LOCUS       NM_001111110            9747 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus cytidine monophospho-N-acetylneuraminic acid
            hydroxylase (Cmah), transcript variant 2, mRNA.
ACCESSION   NM_001111110
VERSION     NM_001111110.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9747)
  AUTHORS   Lee,G.Y. and Song,J.
  TITLE     Single missense mutations in Vi capsule synthesis genes confer
            hypervirulence to Salmonella Typhi
  JOURNAL   Nat Commun 15 (1), 5258 (2024)
   PUBMED   38898034
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9747)
  AUTHORS   Takeda,R., Tabuchi,A., Nonaka,Y., Kano,R., Sudo,M., Kano,Y. and
            Hoshino,D.
  TITLE     Cmah deficiency blunts cellular senescence in adipose tissues and
            improves whole-body glucose metabolism in aged mice
  JOURNAL   Geriatr Gerontol Int 23 (12), 958-964 (2023)
   PUBMED   37968438
  REMARK    GeneRIF: Cmah deficiency blunts cellular senescence in adipose
            tissues and improves whole-body glucose metabolism in aged mice.
REFERENCE   3  (bases 1 to 9747)
  AUTHORS   Kawanishi,K., Coker,J.K., Grunddal,K.V., Dhar,C., Hsiao,J.,
            Zengler,K., Varki,N., Varki,A. and Gordts,P.L.S.M.
  TITLE     Dietary Neu5Ac Intervention Protects Against Atherosclerosis
            Associated With Human-Like Neu5Gc Loss-Brief Report
  JOURNAL   Arterioscler Thromb Vasc Biol 41 (11), 2730-2739 (2021)
   PUBMED   34587757
REFERENCE   4  (bases 1 to 9747)
  AUTHORS   Martin,P.T., Kawanishi,K., Ashbrook,A., Golden,B., Samraj,A.,
            Crowe,K.E., Zygmunt,D.A., Okerblom,J., Yu,H., Maki,A., Diaz,S.,
            Chen,X., Janssen,P.M.L. and Varki,A.
  TITLE     Serum Antibodies to N-Glycolylneuraminic Acid Are Elevated in
            Duchenne Muscular Dystrophy and Correlate with Increased Disease
            Pathology in Cmah-/-mdx Mice
  JOURNAL   Am J Pathol 191 (8), 1474-1486 (2021)
   PUBMED   34294193
REFERENCE   5  (bases 1 to 9747)
  AUTHORS   Saha,S., Coady,A., Sasmal,A., Kawanishi,K., Choudhury,B., Yu,H.,
            Sorensen,R.U., Inostroza,J., Schoenhofen,I.C., Chen,X.,
            Munster-Kuhnel,A., Sato,C., Kitajima,K., Ram,S., Nizet,V. and
            Varki,A.
  TITLE     Exploring the Impact of Ketodeoxynonulosonic Acid in Host-Pathogen
            Interactions Using Uptake and Surface Display by Nontypeable
            Haemophilus influenzae
  JOURNAL   mBio 12 (1), e03226-20 (2021)
   PUBMED   33468699
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9747)
  AUTHORS   Naito,Y., Takematsu,H., Koyama,S., Miyake,S., Yamamoto,H.,
            Fujinawa,R., Sugai,M., Okuno,Y., Tsujimoto,G., Yamaji,T.,
            Hashimoto,Y., Itohara,S., Kawasaki,T., Suzuki,A. and Kozutsumi,Y.
  TITLE     Germinal center marker GL7 probes activation-dependent repression
            of N-glycolylneuraminic acid, a sialic acid species involved in the
            negative modulation of B-cell activation
  JOURNAL   Mol Cell Biol 27 (8), 3008-3022 (2007)
   PUBMED   17296732
REFERENCE   7  (bases 1 to 9747)
  AUTHORS   Hayakawa,T., Satta,Y., Gagneux,P., Varki,A. and Takahata,N.
  TITLE     Alu-mediated inactivation of the human CMP- N-acetylneuraminic acid
            hydroxylase gene
  JOURNAL   Proc Natl Acad Sci U S A 98 (20), 11399-11404 (2001)
   PUBMED   11562455
REFERENCE   8  (bases 1 to 9747)
  AUTHORS   Koyama,S., Yamaji,T., Takematsu,H., Kawano,T., Kozutsumi,Y.,
            Suzuki,A. and Kawasaki,T.
