LOCUS       NM_028940               3628 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus clavesin 1 (Clvs1), transcript variant 1, mRNA.
ACCESSION   NM_028940 XM_131279 XM_489818
VERSION     NM_028940.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3628)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3628)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3628)
  AUTHORS   Fritz,K.R., Zhang,Y. and Ruest,L.B.
  TITLE     Cdc42 activation by endothelin regulates neural crest cell
            migration in the cardiac outflow tract
  JOURNAL   Dev Dyn 248 (9), 795-812 (2019)
   PUBMED   31219639
REFERENCE   4  (bases 1 to 3628)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 3628)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 3628)
  AUTHORS   Kawaguchi,A., Ikawa,T., Kasukawa,T., Ueda,H.R., Kurimoto,K.,
            Saitou,M. and Matsuzaki,F.
  TITLE     Single-cell gene profiling defines differential progenitor
            subclasses in mammalian neurogenesis
  JOURNAL   Development 135 (18), 3113-3124 (2008)
   PUBMED   18725516
REFERENCE   7  (bases 1 to 3628)
  AUTHORS   Wang,K.S., Zahn,L.E., Favor,J., Huang,K.M. and Stambolian,D.
  TITLE     Genetic and phenotypic analysis of Tcm, a mutation affecting early
            eye development
  JOURNAL   Mamm Genome 16 (5), 332-343 (2005)
   PUBMED   16104381
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK083810.1, AK084350.1 and BC100556.1.
            
            On Apr 29, 2010 this sequence version replaced NM_028940.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062923.1, SRR1660811.186021.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AK083810.1         3-7
            6-1340              AK084350.1         2-1336
            1341-3628           BC100556.1         561-2848
FEATURES             Location/Qualifiers
     source          1..3628
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 4.07 cM"
     gene            1..3628
                     /gene="Clvs1"
                     /gene_synonym="4933402J24Rik; Clvl1; Rlbp1l1"
                     /note="clavesin 1"
                     /db_xref="GeneID:74438"
                     /db_xref="MGI:MGI:1921688"
     exon            1..155
                     /gene="Clvs1"
                     /gene_synonym="4933402J24Rik; Clvl1; Rlbp1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            156..780
                     /gene="Clvs1"
                     /gene_synonym="4933402J24Rik; Clvl1; Rlbp1l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             326..1390
                     /gene="Clvs1"
                     /gene_synonym="4933402J24Rik; Clvl1; Rlbp1l1"
                     /note="retinaldehyde-binding protein 1-like 1"
                     /codon_start=1
                     /product="clavesin-1"
                     /protein_id="NP_083216.1"
                     /db_xref="CCDS:CCDS17957.1"
                     /db_xref="GeneID:74438"
                     /db_xref="MGI:MGI:1921688"
                     /translation="MGPVSVLPSPQSLSTWEGDLAKMTHLQAGLSPDTIEKARLELNE
                     NPDILHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFRLLAQYFQYRQ
                     LNLDMFKNFKADDPGIKRALIDGFPGVLENRDHYGRKILLLFAANWDQSRNSFTDILR
                     AILLSLEVLIEDPELQINGFILIIDWSNFSFKQASKLTPSILKLAIEGLQDSFPARFG
                     GVHFVNQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQLIHPEFLPSEFGGTLP
                     PYDMGTWARTLLGPDYSDENDYTHTSYNAMHVKHTCSNLERECSPKPMKRSQSVVEAG
                     TLKHEEKGENENTQPLLALD"
     exon            781..955
                     /gene="Clvs1"
                     /gene_synonym="4933402J24Rik; Clvl1; Rlbp1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1066
                     /gene="Clvs1"
                     /gene_synonym="4933402J24Rik; Clvl1; Rlbp1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1302
                     /gene="Clvs1"
                     /gene_synonym="4933402J24Rik; Clvl1; Rlbp1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..3604
                     /gene="Clvs1"
                     /gene_synonym="4933402J24Rik; Clvl1; Rlbp1l1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3580..3585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clvs1"
                     /gene_synonym="4933402J24Rik; Clvl1; Rlbp1l1"
                     /note="hexamer: AATAAA"
     polyA_site      3604
                     /gene="Clvs1"
                     /gene_synonym="4933402J24Rik; Clvl1; Rlbp1l1"
                     /note="major polyA site"
ORIGIN      
