LOCUS       NM_026036               3353 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus CKLF-like MARVEL transmembrane domain containing 6
            (Cmtm6), transcript variant 1, mRNA.
ACCESSION   NM_026036
VERSION     NM_026036.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3353)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3353)
  AUTHORS   Liu,Q., Wang,J., Guo,Z., Zhang,H., Zhou,Y., Wang,P., Li,T., Lu,W.,
            Liu,F. and Han,W.
  TITLE     CMTM6 promotes hepatocellular carcinoma progression through
            stabilizing beta-catenin
  JOURNAL   Cancer Lett 583, 216585 (2024)
   PUBMED   38101607
  REMARK    GeneRIF: CMTM6 promotes hepatocellular carcinoma progression
            through stabilizing beta-catenin.
REFERENCE   3  (bases 1 to 3353)
  AUTHORS   Zhou,Y., Ma,B., Liu,Q., Duan,H., Huo,Y., Zhao,L., Chen,J., Han,W.
            and Qi,H.
  TITLE     Transmembrane Protein CMTM6 Alleviates Ocular Inflammatory Response
            and Improves Corneal Epithelial Barrier Function in Experimental
            Dry Eye
  JOURNAL   Invest Ophthalmol Vis Sci 65 (1), 4 (2024)
   PUBMED   38165704
  REMARK    GeneRIF: Transmembrane Protein CMTM6 Alleviates Ocular Inflammatory
            Response and Improves Corneal Epithelial Barrier Function in
            Experimental Dry Eye.
REFERENCE   4  (bases 1 to 3353)
  AUTHORS   Mohapatra,P., Mohanty,S., Ansari,S.A., Shriwas,O., Ghosh,A.,
            Rath,R., Majumdar,S.K.D., Swain,R.K., Raghav,S.K. and Dash,R.
  TITLE     CMTM6 attenuates cisplatin-induced cell death in OSCC by regulating
            AKT/c-Myc-driven ribosome biogenesis
  JOURNAL   FASEB J 36 (10), e22566 (2022)
   PUBMED   36165231
  REMARK    GeneRIF: CMTM6 attenuates cisplatin-induced cell death in OSCC by
            regulating AKT/c-Myc-driven ribosome biogenesis.
REFERENCE   5  (bases 1 to 3353)
  AUTHORS   Mohapatra,P., Shriwas,O., Mohanty,S., Ghosh,A., Smita,S.,
            Kaushik,S.R., Arya,R., Rath,R., Das Majumdar,S.K., Muduly,D.K.,
            Raghav,S.K., Nanda,R.K. and Dash,R.
  TITLE     CMTM6 drives cisplatin resistance by regulating Wnt signaling
            through the ENO-1/AKT/GSK3beta axis
  JOURNAL   JCI Insight 6 (4), 143643 (2021)
   PUBMED   33434185
  REMARK    GeneRIF: CMTM6 drives cisplatin resistance by regulating Wnt
            signaling through the ENO-1/AKT/GSK3beta axis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3353)
  AUTHORS   Eichel,M.A., Gargareta,V.I., D'Este,E., Fledrich,R., Kungl,T.,
            Buscham,T.J., Luders,K.A., Miracle,C., Jung,R.B., Distler,U.,
            Kusch,K., Mobius,W., Hulsmann,S., Tenzer,S., Nave,K.A. and
            Werner,H.B.
  TITLE     CMTM6 expressed on the adaxonal Schwann cell surface restricts
            axonal diameters in peripheral nerves
  JOURNAL   Nat Commun 11 (1), 4514 (2020)
   PUBMED   32908139
  REMARK    GeneRIF: CMTM6 expressed on the adaxonal Schwann cell surface
            restricts axonal diameters in peripheral nerves.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3353)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3353)
  AUTHORS   Han,W., Ding,P., Xu,M., Wang,L., Rui,M., Shi,S., Liu,Y., Zheng,Y.,
            Chen,Y., Yang,T. and Ma,D.
  TITLE     Identification of eight genes encoding chemokine-like factor
            superfamily members 1-8 (CKLFSF1-8) by in silico cloning and
            experimental validation
  JOURNAL   Genomics 81 (6), 609-617 (2003)
   PUBMED   12782130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161419.2.
