LOCUS       NM_001163262            4539 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus c-Maf inducing protein (Cmip), transcript variant 1,
            mRNA.
ACCESSION   NM_001163262 XM_001004724 XM_924798
VERSION     NM_001163262.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4539)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4539)
  AUTHORS   Lee,J., Song,J.H., Park,J.H., Chung,M.Y., Lee,S.H., Jeon,S.B.,
            Park,S.H., Hwang,J.T. and Choi,H.K.
  TITLE     Dnmt1/Tet2-mediated changes in Cmip methylation regulate the
            development of nonalcoholic fatty liver disease by controlling the
            Gbp2-Ppargamma-CD36 axis
  JOURNAL   Exp Mol Med 55 (1), 143-157 (2023)
   PUBMED   36609599
  REMARK    GeneRIF: Dnmt1/Tet2-mediated changes in Cmip methylation regulate
            the development of nonalcoholic fatty liver disease by controlling
            the Gbp2-Ppargamma-CD36 axis.
REFERENCE   3  (bases 1 to 4539)
  AUTHORS   Oniszczuk,J., Sendeyo,K., Chhuon,C., Savas,B., Cogne,E., Vachin,P.,
            Henique,C., Guerrera,I.C., Astarita,G., Frontera,V., Pawlak,A.,
            Audard,V., Sahali,D. and Ollero,M.
  TITLE     CMIP is a negative regulator of T cell signaling
  JOURNAL   Cell Mol Immunol 17 (10), 1026-1041 (2020)
   PUBMED   31395948
  REMARK    GeneRIF: CMIP is a negative regulator of T cell signaling.
REFERENCE   4  (bases 1 to 4539)
  AUTHORS   Ingham,N.J., Rook,V., Di Domenico,F., James,E., Lewis,M.A.,
            Girotto,G., Buniello,A. and Steel,K.P.
  TITLE     Functional analysis of candidate genes from genome-wide association
            studies of hearing
  JOURNAL   Hear Res 387, 107879 (2020)
   PUBMED   31927188
REFERENCE   5  (bases 1 to 4539)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4539)
  AUTHORS   Moktefi,A., Zhang,S.Y., Vachin,P., Ory,V., Henique,C., Audard,V.,
            Rucker-Martin,C., Gouadon,E., Eccles,M., Schedl,A., Heidet,L.,
            Ollero,M., Sahali,D. and Pawlak,A.
  TITLE     Repression of CMIP transcription by WT1 is relevant to podocyte
            health
  JOURNAL   Kidney Int 90 (6), 1298-1311 (2016)
   PUBMED   27650733
  REMARK    GeneRIF: Unlike the human CMIP gene, only one Wt1 response element
            was identified in the mouse Cmip proximal promoter located at
            position -217/-206.
REFERENCE   7  (bases 1 to 4539)
  AUTHORS   Yu,L., Lin,Q., Feng,J., Dong,X., Chen,W., Liu,Q. and Ye,J.
  TITLE     Inhibition of nephrin activation by c-mip through Csk-Cbp-Fyn axis
            plays a critical role in Angiotensin II-induced podocyte damage
  JOURNAL   Cell Signal 25 (3), 581-588 (2013)
   PUBMED   23200848
  REMARK    GeneRIF: the c-mip protein is involve in regulating nephrin
            phosphorylation through Csk-Cbp/PAG-Fyn signaling pathway.
REFERENCE   8  (bases 1 to 4539)
  AUTHORS   Ory,V., Fan,Q., Hamdaoui,N., Zhang,S.Y., Desvaux,D., Audard,V.,
            Candelier,M., Noel,L.H., Lang,P., Guellaen,G., Pawlak,A. and
            Sahali,D.
  TITLE     c-mip down-regulates NF-kappaB activity and promotes apoptosis in
            podocytes
  JOURNAL   Am J Pathol 180 (6), 2284-2292 (2012)
   PUBMED   22507836
REFERENCE   9  (bases 1 to 4539)
  AUTHORS   Li,Z., Mulligan,M.K., Wang,X., Miles,M.F., Lu,L. and Williams,R.W.