  TITLE     A naturally occurring 46-amino acid deletion of cytidine
            monophospho-N-acetylneuraminic acid hydroxylase leads to a change
            in the intracellular distribution of the protein
  JOURNAL   Glycoconj J 13 (3), 353-358 (1996)
   PUBMED   8781965
REFERENCE   9  (bases 1 to 9747)
  AUTHORS   Kawano,T., Koyama,S., Takematsu,H., Kozutsumi,Y., Kawasaki,H.,
            Kawashima,S., Kawasaki,T. and Suzuki,A.
  TITLE     Molecular cloning of cytidine monophospho-N-acetylneuraminic acid
            hydroxylase. Regulation of species- and tissue-specific expression
            of N-glycolylneuraminic acid
  JOURNAL   J Biol Chem 270 (27), 16458-16463 (1995)
   PUBMED   7608218
REFERENCE   10 (bases 1 to 9747)
  AUTHORS   Kawano,T., Kozutsumi,Y., Kawasaki,T. and Suzuki,A.
  TITLE     Biosynthesis of N-glycolylneuraminic acid-containing
            glycoconjugates. Purification and characterization of the key
            enzyme of the cytidine monophospho-N-acetylneuraminic acid
            hydroxylation system
  JOURNAL   J Biol Chem 269 (12), 9024-9029 (1994)
   PUBMED   8132639
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590864.12, AB061276.1, AK083394.1, AL589744.18 and AA122526.1.
            
            On Oct 2, 2013 this sequence version replaced NM_001111110.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 3. Variants 1, 2, and 3 encode the same protein (isoform
            a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB061276.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AL590864.12        162029-162044
            17-2298             AB061276.1         1-2282
            2299-4004           AK083394.1         1832-3537
            4005-9616           AL589744.18        111315-116926
            9617-9747           AA122526.1         414-544
FEATURES             Location/Qualifiers
     source          1..9747
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 10.34 cM"
     gene            1..9747
                     /gene="Cmah"
                     /note="cytidine monophospho-N-acetylneuraminic acid
                     hydroxylase"
                     /db_xref="GeneID:12763"
                     /db_xref="MGI:MGI:103227"
     exon            1..85
                     /gene="Cmah"
                     /inference="alignment:Splign:2.1.0"
     exon            86..374
                     /gene="Cmah"
                     /inference="alignment:Splign:2.1.0"
     exon            375..484
                     /gene="Cmah"
                     /inference="alignment:Splign:2.1.0"
     exon            485..685
                     /gene="Cmah"
                     /inference="alignment:Splign:2.1.0"
     exon            686..777
                     /gene="Cmah"
                     /inference="alignment:Splign:2.1.0"
     exon            778..887
                     /gene="Cmah"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1078
                     /gene="Cmah"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1226
                     /gene="Cmah"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1308
                     /gene="Cmah"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1446
                     /gene="Cmah"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1582
                     /gene="Cmah"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1723
