSGLVAGAIFGFLASFLCLASLWLSYKITCIT
                     QSSDASA"
     exon            327..500
                     /gene="Cmtm7"
                     /gene_synonym="Cklfsf7; LNV"
                     /inference="alignment:Splign:2.1.0"
     exon            501..599
                     /gene="Cmtm7"
                     /gene_synonym="Cklfsf7; LNV"
                     /inference="alignment:Splign:2.1.0"
     exon            600..681
                     /gene="Cmtm7"
                     /gene_synonym="Cklfsf7; LNV"
                     /inference="alignment:Splign:2.1.0"
     exon            682..1137
                     /gene="Cmtm7"
                     /gene_synonym="Cklfsf7; LNV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1117..1122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cmtm7"
                     /gene_synonym="Cklfsf7; LNV"
                     /note="hexamer: AATAAA"
     polyA_site      1134
                     /gene="Cmtm7"
                     /gene_synonym="Cklfsf7; LNV"
                     /note="major polyA site"
ORIGIN      
        1 agtccaactt ccgcgtgtct agagggcagg ggcttgcggg gcatctgctc ccgagtcctc
       61 tccgggtccg gccgcagctg ggaagaggga gccgtgcgcc ccgcccctga ggctccgccc
      121 cgtcccgtcc cagcttcacc ggccagaggt ccccgggcct cggaggcggc cagcccgggc
      181 tgggtcgcgc gatgtctcat ggatcggggc tcgtccggac cacgtgcagc agcggcggcg
      241 cgctggggcc aggccagccc tcggagggac tgctggaccg ggtgtacccg ctcacccacg
      301 gcgccctgtt caaagtggcg cagatggtca ccctgctgat tgccttcatc tgtgtacgaa
      361 gctccgttcc gatcgactat ggtgcccaca gcttcttcga agtcgtcacc atgtgcgacc
      421 tgataatgat cctcatcttt tacctggtgc acctcttccg cttctaccgt gtgctcacct
      481 gcatcagctg gcccctgtcg gaactgctgc actatttaat cggcacgctg cttctcctca
      541 tcgcctccat agtgatagcc tccaagagtt acaaccagag tggcctggta gccggagcga
      601 tctttgggtt cctggccagc ttcctctgcc tagcgagctt gtggctgtcc tacaagatca
      661 cctgtataac ccagtcttca gatgcatctg cctgatgagg ccacagcctc tggaggaccc
      721 tcgccatggc tgtggactct tcaggcgaca aggcctgtgc cttccctgct ttgccaggat
      781 actgggctcc tgggcatcta cagcctcctt tcacagtctg ctgcagagga catccctccg
      841 ttctgggctg ttagcaccac tcaggtacca aggactgctc tgagcacagt agagagactt
      901 gtggatctgc ctgcatagac acgcctttct tcataccctc aggaccgaga ccacacagag
      961 gccgaagacc ctaatttatc tggcctgtca atctggtctt gaagcgtctc taagtgaaga
     1021 gccagaagaa acactatgtg gccatcctgt ctcctgcccc tatctctgcc tttgtcactg
     1081 tgggtggggg tgggggtggg gaggtgcata gtttttaata aaatgtcaat tgcagcaaaa
     1141 aaaaaaaaaa aaaaaaaa
//