  TITLE     A transposon in Comt generates mRNA variants and causes widespread
            expression and behavioral differences among mice
  JOURNAL   PLoS One 5 (8), e12181 (2010)
   PUBMED   20808911
  REMARK    GeneRIF: Expression of Cmip in the mouse hippocampus is modulated
            by a sequence variant (B2 SINE indel) in the 3' UTR of Comt
            (catechol-O-methyltransferase).
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 4539)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121116.7, BY792820.1, AK016712.1, BY243950.1, CA552751.1,
            AK165728.1, AC118207.13 and BX514237.1.
            
            On or before Jul 17, 2009 this sequence version replaced
            XM_924798.2, XM_001004724.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.869207.1,
                                           SRR9219381.109090.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AC121116.7         68299-68474         c
            177-444             BY792820.1         58-325
            445-494             AK016712.1         269-318
            495-495             BY243950.1         364-364
            496-1099            AK016712.1         320-923
            1100-1100           CA552751.1         491-491
            1101-2187           AK016712.1         925-2011
            2188-2189           AK165728.1         743-744
            2190-2453           AK016712.1         2014-2277
            2454-4127           AC118207.13        32221-33894         c
            4128-4539           BX514237.1         1-412
FEATURES             Location/Qualifiers
     source          1..4539
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 63.87 cM"
     gene            1..4539
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /note="c-Maf inducing protein"
                     /db_xref="GeneID:74440"
                     /db_xref="MGI:MGI:1921690"
     exon            1..383
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..2405
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     C-Maf-inducing protein; c-Mip"
                     /codon_start=1
                     /product="C-Maf-inducing protein isoform 1"
                     /protein_id="NP_001156734.1"
                     /db_xref="CCDS:CCDS52680.1"
                     /db_xref="GeneID:74440"
                     /db_xref="MGI:MGI:1921690"
                     /translation="MDVTSSSGGGDPRQIEETKPLLGSDVSGPEGTKVMGAVPCRRAL
                     LLCNGMRYKLLQEGDIQVCVIRHPRTFLSKILTSKFLRRWEPHHLTLADNSLASATPS
                     GYMENSVSYSAIEDVQPLSWENAPKYCLQLTIPGGTVLLQAANSYLRDQWFHSLQWKK
                     KIYKYKKVLSNPSRWEVVLKEIRTLVDMALTSPLQDDSINQAPLEIVSKLLSENTNLT
                     TQEHENIIVAIAPLLENNHPPPDLCEFFCKHCRERPRSMVVIEVFTPVVQRILKHNMD
                     FGKCPRLRLFTQEYILALNELNAGMEVVKKFIQSMHGPTGHCPHPRVLPNLVAVCLAA
                     IYSCYEEFINSRDNSPSLKEIRNGCQQPCDRKPTLPLRLLHPSPDLVSQEATLSEPRL
                     KSVVVASSEVHVEVERTSTAKPALTASTGNDSEPNLIDCLMVSPACGTMSIELGPQAG
                     RTLGCHVEILKLLSDYDDWRPSLASLLQPIPFPKEALAHEKFTKELKYVIQRFAEDPR
                     QEVHSCLLSVRAGKDGWFQLYSPGGVACDDDGELFASMVHILMGSCYKTKKFLLSLAE
                     NKLGPCMLLALRGNQTMAEILCLMLEYNIIDNNDTQLQIISTLESTDVGKRMYEQLCD
                     RQRELKELQRKGGPTRLTLPSKSTDADLARLLSSGSFGNLENLSLAFTNVTSACAEHL
                     IKLPSLKQLNLWSTQFGDAGLRLLSEHLTMLQVLNLCETPVTDAGLLALSSMKSLCSL
                     NMNSTKLSADTYEDLKAKLPNLKEVDVRYTEAW"
     exon            384..509
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            510..560
