LOCUS       NM_013492               1832 bp    mRNA    linear   ROD 23-MAY-2023
DEFINITION  Mus musculus clusterin (Clu), mRNA.
ACCESSION   NM_013492 XM_908991
VERSION     NM_013492.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1832)
  AUTHORS   Zhou J, Singh N, Galske J, Hudobenko J, Hu X and Yan R.
  TITLE     BACE1 regulates expression of Clusterin in astrocytes for enhancing
            clearance of beta-amyloid peptides
  JOURNAL   Mol Neurodegener 18 (1), 31 (2023)
   PUBMED   37143090
  REMARK    GeneRIF: BACE1 regulates expression of Clusterin in astrocytes for
            enhancing clearance of beta-amyloid peptides.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1832)
  AUTHORS   Tian Y, Xiao YH, Sun C, Liu B and Sun F.
  TITLE     N6-Methyladenosine Methyltransferase METTL3 Alleviates
            Diabetes-Induced Testicular Damage through Modulating
            TUG1/Clusterin Axis
  JOURNAL   Diabetes Metab J 47 (2), 287-300 (2023)
   PUBMED   36653890
  REMARK    GeneRIF: N6-Methyladenosine Methyltransferase METTL3 Alleviates
            Diabetes-Induced Testicular Damage through Modulating
            TUG1/Clusterin Axis.
REFERENCE   3  (bases 1 to 1832)
  AUTHORS   Du J, Sarkar R, Li Y, He L, Kang W, Liao W, Liu W, Nguyen T, Zhang
            L, Deng Z, Dougherty U, Kupfer SS, Chen M, Pekow J, Bissonnette M,
            He C and Li YC.
  TITLE     N6-adenomethylation of GsdmC is essential for Lgr5+ stem cell
            survival to maintain normal colonic epithelial morphogenesis
  JOURNAL   Dev Cell 57 (16), 1976-1994 (2022)
   PUBMED   35917813
REFERENCE   4  (bases 1 to 1832)
  AUTHORS   Ahuja N, Hiltabidle MS, Rajasekhar H, Voss S, Lu SZ, Barlow HR,
            Cowdin MA, Daniel E, Vaddaraju V, Anandakumar T, Black E, Cleaver O
            and Maynard C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   5  (bases 1 to 1832)
  AUTHORS   Liu J, Wu X and Lu Q.
  TITLE     Molecular divergence of mammalian astrocyte progenitor cells at
            early gliogenesis
  JOURNAL   Development 149 (5) (2022)
   PUBMED   35253855
REFERENCE   6  (bases 1 to 1832)
  AUTHORS   Avraham S, London R, Fu Y, Ota S, Hiregowdara D, Li J, Jiang S,
            Pasztor LM, White RA, Groopman JE et al.
  TITLE     Identification and characterization of a novel related adhesion
            focal tyrosine kinase (RAFTK) from megakaryocytes and brain
  JOURNAL   J Biol Chem 270 (46), 27742-27751 (1995)
   PUBMED   7499242
REFERENCE   7  (bases 1 to 1832)
  AUTHORS   Shull MM, Ormsby I, Kier AB, Pawlowski S, Diebold RJ, Yin M, Allen
            R, Sidman C, Proetzel G, Calvin D et al.
  TITLE     Targeted disruption of the mouse transforming growth factor-beta 1
            gene results in multifocal inflammatory disease
  JOURNAL   Nature 359 (6397), 693-699 (1992)
   PUBMED   1436033
REFERENCE   8  (bases 1 to 1832)
  AUTHORS   Harding MA, Chadwick LJ, Gattone VH 2nd and Calvet JP.
  TITLE     The SGP-2 gene is developmentally regulated in the mouse kidney and
            abnormally expressed in collecting duct cysts in polycystic kidney
            disease
  JOURNAL   Dev Biol 146 (2), 483-490 (1991)
   PUBMED   1864465
REFERENCE   9  (bases 1 to 1832)
  AUTHORS   Purrello M, Bettuzzi S, Di Pietro C, Mirabile E, Di Blasi M, Rimini
            R, Grzeschik KH, Ingletti C, Corti A and Sichel G.
  TITLE     The gene for SP-40,40, human homolog of rat sulfated glycoprotein
            2, rat clusterin, and rat testosterone-repressed prostate message
            2, maps to chromosome 8
  JOURNAL   Genomics 10 (1), 151-156 (1991)
   PUBMED   2045098
REFERENCE   10 (bases 1 to 1832)
  AUTHORS   Jenne DE and Tschopp J.
