LOCUS       NM_008153               2845 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus chemerin chemokine-like receptor 1 (Cmklr1),
            transcript variant 2, mRNA.
ACCESSION   NM_008153 XM_914017 XM_923038
VERSION     NM_008153.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2845)
  AUTHORS   Chen,Y., Song,Y., Wang,Z., Lai,Y., Yin,W., Cai,Q., Han,M., Cai,Y.,
            Xue,Y., Chen,Z., Li,X., Chen,J., Li,M., Li,H. and He,R.
  TITLE     The chemerin-CMKLR1 axis in keratinocytes impairs innate host
            defense against cutaneous Staphylococcus aureus infection
  JOURNAL   Cell Mol Immunol 21 (6), 533-545 (2024)
   PUBMED   38532043
  REMARK    GeneRIF: The chemerin-CMKLR1 axis in keratinocytes impairs innate
            host defense against cutaneous Staphylococcus aureus infection.
REFERENCE   2  (bases 1 to 2845)
  AUTHORS   Johnston,R.A., Pilkington,A.W. 4th, Atkins,C.L., Boots,T.E.,
            Brown,P.L., Jackson,W.T., Spencer,C.Y., Siddiqui,S.R. and
            Haque,I.U.
  TITLE     Inconsequential role for chemerin-like receptor 1 in the
            manifestation of ozone-induced lung pathophysiology in male mice
  JOURNAL   Physiol Rep 12 (8), e16008 (2024)
   PUBMED   38631890
REFERENCE   3  (bases 1 to 2845)
  AUTHORS   Liu,L., Zhang,J., Lu,K., Zhang,Y., Xu,X., Deng,J., Zhang,X.,
            Zhang,H., Zhao,Y. and Wang,X.
  TITLE     ChemR23 signaling ameliorates brain injury via inhibiting NLRP3
            inflammasome-mediated neuronal pyroptosis in ischemic stroke
  JOURNAL   J Transl Med 22 (1), 23 (2024)
   PUBMED   38178174
  REMARK    GeneRIF: ChemR23 signaling ameliorates brain injury via inhibiting
            NLRP3 inflammasome-mediated neuronal pyroptosis in ischemic stroke.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2845)
  AUTHORS   Zhang,J., Yin,Z., Xu,Y., Wei,C., Peng,S., Zhao,M., Liu,J., Xu,S.,
            Pan,W., Zheng,Z., Liu,S., Ye,J., Qin,J.J., Wan,J. and Wang,M.
  TITLE     Resolvin E1/ChemR23 Protects Against Hypertension and Vascular
            Remodeling in Angiotensin II-Induced Hypertensive Mice
  JOURNAL   Hypertension 80 (12), 2650-2664 (2023)
   PUBMED   37800344
  REMARK    GeneRIF: Resolvin E1/ChemR23 Protects Against Hypertension and
            Vascular Remodeling in Angiotensin II-Induced Hypertensive Mice.
REFERENCE   5  (bases 1 to 2845)
  AUTHORS   Hernandez,J., Schaffer,J., Herden,C., Pflieger,F.J., Reiche,S.,
            Korber,S., Kitagawa,H., Welter,J., Michels,S., Culmsee,C., Bier,J.,
            Sommer,N., Kang,J.X., Mayer,K., Hecker,M. and Rummel,C.
  TITLE     n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the
            Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice
            Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin
            Receptor 23 Knockout
  JOURNAL   Int J Mol Sci 24 (17), 13524 (2023)
   PUBMED   37686333
  REMARK    GeneRIF: n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS
            and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1
            Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin
            Receptor 23 Knockout.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2845)
  AUTHORS   Zabel,B.A., Ohyama,T., Zuniga,L., Kim,J.Y., Johnston,B.,
            Allen,S.J., Guido,D.G., Handel,T.M. and Butcher,E.C.
  TITLE     Chemokine-like receptor 1 expression by macrophages in vivo:
            regulation by TGF-beta and TLR ligands
  JOURNAL   Exp Hematol 34 (8), 1106-1114 (2006)
   PUBMED   16863918
REFERENCE   7  (bases 1 to 2845)
  AUTHORS   Martensson,U.E., Bristulf,J., Owman,C. and Olde,B.
  TITLE     The mouse chemerin receptor gene, mcmklr1, utilizes alternative
            promoters for transcription and is regulated by all-trans retinoic
            acid
  JOURNAL   Gene 350 (1), 65-77 (2005)
   PUBMED   15792532
REFERENCE   8  (bases 1 to 2845)
  AUTHORS   Arita,M., Bianchini,F., Aliberti,J., Sher,A., Chiang,N., Hong,S.,
            Yang,R., Petasis,N.A. and Serhan,C.N.
