LOCUS       NM_175448               2632 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus clavesin 2 (Clvs2), transcript variant 1, mRNA.
ACCESSION   NM_175448
VERSION     NM_175448.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2632)
  AUTHORS   Fritz,K.R., Zhang,Y. and Ruest,L.B.
  TITLE     Cdc42 activation by endothelin regulates neural crest cell
            migration in the cardiac outflow tract
  JOURNAL   Dev Dyn 248 (9), 795-812 (2019)
   PUBMED   31219639
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD354378.1, AK039308.1 and AK169009.1.
            
            On Dec 21, 2017 this sequence version replaced NM_175448.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169009.1, AK139868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                CD354378.1         1-84
            85-2584             AK039308.1         2-2501
            2585-2632           AK169009.1         2671-2718
FEATURES             Location/Qualifiers
     source          1..2632
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 18.62 cM"
     gene            1..2632
                     /gene="Clvs2"
                     /gene_synonym="A330019N05Rik; Rlbp1l2"
                     /note="clavesin 2"
                     /db_xref="GeneID:215890"
                     /db_xref="MGI:MGI:2443223"
     exon            1..549
                     /gene="Clvs2"
                     /gene_synonym="A330019N05Rik; Rlbp1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            550..1064
                     /gene="Clvs2"
                     /gene_synonym="A330019N05Rik; Rlbp1l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             676..1659
                     /gene="Clvs2"
                     /gene_synonym="A330019N05Rik; Rlbp1l2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     retinaldehyde-binding protein 1-like protein 2;
                     retinaldehyde-binding protein 1-like 2"
                     /codon_start=1
                     /product="clavesin-2 isoform 1"
                     /protein_id="NP_780657.1"
                     /db_xref="CCDS:CCDS23770.1"
                     /db_xref="GeneID:215890"
                     /db_xref="MGI:MGI:2443223"
                     /translation="MTHLQAGLSPETLEKARLELNENPDTLHQDIQEVRDMVITRPDI
                     GFLRTDDAFILRFLRARKFHHFEAFRLLAQYFEYRQQNLDMFKSFKATDPGIKQALKD
                     GFPGGLANLDHYGRKILVLFAANWDQSRYTLVDILRAILLSLEAMIEDPELQVNGFVL
                     IIDWSNFTFKQASKLTPNMLRLAIEGLQDSFPARFGGIHFVNQPWYIHALYTVIRPFL
                     KEKTRKRIFLHGNNLNSLHQLIHPEILPSEFGGMLPPYDMGTWARTLLDHEYDDDSEY
                     NVDSYNMPVKDVDKELSPKSMKRSQSVVDPTALKRMDKSEEENMQPLLALD"
     exon            1065..1239
                     /gene="Clvs2"
                     /gene_synonym="A330019N05Rik; Rlbp1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1350
                     /gene="Clvs2"
                     /gene_synonym="A330019N05Rik; Rlbp1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1571
                     /gene="Clvs2"
                     /gene_synonym="A330019N05Rik; Rlbp1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..2632
                     /gene="Clvs2"
                     /gene_synonym="A330019N05Rik; Rlbp1l2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2301..2306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clvs2"
                     /gene_synonym="A330019N05Rik; Rlbp1l2"
                     /note="hexamer: AAGAAA"
     polyA_site      2346
                     /gene="Clvs2"
                     /gene_synonym="A330019N05Rik; Rlbp1l2"
                     /note="major polyA site"
     regulatory      2448..2453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clvs2"
                     /gene_synonym="A330019N05Rik; Rlbp1l2"
                     /note="hexamer: AATATA"
