LOCUS       NM_020557               3215 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus cytidine/uridine monophosphate kinase 2 (Cmpk2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_020557
VERSION     NM_020557.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3215)
  AUTHORS   Natarajan,N., Florentin,J., Johny,E., Xiao,H., O'Neil,S.P., Lei,L.,
            Shen,J., Ohayon,L., Johnson,A.R., Rao,K., Li,X., Zhao,Y., Zhang,Y.,
            Tavakoli,S., Shiva,S., Das,J. and Dutta,P.
  TITLE     Aberrant mitochondrial DNA synthesis in macrophages exacerbates
            inflammation and atherosclerosis
  JOURNAL   Nat Commun 15 (1), 7337 (2024)
   PUBMED   39187565
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3215)
  AUTHORS   Guan,X., Zhu,S., Song,J., Liu,K., Liu,M., Xie,L., Wang,Y., Wu,J.,
            Xu,X. and Pang,T.
  TITLE     Microglial CMPK2 promotes neuroinflammation and brain injury after
            ischemic stroke
  JOURNAL   Cell Rep Med 5 (5), 101522 (2024)
   PUBMED   38701781
  REMARK    GeneRIF: Microglial CMPK2 promotes neuroinflammation and brain
            injury after ischemic stroke.
REFERENCE   3  (bases 1 to 3215)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3215)
  AUTHORS   Sun,Z.L., You,T., Zhang,B.H., Liu,Y. and Liu,J.
  TITLE     Bone marrow mesenchymal stem cell-derived exosomes miR-202-5p
            inhibited pyroptosis to alleviate lung ischemic-reperfusion injury
            by targeting CMPK2
  JOURNAL   Kaohsiung J Med Sci 39 (7), 688-698 (2023)
   PUBMED   37092308
  REMARK    GeneRIF: Bone marrow mesenchymal stem cell-derived exosomes
            miR-202-5p inhibited pyroptosis to alleviate lung
            ischemic-reperfusion injury by targeting CMPK2.
REFERENCE   5  (bases 1 to 3215)
  AUTHORS   Xian,H., Liu,Y., Rundberg Nilsson,A., Gatchalian,R., Crother,T.R.,
            Tourtellotte,W.G., Zhang,Y., Aleman-Muench,G.R., Lewis,G., Chen,W.,
            Kang,S., Luevanos,M., Trudler,D., Lipton,S.A., Soroosh,P.,
            Teijaro,J., de la Torre,J.C., Arditi,M., Karin,M. and
            Sanchez-Lopez,E.
  TITLE     Metformin inhibition of mitochondrial ATP and DNA synthesis
            abrogates NLRP3 inflammasome activation and pulmonary inflammation
  JOURNAL   Immunity 54 (7), 1463-1477 (2021)
   PUBMED   34115964
REFERENCE   6  (bases 1 to 3215)
  AUTHORS   Xu,Y., Johansson,M. and Karlsson,A.
  TITLE     Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase
            localized in mitochondria
  JOURNAL   J Biol Chem 283 (3), 1563-1571 (2008)
   PUBMED   17999954
REFERENCE   7  (bases 1 to 3215)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
REFERENCE   8  (bases 1 to 3215)
  AUTHORS   Liang,P., Averboukh,L., Zhu,W., Haley,T. and Pardee,A.B.
  TITLE     Molecular characterization of the murine thymidylate kinase gene
  JOURNAL   Cell Growth Differ 6 (10), 1333-1338 (1995)
   PUBMED   8845311
REFERENCE   9  (bases 1 to 3215)
  AUTHORS   Lee,C.G. and O'Brien,W.E.
  TITLE     A unique member of the thymidylate kinase family that is induced
            during macrophage activation
  JOURNAL   J Immunol 154 (11), 6094-6102 (1995)
   PUBMED   7751651
REFERENCE   10 (bases 1 to 3215)
  AUTHORS   Lee,C.G., Gilbert,D.J., O'Brien,W.E., Jenkins,N.A. and
            Copeland,N.G.
  TITLE     Localization of a novel, LPS-inducible member of the thymidylate
            kinase family to mouse chromosome 12
  JOURNAL   Mamm Genome 5 (11), 742-743 (1994)
   PUBMED   7873892
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA528639.1 and BC057565.1.
