LOCUS       NM_010780               1090 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Mus musculus chymase 1, mast cell (Cma1), mRNA.
ACCESSION   NM_010780
VERSION     NM_010780.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1090)
  AUTHORS   Kim,J.H., Kim,K., Kim,I., Seong,S., Koh,J.T. and Kim,N.
  TITLE     MCP-5 suppresses osteoclast differentiation through Ccr5
            upregulation
  JOURNAL   J Cell Physiol 239 (2), e31171 (2024)
   PUBMED   38214098
  REMARK    GeneRIF: MCP-5 suppresses osteoclast differentiation through Ccr5
            upregulation.
REFERENCE   2  (bases 1 to 1090)
  AUTHORS   Sasaki,H., Imanishi,M., Fujikura,D., Sugiyama,M., Tanimoto,K.,
            Mochiji,Y., Takahashi,Y., Hiura,K., Watanabe,M., Kashimoto,T.,
            Nakano,K., Okamura,T. and Sasaki,N.
  TITLE     New inducible mast cell-deficient mouse model (Mcpt5/Cma1DTR)
  JOURNAL   Biochem Biophys Res Commun 551, 127-132 (2021)
   PUBMED   33725574
REFERENCE   3  (bases 1 to 1090)
  AUTHORS   Valero-Jimenez,A., Zuniga,J., Cisneros,J., Becerril,C., Salgado,A.,
            Checa,M., Buendia-Roldan,I., Mendoza-Milla,C., Gaxiola,M., Pardo,A.
            and Selman,M.
  TITLE     Transmembrane protease, serine 4 (TMPRSS4) is upregulated in IPF
            lungs and increases the fibrotic response in bleomycin-induced lung
            injury
  JOURNAL   PLoS One 13 (3), e0192963 (2018)
   PUBMED   29529050
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1090)
  AUTHORS   Stevens,R.L., McNeil,H.P., Wensing,L.A., Shin,K., Wong,G.W.,
            Hansbro,P.M. and Krilis,S.A.
  TITLE     Experimental Arthritis Is Dependent on Mouse Mast Cell Protease-5
  JOURNAL   J Biol Chem 292 (13), 5392-5404 (2017)
   PUBMED   28193842
  REMARK    GeneRIF: Fibronectin was identified as a target of mMCP-5, and the
            exocytosis of mMCP-5 from the MCs in the mouse's peritoneal cavity
            resulted in the expression of metalloproteinase protease-9, which
            has been implicated in arthritis.
REFERENCE   5  (bases 1 to 1090)
  AUTHORS   Shubin,N.J., Glukhova,V.A., Clauson,M., Truong,P., Abrink,M.,
            Pejler,G., White,N.J., Deutsch,G.H., Reeves,S.R., Vaisar,T.,
            James,R.G. and Piliponsky,A.M.
  TITLE     Proteome analysis of mast cell releasates reveals a role for
            chymase in the regulation of coagulation factor XIIIA levels via
            proteolytic degradation
  JOURNAL   J Allergy Clin Immunol 139 (1), 323-334 (2017)
   PUBMED   27302551
  REMARK    GeneRIF: Mast cells have the ability to produce and degrade FXIIIA
            depending on their chymase expression profile: mast cells
            expressing chymase degrade FXIIIA, whereas mast cells that do not
            express chymase mainly produce FXIIIA
REFERENCE   6  (bases 1 to 1090)
  AUTHORS   McNeil,H.P., Frenkel,D.P., Austen,K.F., Friend,D.S. and
            Stevens,R.L.
  TITLE     Translation and granule localization of mouse mast cell protease-5.
            Immunodetection with specific antipeptide Ig
  JOURNAL   J Immunol 149 (7), 2466-2472 (1992)
   PUBMED   1527387
REFERENCE   7  (bases 1 to 1090)
  AUTHORS   Chu,W., Johnson,D.A. and Musich,P.R.
  TITLE     Molecular cloning and characterization of mouse mast cell chymases
  JOURNAL   Biochim Biophys Acta 1121 (1-2), 83-87 (1992)
   PUBMED   1376147
REFERENCE   8  (bases 1 to 1090)
  AUTHORS   McNeil,H.P., Austen,K.F., Somerville,L.L., Gurish,M.F. and
            Stevens,R.L.
  TITLE     Molecular cloning of the mouse mast cell protease-5 gene. A novel
            secretory granule protease expressed early in the differentiation
            of serosal mast cells
  JOURNAL   J Biol Chem 266 (30), 20316-20322 (1991)
   PUBMED   1939089
REFERENCE   9  (bases 1 to 1090)
  AUTHORS   Huang,R.Y., Blom,T. and Hellman,L.
  TITLE     Cloning and structural analysis of MMCP-1, MMCP-4 and MMCP-5, three
            mouse mast cell-specific serine proteases
  JOURNAL   Eur J Immunol 21 (7), 1611-1621 (1991)
   PUBMED   2060576
REFERENCE   10 (bases 1 to 1090)
  AUTHORS   Reynolds,D.S., Stevens,R.L., Lane,W.S., Carr,M.H., Austen,K.F. and
            Serafin,W.E.
  TITLE     Different mouse mast cell populations express various combinations
            of at least six distinct mast cell serine proteases
  JOURNAL   Proc Natl Acad Sci U S A 87 (8), 3230-3234 (1990)
   PUBMED   2326280
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC163646.2 and BC139457.1.
            
            On Nov 13, 2015 this sequence version replaced NM_010780.2.