  TITLE     Molecular structure and functional characterization of a human
            complement cytolysis inhibitor found in blood and seminal plasma:
            identity to sulfated glycoprotein 2, a constituent of rat testis
            fluid
  JOURNAL   Proc Natl Acad Sci U S A 86 (18), 7123-7127 (1989)
   PUBMED   2780565
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY248781.1, BC075668.1 and
            BP769702.1.
            
            [WARNING] On Jun 2, 2023 this sequence was replaced by NM_013492.4.
            
            On Nov 11, 2015 this sequence version replaced NM_013492.2.
            
            Summary: The protein encoded by this gene is a secreted chaperone
            that can, under some stress conditions, also be found in the cell
            cytosol. It has been suggested to be involved in several basic
            biological events such as cell death, tumor progression, and
            neurodegenerative disorders. The encoded preproprotein undergoes
            proteolytic processing to generate a disulfide-linked heterodimeric
            mature protein comprised of alpha and beta subunits. Mice lacking
            the encoded protein exhibit increased severity of autoimmune
            myocarditis, faster progression of the acute inflammation to
            myocardial scarring and decreased brain injury following neonatal
            hypoxic-ischemic injury. [provided by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L05670.1, SRR1660817.34394.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               BY248781.1         1-171
            172-1659            BC075668.1         1-1488
            1660-1832           BP769702.1         1-173               c
FEATURES             Location/Qualifiers
     source          1..1832
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.36 cM"
     gene            1..1832
                     /gene="Clu"
                     /gene_synonym="ApoJ; Cli; D14Ucla3; Sgp-2; Sgp2; SP-40;
                     Sugp-2"
                     /note="clusterin"
                     /db_xref="GeneID:12759"
                     /db_xref="MGI:MGI:88423"
     exon            1..206
                     /gene="Clu"
                     /gene_synonym="ApoJ; Cli; D14Ucla3; Sgp-2; Sgp2; SP-40;
                     Sugp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            207..327
                     /gene="Clu"
                     /gene_synonym="ApoJ; Cli; D14Ucla3; Sgp-2; Sgp2; SP-40;
                     Sugp-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1580
                     /gene="Clu"
                     /gene_synonym="ApoJ; Cli; D14Ucla3; Sgp-2; Sgp2; SP-40;
                     Sugp-2"
                     /note="clustrin; sulfated glycoprotein 2; Apolipoprotein
                     J; testosterone repressed prostate message-2; complement
                     lysis inhibitor"
                     /codon_start=1
                     /product="clusterin preproprotein"
                     /protein_id="NP_038520.2"
                     /db_xref="CCDS:CCDS36957.1"
                     /db_xref="GeneID:12759"
                     /db_xref="MGI:MGI:88423"
                     /translation="MKILLLCVALLLIWDNGMVLGEQEVSDNELQELSTQGSRYINKE
                     IQNAVQGVKHIKTLIEKTNAERKSLLNSLEEAKKKKEDALEDTRDSEMKLKAFPEVCN
                     ETMMALWEECKPCLKHTCMKFYARVCRSGSGLVGQQLEEFLNQSSPFYFWMNGDRIDS
                     LLESDRQQSQVLDAMQDSFARASGIIDTLFQDRFFARELHDPHYFSPIGFPHKRPHFL
                     YPKSRLVRSLMSPSHYGPPSFHNMFQPFFEMIHQAQQAMDVQLHSPAFQFPDVDFLRE
                     GEDDRTVCKEIRRNSTGCLKMKGQCEKCQEILSVDCSTNNPAQANLRQELNDSLQVAE
                     RLTEQYKELLQSFQSKMLNTSSLLEQLNDQFNWVSQLANLTQGEDKYYLRVSTVTTHS
                     SDSEVPSRVTEVVVKLFDSDPITVVLPEEVSKDNPKFMDTVAEKALQEYRRKSRAE"
     exon            328..476
                     /gene="Clu"
                     /gene_synonym="ApoJ; Cli; D14Ucla3; Sgp-2; Sgp2; SP-40;
