LOCUS       NM_001081158            5397 bp    mRNA    linear   ROD 11-JUN-2024
DEFINITION  Mus musculus clustered mitochondria homolog (Cluh), transcript
            variant 1, mRNA.
ACCESSION   NM_001081158 NM_028786 XM_181333
VERSION     NM_001081158.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5397)
  AUTHORS   Zaninello,M., Schlegel,T., Nolte,H., Pirzada,M., Savino,E.,
            Barth,E., Klein,I., Wustenberg,H., Uddin,T., Wolff,L., Wirth,B.,
            Lehmann,H.C., Cioni,J.M., Langer,T. and Rugarli,E.I.
  TITLE     CLUH maintains functional mitochondria and translation in
            motoneuronal axons and prevents peripheral neuropathy
  JOURNAL   Sci Adv 10 (22), eadn2050 (2024)
   PUBMED   38809982
  REMARK    GeneRIF: CLUH maintains functional mitochondria and translation in
            motoneuronal axons and prevents peripheral neuropathy.
REFERENCE   2  (bases 1 to 5397)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5397)
  AUTHORS   Singh,S., Gaur,A., Sharma,R.K., Kumari,R., Prakash,S., Kumari,S.,
            Chaudhary,A.D., Prasun,P., Pant,P., Hunkler,H., Thum,T.,
            Jagavelu,K., Bharati,P., Hanif,K., Chitkara,P., Kumar,S., Mitra,K.
            and Gupta,S.K.
  TITLE     Musashi-2 causes cardiac hypertrophy and heart failure by inducing
            mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA
  JOURNAL   Basic Res Cardiol 118 (1), 46 (2023)
   PUBMED   37923788
  REMARK    GeneRIF: Musashi-2 causes cardiac hypertrophy and heart failure by
            inducing mitochondrial dysfunction through destabilizing Cluh and
            Smyd1 mRNA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5397)
  AUTHORS   Ralevski,A., Apelt,F., Olas,J.J., Mueller-Roeber,B., Rugarli,E.I.,
            Kragler,F. and Horvath,T.L.
  TITLE     Plant mitochondrial FMT and its mammalian homolog CLUH controls
            development and behavior in Arabidopsis and locomotion in mice
  JOURNAL   Cell Mol Life Sci 79 (6), 334 (2022)
   PUBMED   35652974
  REMARK    GeneRIF: Plant mitochondrial FMT and its mammalian homolog CLUH
            controls development and behavior in Arabidopsis and locomotion in
            mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5397)
  AUTHORS   Pla-Martin,D., Schatton,D., Wiederstein,J.L., Marx,M.C., Khiati,S.,
            Kruger,M. and Rugarli,E.I.
  TITLE     CLUH granules coordinate translation of mitochondrial proteins with
            mTORC1 signaling and mitophagy
  JOURNAL   EMBO J 39 (9), e102731 (2020)
   PUBMED   32149416
  REMARK    GeneRIF: CLUH granules coordinate translation of mitochondrial
            proteins with mTORC1 signaling and mitophagy.
REFERENCE   6  (bases 1 to 5397)
  AUTHORS   Schatton,D., Pla-Martin,D., Marx,M.C., Hansen,H., Mourier,A.,
            Nemazanyy,I., Pessia,A., Zentis,P., Corona,T., Kondylis,V.,
            Barth,E., Schauss,A.C., Velagapudi,V. and Rugarli,E.I.
  TITLE     CLUH regulates mitochondrial metabolism by controlling translation
            and decay of target mRNAs
  JOURNAL   J Cell Biol 216 (3), 675-693 (2017)
   PUBMED   28188211
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645971.12 and AL607024.17.