  TITLE     Stereochemical assignment, antiinflammatory properties, and
            receptor for the omega-3 lipid mediator resolvin E1
  JOURNAL   J Exp Med 201 (5), 713-722 (2005)
   PUBMED   15753205
REFERENCE   9  (bases 1 to 2845)
  AUTHORS   Martensson,U.E., Owman,C. and Olde,B.
  TITLE     Genomic organization and promoter analysis of the gene encoding the
            mouse chemoattractant-like receptor, CMKLR1
  JOURNAL   Gene 328, 167-176 (2004)
   PUBMED   15019996
  REMARK    GeneRIF: Results provide a necessary basis for further studies of
            the gene regulation and function of this chemoattractant-like
            receptor and will be useful when manipulating the gene in the
            development of transgenic animal models.
REFERENCE   10 (bases 1 to 2845)
  AUTHORS   Methner,A., Hermey,G., Schinke,B. and Hermans-Borgmeyer,I.
  TITLE     A novel G protein-coupled receptor with homology to neuropeptide
            and chemoattractant receptors expressed during bone development
  JOURNAL   Biochem Biophys Res Commun 233 (2), 336-342 (1997)
   PUBMED   9144535
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY347978.1 and AC241893.3.
            
            On May 7, 2009 this sequence version replaced NM_008153.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100612.1, U79525.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               BY347978.1         38-355
            319-2845            AC241893.3         66729-69255         c
FEATURES             Location/Qualifiers
     source          1..2845
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.55 cM"
     gene            1..2845
                     /gene="Cmklr1"
                     /gene_synonym="ChemR23; DEZ; Gpcr27; mcmklr1"
                     /note="chemerin chemokine-like receptor 1"
                     /db_xref="GeneID:14747"
                     /db_xref="MGI:MGI:109603"
     exon            1..170
                     /gene="Cmklr1"
                     /gene_synonym="ChemR23; DEZ; Gpcr27; mcmklr1"
                     /inference="alignment:Splign:2.1.0"
     exon            171..259
                     /gene="Cmklr1"
                     /gene_synonym="ChemR23; DEZ; Gpcr27; mcmklr1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..2845
                     /gene="Cmklr1"
                     /gene_synonym="ChemR23; DEZ; Gpcr27; mcmklr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..1377
                     /gene="Cmklr1"
                     /gene_synonym="ChemR23; DEZ; Gpcr27; mcmklr1"
                     /note="chemerin receptor; chemokine receptor-like 1;
                     chemokine-like receptor 1; G-protein coupled receptor DEZ;
                     G-protein coupled receptor 27"
                     /codon_start=1
                     /product="chemerin-like receptor 1"
                     /protein_id="NP_032179.1"
                     /db_xref="CCDS:CCDS19551.1"
                     /db_xref="GeneID:14747"
                     /db_xref="MGI:MGI:109603"
                     /translation="MEYDAYNDSGIYDDEYSDGFGYFVDLEEASPWEAKVAPVFLVVI
                     YSLVCFLGLLGNGLVIVIATFKMKKTVNTVWFVNLAVADFLFNIFLPMHITYAAMDYH
                     WVFGKAMCKISNFLLSHNMYTSVFLLTVISFDRCISVLLPVWSQNHRSIRLAYMTCSA
                     VWVLAFFLSSPSLVFRDTANIHGKITCFNNFSLAAPESSPHPAHSQVVSTGYSRHVAV
                     TVTRFLCGFLIPVFIITACYLTIVFKLQRNRLAKNKKPFKIIITIIITFFLCWCPYHT
                     LYLLELHHTAVPSSVFSLGLPLATAVAIANSCMNPILYVFMGHDFRKFKVALFSRLAN
                     ALSEDTGPSSYPSHRSFTKMSSLNEKASVNEKETSTL"
     regulatory      2791..2796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cmklr1"
                     /gene_synonym="ChemR23; DEZ; Gpcr27; mcmklr1"
                     /note="hexamer: CATAAA"
     polyA_site      2839
