LOCUS       NM_020626               1262 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus collectrin, amino acid transport regulator (Cltrn),
            transcript variant 1, mRNA.
ACCESSION   NM_020626
VERSION     NM_020626.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1262)
  AUTHORS   Kano,Y., Yamaguchi,S., Mise,K., Kawakita,C., Onishi,Y., Kurooka,N.,
            Sugawara,R., Albuayjan,H.H.H., Nakatsuka,A., Eguchi,J. and Wada,J.
  TITLE     Inhibition of Amino Acids Influx into Proximal Tubular Cells
            Improves Lysosome Function in Diabetes
  JOURNAL   Kidney360 5 (2), 182-194 (2024)
   PUBMED   38062578
REFERENCE   2  (bases 1 to 1262)
  AUTHORS   Chu,P.L., Gigliotti,J.C., Cechova,S., Bodonyi-Kovacs,G., Wang,Y.T.,
            Chen,L., Wassertheil-Smoller,S., Cai,J., Isakson,B.E.,
            Franceschini,N. and Le,T.H.
  TITLE     Collectrin (Tmem27) deficiency in proximal tubules causes
            hypertension in mice and a TMEM27 variant associates with blood
            pressure in males in a Latino cohort
  JOURNAL   Am J Physiol Renal Physiol 324 (1), F30-F42 (2023)
   PUBMED   36264884
REFERENCE   3  (bases 1 to 1262)
  AUTHORS   Treleaven,T., Zada,M., Nagarajah,R., Bailey,C.G., Rasko,J.E.J.,
            Morris,M.B. and Day,M.L.
  TITLE     Stage-Specific L-Proline Uptake by Amino Acid Transporter
            Slc6a19/B0AT1 Is Required for Optimal Preimplantation Embryo
            Development in Mice
  JOURNAL   Cells 12 (1), 18 (2022)
   PUBMED   36611813
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1262)
  AUTHORS   Niborski,L.L., Paces-Fessy,M., Ricci,P., Bourgeois,A.,
            Magalhaes,P., Kuzma-Kuzniarska,M., Lesaulnier,C., Reczko,M.,
            Declercq,E., Zurbig,P., Doucet,A., Umbhauer,M. and Cereghini,S.
  TITLE     Hnf1b haploinsufficiency differentially affects developmental
            target genes in a new renal cysts and diabetes mouse model
  JOURNAL   Dis Model Mech 14 (5) (2021)
   PUBMED   33737325
REFERENCE   5  (bases 1 to 1262)
  AUTHORS   Christians,A., Weiss,A.C., Martens,H., Klopf,M.G., Hennies,I.,
            Haffner,D., Kispert,A. and Weber,R.G.
  TITLE     Inflammation-like changes in the urothelium of Lifr-deficient mice
            and LIFR-haploinsufficient humans with urinary tract anomalies
  JOURNAL   Hum Mol Genet 29 (7), 1192-1204 (2020)
   PUBMED   32179912
REFERENCE   6  (bases 1 to 1262)
  AUTHORS   Akpinar,P., Kuwajima,S., Krutzfeldt,J. and Stoffel,M.
  TITLE     Tmem27: a cleaved and shed plasma membrane protein that stimulates
            pancreatic beta cell proliferation
  JOURNAL   Cell Metab 2 (6), 385-397 (2005)
   PUBMED   16330324
  REMARK    GeneRIF: Tmem27 is a pancreatic beta cell transmembrane protein
            that regulates cell growth of pancreatic islets
REFERENCE   7  (bases 1 to 1262)
  AUTHORS   Fukui,K., Yang,Q., Cao,Y., Takahashi,N., Hatakeyama,H., Wang,H.,
            Wada,J., Zhang,Y., Marselli,L., Nammo,T., Yoneda,K., Onishi,M.,
            Higashiyama,S., Matsuzawa,Y., Gonzalez,F.J., Weir,G.C., Kasai,H.,
            Shimomura,I., Miyagawa,J., Wollheim,C.B. and Yamagata,K.
  TITLE     The HNF-1 target collectrin controls insulin exocytosis by SNARE
            complex formation
  JOURNAL   Cell Metab 2 (6), 373-384 (2005)
   PUBMED   16330323
REFERENCE   8  (bases 1 to 1262)
  AUTHORS   Takasato,M., Osafune,K., Matsumoto,Y., Kataoka,Y., Yoshida,N.,
            Meguro,H., Aburatani,H., Asashima,M. and Nishinakamura,R.
  TITLE     Identification of kidney mesenchymal genes by a combination of
            microarray analysis and Sall1-GFP knockin mice
  JOURNAL   Mech Dev 121 (6), 547-557 (2004)
   PUBMED   15172686
REFERENCE   9  (bases 1 to 1262)
  AUTHORS   Zhang,H., Wada,J., Hida,K., Tsuchiyama,Y., Hiragushi,K.,
            Shikata,K., Wang,H., Lin,S., Kanwar,Y.S. and Makino,H.
  TITLE     Collectrin, a collecting duct-specific transmembrane glycoprotein,
            is a novel homolog of ACE2 and is developmentally regulated in
            embryonic kidneys
  JOURNAL   J Biol Chem 276 (20), 17132-17139 (2001)
   PUBMED   11278314
REFERENCE   10 (bases 1 to 1262)
  AUTHORS   Zhang,H., Wada,J., Kanwar,Y.S., Tsuchiyama,Y., Hiragushi,K.,
            Hida,K., Shikata,K. and Makino,H.