     polyA_site      2470
                     /gene="Clvs2"
                     /gene_synonym="A330019N05Rik; Rlbp1l2"
                     /note="major polyA site"
     regulatory      2610..2615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clvs2"
                     /gene_synonym="A330019N05Rik; Rlbp1l2"
                     /note="hexamer: AATAAA"
     polyA_site      2632
                     /gene="Clvs2"
                     /gene_synonym="A330019N05Rik; Rlbp1l2"
                     /note="major polyA site"
ORIGIN      
        1 agagaggagc ggagagcatg tgtgagcgct tacaacgcta ggagctctct tctgggataa
       61 tcaagagttg ggatgagccg gatcctcttt tagcagcagc gggctcagga gtggctgcgg
      121 aagccccagg ggcgcgcggg acccagtggc tctgggggca gtggaacagc ccctgcgggc
      181 cgcgccgtgc taccgcttag gcgtacaaag gtaaaggcgg ccgcagccct agtggacttg
      241 caccgtcccg gcgttcccat cccttctctt cctctctcga aggcaaaaaa ggctggccgg
      301 gcagcgaggt cctagctctg cgggtcccca cccttcctgc tgacaggctg gctgtccttg
      361 gatgaggtcg tcgaggctgc tccctggtga atcctcaggc gggtctcagc caccatctct
      421 ctccactgct ccatccctct gagaggagta gatgctgctg ctgcccccac ccccgccacc
      481 acctccgcca gggctgatgg atgctgggga gtgccgcatt gcttagtgac tctgcctcgc
      541 ggtttgctgg aaaggaagca gacagcagtg aggagaaccg gaggccagag tgtggtgtgg
      601 aggtgacaag taccaggtat attgttggac acacaaagag agaatcagag tagacagctt
      661 ggatacaagg ggacaatgac tcatttgcaa gctggcctct ctcctgagac tttggaaaaa
      721 gctcgcctgg aactcaatga gaacccagac actctgcacc aggacatcca agaagtaagg
      781 gacatggtca tcactaggcc ggacattggc tttctgcgca cagatgacgc tttcatctta
      841 cgcttcttga gggccaggaa atttcatcac ttcgaagctt ttcgcctctt ggcccagtac
      901 tttgagtacc ggcagcagaa cctggatatg ttcaaaagct tcaaggccac tgaccctggc
      961 atcaagcagg cactgaagga tggctttcct gggggcctgg ccaatctgga ccattatggg
     1021 aggaagattt tagtcctttt tgctgccaac tgggatcaga gcaggtacac actggtggat
     1081 attttgcgtg ccatcttact ttctttagaa gccatgattg aagatccaga gcttcaagta
     1141 aatggatttg ttttgatcat agactggagt aacttcacct tcaagcaagc ttctaagctt
     1201 acaccaaaca tgctgcgact tgcaattgaa ggtcttcagg acagcttccc agcaagattt
     1261 ggaggaattc attttgtcaa tcaaccttgg tatatccatg ccctgtacac tgtgatacgc
     1321 ccattcctga aagagaagac tcggaaaagg atatttttgc atggtaacaa cctgaacagt
     1381 ctacaccaac taattcatcc tgagatccta ccttctgagt ttggaggaat gttgccccca
     1441 tatgacatgg gcacatgggc acgaaccctg ctagaccatg agtatgatga tgacagtgag
     1501 tacaacgtgg attcctataa catgcctgtg aaggacgtgg acaaggaact ctcccccaaa
     1561 tccatgaaga gatctcagtc agtagtggac cctacagcac tgaaacgaat ggataaaagt
     1621 gaagaagaaa acatgcagcc tttacttgct ctggactgag aacttctcca cccctacacc
     1681 atggattaaa aatgggaggt cctggctttc agcaacaggg acaacactgt gggattgacc
     1741 tgctggaaaa ctttactcat gttcatgtag cataatgcac acgacatctg gctttcacat
     1801 ttgcctaaac catgggtgcc ctgagctaga ttttaaaaag tcaataattt attctgtaag
     1861 tgccaagttc tttgtaaata caatattgtg gtcacatcta gtttgtaaat tttgttagta
     1921 atttagtttg ggaaagattg actcacatgt ttgagccagt gatatggact acaataagaa
     1981 gcttaaggac atgtaaccta taaaatttaa ttaaatgtat ccctgtttcc tatgaagcca
     2041 tatatctgct atcatagtga ttatttcaat attttcctac aaaacactgt cattattcaa
     2101 atatacttgg gtcacagaag gttaattatc tcctggaaat tgttattatt aatgttttcc
     2161 tgcttagtaa tttttgtttc agaggaactt ttctggaacc atcactggct gcattctgaa
     2221 gaaagaaaat ggctgatgag ctggaaaact gaaccaaatg gcaaatcgtc tccgttgtgt
     2281 gatttagagt tttttttttc aagaaaatgt tttttcccaa ttaagatgag gaattctaaa
     2341 aaagaatggg ttttttgttt ttgttcgttt gtttttgtct aaatgattgt cttaacaatg
     2401 ttcctttact taagttgcca ttgtaacccc tatctgatat actttagaat atattttcac
     2461 ccaaagtaaa tgagagttag ttcctgaatc attttgacaa ttttgcacat aaaatttgtc
     2521 acttgaagat gagggctaat ttcagatcat tgtggaaatg ttgaagatat aaataattac
     2581 taacaacata tatagtttta ttgactttta ataaattctt gataagacag gc
//