                     /gene="Cmah"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1898
                     /gene="Cmah"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2015
                     /gene="Cmah"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2131
                     /gene="Cmah"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2228
                     /gene="Cmah"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..9747
                     /gene="Cmah"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3451..3456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cmah"
                     /note="hexamer: AATAAA"
     polyA_site      3473
                     /gene="Cmah"
     regulatory      9698..9703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cmah"
                     /note="hexamer: AATAAA"
     regulatory      9717..9722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cmah"
                     /note="hexamer: AATAAA"
     polyA_site      9723
                     /gene="Cmah"
                     /note="major polyA site"
     polyA_site      9743
                     /gene="Cmah"
ORIGIN      
        1 ggatgagtgc ccttttggac cctccattct ggcagtggca gctgtgaagt ctagcgatct
       61 tcttctggag agaacagatc agcagggtgg agctgggaga ggggtagtgt tgatgttaga
      121 cacataatgt gacatcagcc tgctctgcat ctgtgtctcc agaggaactt gaacttccca
      181 gctgtacttt ggtaattgct tctgaaaaaa acctcctggc cacacagaaa tcaaataaaa
      241 tttttaatca agcaaattga aaaatccagg ctgtattata aacatcaatt aaaagaagat
      301 ctgggcctgg gccttttgat gtttcctgac cagcttggat gctgtcacct ttgtctactc
      361 agaagggagt aaaggcagtc taaagtcatc ctcgccatcc tcgccttcct ggtgtgattc
      421 gcagaagtag aaagaacacc agcagctgct ttgaaatacc ctggagctgg cagatgatgg
      481 acaggaaaca gacagctgag accctgctga ccctgtctcc tgctgaagtt gccaacctca
      541 aggaagggat caattttttt cgaaataaga ctactgggaa agagtacatt ttatacaagg
      601 agaaggacca tctaaaggca tgcaagaacc tctgcaagca ccagggaggc ctgttcatga
      661 aagacatcga ggatttagat ggaaggtccg ttaaatgcac aaagcacaac tggaagttag
      721 acgtgagcac catgaaatat atcaaccctc cagggagctt ctgtcaagac gagctcgtta
      781 ttgaaatgga tgaaaacaat gggctttccc tggtagaact gaaccctcct aacccctggg
      841 actctgatcc caggtctcct gaagaattag cttttgggga agtacagata acatatctca
      901 ctcatgcctg catggacctc aagttgggag acaagcgaat ggtatttgac ccttggttaa
      961 ttggccctgc ttttgcccga ggatggtggt tgctacatga gcctccatct gactggttgg
     1021 agaggctgtg caaagcagac ctcatttata tcagccacat gcactcagac cacctgagct
     1081 accctaccct gaagcagctt tcccagagac gaccagacat tcccatttat gttggcgaca
     1141 cagaaaggcc tgtgttttgg aacctggatc agagtggcgt cgggttaact aacatcaacg
     1201 tggttccatt tggaatatgg caacaggtag acaaaagtct gcggttcatg atcttgatgg
     1261 acggcgttca tcctgagatg gacacatgca ttatcgtgga gtacaaaggt cataaaatac
     1321 tcaacacagt ggactgcacc agacccaatg ggggaaggct tcctgagaaa gttgctctaa
     1381 tgatgagtga tttcgcagga ggtgcatcag gctttccaat gactttcagt ggtggaaaat
     1441 ttactgagga atggaaagcc cagttcatta aggctgaaag aagaaagctt ctgaattaca
     1501 aagctcagct ggtgaaggac ctgcagcccc gaatctactg tccgtttgct gggtactttg
     1561 tggagtctca cccatctgac aagtacatta aggaaacaaa caccaaaaat gacccaaatc
     1621 agctcaacaa tcttatcagg aaaaactctg acgtggtgac atggacccca cgacctggcg
     1681 ctgtcctcga ccttggcagg atgctgaagg acccaacaga cagcaagggc attgtggagc