            
            On Mar 24, 2023 this sequence version replaced NM_026036.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY241868.1, BC027248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               AC161419.2         193284-193454
            172-348             AC161419.2         199264-199440
            349-447             AC161419.2         202140-202238
            448-3353            AC161419.2         208520-211425
FEATURES             Location/Qualifiers
     source          1..3353
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 65.06 cM"
     gene            1..3353
                     /gene="Cmtm6"
                     /gene_synonym="2810051A14Rik; Cklfsf6"
                     /note="CKLF-like MARVEL transmembrane domain containing 6"
                     /db_xref="GeneID:67213"
                     /db_xref="MGI:MGI:2447165"
     exon            1..171
                     /gene="Cmtm6"
                     /gene_synonym="2810051A14Rik; Cklfsf6"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..585
                     /gene="Cmtm6"
                     /gene_synonym="2810051A14Rik; Cklfsf6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     chemokine-like factor super family 6; CKLF-like MARVEL
                     transmembrane domain-containing protein 6; chemokine-like
                     factor superfamily 6; chemokine-like factor superfamily
                     member 6"
                     /codon_start=1
                     /product="CKLF-like MARVEL transmembrane domain-containing
                     protein 6 isoform 1"
                     /protein_id="NP_080312.1"
                     /db_xref="CCDS:CCDS23596.1"
                     /db_xref="GeneID:67213"
                     /db_xref="MGI:MGI:2447165"
                     /translation="MENGAVYSPTTEAAPGTGRGARSGLAAYFVLGRLPWHRRILKGL
                     QLLLSLLAFICEEVVSECGLCGGLYFFEFVSCSAFLLSLLLLIVYCTPVHDRVDTGKV
                     KSSDFYITLGTGCVFLLASIIFVSTHSGTSAEIAAIVFGFLASSMFLLDFVVMLCEKL
                     RESPLRKPENNAKVEALTEPLNA"
     exon            172..348
                     /gene="Cmtm6"
                     /gene_synonym="2810051A14Rik; Cklfsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            349..447
                     /gene="Cmtm6"
                     /gene_synonym="2810051A14Rik; Cklfsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            448..3353
                     /gene="Cmtm6"
                     /gene_synonym="2810051A14Rik; Cklfsf6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3334..3339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cmtm6"
                     /gene_synonym="2810051A14Rik; Cklfsf6"
                     /note="hexamer: AATAAA"
     polyA_site      3353
                     /gene="Cmtm6"
                     /gene_synonym="2810051A14Rik; Cklfsf6"
                     /note="major polyA site"
ORIGIN      
        1 gagtttagct gggtgagcga gtgtttgcgg gcgatggaga acggagcggt ctacagtccc
       61 accaccgagg cggccccggg cactggcagg ggtgcgcgca gcggcctggc cgcctacttc
      121 gtcctgggca ggctcccttg gcatcggcgc atcctcaaag gcttgcagct gctgctgtct
      181 ctcctggcct tcatctgtga agaggttgtg tccgagtgtg ggttgtgtgg aggcctctac
      241 ttctttgaat ttgtgagctg tagcgccttt ctcctgagcc tcctcctgct gatcgtgtac
      301 tgcaccccag tgcacgacag agtggatact ggaaaagtca agtcatcgga tttttacatc
      361 accctgggaa ctgggtgtgt gttcctgctg gcatctatca tttttgtctc cacccattct
      421 gggacctcag ctgaaattgc tgcaattgtg tttggcttct tggcaagctc catgttccta
      481 ctggacttcg ttgtcatgct gtgtgagaag ctgcgggaga gcccgctgag aaagcccgag