                     /gene="Cmklr1"
                     /gene_synonym="ChemR23; DEZ; Gpcr27; mcmklr1"
                     /note="major polyA site"
ORIGIN      
        1 gagggaggct cttaggatgt tgtgctccgc ggggctcaga cgaaatcttc tgtgaatgga
       61 agaaatgctt ccaagcaaac agccactacc agaacaactg agaaagaggc cagagcgcga
      121 gttctcaaac cctgaagtcg caggagccgg agggggatat tggagagaag gtatttccag
      181 tcacgcgcag taacagacca gccaaggacc aggactggag ttctgttcta caacggtgaa
      241 cagtgaaagg tctccaaaga gatggagtac gacgcttaca acgactccgg catctatgat
      301 gatgagtact ctgatggctt tggctacttt gtggacttgg aggaggcgag tccgtgggag
      361 gccaaggtgg ccccggtctt cctggtggtg atctacagct tggtgtgctt cctcggtctc
      421 ctaggcaacg gcctggtgat tgtcatcgcc accttcaaga tgaagaagac cgtgaacact
      481 gtgtggtttg tcaacctggc tgtggccgac ttcctgttca acatcttttt gccgatgcac
      541 atcacctacg cggccatgga ctaccactgg gtgttcggga aggccatgtg caagatcagc
      601 aacttcttgc tcagccacaa catgtacacc agcgtcttcc tgctgactgt catcagcttt
      661 gaccgctgca tctccgtgct gctccccgtc tggtcccaga accaccgcag catccgcctg
      721 gcctacatga cctgctcggc cgtctgggtc ctggctttct tcttgagctc cccgtccctt
      781 gtcttccggg acaccgccaa cattcatggg aagataacct gcttcaacaa cttcagcttg
      841 gccgcgcctg agtcctcccc acatcccgcc cactcgcaag tagtttccac agggtacagc
      901 agacacgtgg cggtcactgt cacccgcttc ctttgcggct tcctgatccc cgtcttcatc
      961 atcacggcct gctaccttac catcgtcttc aagctgcagc gcaaccgcct ggccaagaac
     1021 aagaagccct tcaagatcat tatcaccatc atcatcacct tcttcctctg ctggtgcccc
     1081 taccacaccc tctacctgct ggagctccac cacacagctg tgccaagctc tgtcttcagc
     1141 ctggggctac ccctggccac ggccgtcgcc atcgccaaca gctgcatgaa ccccattctg
     1201 tacgtcttca tgggccacga cttcagaaaa ttcaaggtgg ccctcttctc ccgcctggcc
     1261 aacgccctga gtgaggacac aggcccctcc tcctacccca gtcacaggag cttcaccaag
     1321 atgtcgtctt tgaatgagaa ggcttcggtg aatgagaagg agaccagtac cctctgaacc
     1381 tcacctggga atgtccccca aaggtgccac ggcccaggga cgcctaggga cttgtctccg
     1441 gaagtgggag acatgccggg agcctttggg aatgctccaa tgcccactga attttgcaca
     1501 aggcggctca tgttttaagt ggggttccca agtgtggaca ctcttccagt aaaatggcag
     1561 gcaagcaacc cgagcctcta caacaggagc aggggaccga ctgtgactga ctcagaaaag
     1621 ggagcatctc tgaagccaag acttgagctg tgaccaacat acaggccaac atacacgatg
     1681 tcgccgtgca tgccctgaac atgctgcgca gtcttcgtgg gtgaggaagt taccgcaaac
     1741 ccattgcaga cctgttatgg caacatgaca gtcaaaccaa caaagcccac tacaccccaa
     1801 catcctccaa gaccttgact ttggatttca gaagaacggg gggtgggggg aacgaggacc
     1861 tgaggggctt catggaactt tgcaagggca acacagggtt ctgtgtgtgt gtgtgtgtgt
     1921 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgg taaagaggag gagacggaga gcagagaatc
     1981 ccaaaggatg tgggtacagg atatcttaca ccatcatgcc acggaggaga cagagagcta
     2041 tagtggtggt tgcttggggg ttcaggtggt ggcagctctt tgcttcagtg tgtatactca
     2101 cttagcactg aaccctgagg ctgggtggag gccttttcac agaagactcc atctgatccc
     2161 atcccatccc ctcccctccc ctcccctccc ctcccctccc ctcccctccc ctcccctccc
     2221 ctcccctccc agggtctctt ctcccctaat cccctcaatg ctggctggaa aaagggctta
     2281 gaatgtccca gagactggtc tagaacggag ttttgggact ccatcttcag agtgtcttcc
     2341 caaggctgtc tggctggtca tctgggcagc tgaccagctt tcccgagtcc tccttgaatg
     2401 tatcaacagc cccgtgggca gcccaggatc aggctttcct cccctggcag gaaaatggct
     2461 cactcacccc ccccccacac acacacactg ttcatcagta gcaaaagacc cgagccctgc
     2521 tccgtctggc ttgacatcat tcctcatgga ggaggggtgg tgtgcacttc gttagcatgt
     2581 cccatgcatg ttaagtattt cacatgcacc ttctcattta ttcttcacag aaacctcata
     2641 tgtatgagga caagcagaga ctcagagagg ttaagcaact ggcccgaggg gacccagtta
     2701 gatgttggta gagactggat tcgaatcgca gtgggcttgg ctcgaaggaa gatgaagagt
     2761 ctggggaaac taataggttg gggttttagc cataaatgct gttttgttct gttttttcca
     2821 tgtaaacatc ttaatggtct ttttg
//