            
            On Feb 20, 2019 this sequence version replaced NM_001081158.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154925.1, AK150045.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AL645971.12        102873-102898
            27-191              AL607024.17        2001-2165
            192-394             AL607024.17        8894-9096
            395-566             AL607024.17        9639-9810
            567-710             AL607024.17        11657-11800
            711-835             AL607024.17        11954-12078
            836-990             AL607024.17        12165-12319
            991-1116            AL607024.17        12420-12545
            1117-1264           AL607024.17        12823-12970
            1265-1357           AL607024.17        13135-13227
            1358-2052           AL607024.17        13868-14562
            2053-2279           AL607024.17        15851-16077
            2280-2384           AL607024.17        16255-16359
            2385-2485           AL607024.17        16502-16602
            2486-2638           AL607024.17        17245-17397
            2639-2701           AL607024.17        17478-17540
            2702-2946           AL607024.17        17653-17897
            2947-3031           AL607024.17        18164-18248
            3032-3185           AL607024.17        18394-18547
            3186-3325           AL607024.17        18626-18765
            3326-3406           AL607024.17        19413-19493
            3407-3532           AL607024.17        19571-19696
            3533-3654           AL607024.17        19788-19909
            3655-3748           AL607024.17        20138-20231
            3749-3883           AL607024.17        20318-20452
            3884-3957           AL607024.17        20538-20611
            3958-5397           AL607024.17        21886-23325
FEATURES             Location/Qualifiers
     source          1..5397
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.76 cM"
     gene            1..5397
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /note="clustered mitochondria homolog"
                     /db_xref="GeneID:74148"
                     /db_xref="MGI:MGI:1921398"
     exon            1..191
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..4153
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /note="isoform 1 is encoded by transcript variant 1;
                     clustered mitochondria protein homolog; clustered
                     mitochondria (cluA/CLU1) homolog"
                     /codon_start=1
                     /product="clustered mitochondria protein homolog isoform
                     1"
                     /protein_id="NP_001074627.1"
                     /db_xref="CCDS:CCDS36223.1"
                     /db_xref="GeneID:74148"
                     /db_xref="MGI:MGI:1921398"
                     /translation="MVIKTDELPAAAPADSAREHGSQAGGKGRPNAADLPSVMLLNGD
                     CSENLKKEEGTSEPPRENGLDEGEPGDETTGQEVIVIQDTGFSVKILAPGIEPFSLQV
                     SPQEMVQEIHQVLMDREDTCHRTCFSLHLDGNMLDHFSELRSVEGLQEGSVLRVVEEP
                     YTVREARIHVRHVRDLLKSLDPSDAFNGVDCNSLSFLSVFTDGDLGDSGKRKKGLEMD
                     PIDCTPPEYILPGSRERPLCPLQPQNRDWKPLQCLKVLTMSGWNPPPGNRKMHGDLMY
                     LFVITAEDRQVSITASTRGFYLNQSTAYHFNPKPASPRFLSHSLVELLNQISPTFKKN
