LOCUS       NM_181588               1138 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus carboxymethylenebutenolidase homolog (Cmbl), mRNA.
ACCESSION   NM_181588
VERSION     NM_181588.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1138)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1138)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1138)
  AUTHORS   Tuck,E., Estabel,J., Oellrich,A., Maguire,A.K., Adissu,H.A.,
            Souter,L., Siragher,E., Lillistone,C., Green,A.L., Wardle-Jones,H.,
            Carragher,D.M., Karp,N.A., Smedley,D., Adams,N.C., Bussell,J.N.,
            Adams,D.J., Ramirez-Solis,R., Steel,K.P., Galli,A. and White,J.K.
  CONSRTM   Sanger Institute Mouse Genetics Project
  TITLE     A gene expression resource generated by genome-wide lacZ profiling
            in the mouse
  JOURNAL   Dis Model Mech 8 (11), 1467-1478 (2015)
   PUBMED   26398943
REFERENCE   4  (bases 1 to 1138)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB863032.1, BY793531.1, AI426411.1 and BM899338.1.
            
            On Jan 26, 2018 this sequence version replaced NM_181588.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024580.2, BI143841.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BB863032.1         44-77
            35-347              BY793531.1         2-314
            348-571             AI426411.1         150-373
            572-1138            BM899338.1         1-567               c
FEATURES             Location/Qualifiers
     source          1..1138
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 13.0 cM"
     gene            1..1138
                     /gene="Cmbl"
                     /gene_synonym="2310016A09Rik"
                     /note="carboxymethylenebutenolidase homolog"
                     /db_xref="GeneID:69574"
                     /db_xref="MGI:MGI:1916824"
     exon            1..107
                     /gene="Cmbl"
                     /gene_synonym="2310016A09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            108..341
                     /gene="Cmbl"
                     /gene_synonym="2310016A09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..864
                     /gene="Cmbl"
                     /gene_synonym="2310016A09Rik"
                     /note="carboxymethylenebutenolidase-like (Pseudomonas)"
                     /codon_start=1
                     /product="carboxymethylenebutenolidase homolog"
                     /protein_id="NP_853619.1"
                     /db_xref="CCDS:CCDS27410.1"
                     /db_xref="GeneID:69574"
                     /db_xref="MGI:MGI:1916824"
                     /translation="MANEANPCPCDIGHKLEYGGMGHEVQVEHIKAYVTRSPVDAGKA
                     VIVVQDIFGWQLPNTRYMADMIARNGYTTIVPDFFVGQEPWDPAGDWSTFPAWLKSRN
                     ARKVNREVDAVLRYLRQQCHAQKIGIVGFCWGGVVVHQVMTAYPDIRAGVSVYGIIRD
                     SEDVYNLKNPTLFIFAENDTVIPLEQVSTLTQKLKEHCIVNYQVKTFSGQTHGFVHRK
                     REDCSPADKPYIEEARRNLIEWLNKYV"
     exon            342..449
                     /gene="Cmbl"
                     /gene_synonym="2310016A09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            450..592
                     /gene="Cmbl"
                     /gene_synonym="2310016A09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            593..684
                     /gene="Cmbl"
                     /gene_synonym="2310016A09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            685..1120
                     /gene="Cmbl"
                     /gene_synonym="2310016A09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1098..1103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cmbl"
                     /gene_synonym="2310016A09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1120
                     /gene="Cmbl"
                     /gene_synonym="2310016A09Rik"
                     /note="major polyA site"
ORIGIN      
        1 acttcccgtg cagactgaga ctcctccctt cttctgcatg tccctcccta ccgggtcagc
       61 tccagggcgt ctgcctcctg ctgacttgct cttcaccatt agacaagccc tgacgtcaag
      121 accccaatgg ctaacgaagc taacccttgc ccatgtgaca ttggtcacaa actagagtat
      181 ggtggcatgg gccacgaagt tcaggttgag cacatcaagg catatgtcac ccggtccccc
      241 gtggatgcag gcaaagccgt gattgtcgtc caggatatat ttggctggca gctgcccaac
      301 accaggtata tggctgacat gattgccaga aatggataca caactattgt cccagacttc
      361 tttgtgggtc aagagccatg ggacccagct ggtgactggt ccaccttccc cgcgtggttg
      421 aaatcaagaa atgccagaaa agtcaatcgg gaggttgatg ctgtcttgag gtatctgaga
      481 caacagtgtc atgctcagaa gattggcatt gtgggcttct gctggggggg tgttgtggtg
      541 caccaagtga tgacggcata cccggacatc agggcggggg tgtctgtcta tggtatcatc
      601 agagattctg aagatgttta taatttgaag aacccaacgt tgtttatttt tgcagaaaat
      661 gacactgtga ttccacttga gcaggtttct acactgaccc agaagcttaa agaacactgc
      721 atagttaatt accaagttaa aacgttttct gggcaaactc atggctttgt gcatcggaag
      781 agagaagact gctcccctgc tgacaagccc tacatcgagg aggcaaggag gaacctaatt
      841 gaatggctga acaagtatgt ctaacagcac ccaagcacaa ggcagctgtt gcccaaattt
      901 gcctgaataa ttaaccatct cttactatcc atgatagcat gactgttagg ggaactgggg
      961 gcaattcagg gaccagctag attctcagat atggccttac attggtaatt caagtgttaa
     1021 aatgtacaaa accaggaaga gcagttgtca ctatgtatat tcaacttccc ctaatgagca
     1081 gtgtcgacat tcaacctaat aaagtgattt ttaaaacttg aaaaaaaaaa aaaaaaaa
//
