LOCUS       NM_028524                898 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus CKLF-like MARVEL transmembrane domain containing 2B
            (Cmtm2b), mRNA.
ACCESSION   NM_028524 XM_993919
VERSION     NM_028524.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 898)
  AUTHORS   Fujihara,Y., Noda,T., Kobayashi,K., Oji,A., Kobayashi,S.,
            Matsumura,T., Larasati,T., Oura,S., Kojima-Kita,K., Yu,Z.,
            Matzuk,M.M. and Ikawa,M.
  TITLE     Identification of multiple male reproductive tract-specific
            proteins that regulate sperm migration through the oviduct in mice
  JOURNAL   Proc Natl Acad Sci U S A 116 (37), 18498-18506 (2019)
   PUBMED   31455729
REFERENCE   2  (bases 1 to 898)
  AUTHORS   Kumar,S., Kang,H., Park,E., Park,H.S. and Lee,K.
  TITLE     The expression of CKLFSF2B is regulated by GATA1 and CREB in the
            Leydig cells, which modulates testicular steroidogenesis
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1861 (12), 1063-1075 (2018)
   PUBMED   30321752
  REMARK    GeneRIF: These findings suggest that CKLFSF2B might be involved in
            the development and function of Leydig cells and regulate
            testicular testosterone production by fine-tuning the expression of
            steroidogenic genes
REFERENCE   3  (bases 1 to 898)
  AUTHORS   Fujihara,Y., Oji,A., Kojima-Kita,K., Larasati,T. and Ikawa,M.
  TITLE     Co-expression of sperm membrane proteins CMTM2A and CMTM2B is
            essential for ADAM3 localization and male fertility in mice
  JOURNAL   J Cell Sci 131 (19) (2018)
   PUBMED   30209135
  REMARK    GeneRIF: co-expression of sperm membrane proteins CMTM2A and CMTM2B
            is required for male fertility and affects the localization of the
            sperm membrane protein ADAM3 in regulating sperm fertilizing
            ability.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 898)
  AUTHORS   Li,T., Han,W., Yang,T., Ding,P., Rui,M., Liu,D., Wang,Y. and Ma,D.
  TITLE     Molecular cloning and identification of mouse Cklfsf2a and
            Cklfsf2b, two homologues of human CKLFSF2
  JOURNAL   Int J Biochem Cell Biol 38 (3), 420-429 (2006)
   PUBMED   16343975
  REMARK    GeneRIF: Data show that mouse Cklfsf2a and Cklfsf2b are two
            homologues of human CKLFSF2.
REFERENCE   5  (bases 1 to 898)
  AUTHORS   Han,W., Ding,P., Xu,M., Wang,L., Rui,M., Shi,S., Liu,Y., Zheng,Y.,
            Chen,Y., Yang,T. and Ma,D.
  TITLE     Identification of eight genes encoding chemokine-like factor
            superfamily members 1-8 (CKLFSF1-8) by in silico cloning and
            experimental validation
  JOURNAL   Genomics 81 (6), 609-617 (2003)
   PUBMED   12782130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121952.4, AK005970.1 and BC050983.1.
            
            On Aug 9, 2013 this sequence version replaced NM_028524.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050983.1, BF319639.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC121952.4         84792-84801         c
            11-875              AK005970.1         5-869
            876-898             BC050983.1         873-895
FEATURES             Location/Qualifiers
     source          1..898
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..898
                     /gene="Cmtm2b"
                     /gene_synonym="1700013O04Rik; Cklfsf22; Cklfsf2b"
                     /note="CKLF-like MARVEL transmembrane domain containing
                     2B"
                     /db_xref="GeneID:75502"
                     /db_xref="MGI:MGI:2447311"
     exon            1..272
                     /gene="Cmtm2b"
                     /gene_synonym="1700013O04Rik; Cklfsf22; Cklfsf2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..761
                     /gene="Cmtm2b"
                     /gene_synonym="1700013O04Rik; Cklfsf22; Cklfsf2b"
                     /note="chemokine-like factor super family 2B;
                     chemokine-like factor superfamily protein 2-2;
                     chemokine-like factor superfamily member 2B"
                     /codon_start=1
                     /product="CKLF-like MARVEL transmembrane domain-containing
                     protein 2B"
                     /protein_id="NP_082800.1"
                     /db_xref="CCDS:CCDS22576.1"
                     /db_xref="GeneID:75502"
                     /db_xref="MGI:MGI:2447311"
                     /translation="MAAPAPRARTGGKKKDERRGFKGYKWEFRDSNKDFWAQGHAECK
                     SLIMILLIAAMVCFQRVATHPIVILLLTMELSICAFFFFLYSLAINRYIPFVFWPMMD
                     LMNDLACSTFLIGGIFFALEARRELPVPYLTGMILMGVTAFISIIDLCLQRRQFKSRK
                     LRKFILLTPDRKGKKQDPKLLLMLAAKEDEEERQRELAEKAKRESMDPGW"
     exon            273..431
                     /gene="Cmtm2b"
                     /gene_synonym="1700013O04Rik; Cklfsf22; Cklfsf2b"
                     /inference="alignment:Splign:2.1.0"
     exon            432..533
                     /gene="Cmtm2b"
                     /gene_synonym="1700013O04Rik; Cklfsf22; Cklfsf2b"
                     /inference="alignment:Splign:2.1.0"
     exon            534..883
                     /gene="Cmtm2b"
                     /gene_synonym="1700013O04Rik; Cklfsf22; Cklfsf2b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      860..865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cmtm2b"
                     /gene_synonym="1700013O04Rik; Cklfsf22; Cklfsf2b"
                     /note="hexamer: AATAAA"
     polyA_site      881
                     /gene="Cmtm2b"
                     /gene_synonym="1700013O04Rik; Cklfsf22; Cklfsf2b"
                     /note="major polyA site"
ORIGIN      
        1 cccagtggtc agttgagagc cacccttgaa caggtcagga gacaccaggc tctctctcga
       61 gctgggcctg ttcagcgact gcagacaagg ctgggcggtt ggaagctgag aactacctgc
      121 taacaaccat ggcagcgccc gcgccgcgag cccggacagg tggcaagaag aaagatgaaa
      181 gaagagggtt caaaggctac aagtgggaat tcagagacag caataaagac ttctgggcgc
      241 agggacatgc agagtgcaag tctctgatta tgatcctcct cattgctgca atggtctgtt
      301 tccaaagagt ggccactcat ccaattgtaa tcctgctgct tactatggaa ctgtcaatct
      361 gtgctttctt cttcttcctc tactccttag ccatcaacag atacattccc ttcgtcttct
      421 ggcctatgat ggatctgatg aacgacctgg cctgttccac attcctcata ggtggtatat
      481 tctttgctct tgaagcaaga cgagaattgc cagtgcccta cttaactggt atgatcctca
      541 tgggtgttac ggcatttata agtatcattg acctgtgtct tcagaggaga caatttaaaa
      601 gcaggaagct tcgaaagttt attctactta ccccagacag gaaaggcaag aagcaggacc
      661 cgaaactcct tttaatgctg gctgccaaag aggatgagga ggagaggcaa agggaactgg
      721 cagagaaagc gaagagggag tcgatggacc ctggatggtg actgcgcagc cacacctgtg
      781 gtcagggaca gctgcgaact ctgcagccag gcctttctac tctctctctt ttgccagatt
      841 tccagcagag ttctccatca ataaagacat cctggaaaag acaaaaaaaa aaaaaaaa
//