     1741 ctccagaggg gacaaagatt tacaaggatt cctgggactt tggcccgtac ctggagatct
     1801 tgaattctgc tgtcagagat gaaatcttct gtcattcatc ctggattaaa gagtacttca
     1861 cgtgggctgg atttaagaat tacaacctgg tggtcaggat gattgaaaca gatgaagatt
     1921 tcagcccttt tcctggaggg tacgactatc tggtggactt tctagattta tcctttccga
     1981 aagaaagacc cagccgggag catccttatg aagaaatcca tagccgggtg gatgtcatca
     2041 ggtacgtggt gaagaacggc ctgctgtggg atgatctgta tattggattc cagacccgat
     2101 tgctgcggga ccctgatata taccatcatc tgttttggaa tcattttcag ataaaactcc
     2161 ctctaacacc acccaactgg aagtcgttcc taatgcactg tgattagtct ggacctggta
     2221 agtcccagga ccccagccca gaggatggtg cctgaacatt caagatgggt ctcccctgct
     2281 tcgataaacc tttctggaaa cactttcata gacacagcca taactaccat tattcattgg
     2341 cagtgtcttt tattcagaga tggcaaacaa tgcccccaaa tcaagaattt gctcttaaat
     2401 cttgaacaca gcagcagttt ataccaaaga agacaagttt ctctcagcaa tgggcaaaca
     2461 ctacatttaa gggatgttca catatgtgcc tggtgtgcat tgtcgcatag acggactcag
     2521 aactactttt atcggggctg gtgttgtggc ttggtagtat agcatgtgct tagagcatat
     2581 gaggccctgg gttccaacac acacacacac acacacacac acacacacac acacacacac
     2641 ctgtataacc ctaaattcat cccatgtaca ctcttgtgca aggagaacca aggaaagcca
     2701 agaatgagct ctgcatggga gataaagcct aacagaagga aaagtgagtg tcagcacagt
     2761 aggaacagga aaggaaggct accagactcc agcagcaaaa aagaagaaag ctagagaaga
     2821 catgtgggct gggaggaagg tggggagact agaagaaaat gggaatgaga agatgctgcc
     2881 ggtagagaga agaatgtaaa aatggctctt gtgttctttg atagatccgt accccaggca
     2941 gctgcaggac aatgttttca gcttttcaga gagctcttgg caccatctac ttcccatctc
     3001 actagaaccg aaatgacttt gattctgttg tgaaatgtgt caattaatga agcccggggg
     3061 tcctaagagt cttacacgcg ttcgccaccg gccaggaaag acgcaacaaa ccggaatctt
     3121 ctgcggcaaa agctttattg cttacatctt caggagcaag agagagaatg gtgaaacccc
     3181 gtccctttta aggagaatta tcctccgcct agaacgtgtc gctccctgat tggctgcagc
     3241 ccattggccg agttgtcgtc atggggaagg cagagcacat ggagtggaga actacccttg
     3301 gcacacgtgc agattatttg tttaccattt agaacacagg atgtcagcgc catcttgtaa
     3361 cggtgaatgt gagggcggct ccccacataa gagttcaata gatctttgat tgatggctca
     3421 tgagaattgg gctgccgact gtaagtcatc aataaattcc tttactatct agagactatc
     3481 cataagttct gtgactctag agaaccctga ctaatacaac tagttaataa tcttagggag
     3541 aaaatatttt taaaatctat agaatattgt tgtgtctggc cagcagatca caacctgggt
     3601 tctagcctgg aaaggcattt tggaaacctg gaagagaaga ggggctaggc ggtgagagaa
     3661 agaaatgcag ctaagacagg cattctgatc aaagctcaat tttactgttc tgcacgcaat
     3721 tataaagcag gggaaggggg cccgattccc gccaattaat cttggggtcc aatagcaagg
     3781 tgaccacgtg caaggctctg aacagcaaag tggcaggttc cagcagtggg catggcagaa
     3841 tgattgagca ggaagctcca cccctgagca agcaggtttc aggctggggg aggggagact
     3901 acatctcctc cctgttgtta ataaaaataa aaaaaaatag aaaaggctgg cctgaggcaa
     3961 aaaatcaatc tatgctcaat agtcctgcct gaattcttag ggctaaagaa aaaaaaaaaa
     4021 cctgtctccg tgggatttcc tatcttttct tatggtaaac tgtatctggc taagactgta
     4081 ctttctatcc tagtaaacaa ctaacagaaa agccctgagc tgtaggctct gactttataa
     4141 tgctaattag tactgaatag gtaacttcct agttgaattt taagtagggc attggaaccc
     4201 tggctaagtt tgactgaaca aatttgaaat acactttatt aagaataaca ctgagttgat
     4261 attcctcagc atttttggat gacaggtggg aaacagggag gaagggtatg accggctcgg
     4321 tagtacaagg ccaattgtct tttttagggt gggagactgt gaagggcttg cccttctaac