                     FAVLQKKRVQRHPFERIATPFQVYSWTAPQAEHAMDCVRAEDAYTSRLGYEEHIPGQT
                     RDWNEELQTTRELPRKNLPERLLRERAIFKVHSDFTAAATRGAMAVIDGNVMAINPSE
                     ETKMQMFIWNNIFFSLGFDVRDHYKDFGGDVAAYVAPTNDLNGVRTYNAVDVEGLYTL
                     GTVVVDYRGYRVTAQSIIPGILERDQEQSVIYGSIDFGKTVVSHPRYLELLERTSRPL
                     KILRHRVLNDRDEEVELCSSVECKGIIGNDGRHYILDLLRTFPPDLNFLPVPGEELPE
                     ECSRAGFPRTHRHKLCCLRQELVDAFVEHRYLLFMKLAALQLMQQKASKVETTTSLEN
                     GGLPSSAETKSEDSIGPEAGCEEEGSSVSGLAKVKELAETIASDDGTVDPRSREVIRN
                     ACKAVGSISSTAFDIRFNPDIFSPGVRFPESCQDEVRDQKQLLKDAAAFLLSCQIPGL
                     VKDCTEYAVLPMDGATLAEVMRQRGINMRYLGKVLDLVLRSPARDQLDHIYKIGIGEL
                     ITRSAKHIFKTYLQGVELSGLSAAISHFLNCFLSSYPNPVAHLPADELLSKKRNKRRK
                     NRPPGAADNTAWAVMTPQELWKNICHEAKNYFDFTLECDSVDQAVETYGLQKITLLRE
                     ISLKTGIQILLKEYSFDSRHKPAFTEEDVLNIFPVVKHVNPKASDAFHFFQSGQAKVQ
                     QGFLKEGCELINEALNLFNNVYGAMHVEICACLRLLARLHYIMGDYAEALSNQQKAVL
                     MSERVMGIEHPNTIQEYMHLALYCFASSQLSTALSLLYRARYLMLLVFGEDHPEMALL
                     DNNIGLVLHGVMEYDLSLRFLENALAVTTKYHGPKALKVALSHHLVARVYESKAEFRS
                     ALQHEKEGYTIYKTQLGEDHEKTKESSEYLKCLTQQAVALQRTMNEIYRNGSSANIPP
                     LKFTAPSMTSVLEQLNVINGILFIPLSQKDLENLKAEVARRHQLQEANRNRDKAEEQP
                     MAPEPEPEPERAVEDMGSPQTAKEGPSSLNLQG"
     exon            192..394
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            395..566
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            567..710
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            711..835
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            836..990
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1116
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1264
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1357
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..2052
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2279
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2384
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2485
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2638
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2701
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2946
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3031
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3185
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            3186..3325
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3406
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            3407..3532
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            3533..3654
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            3655..3748
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            3749..3883
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            3884..3957
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     exon            3958..5397
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5366..5371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /note="hexamer: AATAAA"
     polyA_site      5390
                     /gene="Cluh"
                     /gene_synonym="1300001I01Rik; Kiaa0664; mKIAA0664"
                     /note="major polyA site"
ORIGIN      
        1 gtccttcccg cagcggccgt ggcgcgcagg gcacttgggt tagtggcgcg gcgtgcggcg