        1 aaatcacagc cccatgcagc ccgggctctc attcacagct ttctagagaa atctgagctc
       61 caactgccag ggtaggggat ctcacccacc cagttcagcc gcgaggacac ctgcagaaac
      121 acattctcaa agcaagcctg ggaggcggtg tgaagtaagc aatggcttcg gtttccctcc
      181 tcttttggat ggccaccacc acatagggcc tgaatgtcct gctgttctcc aaggacagaa
      241 agaagactct gtacccgtct gtttggggag cagtcttgta ggggagccat cgaatgggcc
      301 acggattcag cacacttcca tgtgaatggg accagtttct gttcttccct cacctcagag
      361 cttaagcact tgggaaggag atttggccaa gatgacgcat ttgcaggctg ggctcagtcc
      421 agacactata gaaaaagctc gtctggaact gaatgaaaac ccagatattt tacatcagga
      481 cattcaacaa gtcagagaca tgatcatcac cagaccagac attgggtttt tacgtacaga
      541 tgatgccttc attctgcgat ttcttcgagc caggaagttt caccaagccg atgccttcag
      601 actcctggcc cagtactttc agtaccgcca gctgaacctg gacatgttca aaaactttaa
      661 ggcagatgat cccgggatta agagggcttt gatcgacgga ttccccggag tgctggaaaa
      721 tcgtgaccac tatggcagga agattctctt gctgtttgct gccaattggg atcagagtag
      781 gaactccttc acggacatcc tccgtgccat tctcctgtcc ttggaagtcc ttattgaaga
      841 tcccgagctc cagataaacg gtttcatttt aattatagac tggagcaact tttccttcaa
      901 gcaagcatcc aagctgacac cctctatcct gaaactggcc attgaagggc tgcaggacag
      961 ctttcctgct cgctttggag gcgtccattt tgtcaaccag ccctggtaca tccacgccct
     1021 gtacacactc atcaagccat tccttaagga caagacaaga aaacggattt tcctacatgg
     1081 aaacaattta aacagtcttc accagctaat acaccccgag ttcctgccct ctgaatttgg
     1141 aggaaccctt cctccttacg acatggggac ttgggcccgg acattacttg gccctgacta
     1201 cagcgatgaa aatgactata cccatacttc ctacaatgcc atgcatgtga aacacacctg
     1261 ttccaacctg gagagagagt gctcacccaa gcccatgaaa agatctcagt ctgtggtaga
     1321 agctgggacc ttgaaacatg aagagaaagg agaaaatgag aacacccagc cactgctggc
     1381 tctggactga gccagccagc atcatgtgac atctccagtg gagcaaccgt ccagcaagcc
     1441 tgtgcaactg acctacagac actctgtgtg ctctgcttga catgaggtcc tccatcccag
     1501 tcccagccat gactgtcagc aaccattggt ctgggtagcc cacaccggac aaagatctga
     1561 gagacgcttt taaaaattta acgaattaat ttatgtttta gtgaggaatg gtgacgggga
     1621 tgaagaaagg catttatgta aaaaggattc tcccctcata tttttggcag caaatatact
     1681 tcaaaagggg aaaaaaaccc taaattagtt gcatatacat cactctaaag actcacacag
     1741 gaaccctctc caggttttgc aaattaagat gaaatgcatt ccgaaataaa taaaacagag
     1801 ttaaaatgtg cagacacatc agcaagttta atgtagtgct gaaccccagc agcagtagct
     1861 ccaataattt ccagtcctat tgacttattt cctgacctca tcaccagcat ctaagtagtc
     1921 agcctaagag tgtgatctcc cacgtctggc tatttgcaaa gtttttcatt taaatctctc
     1981 tcctacaaga atgatttgga catcgtgttg cttgtcagac catcagctga ctttcatgaa
     2041 ttgcttttta agacaaagag gcagtttgaa aaaaaaagag gctgcttcat tgtagcaaag
     2101 tgatttcctg taggcgaatg cctacagaga gggggcaact cattggaaca cacaccacac
     2161 accacacaca cacacacaca cacactggtg actgattacc cttttaagtt aattcttggg
     2221 ttactacagc aaaaacttgc tatcaaataa gtccctttgt ccccatgctc ctattacctg
     2281 tggagaaagg ccctgagggg gcaggcattc aaatctcaca gaaagaccct taaggatgga
     2341 tcagcatgta agtaccaagc taaagaggac caagaatgca agatgaaatg ccaaagacca
     2401 gcctacttcc ttatccattc tccttagaaa tggatcccag cccccatgca taggaagtca
     2461 gacagagaac agcaaagggg aggatatttt atctgtgcca tgtttcctga gaccagctga
     2521 gtatgtgtag ataccttatt ctctagcatc tgtacgacac agacacttac taatatgacc
     2581 agagtgataa tgtcaaaatt tttaattgct aacacttatt aaaatacttt acattttaag
     2641 cacttggtag agtgatttac tagctgaaca gcctaaagaa aagaggaaac caattcaact
     2701 tacttcccgc cataaacaca aaacattact gactatggcc acttccctct ctccatctct
     2761 ctctttccct gttccttccc acttctctcc tccttacact cctctccttt tcctttgtct
     2821 ttctttctct gtctccctgt taccctctct tctctgtctc cctccaatgc tgaagatcaa
     2881 acccagggcc taacccctga gccctgagct acaaactaga tgtatactcc tcagttgatc
     2941 tactgtttta ttattttttt ctactggcag agaatagtaa cagaagctat ttttatgttc
     3001 caaccttgaa gaagcaaaat tgaaacagaa ttttaaaata tttcccaaac aattgcatca
     3061 tagtatatta aaaaaaaaac cctaccaatt cattttgtat agacctttag aattgtaaaa
     3121 taataacctt gaaaaatgtt taccaagaca tggatggaaa ttcttttctt atgacacaag
     3181 taagagcgag gaaaaattaa agtgaattag aaaatctttt attgcttgtg tttataagat
     3241 caacgtggga tccaagtact taaaatgctg ttggagtgca ccactgccaa cacttgcaaa
     3301 agtaacggta ctgctggctt ttcacaaggc aagatttaga atcctactgt aatgaccata
     3361 ttttaaaaaa catgttatat ttactaagtt aacagctaat tttcactcat ttcctccatt
     3421 ttattccatg gatgtaaggt gatagtttaa caatgagaac acatggtttg catttcgcta
     3481 tgtatatgta gtatagagga gaactaaacc cagcaggtaa ccgagggtta ctacatgaac
     3541 actggattgt attgcctttg tcagtaagtt cctctgttta ataaatactg aagaacacaa
     3601 ataaaaaaaa aaaaaaaaaa aaaaaaaa
//
