LOCUS       NM_027022               1084 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus CKLF-like MARVEL transmembrane domain containing 2A
            (Cmtm2a), mRNA.
ACCESSION   NM_027022
VERSION     NM_027022.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1084)
  AUTHORS   Ma,W.Y., Wu,Q.L., Wang,S.S., Wang,H.Y., Ye,J.R., Sun,H.S.,
            Feng,Z.P., He,W.B., Chu,S.F., Zhang,Z. and Chen,N.H.
  TITLE     A breakdown of metabolic reprogramming in microglia induced by
            CKLF1 exacerbates immune tolerance in ischemic stroke
  JOURNAL   J Neuroinflammation 20 (1), 97 (2023)
   PUBMED   37098609
  REMARK    GeneRIF: A breakdown of metabolic reprogramming in microglia
            induced by CKLF1 exacerbates immune tolerance in ischemic stroke.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1084)
  AUTHORS   Fujihara,Y., Noda,T., Kobayashi,K., Oji,A., Kobayashi,S.,
            Matsumura,T., Larasati,T., Oura,S., Kojima-Kita,K., Yu,Z.,
            Matzuk,M.M. and Ikawa,M.
  TITLE     Identification of multiple male reproductive tract-specific
            proteins that regulate sperm migration through the oviduct in mice
  JOURNAL   Proc Natl Acad Sci U S A 116 (37), 18498-18506 (2019)
   PUBMED   31455729
REFERENCE   3  (bases 1 to 1084)
  AUTHORS   Chen,C., Chu,S.F., Ai,Q.D., Zhang,Z., Guan,F.F., Wang,S.S.,
            Dong,Y.X., Zhu,J., Jian,W.X. and Chen,N.H.
  TITLE     CKLF1 Aggravates Focal Cerebral Ischemia Injury at Early Stage
            Partly by Modulating Microglia/Macrophage Toward M1 Polarization
            Through CCR4
  JOURNAL   Cell Mol Neurobiol 39 (5), 651-669 (2019)
   PUBMED   30982091
  REMARK    GeneRIF: CKLF1 is an important mediator that skewing
            microglia/macrophage toward M1 phenotype at early stage of cerebral
            ischemic injury
            Erratum:[Cell Mol Neurobiol. 2024 May 10;44(1):45. doi:
            10.1007/s10571-024-01480-7.. PMID: 38727836]
REFERENCE   4  (bases 1 to 1084)
  AUTHORS   Fujihara,Y., Oji,A., Kojima-Kita,K., Larasati,T. and Ikawa,M.
  TITLE     Co-expression of sperm membrane proteins CMTM2A and CMTM2B is
            essential for ADAM3 localization and male fertility in mice
  JOURNAL   J Cell Sci 131 (19) (2018)
   PUBMED   30209135
  REMARK    GeneRIF: co-expression of sperm membrane proteins CMTM2A and CMTM2B
            is required for male fertility and affects the localization of the
            sperm membrane protein ADAM3 in regulating sperm fertilizing
            ability.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1084)
  AUTHORS   Qamar,I., Ahmad,M.F. and Narayanasamy,A.
  TITLE     A time-course study of long term over-expression of ARR19 in mice
  JOURNAL   Sci Rep 5, 13014 (2015)
   PUBMED   26260329
  REMARK    GeneRIF: Taken together, these results suggest that ARR19 may play
            an important role in the differentiation of male reproductive
            organs such as testis and prostate
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1084)
  AUTHORS   Li,T., Han,W., Yang,T., Ding,P., Rui,M., Liu,D., Wang,Y. and Ma,D.
  TITLE     Molecular cloning and identification of mouse Cklfsf2a and
            Cklfsf2b, two homologues of human CKLFSF2
  JOURNAL   Int J Biochem Cell Biol 38 (3), 420-429 (2006)
   PUBMED   16343975
  REMARK    GeneRIF: Data show that mouse Cklfsf2a and Cklfsf2b are two
            homologues of human CKLFSF2.
REFERENCE   7  (bases 1 to 1084)
  AUTHORS   Jeong,B.C., Hong,C.Y., Chattopadhyay,S., Park,J.H., Gong,E.Y.,
            Kim,H.J., Chun,S.Y. and Lee,K.