       61 cggacaggcg agccggacgc ctgctcccgc catggtcatc aagacggacg agttgccggc
      121 ggccgccccg gccgacagcg cccgggagca cggctcgcag gccggcggca aggggcggcc
      181 gaacgcggct gatctcccct cggtcatgct gttgaatggt gactgctcag agaatttgaa
      241 gaaggaagaa gggacatctg agccacctag ggaaaatggg ctagatgagg gtgagcctgg
      301 agatgagacc actggacagg aagtcattgt cattcaggac acaggctttt ctgtgaagat
      361 tctggcccct ggcatcgagc ccttttccct gcaggtgtcc ccccaggaga tggtgcagga
      421 gatccaccag gtgctcatgg accgtgagga tacttgtcat cgtacctgct tctcactaca
      481 cttggatggc aatatgctgg accacttttc agagctacgc agtgtggagg ggctgcagga
      541 gggctcggtg ctccgagttg tggaagagcc ttacacggtg cgtgaggccc gaatccatgt
      601 gcgtcatgtc agagacctcc tcaagagctt ggacccatct gatgccttca atggagttga
      661 ctgtaactcc ttgtccttcc tgagtgtctt cactgatggt gacttaggag acagtgggaa
      721 gcggaagaaa ggcttggaga tggaccccat cgactgcacc ccacctgagt atatcctgcc
      781 ggggagccgg gagcggcctc tctgtcccct gcagccccag aaccgtgact ggaagcccct
      841 gcagtgtctg aaagtactta ccatgagtgg ctggaaccca cctcctggga accgcaagat
      901 gcatggggac ctcatgtacc tgtttgtgat cactgctgag gaccggcaag tcagcatcac
      961 tgcatcgacg aggggcttct acctgaatca gtccacggcc taccacttca accccaagcc
     1021 tgccagcccc cgcttcctca gccattccct agtagagctg ctcaaccaga tcagcccaac
     1081 cttcaaaaag aactttgctg tgctgcagaa gaaaagggtc cagcgccacc cattcgagag
     1141 gatcgccacc ccgttccagg tatacagctg gacagccccc caggcagagc atgccatgga
     1201 ctgtgtgcgt gcggaggacg cctacacctc gaggctgggc tacgaggagc acattcctgg
     1261 acagacccgg gactggaatg aagagctgca gacaacaagg gagctgcccc gcaagaacct
     1321 gcctgagcgg ttgctccgag aacgagccat attcaaggtg cacagtgatt tcacagcggc
     1381 agccacaagg ggtgccatgg cagttattga tggcaatgtg atggccatca accccagtga
     1441 ggagaccaag atgcagatgt tcatctggaa caacatcttc ttcagcctgg gctttgatgt
     1501 ccgggaccac tacaaagact ttggtgggga tgtggcagcc tacgtggcac ccaccaatga
     1561 cctgaatggt gttcgcacat acaatgccgt ggatgtagag ggactgtaca cactgggtac
     1621 agtggtagtg gattaccgtg gctaccgggt cacagctcag tccatcatcc ctggcatcct
     1681 ggaacgagac caggagcaga gtgtcatcta tggctccatt gactttggca agacggtggt
     1741 gtctcaccca cgctatctgg agctgttgga gcgcaccagc cggcccctca agatccttcg
     1801 tcaccgagta ctcaatgacc gagacgagga ggtggagctc tgctcctcgg tcgagtgtaa
     1861 gggcatcatt ggcaatgatg ggcgccacta catccttgac ctactgcgca ccttcccacc
     1921 agacctcaac ttccttcctg tgcctggtga ggagctaccc gaggagtgct ctcgagctgg
     1981 cttcccccga acccatcgac acaagctgtg ctgtttgcgc caggagctag tggatgcttt
     2041 tgtggagcac aggtaccttc tcttcatgaa gctggctgcc ttacagttga tgcaacagaa
     2101 ggccagcaag gtggagacca ccacctccct ggagaatggt ggccttccct cctcagcaga
     2161 gaccaaatct gaagattcaa taggacctga agcaggatgt gaggaggagg gcagcagtgt
     2221 gagtggcctc gccaaggtga aggagctggc agagaccatc gcctcagatg atggcacagt
     2281 agaccctcga agccgagagg tgatccgaaa tgcctgcaag gctgttggct ccatcagcag
     2341 cacggccttt gatattcgct tcaatcctga catcttctcc ccaggggttc gatttcctga
     2401 gtcctgccag gatgaagttc gggaccagaa gcagctgttg aaagatgctg ctgctttcct
     2461 gctctcctgc cagatccccg gtttggtaaa ggattgcaca gagtatgctg tgctgcccat
     2521 ggatggggcc acactggccg aggtgatgcg ccagcgtggc atcaacatgc gatacctggg
     2581 caaggtgctg gatctggtgc tgcggagccc agcccgagac cagctggacc acatttataa
     2641 aatcggcatc ggagagctca tcacccgctc cgccaagcac atcttcaaga catatctaca