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            561..722
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            723..764
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            765..827
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            828..908
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1012
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1117
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1471
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1537
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1564
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1613
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1721
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1838
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1979
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2027
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2174
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2280
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2351
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..4529
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4505..4510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4529
                     /gene="Cmip"
                     /gene_synonym="4933407C03Rik; 5830471E12Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggtgcgggcc ctccgcgggg gccccgccgg cccggcccca cgccagccgc gatcgcgcgc
       61 gcggcccccg ccccggcgcg gccatggatg tgacgagcag ctcgggcggc ggcgaccccc
      121 ggcagatcga ggagaccaag ccgctgcttg ggagcgacgt gtctggcccc gagggcacca
      181 aggtgatggg cgccgtgcct tgccgccggg ccctgctgct ttgcaacggg atgaggtaca
      241 agctgctgca ggagggcgac attcaggtct gtgtcatccg gcaccctcgg acctttctca
      301 gcaagatcct cacctccaaa ttcctgaggc gctgggagcc gcaccaccta acgctggccg
      361 acaacagctt agcatccgcc acgccgtctg ggtacatgga aaactcggtc tcctacagcg
      421 ccattgaaga cgttcagccg ctgtcctggg agaacgcccc gaagtactgt ttacagctca
      481 cgatccccgg agggaccgtc ctgctgcagg ctgccaacag ctacctgcga gatcagtggt
      541 tccattctct gcagtggaag aaaaagattt acaaatacaa gaaagtcctg agtaacccaa
      601 gccgctggga ggttgtcttg aaggagatac ggacgctggt ggacatggcc ctcacgtcgc
      661 ctctgcagga tgattctatc aaccaggctc cgctggaaat cgtctcaaaa ctgctctcag
      721 agaacacaaa cctgaccact caggagcacg agaacatcat tgtggcaatt gcgcctctgc
      781 tagaaaacaa ccacccaccc ccagacctct gcgaattctt ctgcaagcac tgcagagagc
      841 ggccccggtc tatggtggtc atcgaggtgt tcacaccagt ggttcagagg atccttaaac
      901 ataatatgga ctttgggaag tgcccaaggc tgaggctctt cacccaggag tatattcttg
      961 ccctgaacga gctcaacgca ggcatggagg tggtaaagaa gttcatacaa agcatgcatg
     1021 gccccacagg gcactgccca catccccggg tcctgcccaa tctcgtggct gtgtgcctgg
     1081 ctgccatata ctcctgctat gaagagttca tcaacagtcg cgacaactcc cccagcctga
     1141 aagagatccg aaacggctgc cagcagccat gcgaccgaaa gcccacctta cctctgcgtc
     1201 tgctgcaccc cagcccggac ctggtgtctc aggaagccac attgtctgag ccacggctga
     1261 agtcggtggt tgtggcctcc agcgaggtcc acgtggaggt ggagcgcacc agcactgcca
     1321 agccggcgct gaccgccagc acgggcaacg acagcgagcc caaccttatt gactgtctga
     1381 tggtcagccc agcctgtggg accatgagca tcgagctggg cccccaggcc ggccgcacgc
     1441 tcggttgcca cgtggagatc ctcaagctgc tgtccgacta cgatgactgg agaccgtctc
     1501 tggccagctt gcttcaaccc attccattcc ccaaagaagc tctcgcccac gagaagttca
     1561 caaaggaact gaagtacgtg attcagaggt ttgcagaaga tccaagacag gaagtccact
     1621 cctgtctgct gagcgtgcgg gcaggcaagg atggctggtt ccagctctac agccctggag
     1681 gggtggcctg tgatgatgac ggggagctgt ttgccagcat ggtgcacatt ctcatgggct
