LOCUS       NM_001357045            1812 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus chemerin chemokine-like receptor 2 (Cmklr2),
            transcript variant 2, mRNA.
ACCESSION   NM_001357045 XM_011238519
VERSION     NM_001357045.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1812)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1812)
  AUTHORS   Degroot,G.N., Lepage,V., Parmentier,M. and Springael,J.Y.
  TITLE     The Atypical Chemerin Receptor GPR1 Displays Different Modes of
            Interaction with beta-Arrestins in Humans and Mice with Important
            Consequences on Subcellular Localization and Trafficking
  JOURNAL   Cells 11 (6), 1037 (2022)
   PUBMED   35326488
  REMARK    GeneRIF: The Atypical Chemerin Receptor GPR1 Displays Different
            Modes of Interaction with beta-Arrestins in Humans and Mice with
            Important Consequences on Subcellular Localization and Trafficking.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1812)
  AUTHORS   Al Delbany,D., Robert,V., Dubois-Vedrenne,I., Del Prete,A.,
            Vernimmen,M., Radi,A., Lefort,A., Libert,F., Wittamer,V.,
            Sozzani,S. and Parmentier,M.
  TITLE     Expression of CCRL2 Inhibits Tumor Growth by Concentrating Chemerin
            and Inhibiting Neoangiogenesis
  JOURNAL   Cancers (Basel) 13 (19), 5000 (2021)
   PUBMED   34638484
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1812)
  AUTHORS   Li,R., Ma,C., Xiong,Y., Zhao,H., Yang,Y., Xue,L., Wang,B., Xiao,T.,
            Chen,J., Lei,X., Ma,B. and Zhang,J.
  TITLE     An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced Depression
            through the Hypothalamic-Pituitary-Ovarian Axis
  JOURNAL   Biomolecules 11 (6), 857 (2021)
   PUBMED   34207497
  REMARK    GeneRIF: An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced
            Depression through the Hypothalamic-Pituitary-Ovarian Axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1812)
  AUTHORS   Jiang,W., Shi,J., Zhao,J., Wang,Q., Cong,D., Chen,F., Zhang,Y.,
            Liu,Y., Zhao,J., Chen,Q., Gu,L., Zhou,W., Wang,C., Fang,Z.,
            Geng,S., Xie,W., Chen,L.N., Yang,Y., Bai,Y., Lin,H. and Li,X.
  TITLE     ZFP57 dictates allelic expression switch of target imprinted genes
  JOURNAL   Proc Natl Acad Sci U S A 118 (5) (2021)
   PUBMED   33500348
REFERENCE   6  (bases 1 to 1812)
  AUTHORS   Duffie,R., Ajjan,S., Greenberg,M.V., Zamudio,N., Escamilla del
            Arenal,M., Iranzo,J., Okamoto,I., Barbaux,S., Fauque,P. and
            Bourc'his,D.
  TITLE     The Gpr1/Zdbf2 locus provides new paradigms for transient and
            dynamic genomic imprinting in mammals
  JOURNAL   Genes Dev 28 (5), 463-478 (2014)
   PUBMED   24589776
  REMARK    GeneRIF: a maternal germline differentially methylated region (DMR)
            at the mouse Gpr1/Zdbf2 (DBF-type zinc finger-containing protein 2)
            locus, which controls the paternal-specific expression of long
            isoforms of Zdbf2 (Liz) in the early embryo
REFERENCE   7  (bases 1 to 1812)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 1812)
  AUTHORS   Kobayashi,H., Sakurai,T., Sato,S., Nakabayashi,K., Hata,K. and
            Kono,T.
  TITLE     Imprinted DNA methylation reprogramming during early mouse
            embryogenesis at the Gpr1-Zdbf2 locus is linked to long
            cis-intergenic transcription
  JOURNAL   FEBS Lett 586 (6), 827-833 (2012)
   PUBMED   22449967
  REMARK    GeneRIF: Results identified a novel, paternally expressed, long
            intergenic non-coding Zdbf2 variant (Zdbf2linc) transcribed from
            maternally methylated Gpr1 during early embryogenesis in the mouse.
REFERENCE   9  (bases 1 to 1812)
  AUTHORS   Hiura,H., Sugawara,A., Ogawa,H., John,R.M., Miyauchi,N.,
            Miyanari,Y., Horiike,T., Li,Y., Yaegashi,N., Sasaki,H., Kono,T. and
            Arima,T.
  TITLE     A tripartite paternally methylated region within the Gpr1-Zdbf2
            imprinted domain on mouse chromosome 1 identified by meDIP-on-chip
  JOURNAL   Nucleic Acids Res 38 (15), 4929-4945 (2010)
   PUBMED   20385583
  REMARK    GeneRIF: Identification of differentially methylated regions within
            the Gpr1-Zdbf2 imprinted domain.
REFERENCE   10 (bases 1 to 1812)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645950.13.