     2701 gggagtggag ctctcaggcc tctcagctgc catcagccac ttcctgaact gtttcctgag
     2761 ctcttacccc aaccccgtgg cccacctgcc tgctgatgag ctgctctcca agaaaaggaa
     2821 caagaggagg aaaaacaggc ccccaggagc tgcagacaac actgcctggg ctgtgatgac
     2881 cccccaagag ctctggaaga acatatgcca tgaggccaaa aactactttg acttcaccct
     2941 tgagtgtgat tctgtggacc aggctgtgga gacctacggg ctgcagaaga taacactgct
     3001 gcgggagatc tcactgaaaa ccgggatcca gattctgctg aaggaataca gctttgatag
     3061 ccgccacaag cctgccttca ctgaggaaga tgtgctcaat atcttccctg tggtcaagca
     3121 tgtcaacccc aaggcgtcgg atgccttcca cttcttccag agtggacagg ccaaagtaca
     3181 gcagggcttc ctgaaagagg gctgtgagct catcaacgag gctctgaacc tgttcaacaa
     3241 tgtctacgga gccatgcacg tggagatctg tgcctgtctg cgtcttctgg cccgcctcca
     3301 ctacatcatg ggtgattatg ctgaggccct cagcaatcaa cagaaggccg tgctgatgag
     3361 tgagcgggtg atgggcattg agcaccccaa caccattcag gaatatatgc acctggccct
     3421 gtactgcttc gccagcagcc agctgtccac agccctgagc ctcctgtacc gtgcccgcta
     3481 cctcatgctg cttgtgtttg gggaggatca ccctgagatg gcattgttgg ataacaacat
     3541 cgggctggtg ctgcatggag taatggagta tgacctgtcc ctgcgcttct tggagaacgc
     3601 actggctgtc actacaaagt accatgggcc caaggccctt aaggtggctc tcagccacca
     3661 ccttgtcgcg cgggtttatg agagcaaagc tgagttccgg tcggccctcc agcatgagaa
     3721 ggagggttac accatctaca agacgcagct cggtgaggac catgagaaaa ccaaggagag
     3781 ctctgagtac ctcaagtgcc tgacccagca ggctgtggcc ctgcagcgca ccatgaatga
     3841 gatctaccgt aatggctcca gtgccaatat cccacccctc aagttcacag ctcccagcat
     3901 gaccagtgtc ctggagcagc tcaatgtcat caatggcatc ctcttcattc ctctcagcca
     3961 aaaagacttg gaaaacctga aggcagaggt ggcacggcga caccagctcc aagaggccaa
     4021 cagaaacagg gataaggctg aagaacaacc catggccccc gagcctgagc ctgagccaga
     4081 gagagccgtg gaggacatgg gctcccctca gactgccaag gaaggtcctt cttccctgaa
     4141 cttacaggga taaaaaaaga aagaaagatg gacagtccag cagccccatt acccggcgat
     4201 gcagacagat tccaggagaa ttctgggggc gtgccctgca gattgggaga ggaagctagt
     4261 cctcaacttt atacccccac ctcaccccac catctgcctg gggccctgcc ctggtttgcc
     4321 tgcccctaaa agatggtttt gcactggttc aatgaatatt caatgcagag gcctaattga
     4381 agacacgaaa gtaaagtgtg taggcatcag ctccagctga gggggcaagt gcctccccag
     4441 catcaagcag atgtgtgtgt gtgtccatgc ctgtggatgt cttgctccgt ccttcctgat
     4501 gtacatagcc cagtcagttc tgagtggatg acgtgcagat gcaatttctc aggtcattta
     4561 tatgtttgac attatggctg ctgcttttgt tgccactacc cctgggtcca gcctggctta
     4621 aagtccaggt ttcagccaaa aaagatgggg gctttcgtgt gtcctgggag ggggagccag
     4681 atgtcttctg gtagggtgca aggtgagacc tgcagtggct ttactgtgat tgggcctggc
     4741 ctacctgtag cctcagggtg aagggaaggg gccagcagtg gtagacccca cacatccatg
     4801 tgcctggcct tggccaagca ggagaggagg tcctgctaca ggctttgact tgcctccctg
     4861 ctccctgtac cccaggtgag cataaccttg ggggccaaca gtctgaatgt atctttctcc
     4921 ccatttaaac ctgagctgcc taatgcacag ttgggtaagg ggtggggacc cagggctgaa
     4981 ttgtggatcc cagggaaagt gctatgcaca ggagtgattt gtcacctctg gagcctggct
     5041 cctccttggt ctttgccata taagcactta tacaaagaag ctctggggtg ttggggctcc
     5101 tactgccttg gctgccctct ctctcccctc cctgcctgtg tcgcttctct ttgtctgctg
     5161 tccctgaagg agatggccac cctttgagct taagggagct gttttaggca gagcctctgc
     5221 ttggggcttt tctggagctg ctgatggata gtatctgtcc agggaccttg tttcaaaggg
     5281 aatgggcatg ggccagcaag gcacccccac agctatcaag aacgttttct tgtttttaaa
     5341 ccatcacgtc ttcatttcac attggaataa agtgagtttt tgaaacctgc tgcccca
//