     1741 cctgttacaa gaccaaaaag tttctgctct cactggcaga aaacaagctg ggcccctgta
     1801 tgctcctggc cctgagaggg aaccagacca tggcagagat cctgtgtttg atgctggaat
     1861 acaacatcat cgacaacaac gacacccaac tgcagatcat ctccacgctg gagagcacgg
     1921 acgtgggcaa gcgcatgtat gaacagctgt gcgaccggca gcgggagctg aaggagctgc
     1981 aaaggaaagg cggacccacc aggctaacac tgccctccaa gtccacggat gcggacctgg
     2041 cccgcctgct gagctctggc tcctttggaa acctggagaa cctcagcttg gccttcacca
     2101 acgtcaccag tgcctgcgcc gagcacctca tcaaactgcc ttccctcaag cagctcaatc
     2161 tgtggtccac gcagtttgga gacgccggcc tgcggctcct ttcggagcac ctcactatgc
     2221 tccaagtgct gaacctgtgt gagaccccag tcaccgacgc gggcttgctg gccctcagct
     2281 ccatgaagag tctttgcagt ttaaatatga acagcaccaa gctctcggct gacacctacg
     2341 aggatctgaa ggccaagctt cctaacctaa aggaggttga tgttcgctac acggaagcct
     2401 ggtgaagccc cctctgtgca caggatgggc tcgcacaaaa caaaacaaaa aagaaacaaa
     2461 aacaaaaaaa gaaacaaaca aacaaacaaa aaaaaacccg actcttgact aatagccgta
     2521 gagcagagca gtgggtcccg gggtggtccc agcacctggc tgcgggatag atgggggagt
     2581 cttggggggg cggagggggg acgggtgggg aatcctcggc acgcccagcc cccacctaat
     2641 tcttagagct tcatattgga acctttgacc ttgatcaaaa gcagccttgg tggcaacaag
     2701 aggaagaact gcgggtaggg agggcagggg aggggtgggg gggttccctt tgtggatttt
     2761 ctttgccttt tgttgtgtga taccgtaggg gggggcgggg ggagggcatt catccagcct
     2821 gatgctgtcc actcgggcca gaaggaggac gctttcttcc tggaggtgca ccgagccgag
     2881 atctcgcccc taccattggg acaggaatgt catgtcaccc catcgtcctg tgtctcccac
     2941 catcgctatg caaagtggtt cttgttgtac ataagattta aataacgcac ctatttaaga
     3001 aacgttgaca aattgtgggt ctgggacccg ctcttattta tgaagtcttt gaccggccct
     3061 ccctcctcac ctgcccccac ttgcctgccc ttctcacctc ccccatggcg tgtagtactg
     3121 tctggaccag tcagctgtcg ggttagtgct agtggttctg ttttgttttt gttttttgtt
     3181 ttttaaggaa acaaacaaca acaggggggg aaaaaaaaaa gacctttgga aacttaattg
     3241 cttttttttc ttaagggact cttgtatgct aatgctctcc tggtcagtca gtctgcccac
     3301 tcgctactct gtataatttc catgtgtctc cagtttcctt gtgggtgggg atcaaggtgg
     3361 gagggaagag gaagaaagag atagattctc cacgttgtag ctcacacctc ccctcctctg
     3421 cttctgtgaa tttggaaggg ccttgacctt ccctccctgt ataccccata ggagagttgg
     3481 tcctccaagg tccagctgtt gtccctcacc cccttttaag ctgtccttgt cccctactga
     3541 gacttgcaac ctgtggcctc ccccccccag ccctctgtgg ttcactaagc atgccccacg
     3601 cccacttctt tgcatggtct cttgggagag aagagctact tcacccagcc agcctgacct
     3661 cacccgactg tccacacctt ccctccactg acgtggacac tgcagcatcc ccttcccatc
     3721 gtgtcccgag gcagaccaac ctcatttctt tttacagaca gttggctttt tcttaccaag
     3781 ccccttcact gtacagaaac aaccctttga caattctttt gggagtcccc cctctctttc
     3841 cccgactcca gcccttttta tgttggttta gcacaaatct ccccccaacc tccaaaccag
     3901 accccctacc agtcgatatt aattgtttta tatctattta atcttattcg atggagacca
     3961 tgcttcggtt gttttatact ttgccaggta aactttatta cccaccccac ctccaactat
     4021 gccctaattt ttttaaaaaa ggaaaaaaaa aacacacaca aaaaaaacaa aacaaaacaa
     4081 acacagagac tttgggttcg agtctcggtc ttaattccct ttctgtggca ggttttcttc
     4141 cgtgcgtgtg cctgtgtgtg tgtgtggagt gagttctgat ttgtgttcgt ttctctgttg
     4201 atttctcttg ttgctttctt ccaaccccga ccctggtttc cgtatttcac agcacccggt
     4261 gcagagagaa gcagaagcag aaaataaaaa ataaaataaa gtaaaaaaaa aaattaaaaa
     4321 tttttaaaaa aaaagaaaaa aaagggaaaa aaattaaaaa ggaaaaaaaa aaaccaaaag
     4381 aactaagaca tgccaccccc gccccgcccc cacttccacc ccgcaatgtt gcttttcttg
     4441 atggttaata ataaatactg tcacgtagct gtgtacaaag agatgtgaaa tactttcagg
     4501 caaaaataaa ctgtaagtga ctcatgaaaa aaaaaaaaa
//