  TITLE     Androgen receptor corepressor-19 kDa (ARR19), a leucine-rich
            protein that represses the transcriptional activity of androgen
            receptor through recruitment of histone deacetylase
  JOURNAL   Mol Endocrinol 18 (1), 13-25 (2004)
   PUBMED   14576337
  REMARK    GeneRIF: ARR19 may act as an androgen receptor corepressor in vivo
            and play an important role in male reproductive functions
REFERENCE   8  (bases 1 to 1084)
  AUTHORS   Rui,M., Xia,D., Zhang,Y., Han,W., Wang,L., Ding,P., Zhong,Y.,
            Song,Q. and Ma,D.
  TITLE     Molecular cloning and characterization of four isoforms of mCKLF,
            mouse homologues of human chemokine-like factor
  JOURNAL   Mol Biol Rep 30 (4), 229-237 (2003)
   PUBMED   14672409
  REMARK    GeneRIF: Results show that mouse chemokine-like factors (CKLF) 2,
            4, 5 and 6 are four splicing variants which are homologues of human
            CKLFs, and that murine CKLFs possess distinct features compared to
            their human counterparts.
REFERENCE   9  (bases 1 to 1084)
  AUTHORS   Han,W., Ding,P., Xu,M., Wang,L., Rui,M., Shi,S., Liu,Y., Zheng,Y.,
            Chen,Y., Yang,T. and Ma,D.
  TITLE     Identification of eight genes encoding chemokine-like factor
            superfamily members 1-8 (CKLFSF1-8) by in silico cloning and
            experimental validation
  JOURNAL   Genomics 81 (6), 609-617 (2003)
   PUBMED   12782130
REFERENCE   10 (bases 1 to 1084)
  AUTHORS   Xia,D., Li,X., Lou,Y., Han,W., Ding,P., Zhang,Y., Di,C., Song,Q.
            and Ma,D.
  TITLE     Overexpression of chemokine-like factor 2 promotes the
            proliferation and survival of C2C12 skeletal muscle cells
  JOURNAL   Biochim Biophys Acta 1591 (1-3), 163-173 (2002)
   PUBMED   12183067
  REMARK    GeneRIF: Overexpression of chemokine-like factor 2 promotes the
            proliferation and survival of C2C12 skeletal muscle cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK006874.1 and AY241871.1.
            
            On Feb 24, 2007 this sequence version replaced NM_027022.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY241871.1, AK161303.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AK006874.1         2-4
            4-1084              AY241871.1         4-1084
FEATURES             Location/Qualifiers
     source          1..1084
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..1084
                     /gene="Cmtm2a"
                     /gene_synonym="1700001K04Rik; 1700041N15Rik;
                     1700063K20Rik; ARR19; C32; Cklf; Cklf1; CKLF3; CKLF4;
                     CKLF5; Cklfsf2-1b; Cklfsf2a; UCK-1"
                     /note="CKLF-like MARVEL transmembrane domain containing
                     2A"
                     /db_xref="GeneID:73381"
                     /db_xref="MGI:MGI:2447160"
     exon            1..284
                     /gene="Cmtm2a"
                     /gene_synonym="1700001K04Rik; 1700041N15Rik;
                     1700063K20Rik; ARR19; C32; Cklf; Cklf1; CKLF3; CKLF4;
                     CKLF5; Cklfsf2-1b; Cklfsf2a; UCK-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..635
                     /gene="Cmtm2a"
                     /gene_synonym="1700001K04Rik; 1700041N15Rik;
                     1700063K20Rik; ARR19; C32; Cklf; Cklf1; CKLF3; CKLF4;
                     CKLF5; Cklfsf2-1b; Cklfsf2a; UCK-1"
                     /note="chemokine-like factor super family 2A;
                     chemokine-like factor superfamily 2-1b; chemokine-like
                     factor superfamily member 2A"
                     /codon_start=1
                     /product="CKLF-like MARVEL transmembrane domain-containing