            
            Summary: This gene encodes a serine protease that belongs to the
            peptidase family S1. It is expressed in mast cells and is thought
            to function in the degradation of the extracellular matrix, the
            regulation of submucosal gland secretion, and the generation of
            vasoactive peptides. The encoded preproprotein undergoes
            proteolytic processing to generate a functional enzyme with
            elastase-like activity. Mice lacking the encoded protein exhibit
            significant attenuation of ischemia-reperfusion injury of the
            skeletal muscle. This gene is located in a cluster of related mast
            cell protease genes on chromosome 14. [provided by RefSeq, Nov
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X68805.1, M68898.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AC163646.2         120243-120267
            26-916              BC139457.1         1-891
            917-1090            AC163646.2         123294-123467
FEATURES             Location/Qualifiers
     source          1..1090
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..1090
                     /gene="Cma1"
                     /gene_synonym="Mcp-5; Mcp5; Mcpt5; MMCP-5"
                     /note="chymase 1, mast cell"
                     /db_xref="GeneID:17228"
                     /db_xref="MGI:MGI:96941"
     exon            1..201
                     /gene="Cma1"
                     /gene_synonym="Mcp-5; Mcp5; Mcpt5; MMCP-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..887
                     /gene="Cma1"
                     /gene_synonym="Mcp-5; Mcp5; Mcpt5; MMCP-5"
                     /EC_number="3.4.21.39"
                     /note="alpha-chymase; mast cell chymase 1; mast cell
                     protease I; mast cell protease 5"
                     /codon_start=1
                     /product="chymase preproprotein"
                     /protein_id="NP_034910.2"
                     /db_xref="CCDS:CCDS27135.2"
                     /db_xref="GeneID:17228"
                     /db_xref="MGI:MGI:96941"
                     /translation="MHLLTLHLLLLLLGSSTKAGEIIGGTECIPHSRPYMAYLEIVTS
                     ENYLSACSGFLIRRNFVLTAAHCAGRSITVLLGAHNKTSKEDTWQKLEVEKQFLHPKY
                     DENLVVHDIMLLKLKEKAKLTLGVGTLPLSANFNFIPPGRMCRAVGWGRTNVNEPASD
                     TLQEVKMRLQEPQACKHFTSFRHNSQLCVGNPKKMQNVYKGDSGGPLLCAGIAQGIAS
                     YVHRNAKPPAVFTRISHYRPWINKILREN"
     exon            202..352
                     /gene="Cma1"
                     /gene_synonym="Mcp-5; Mcp5; Mcpt5; MMCP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            353..488
                     /gene="Cma1"
                     /gene_synonym="Mcp-5; Mcp5; Mcpt5; MMCP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            489..743
                     /gene="Cma1"
                     /gene_synonym="Mcp-5; Mcp5; Mcpt5; MMCP-5"
                     /inference="alignment:Splign:2.1.0"
     exon            744..1090
                     /gene="Cma1"
                     /gene_synonym="Mcp-5; Mcp5; Mcpt5; MMCP-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1064..1069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cma1"
                     /gene_synonym="Mcp-5; Mcp5; Mcpt5; MMCP-5"
                     /note="hexamer: AATAAA"
     polyA_site      1090
                     /gene="Cma1"
                     /gene_synonym="Mcp-5; Mcp5; Mcpt5; MMCP-5"
                     /note="major polyA site"
ORIGIN      
        1 agttatgaag acaacttaaa gaagacgcct tgaccacaca gttcctgtga taacagctct
       61 gccactcccc tgcccgctgg gagtaataag cctaaggccc aaatatgaag cctgcagcag
      121 ccctgaggag gccctctgag aggatgcatc ttcttactct tcatctgctg ctccttctcc
      181 tgggttccag caccaaagct ggagagatca ttggaggcac ggagtgcata ccacactccc
      241 gcccctacat ggcctatctg gaaattgtca cttctgagaa ctacctgtcg gcctgcagtg
      301 gcttcctgat aagaagaaac tttgtgctga ctgcagctca ctgtgcggga aggtctataa
      361 cagtcctcct aggagcccat aacaaaacat ctaaagaaga cacgtggcag aagcttgagg
      421 tggaaaagca attccttcat ccaaaatatg atgagaattt ggttgtccac gacatcatgc
      481 tactgaagtt gaaggagaaa gccaagctaa ccctaggtgt gggaaccctc ccactctctg
      541 ccaacttcaa ctttatccca cccgggagaa tgtgcagggc agttggctgg ggcagaacaa
      601 acgtgaatga gccagcctcc gacacactgc aggaagtaaa gatgagactc caggagcccc
      661 aagcctgcaa acacttcacc agttttcgac acaattccca gctgtgtgtg ggcaacccca
      721 agaagatgca aaatgtatac aagggagact ctggaggacc tctgctgtgt gctgggatag
      781 cccaaggcat tgcatcctat gtacatcgga atgcaaagcc ccctgctgtc tttaccagaa
      841 tctcccatta caggccctgg atcaataaga tcttgaggga gaattaactc tggagctttt
      901 gccagcctgt gaggaaatct ggaactggaa tagtgcaggt tttgtgtgcc atgcgatctg
      961 gcctgtctgt agttcctgct gaagccctgc ctggtccctg agcttccaga aggttcttac
     1021 aagtcacaga atgttcctaa aagccaccat cttcattaac ctcaataaag acccagattg
     1081 tcaactgcaa
//