                     Sugp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            477..647
                     /gene="Clu"
                     /gene_synonym="ApoJ; Cli; D14Ucla3; Sgp-2; Sgp2; SP-40;
                     Sugp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            648..1059
                     /gene="Clu"
                     /gene_synonym="ApoJ; Cli; D14Ucla3; Sgp-2; Sgp2; SP-40;
                     Sugp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1164
                     /gene="Clu"
                     /gene_synonym="ApoJ; Cli; D14Ucla3; Sgp-2; Sgp2; SP-40;
                     Sugp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1394
                     /gene="Clu"
                     /gene_synonym="ApoJ; Cli; D14Ucla3; Sgp-2; Sgp2; SP-40;
                     Sugp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1570
                     /gene="Clu"
                     /gene_synonym="ApoJ; Cli; D14Ucla3; Sgp-2; Sgp2; SP-40;
                     Sugp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1811
                     /gene="Clu"
                     /gene_synonym="ApoJ; Cli; D14Ucla3; Sgp-2; Sgp2; SP-40;
                     Sugp-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1786..1791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clu"
                     /gene_synonym="ApoJ; Cli; D14Ucla3; Sgp-2; Sgp2; SP-40;
                     Sugp-2"
     polyA_site      1811
                     /gene="Clu"
                     /gene_synonym="ApoJ; Cli; D14Ucla3; Sgp-2; Sgp2; SP-40;
                     Sugp-2"
ORIGIN      
        1 gctgggtgct gcgcctctta cccccacctc taggcttcca gaaagctcct ggtgcattct
       61 ccggcattct ctgggcgtga gtcacgcagg tttgcagcca gccccaaagg gggtgtactt
      121 gagcagagcg ctataaatag ggcgcttccc cggtgctcac cacccgcgtc accaggagga
      181 gcgcactgga gccaagccgc agaccggact ccagattcca aggaggccac gccatgaaga
      241 ttctcctgct gtgcgtggca ctgctgctga tctgggacaa tggcatggtc ctgggagagc
      301 aggaggtctc tgacaatgag ctccaagaac tgtccactca agggagtagg tatattaata
      361 aggagattca gaacgccgtc cagggagtga agcacataaa aactctcata gaaaaaacca
      421 acgcagagcg caagtccttg ctcaacagtt tagaggaagc caagaagaag aaagaggatg
      481 ctctggagga cactagggat tctgaaatga agctgaaggc attcccggaa gtgtgtaacg
      541 agaccatgat ggccctctgg gaggagtgca agccctgcct gaagcatacc tgcatgaagt
      601 tctatgcacg tgtctgcagg agcggctcag ggctggtcgg ccagcagcta gaggagtttc
      661 taaaccagag ctcacccttc tacttctgga tgaacggcga ccgcatcgac tccctgctgg
      721 agagtgaccg gcagcagagc caagtcctgg atgccatgca ggacagcttt gctcgggcat
      781 ctggcatcat agacacgctc tttcaggacc ggttcttcgc ccgtgagctt catgaccccc
      841 actacttctc ccccatcggc ttcccacaca agaggcctca tttcttatat cccaagtccc
      901 gcttggtccg cagcctcatg tctccctccc actatgggcc tccgagcttc cacaacatgt
      961 tccagccttt ctttgagatg atccaccagg ctcaacaggc catggatgtc cagctccaca
     1021 gcccagcctt ccagttccca gacgtggatt tcttaagaga aggtgaagat gaccgcactg
     1081 tgtgcaagga gatccgccgc aactccacag gatgcctgaa gatgaagggc cagtgtgaaa
     1141 agtgccagga gatcttgtct gtggactgtt caaccaacaa tcctgcccag gctaacctgc
     1201 gccaggagct gaacgactcg ctccaggtgg ccgagaggct gacagagcag tacaaggagc
     1261 tgctgcagtc cttccagtcg aagatgctca acacctcatc cctgctggag cagctgaacg
     1321 accagttcaa ctgggtgtcc cagctggcta acctcacaca gggcgaagac aagtactacc
     1381 ttcgggtctc caccgtgacc acccattcct ctgactcaga ggtcccctcc cgtgtcactg
     1441 aggtggtggt gaagctgttt gactctgacc ccatcacagt ggtgttacca gaagaagtct
     1501 ctaaggataa ccctaagttt atggacacag tggcggagaa ggcgctacag gaataccgca
     1561 ggaaaagccg tgcggaatga gatagaagca tcaccttcct atatgtagga gtgtctggga
     1621 gggaatctcc cagctccccg aggtggctgc agacccctag agaactccac atgtctccag
     1681 gcgagtaggc ctcacccaag cagcctgccc ttcctctgga ttctgtacac taatgcctgc
     1741 acttgctgct ctcgggaaga actgattccc ccacgcaact aatccaataa aagccgcctt
     1801 gcgatacgtg taaaaaaaaa aaaaaaaaaa aa
//