            
            On Oct 11, 2022 this sequence version replaced NM_001357045.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.25613.1,
                                           SRR1660815.1642.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene :: PMID: 20385583
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AL645950.13        105594-105740       c
            148-293             AL645950.13        104778-104923       c
            294-1812            AL645950.13        77610-79128         c
FEATURES             Location/Qualifiers
     source          1..1812
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 32.31 cM"
     gene            1..1812
                     /gene="Cmklr2"
                     /gene_synonym="Gpr1"
                     /note="chemerin chemokine-like receptor 2"
                     /db_xref="GeneID:241070"
                     /db_xref="MGI:MGI:2385324"
     exon            1..147
                     /gene="Cmklr2"
                     /gene_synonym="Gpr1"
                     /inference="alignment:Splign:2.1.0"
     exon            148..293
                     /gene="Cmklr2"
                     /gene_synonym="Gpr1"
                     /inference="alignment:Splign:2.1.0"
     exon            294..1812
                     /gene="Cmklr2"
                     /gene_synonym="Gpr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..1385
                     /gene="Cmklr2"
                     /gene_synonym="Gpr1"
                     /note="probable G-protein coupled receptor 1;
                     chemokine-like receptor 2; G protein-coupled receptor 1"
                     /codon_start=1
                     /product="chemerin-like receptor 2"
                     /protein_id="NP_001343974.1"
                     /db_xref="CCDS:CCDS14998.1"
                     /db_xref="GeneID:241070"
                     /db_xref="MGI:MGI:2385324"
                     /translation="MEVSKEMLFEELDNYSYALDYYSQESDPEEKVYLGLVHWISLFL
                     YALAFVLGIPGNAIVIWLMGFKWKKTVTTLWFLNLAIADFIFVLFLPLYISYVALSFH
                     WPFGLWLCKVNSFIAQLNMFSSVFFLTVISLDRYIHLLHPGLSHRHRTLKSSLVVVIL
                     VWLLASLLGGPTLYFRDTMEVNNHIICYNNFQEHELTLMRHHVLTWVKFLFGYLFPLL
                     TMSSCYLCLIFKMKKRNILISRKHLWMILSVVIAFLVCWTPYHLFSIWELSIHHNSSF
                     QNVLQGGIPLSTGLAFLNSCLNPILYVLISKTFQARFRASVAEVLKRSLWEASCSGTV
                     SEQLRSAETKSLSLLETAQ"
     regulatory      1681..1686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cmklr2"
                     /gene_synonym="Gpr1"
                     /note="hexamer: ATTATA"
     polyA_site      1710
                     /gene="Cmklr2"
                     /gene_synonym="Gpr1"
                     /note="major polyA site"
     regulatory      1789..1794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cmklr2"
                     /gene_synonym="Gpr1"
                     /note="hexamer: ACTAAA"
     polyA_site      1812
                     /gene="Cmklr2"
                     /gene_synonym="Gpr1"
                     /note="major polyA site"
ORIGIN      
        1 aaaaaaaact cagtctggtg agatagtttg gagggtaagg gcacttacca ccaagcttaa
       61 taacctgagt tcaatcctgg agtccacaag gtggaagaag agaacagcct cctgcaacgt
      121 gtcccctgac ctctatatat accccagtgt catttcaaaa gtcaaagaaa agctgtttga
      181 ggctagaaag ggtgcgcagc ttaagtgact ggaaaagccc ttccatttca gtctggagtt
      241 ggaagttata ttcaaacacc acgacagctt ggctccgcac agaacattaa cagatttcct
      301 tactcttcac ctacaagatc atcatggaag tctcaaagga aatgttattt gaggagttgg
      361 acaactattc ctatgcctta gattattact cccaggagtc tgacccggag gagaaggtgt
      421 acctgggact cgttcactgg atctccctgt tcttatatgc cctagcattt gttctgggca
      481 tcccaggaaa tgccatcgtc atttggctca tgggattcaa gtggaagaag acagtcacca
      541 ctctttggtt cctcaatctg gccatcgcag acttcatctt tgttctcttc ctgcccctgt
      601 acatttccta cgtggccttg agtttccact ggccctttgg cctgtggctc tgcaaggtta
      661 attccttcat tgcccaactg aacatgtttt ccagtgtttt cttcttgaca gtgatcagcc
      721 tggaccgcta catccacttg ctccatcctg gcttgtctca tcggcaccgg actctaaaga
      781 gctcactggt tgttgttata cttgtctggc tgttggcttc tctgcttgga ggtcctacct
      841 tatacttccg ggacaccatg gaggtcaaca accacatcat ttgttataat aatttccagg
      901 agcatgaact caccttgatg agacaccatg ttctgacctg ggtgaagttc ctctttggct
      961 acctcttccc tttgctaacc atgagctcct gctacttgtg cctcatcttc aagatgaaaa
     1021 agcggaacat cctgatatct agaaagcatc tctggatgat cctgtctgtg gtcattgcct
     1081 tcttggtttg ctggacccct tatcacctgt ttagcatctg ggagctcagc attcatcaca
     1141 acagctcttt ccagaatgtg ctgcagggtg gaatccccct ctcaactggc ttagccttcc
     1201 tcaatagctg cttgaatccc atcctttacg tcctaataag caagacgttc caagcccgct
     1261 tcagggcctc tgttgctgag gtactaaagc gttcgctgtg ggaagccagc tgctctggta
     1321 cagtcagtga acaactcagg agtgctgaaa ccaagagcct gtctctccta gaaactgccc
     1381 agtgagtatt gtgttcccag aaaatcagtg caaagttttc atgtgagcct cataacaaat
     1441 cctttcagat taggttgcat tctgatccac actgatcatg tttttgttca gttatatttt
     1501 tgcttggcta taaaagggag gatttcttcc ctgcaattta aatcatgtat ctttctggct
     1561 gccctctggt ggccgttctg atactgacag cctaaaagtt tcttccacta ttttagcctg
     1621 cgtctgttaa tgtactgcaa tgtatgtatc aaattaagtc atttttatag tgtataccac
     1681 attatattaa ttatctctat tgaaaaagta tcaggctggg ttctttgttt gcttttgcgt
     1741 cattttgtgt acgcgtgcat gttcatgtgt ttggaggtgt aagctgtaac taaatcatgt
     1801 gtttctcatg ga
//