      541 aacaacgcaa aggtggaagc cctcaccgaa ccactgaacg cttaaagaca cagagccggg
      601 gtgtggaccc aaagagaggc tccctctgtg tgacctgtgt cgtgtgtgca ccttttggag
      661 agaagggaag ggacaggaga gcagctttac agcgctgggc tgggtggcag tgctgggctg
      721 ggtggcagcc ccagcaggaa gctcagaggg tttgtaataa tgcttggaac ctgtcgcgag
      781 tggaggagga ttgtttgttt tgttttgttt tgtttgtttg ttttgttttg tttttagaga
      841 tgaggactgc tgtcctttga attgcatgtc tgtcattttg ctataggacg cccctcacca
      901 cgcttacctt ccagactgtg ccttttccgt cctttcagga accggttaac ttctgttgtt
      961 gccggagatt taatgagtgt ttaagatgct ggtgtaggcg tctttcctta atgttatgat
     1021 cctttactgt atcttactca gccttacact taatgtgcta acctcttaaa gcaattattc
     1081 ttaattcctt ctgagccatg cattgcctaa cagaaagcgt gtgggctggt gctgtttatg
     1141 tgtgtgaaag caaccgtgta gcagccttgt ggaggctttt acattgcact gtgattgctg
     1201 agattaagtt tagaagaaaa tgaagttatg taacactgga aagtgaggga gctgatagtc
     1261 tatctaaaga ccaaagagag aagagactgt cccgcaccgc gggtgtaatc acatggctag
     1321 gcctttgcaa ctcggcagag atgtgagggt cggtgctgtg ttcacccgtg caaacagggt
     1381 tgatggcgtc aaactagaga cttgtgggtc tccctccggg cagatggttt ctgctcaagc
     1441 gagcacagct ccgcaggctt ctctgcagag cctaggctgg gatctctggc ccgccagatt
     1501 ctccttcctg actttctcta gaatggtccc gtgccctgcc gtgtgccgtc tgtgaaggcc
     1561 agtgctcgct cttcctctct gttctcttcc cattgtcagc cgtctccagg ccatccagag
     1621 gtgtgtccct tctcaccagg agtctgaggc agaggtgtca ggtccgtgtt ccctcccaca
     1681 ggcctctgct tgggtttctt tctctccagg ggagaggtct tgaagatgta aacccctgaa
     1741 gccctgctag tgagtactgc tggtggtgtg gggaggccgc aggcctcctg ggactctgga
     1801 aggatcgctt gctgctggag ggctgtctta gaaccactgg gcgcccttcc gacccggggg
     1861 acccttcttc ccttcttgcc ttcttcctag agcttgagcg agatccagca cgtccaggcc
     1921 ttctgtgcac tggccaaggt ttcccaggct gggctttctc tttggagtgg tgcgatggat
     1981 cgtgtttccg gggattcact gtaaagtccc cgtcctttcc agtgtcttgc gtgcctggtg
     2041 tgtggaagga gatggtttca gtttcctagt gaggctgtgg cagttcttgg aagtggatga
     2101 atctgggcac acagcttctg ccctgtccct gcctcactgc ctgatctgct gtcctcaagg
     2161 tttacatact ggtgatgtca ccatagctgc tctggagatc atgaaactga tccttaacat
     2221 tgccttactg gacatgccat tccagagagg ggacagtagg ctcttgaaac caagaataga
     2281 gaagttcaaa agtaaccagt ctattgcaga caattttaga gttttatatc aagctgtgct
     2341 gtaaatatca tttagaccta ttgagaatta acagcaaatc tgagctactt tagtgttacc
     2401 aactattagt ctgctgactg tttctataac aaaatacctg agacaatcaa cttaaaaaga
     2461 ggaagggttg gggaaaaggt taatcttggc ttgcagtttt gtaggctttg gcccttagtc
     2521 agacctgctg ttttagacag caacacatca cttggggagt ttgttgtaga tctggaagca
     2581 aggaaagaag ggcggtggct tgaggtcctg aggtcactta agggcacacc ctctctgacc
     2641 taagacctca ctaggccccg cctctaaagg tttctgacct caatagtgcc ttcctggaga
     2701 actagtttct aactctcagg cccttgggga cattgcatct cagtagtagg tgcctctcta
     2761 cctgtgtttg gcttgttcat gattggcaga cactctgcct ggctctgcac agcagcggct
     2821 cagcatcagc atccagctgc ttgctgtgtg ttagttgtct cacagctgag ggctctgcct
     2881 cggctacttc aggctttccg gttaggaaga taatttggtc acttgtgtct gtggccactc
     2941 ttagaatttt ctcttttgag ggaacctgtg actggttggc ttttgcattc tatggaggga
     3001 gatggggtta aagactgtgg caacacacac cctccagaag agctgggacc agagactgtc
     3061 agcacagaaa ggacaatgtc ttttttagta gctgtggcag acttgagttg ctgtaattta
     3121 tacaaattgt ttagaatggt ttttaagact aagaagggaa atatacttat tgcacaagac
     3181 ttttataatt actatactta aattatgctc tatgtgggga ctgagaagtg tatttctacg
     3241 ttgcttatat ctgatcactt ttgtatttgt tgatttaaag cctgtgggtc ttttttttaa
     3301 tcactcttaa tatcaacttt tataatcttt taaaataaat cctcttaatt cca
//