            
            On Nov 8, 2006 this sequence version replaced NM_020557.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048910.1, AK004595.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               CA528639.1         1-187
            188-3215            BC057565.1         1-3028
FEATURES             Location/Qualifiers
     source          1..3215
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 9.69 cM"
     gene            1..3215
                     /gene="Cmpk2"
                     /gene_synonym="1200004E04Rik; TDKI; Tyki"
                     /note="cytidine/uridine monophosphate kinase 2"
                     /db_xref="GeneID:22169"
                     /db_xref="MGI:MGI:99830"
     exon            1..812
                     /gene="Cmpk2"
                     /gene_synonym="1200004E04Rik; TDKI; Tyki"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1481
                     /gene="Cmpk2"
                     /gene_synonym="1200004E04Rik; TDKI; Tyki"
                     /EC_number="2.7.4.6"
                     /EC_number="2.7.4.14"
                     /note="thymidylate kinase homologue; UMP-CMP kinase 2,
                     mitochondrial; thymidylate kinase LPS-inducible member;
                     nucleoside-diphosphate kinase; cytidine monophosphate
                     (UMP-CMP) kinase 2, mitochondrial"
                     /codon_start=1
                     /product="UMP-CMP kinase 2, mitochondrial precursor"
                     /protein_id="NP_065582.3"
                     /db_xref="CCDS:CCDS49039.1"
                     /db_xref="GeneID:22169"
                     /db_xref="MGI:MGI:99830"
                     /translation="MALISRPRAPLWLGRLSRRLCGRHQACMGTMARPRRFTVELPDC
                     SLTHFVLGDATDHRDARLAELLGPPGRSYALCVPLAPGEGCGPRVQAARVHHRLLQQL
                     RRGPLQRCQLSKLLGYGPGDQAGEAQHGFLLRDPCDHPDTRRDLLQLLGSCQEAARPQ
                     LAEFQADSQGLLWQRLWELQGDRQVQVDCACVLPAQEPHLHPLLPDLLNSAVFQDRDA
                     ARAVLEECTSFIPEARAVLDLVDQCPKEVQKGKFQVIAIEGLDATGKTTLTQSVSESL
                     KAVLLQSPPPCISQWRKIFDDEPTIIRRAFYSLGNYLVASEIAKESTNFPVIVDRYWH
                     STATYAIATEVSGGLQYLPPAHHPVYQWPGDLLKPDLVLLLTVNSEERVRRLQGRGQE
                     KTKEEAELEANNVFRQKVEMTYQRMENPSCHLVDASPSRETVLQKVLELIQSSGR"
     exon            813..927
                     /gene="Cmpk2"
                     /gene_synonym="1200004E04Rik; TDKI; Tyki"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1129
                     /gene="Cmpk2"
                     /gene_synonym="1200004E04Rik; TDKI; Tyki"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1363
                     /gene="Cmpk2"
                     /gene_synonym="1200004E04Rik; TDKI; Tyki"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..3189
                     /gene="Cmpk2"
                     /gene_synonym="1200004E04Rik; TDKI; Tyki"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3165..3170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cmpk2"
                     /gene_synonym="1200004E04Rik; TDKI; Tyki"
                     /note="hexamer: AATAAA"
     polyA_site      3189
                     /gene="Cmpk2"
                     /gene_synonym="1200004E04Rik; TDKI; Tyki"
                     /note="major polyA site"
ORIGIN      
        1 ccaagcccgg gagtagctcg gccacactgg aggtctcagc cacagctgcc ttcactttcg
       61 tttcccgggg atcctgggtc tgtggtcacc gcggtttcgt ttccgaggcg tggcggaggg
      121 cgcggcccgg gacacccatg gccctaataa gccgccctcg agccccactg tggctcgggc
      181 gtctgtcgcg gaggctgtgc gggcgacacc aggcctgcat ggggaccatg gctcggccgc
      241 ggcgcttcac tgtggagctg ccagattgct ccctgactca cttcgtcctg ggggatgcaa