  TITLE     Screening for genes up-regulated in 5/6 nephrectomized mouse kidney
  JOURNAL   Kidney Int 56 (2), 549-558 (1999)
   PUBMED   10432394
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732294.18.
            
            On Mar 21, 2007 this sequence version replaced NM_020626.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF178085.1, AK002337.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AL732294.18        82030-82173
            145-203             AL732294.18        82532-82590
            204-289             AL732294.18        86719-86804
            290-403             AL732294.18        97819-97932
            404-598             AL732294.18        100168-100362
            599-1262            AL732294.18        110039-110702
FEATURES             Location/Qualifiers
     source          1..1262
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 76.12 cM"
     gene            1..1262
                     /gene="Cltrn"
                     /gene_synonym="0610008J07Rik; NX-17; NX17; Tmem27"
                     /note="collectrin, amino acid transport regulator"
                     /db_xref="GeneID:57394"
                     /db_xref="MGI:MGI:1926234"
     exon            1..144
                     /gene="Cltrn"
                     /gene_synonym="0610008J07Rik; NX-17; NX17; Tmem27"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..755
                     /gene="Cltrn"
                     /gene_synonym="0610008J07Rik; NX-17; NX17; Tmem27"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; kidney-specific membrane protein; collectrin;
                     transmembrane protein 27"
                     /codon_start=1
                     /product="collectrin isoform 1 precursor"
                     /protein_id="NP_065651.1"
                     /db_xref="CCDS:CCDS30517.1"
                     /db_xref="GeneID:57394"
                     /db_xref="MGI:MGI:1926234"
                     /translation="MLWALFFLVTTIHAELCHPDAENAFKVRLSIRAALGDKAYVWDT
                     DQEYLFRAMVAFSMRKVPNREATEISHVLLCNITQRVSFWFVVTDPSNNYTLPAAEVQ
                     SAIRKNRNRINSAFFLDDHTLEFLKIPSTLAPPMEPSVPVWIIVFGVIFCIVTVAIAL
                     LVLSGIRQRRRNNKGPPGVEDAEDKCENIITIENGIPCDPLDMKGGHINDGFLTEDER
                     LTPL"
     exon            145..203
                     /gene="Cltrn"
                     /gene_synonym="0610008J07Rik; NX-17; NX17; Tmem27"
                     /inference="alignment:Splign:2.1.0"
     exon            204..289
                     /gene="Cltrn"
                     /gene_synonym="0610008J07Rik; NX-17; NX17; Tmem27"
                     /inference="alignment:Splign:2.1.0"
     exon            290..403
                     /gene="Cltrn"
                     /gene_synonym="0610008J07Rik; NX-17; NX17; Tmem27"
                     /inference="alignment:Splign:2.1.0"
     exon            404..598
                     /gene="Cltrn"
                     /gene_synonym="0610008J07Rik; NX-17; NX17; Tmem27"
                     /inference="alignment:Splign:2.1.0"
     exon            599..1262
                     /gene="Cltrn"
                     /gene_synonym="0610008J07Rik; NX-17; NX17; Tmem27"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggtcaca gaatggttaa agcagcttta agtagagagt ggattatttt cccctcagtt
       61 tgtcttctgt ttgcggctct gaaagaatgt tgtgggcgct ctttttcctg gtgactacta
      121 ttcacgctga actctgccat ccagatgcag aaaatgcctt taaagtaaga cttagcatca
      181 gagcagctct tggagataaa gcatatgtct gggacacgga tcaagaatac ctcttcagag
      241 caatggtggc attctccatg agaaaagttc ccaacagaga agcaacagaa atttcccatg
      301 tcctgctttg caacataacc cagagggtgt cgttctggtt tgtggtcacg gacccttcca
      361 acaattatac tcttcctgca gctgaagtac agtcggccat aagaaagaat aggaaccgga
      421 tcaacagtgc attttttctg gatgaccata ctctggaatt tttaaaaatt ccttctactc
      481 ttgctccccc gatggagcca tctgtgcccg tctggattat tgtattcggt gtgatatttt
      541 gcattgttac agttgcaatt gcactactgg ttctatctgg aatccggcaa cgcagaagga
      601 acaacaaagg accacctgga gtggaagatg cagaagacaa gtgtgaaaac atcatcacaa
      661 tagaaaatgg catcccttgt gatcccttgg acatgaaggg agggcacatt aatgatggct
      721 tcttgacaga ggatgagcgc ctcacccctc tctgagagtg acagtcttgt aagaaaattt
      781 taagatgctt gaatgtgatt gacaacaaat tatatccaca aagaccaatg aaatcataag
      841 gtgttagctt ctcaaaatat tctagaattt tctttttgat aactgattat gtaggtatag
      901 tgtgtgtttg tagttactga tttgagcatt tctagaaata aagtcagggc tgtaactata
      961 tttcatattt tgaagaccta agaaaaaaat tttcactgga gaatggctat aacatggcat
     1021 agaaatcatt aaaaatggat ctttttgaat actgtttata ttactctgta tatgatgcat
     1081 cgagtaaaat taaacaagag atggataaaa atggcaaggg aattttattc tgttatcaca
     1141 ccaacagttg cttgtatagt ttctgcatat tagtctttag tagggcaagc agatctattt
     1201 gttgttgcct gcaatttgta cacatcctac ctatgctgat ttaataaagt agtgatcatc
     1261 tc
//