                     protein 2A"
                     /protein_id="NP_081298.1"
                     /db_xref="CCDS:CCDS40451.1"
                     /db_xref="GeneID:73381"
                     /db_xref="MGI:MGI:2447160"
                     /translation="MAAPIKFPFRPRGGQPREDTTPKRGLRRYLLELKESNKEFWLSG
                     HAVFKLLSLGCMISALDYFETMLPHPVLILLICMEAAICIFFIFLNTLAINRYIPFVF
                     WPMADIFNSLFSCVFLGGGIYFAFKARRLLPKPYLTAMILMGAAAICSFIDMLLQFQH
                     FRGLRLRKW"
     exon            285..443
                     /gene="Cmtm2a"
                     /gene_synonym="1700001K04Rik; 1700041N15Rik;
                     1700063K20Rik; ARR19; C32; Cklf; Cklf1; CKLF3; CKLF4;
                     CKLF5; Cklfsf2-1b; Cklfsf2a; UCK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            444..545
                     /gene="Cmtm2a"
                     /gene_synonym="1700001K04Rik; 1700041N15Rik;
                     1700063K20Rik; ARR19; C32; Cklf; Cklf1; CKLF3; CKLF4;
                     CKLF5; Cklfsf2-1b; Cklfsf2a; UCK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..628
                     /gene="Cmtm2a"
                     /gene_synonym="1700001K04Rik; 1700041N15Rik;
                     1700063K20Rik; ARR19; C32; Cklf; Cklf1; CKLF3; CKLF4;
                     CKLF5; Cklfsf2-1b; Cklfsf2a; UCK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..1084
                     /gene="Cmtm2a"
                     /gene_synonym="1700001K04Rik; 1700041N15Rik;
                     1700063K20Rik; ARR19; C32; Cklf; Cklf1; CKLF3; CKLF4;
                     CKLF5; Cklfsf2-1b; Cklfsf2a; UCK-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1065..1070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cmtm2a"
                     /gene_synonym="1700001K04Rik; 1700041N15Rik;
                     1700063K20Rik; ARR19; C32; Cklf; Cklf1; CKLF3; CKLF4;
                     CKLF5; Cklfsf2-1b; Cklfsf2a; UCK-1"
                     /note="hexamer: AATAAA"
     polyA_site      1084
                     /gene="Cmtm2a"
                     /gene_synonym="1700001K04Rik; 1700041N15Rik;
                     1700063K20Rik; ARR19; C32; Cklf; Cklf1; CKLF3; CKLF4;
                     CKLF5; Cklfsf2-1b; Cklfsf2a; UCK-1"
                     /note="major polyA site"
ORIGIN      
        1 agtggtcagt tgagagccac ccttgaacag gtcaggagac accaggctct ctctcgagct
       61 gggcctgttc agcgactgca gacaaggctg ggcggtagga agctgagaac tacctgctaa
      121 caaccatggc agcaccgata aagtttccat ttcggcccag aggaggtcag cccagagagg
      181 acacgacccc aaaaaggggg cttcgacgct atctattgga attgaaagag agcaataaag
      241 agttctggct gtcaggacac gccgtgttca agcttctgtc tttgggctgc atgatctctg
      301 cactagacta ctttgaaaca atgctcccac atccggtcct gatcctgctc atctgtatgg
      361 aagcggcaat ctgcatattc ttcatcttcc ttaacacctt agccatcaac agatacattc
      421 ccttcgtctt ctggcctatg gcggatatct tcaacagcct gttctcctgt gtgttccttg
      481 gaggtggcat atactttgct ttcaaggcta gaagattatt gccaaagccc tacttaactg
      541 ctatgatcct catgggcgct gctgcgatct gttctttcat cgacatgtta cttcaattcc
      601 aacacttcag aggccttagg ttaaggaagt ggtaactgtg acatctatga tctttttcat
      661 cgtgggacaa gcccctgaac catatatcgt cattactggg tttgaagtca ccattatttt
      721 ctgtttcgta gtcttgtata tgtgcagacg tgacaagata atgaaatctt tcttttggcc
      781 tttgcttgta agtgatgaac ttcaacctta aaccttaact aactttcctg ccttaggaag
      841 acaccttagt caactacttg aatctcctaa atctttaagg tgatctctgc tcactgcttg
      901 ggggatgctc tcagggattc aggataccca cagaacataa gttctcttta ctctatctac
      961 cagtaggtat ggctgacctt tctcttaact ataaatgtta tgaaatataa tctggtggcc
     1021 ggccggggta cctggaggac ccatgccaag ctgtgcaact gagaaataaa caccatgaaa
     1081 caga
//