     4381 agtacggtct ccaacctctc tcccccctat taattaagtt taaaaaggcc acacttaact
     4441 gaggtgatca aatgattttc tcatccgtag atgagtgagc ttttaacctt ggcttgggtg
     4501 gacattgacc cgattcctct cgtgggtgct gttacgaccc acacctgtgg ctcttggtat
     4561 cttttgggga ggggaggcag agccgtagat atttttgttt tttagctgta aatagatacc
     4621 aacctccgtc aaaccgggtt tatcccacag gaaactcaga aatggtcaag ctggaccttc
     4681 ccctgcagta attctctgca ccaagccata cccatactgt atttgtaaga tcacgaacca
     4741 gtgtgcacag ttctgaggac tgtgcagctc ctaagggaga attgtcaacc tcagatttag
     4801 caaggcctag gcaagaatta tgtcattagt aacaccacga tttgtggcta aaataggagc
     4861 tggaagtcgt tcctcttcat ccctgttatt cccatagcct gaggaactaa ggacaccttg
     4921 cagtaacagc aagggtgaaa agccagaggc tagctaaggg actaagcccg tctatcagaa
     4981 taaaaaccaa tctctattaa tattagaaat atctactttc ctagccctct tggtaaacct
     5041 aaattttaac tcagactgaa agccacatgc tggaatgtcc ttggaatgaa gatagcattt
     5101 gccacctgtg tgctcttggg ggcgggggat gcatgcccac tgtagttctg ctgaaggtgt
     5161 agattgacct gcttgaaaga caaaaatctt agagagtgaa gagtaacatc acaaagcttc
     5221 ttttggggaa gttcaggtac tttattcatt tgcaaattgt aaggctaagg ctagtctcag
     5281 gcctcctgtg ggggagctgg ctcagagagt agcaggaaaa cagctttcct gggagcttta
     5341 gtttccagct gaattttaag caaaagagga attttagtcc tcaaggtgat acttataaga
     5401 agattcagaa tctgtgttca tctgacgaat taatctctct ggcagccacc atgctctatc
     5461 ttcatctcgt gaaaaaacac aaactgagcc ccttccccag attagaaccg gatccggacc
     5521 ctactatttg ctagtcagtg ggtccttcca ttttaccaat gcataagaat tagaagtaac
     5581 tagatgccag tggcaatcca ctgctgactg acctttaata ttggttgcaa aatatttaga
     5641 acaaataagg taaaggcaag atgagccttt ggtgaccttg ggggatgtgc tctgaattaa
     5701 ctttgctagg taatttagaa tataggaatc tctaacgttg gactgaatat tagaccagtc
     5761 taagattgag ttagaatgac tggtcacact gaagaaaaga gaaaaatcat tatgactcta
     5821 ttaaatgact aattttacca agtcagtatg cacagtctct gatgaactat tgccataaag
     5881 ttaaaaggct agaagctagt ctaaactgga aaaatgacaa gcaaggatgg atctaaaaca
     5941 tgaatttaat ttagtttttt agtcatttca atcagaacac tgagtcaact tacctgccag
     6001 ctcgtcacac gaattaatat gcttctgcag cgttctgtgg agagaacctg ttttttcctt
     6061 tcctaataag gtagctgttt taggatcaat ctataagcca ataagtagat ccctttaaga
     6121 tactataaag catttattaa attctttgac atttaaattt caaatttcga aaataaaggt
     6181 atgatttaaa tagtgtgtat gggaatgcac taaatagtat gtacggggat acaatttctc
     6241 tcttttttgt cttttaagaa gttaaagttt taaaatttca caatacctaa ccttttgaat
     6301 taataacttg ttgacaaaac attttaaata cttggctgta aaggggcagt gactaattgc
     6361 actttcaatc atttttctta aggagcggtt gtaactagaa agcttgaaaa gttattaaga
     6421 gtcacatgtg cataatttat ttattaacta gaaatatgca taagcaattg caaatttgag
     6481 aattaatagt atctgaggga tgaacaattt taagcaattg tgagctcaga gatatggcat
     6541 tgactattaa tatacaaatt aaggtttgat tgttcagcat tttaaaacac catctacagc
     6601 acacaactag attatttgtg ctggaacagg ggagactgtg tgtcttaaga ctctgcccca
     6661 cagcagctag ttgggcccac gtgggccaac aatcggctgg gaggatgaga aaaacgactt
     6721 tacaataatg ttttttctgg ccaaagaatt gtcttgggca caactaatat ttaattacca
     6781 atgaatataa ttaataacaa ttataaaagc tttatttttt tgtaaaacct tttgtagtaa
     6841 actaaaaccc tcagtaataa aaggatattg tctctgaatc tcttgggtga gagcaaggat
     6901 ttaaggtaaa ctttctttaa gaagcattag ttaataaaat actttccact taggaaaaaa
     6961 tatacactga aagattaaaa ctcttggctt cttgtataga agcagaaaca ataaaaattt
     7021 ttcttacata atgtaaagtt acattagcca tacctagagg cagaattttc tagtgattac