      301 cagaccacag ggatgcacgc ctggcagagc tgctcggccc cccagggcgc agctacgcgc
      361 tgtgtgtgcc cctggctcca ggcgaaggct gcgggccccg ggtgcaggcg gcccgggtgc
      421 accatcgcct gctgcagcag ctgcgccggg gtcctttaca gagatgccaa ctgagcaagc
      481 ttctgggcta tggtccgggc gatcaggccg gcgaagccca gcatggcttc ctgctgcggg
      541 acccttgcga ccacccggac actcggcgcg acttgctcca gcttctgggc tcctgccagg
      601 aggcggcgcg cccgcagttg gccgagttcc aggccgactc ccagggtttg ctgtggcagc
      661 gtctgtggga gttgcaggga gacaggcagg tgcaggtgga ctgcgcatgc gtcctgccgg
      721 cacaggaacc tcatctgcac ccattgctgc cagatctgct taactctgcg gtgttccaag
      781 accgggacgc ggcaagggct gtcttggaag agtgcacatc ctttattcca gaagcccggg
      841 cagtacttga cctagttgac cagtgcccaa aggaggtcca gaaagggaag ttccaggtca
      901 ttgccattga aggactggat gccactggta agaccacact gacgcagtca gtgtcagagt
      961 ctctcaaggc tgtcctccta cagtcgccac ccccctgtat cagccagtgg aggaagatct
     1021 ttgatgatga acctactatc attcgaagag ccttttattc tttgggcaat tatctcgtgg
     1081 cttctgaaat agctaaagaa tcaaccaact ttcctgttat tgtagacagg tactggcata
     1141 gcacagccac ctacgccata gctactgagg tgagtggagg cctacagtac ctaccccctg
     1201 cccaccaccc tgtgtaccag tggccagggg acctgctgaa gcccgacttg gtcctgctgc
     1261 tgactgtgaa ttctgaggag agagtgcgga gactgcaggg ccggggtcag gagaaaacta
     1321 aagaagaggc tgaacttgag gccaataatg tgtttcgtca gaaggtggaa atgacgtacc
     1381 agcgtatgga gaacccaagc tgccatctgg tggatgccag cccctcgaga gagacagtcc
     1441 tgcagaaggt tttagagctg atccagagtt ctggtcgtta attgtagttg ttctggccat
     1501 gttcctcatt acaccggaga agctgtgtga tgccccgaaa cccatcactt gccatgcagc
     1561 ttcttagatt tagggggtat gagcatattt ggtggaaaaa aaaaactggg gactgagcag
     1621 tttgctttcc ttctgactga ctgagccagc tgcggctgct gattcatttc tgcctggcca
     1681 tgtaccaact tcttgggata tattttaaca ccccgacttt ctgatccagt ggtgagcctg
     1741 ctggaggact ttctgcagct ggaagctaag gatgtcagtt ttggcccaca ctgatcaatt
     1801 gtgatgagct agcatcattt gtttttaccc caaacccgat aactaaggac tatcacagag
     1861 cctggctatc cgaggacatt cctttggagc tattcatggg tggagacact tggaaagaag
     1921 ccattgctct taattcagag gatcaaagaa caccttggac agtgccctga gtgagtgcct
     1981 tggcactgat agatgtgtgc ccctgaactg caagcgctgc aaacccctct tgttctcttt
     2041 tgcgtgtctg tatctgtatt ccgtttctca gctctgcaat cccgttctaa gtgtaacgag
     2101 caggctgtgc tgatcgggat gcgctgcaca ccaatttgtt tctgttgatg tttacatcat
     2161 gcgtttcctc ggtgtaggag ctgtgtgtga gtcactcaca caaacggagg ccaaggagct
     2221 aaatgcagcg tttgctcaat gttttcacca cacaaattta atttatctta ataagcaccg
     2281 tggattctgg aacgagactt cgtagtaaat tatcatgcac tttgaatgtc ttctgattgc
     2341 atgtgaagtc agcttcgagg gctcttgaga tagagaatag agctgtggag gagaagcctg
     2401 gtggctctgt agccttggct tagtcattta acgttgataa tgtcaacagt ttgatctgaa
     2461 agggggcagt tggtggtcct ctagaaatat ttacttggga ggccaagaaa ggagaattga
     2521 aagctctagg tttaagttta gaactagcct gggcagtgga gtaagacctt gtctcaggat
     2581 aaaaactaca aagaggacta ggggtgaaac tccatagtag aacatggtat tgaatattct
     2641 atccttgggt tcagaatctg gggtccattc ccagtaccat aagaataaaa atataaacag
     2701 aaaaacaaac aagtaaacaa taaaaggaat taagtcatat ttggtcacaa gaaggtggct
     2761 ggaccagact attatttaac attccagttc aaatgttgat gcctctctac atcatttttg
     2821 atcccacatc ccatttctta agaagaatct gttcccaagt aactatatta aattacatga
     2881 aagccttcta aggtttaccc taatcttaaa ctataataag atttaatatt aacatctcaa
     2941 tatttttcac cttgggacta tgtataactt ataaataatg tgtccatgta tataaatata
     3001 ttcttggctt ctgttaaaca tatttttaag ctgataaata acattaaggc tctctgtaat
     3061 gtggcagcta attccacaaa gggttttgtt caagcctctc tgagatgatt gcaccagagg
     3121 ctgaatagga agtcgtagtg ctttcttcat gaaacctgac agtgaataaa cttgctctga
     3181 cattcctaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
