LOCUS       NM_001024714             983 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus chymase 2, mast cell (Cma2), transcript variant 1,
            mRNA.
ACCESSION   NM_001024714 NM_007716 XM_619251
VERSION     NM_001024714.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 983)
  AUTHORS   Lee M, Calabresi L, Chiesa G, Franceschini G and Kovanen PT.
  TITLE     Mast cell chymase degrades apoE and apoA-II in apoA-I-knockout
            mouse plasma and reduces its ability to promote cellular
            cholesterol efflux
  JOURNAL   Arterioscler Thromb Vasc Biol 22 (9), 1475-1481 (2002)
   PUBMED   12231569
  REMARK    GeneRIF: Mast cell chymase inhibits the apolipoprotein-mediated
            removal of macrophage cholesterol in foam cells of apoA-I knockout
            mice.
REFERENCE   2  (bases 1 to 983)
  AUTHORS   Chu W, Johnson DA and Musich PR.
  TITLE     Molecular cloning and characterization of mouse mast cell chymases
  JOURNAL   Biochim Biophys Acta 1121 (1-2), 83-87 (1992)
   PUBMED   1376147
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163646.2.
            
            On Mar 29, 2018 this sequence version replaced NM_001024714.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF361939.1, BC139236.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AC163646.2         93400-93490         c
            92-242              AC163646.2         92750-92900         c
            243-378             AC163646.2         92085-92220         c
            379-633             AC163646.2         91632-91886         c
            634-983             AC163646.2         90887-91236         c
FEATURES             Location/Qualifiers
     source          1..983
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..983
                     /gene="Cma2"
                     /gene_synonym="Mcp10"
                     /note="chymase 2, mast cell"
                     /db_xref="GeneID:545055"
                     /db_xref="MGI:MGI:88426"
     exon            1..91
                     /gene="Cma2"
                     /gene_synonym="Mcp10"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..777
                     /gene="Cma2"
                     /gene_synonym="Mcp10"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="mast cell protease 10 isoform 1 precursor"
                     /protein_id="NP_001019885.1"
                     /db_xref="CCDS:CCDS27136.1"
                     /db_xref="GeneID:545055"
                     /db_xref="MGI:MGI:88426"
                     /translation="MQALLFLMALLLPSRAGAEEIIGGVESEPHSRPYMAYVNTFRRK
                     GYVAICGGFLITPQFVMTAAHCSGRRMTVTLGAHNVRKRECTQQKIKVEKYILPPNYN
                     VSSKFNDIVLLKLKKQANLTSAVDVVPLPAPSDFAKPGTMCWAAGWGRTGLKKSISRT
                     LREVELRIMGKKACKIFKHYKDSLQICVGSSTKVASVYMGDSGGPLLCAGVAHGIVSS
                     GRGNAKPPAIFTRISPHVPWINRVIEGK"
     exon            92..242
                     /gene="Cma2"
                     /gene_synonym="Mcp10"
                     /inference="alignment:Splign:2.1.0"
     exon            243..378
                     /gene="Cma2"
                     /gene_synonym="Mcp10"
                     /inference="alignment:Splign:2.1.0"
     exon            379..633
                     /gene="Cma2"
                     /gene_synonym="Mcp10"
                     /inference="alignment:Splign:2.1.0"
     exon            634..983
                     /gene="Cma2"
                     /gene_synonym="Mcp10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaatctctc tccagactgc gaccgacact ggcaagatgc aggccctact attcctgatg
       61 gcacttctct tgccttctag ggctggagct gaggagatta ttggtggtgt tgagtctgaa
      121 ccacactccc gaccttacat ggcctatgtg aataccttca gaaggaaagg ttatgtggca
      181 atctgtggtg ggtttctcat aacgccccaa tttgtgatga ctgctgcaca ctgtagtgga
      241 agaagaatga ctgtcactct tggagctcat aatgtgagaa agagagaatg cacacagcag
      301 aagataaaag ttgaaaagta catcttgcct ccaaattaca atgtgtcttc caagttcaat
      361 gacatcgtat tactgaagct taaaaagcaa gctaacttga cttctgctgt ggatgtagtt
      421 cccctgcctg ccccctctga ctttgccaag cctgggacga tgtgttgggc agctggctgg
      481 gggcgaactg gattgaaaaa aagtatctca cgtaccctga gagaggtaga actgagaatc
      541 atggggaaaa aggcctgtaa aatatttaag cattacaagg atagcctcca gatctgtgtg
      601 ggcagttcca caaaggtggc atcagtatac atgggagact ctggaggacc tctactgtgt
      661 gctggggtgg cccatggtat tgtatcttct ggacgcggaa atgcaaagcc ccctgcaatc
      721 ttcacccgaa tctccccaca tgtgccctgg attaacagag tcatagaggg caagtagtga
      781 aaagcctgac ctgcgtgcat cagagtcttc aagccagagc tcttctgata acccttgggt
      841 tcaacaaagc atgtgtccat cctgtcccct gcctgccccc agcatgtccc tagcatgtcc
      901 cccgcctgcc ctcagcctgc ccccagtctg tccccaagat gatctgaaaa ataaagtctg
      961 tgatgatgga ctgttccctg taa
//