     7081 agttcactag aagcaaaact ctttgaattt aagcattatt ttaaacatct gaatagatct
     7141 gtaacactgt taaaaagaaa ttttcttgaa cacagggaaa aactttctca ggcactgttt
     7201 gcaaaacaca agaaggccac aagccactct ggggctgccc agagccctgt attgactcaa
     7261 acgtaaaata ctttttaatc tgagcatcct ggccctcctg taataaggac tgattctaga
     7321 ggaacaattt aactgtctat gcctctaatt tttgatactc tatcttaaga tgacttacag
     7381 ttaaaacgtt cttcacaact ttagtgttgt gaaaaaattg cccatactgc agtttcctgc
     7441 caggcagcga ctatagccaa actgattgtc taatctattc acaaagacaa acataactag
     7501 ataactctgt cacagttttt atgaagtgag ctgtattagc tctctcataa gatgattact
     7561 cttgtaataa tcttaattaa caatatatgg gtgagtagaa aatcttaaat ttgccaactg
     7621 caagctgcag tcaatggaac actggcagtt ttaaccataa tttttaagtt ttttgtgcaa
     7681 ggttaggata atacctacaa ccttgggaaa gcaaaaccca agtttaaaac aatttatcat
     7741 ctttaaaatc aatattagaa gcattaccat catattacga agtttggctg ccaattaata
     7801 cctatgaata gctattaaag caagctttga tgctttaata aagaggcatt gctttaaatc
     7861 ttatcttaaa ttttactatt taggatagga accacattaa ttattatcta aactagaaat
     7921 atctttagag acccagcctc ttggcctgcc ttatgccacg tgtcggaagg actctaaact
     7981 tgagttatca aatttaacac taaccatctg tagcaatgta acaattatta atcttaacca
     8041 acaacttatg agctgaatgt gaaaatatgc agagcacatt ttcaataaaa aaggaaccaa
     8101 atgaagcagt tacatttaga ccaatcagag aatattaatt tttgtagcta caatcataga
     8161 ataaaaggaa ctttaccatt tgtcaaacac attaatcatg aaccatttat cagctttttt
     8221 actccaaaac taagaggctg tacactcgcc cttttctcct aaaacgaaca gtttttccag
     8281 caggggccct cctgccatgt gtttgattcc tagctgaagc acgtggcagc tctcggcttt
     8341 gcagataaag ttttttatac catctttatt atccaacata aaacatagaa cattcattca
     8401 tacagacagg acacgaacat acatgaattg aacacgagaa cagattggtg caccagacat
     8461 tacacgagac acaaaaggga cagagtactc ctgctataag gcccagagag aaatttctct
     8521 ctgctttttt gggacatttt cctccctcat gatgcagttt ttattaactg cggcaatccg
     8581 cctgattatt aatttccttt taataaaccc tttcttttct cacgcctaat gtagcttcgg
     8641 agagccacgg cctgttaccc agctcctctt aagcttcact gctgaaccta agtgaaccag
     8701 tgctcgggtt taacgctgtt tcagtttagc ccatactgac cttctctggt atgaatttcc
     8761 tttatccttt aattatttca tggagctcca aaccagcagt gcctcttcca aaaatccttt
     8821 gccgtttctc agtcccgcgt tggttcgcca aatgttgtgt ctggccagca gatcacagcc
     8881 tgggttctag cctggaaagg cattttggaa acctggaaga gaagagggtc taggtggcaa
     8941 gataaaaaaa tgcagctaag acagttattc tgatcaaagc tcaattttac tgttctgcac
     9001 gcagttataa agcaggggaa gggggcccaa ttcccgccaa ttagtcttgg ggtccaatag
     9061 cagtatgacc acgtgcaagg ctctgaacag caaagcggca ggttccagca gtgggcatgg
     9121 cagaatgatt gagcaggaag ctctacccct gagcaagcag gtttcaggct gggggagggg
     9181 agactacaga atataagaat ctcaaaatgt cttcaaatat aactacagca aaaaggccat
     9241 gaaaaagcac cccttttaga atttgaaaaa cattgtttca atgtttaaaa taggcaaata
     9301 agttggctga gggcttgttt gtttgttttt ctgtctattt gattgtttct aatgtactga
     9361 tgtatttcta aggaactgta attgttaccc agggttctcc tttgcacgtt gtttttccat
     9421 cctgcagtca agtgcactct ctgcctctgt cacctacctc ttgaatttga cttcagaatc
     9481 gctgcctagc tctaatcaat gaaagactat ctccttctca ttaaaatgag caacaagaat
     9541 agttgactat tcttgtttat atcatactag aaaaaattta aatacttgga agtcagagat
     9601 tagactttgt aatttatact agagagtaaa ttattcagtt actactaaaa taatataatg
     9661 tttatccaaa tatatgttca gatatatatg atgggcaaat aaaagattgt tttaaaaata
     9721 aaagtttgtt ttctcactct gtagccc
//
