LOCUS       NM_001313719            1019 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus collectrin, amino acid transport regulator (Cltrn),
            transcript variant 2, mRNA.
ACCESSION   NM_001313719
VERSION     NM_001313719.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1019)
  AUTHORS   Kano,Y., Yamaguchi,S., Mise,K., Kawakita,C., Onishi,Y., Kurooka,N.,
            Sugawara,R., Albuayjan,H.H.H., Nakatsuka,A., Eguchi,J. and Wada,J.
  TITLE     Inhibition of Amino Acids Influx into Proximal Tubular Cells
            Improves Lysosome Function in Diabetes
  JOURNAL   Kidney360 5 (2), 182-194 (2024)
   PUBMED   38062578
REFERENCE   2  (bases 1 to 1019)
  AUTHORS   Chu,P.L., Gigliotti,J.C., Cechova,S., Bodonyi-Kovacs,G., Wang,Y.T.,
            Chen,L., Wassertheil-Smoller,S., Cai,J., Isakson,B.E.,
            Franceschini,N. and Le,T.H.
  TITLE     Collectrin (Tmem27) deficiency in proximal tubules causes
            hypertension in mice and a TMEM27 variant associates with blood
            pressure in males in a Latino cohort
  JOURNAL   Am J Physiol Renal Physiol 324 (1), F30-F42 (2023)
   PUBMED   36264884
REFERENCE   3  (bases 1 to 1019)
  AUTHORS   Treleaven,T., Zada,M., Nagarajah,R., Bailey,C.G., Rasko,J.E.J.,
            Morris,M.B. and Day,M.L.
  TITLE     Stage-Specific L-Proline Uptake by Amino Acid Transporter
            Slc6a19/B0AT1 Is Required for Optimal Preimplantation Embryo
            Development in Mice
  JOURNAL   Cells 12 (1), 18 (2022)
   PUBMED   36611813
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1019)
  AUTHORS   Niborski,L.L., Paces-Fessy,M., Ricci,P., Bourgeois,A.,
            Magalhaes,P., Kuzma-Kuzniarska,M., Lesaulnier,C., Reczko,M.,
            Declercq,E., Zurbig,P., Doucet,A., Umbhauer,M. and Cereghini,S.
  TITLE     Hnf1b haploinsufficiency differentially affects developmental
            target genes in a new renal cysts and diabetes mouse model
  JOURNAL   Dis Model Mech 14 (5) (2021)
   PUBMED   33737325
REFERENCE   5  (bases 1 to 1019)
  AUTHORS   Christians,A., Weiss,A.C., Martens,H., Klopf,M.G., Hennies,I.,
            Haffner,D., Kispert,A. and Weber,R.G.
  TITLE     Inflammation-like changes in the urothelium of Lifr-deficient mice
            and LIFR-haploinsufficient humans with urinary tract anomalies
  JOURNAL   Hum Mol Genet 29 (7), 1192-1204 (2020)
   PUBMED   32179912
REFERENCE   6  (bases 1 to 1019)
  AUTHORS   Akpinar,P., Kuwajima,S., Krutzfeldt,J. and Stoffel,M.
  TITLE     Tmem27: a cleaved and shed plasma membrane protein that stimulates
            pancreatic beta cell proliferation
  JOURNAL   Cell Metab 2 (6), 385-397 (2005)
   PUBMED   16330324
  REMARK    GeneRIF: Tmem27 is a pancreatic beta cell transmembrane protein
            that regulates cell growth of pancreatic islets
REFERENCE   7  (bases 1 to 1019)
  AUTHORS   Fukui,K., Yang,Q., Cao,Y., Takahashi,N., Hatakeyama,H., Wang,H.,
            Wada,J., Zhang,Y., Marselli,L., Nammo,T., Yoneda,K., Onishi,M.,
            Higashiyama,S., Matsuzawa,Y., Gonzalez,F.J., Weir,G.C., Kasai,H.,
            Shimomura,I., Miyagawa,J., Wollheim,C.B. and Yamagata,K.
  TITLE     The HNF-1 target collectrin controls insulin exocytosis by SNARE
            complex formation
  JOURNAL   Cell Metab 2 (6), 373-384 (2005)
   PUBMED   16330323
REFERENCE   8  (bases 1 to 1019)
  AUTHORS   Takasato,M., Osafune,K., Matsumoto,Y., Kataoka,Y., Yoshida,N.,
            Meguro,H., Aburatani,H., Asashima,M. and Nishinakamura,R.
  TITLE     Identification of kidney mesenchymal genes by a combination of
            microarray analysis and Sall1-GFP knockin mice
  JOURNAL   Mech Dev 121 (6), 547-557 (2004)
   PUBMED   15172686
REFERENCE   9  (bases 1 to 1019)
  AUTHORS   Zhang,H., Wada,J., Hida,K., Tsuchiyama,Y., Hiragushi,K.,
            Shikata,K., Wang,H., Lin,S., Kanwar,Y.S. and Makino,H.
  TITLE     Collectrin, a collecting duct-specific transmembrane glycoprotein,
            is a novel homolog of ACE2 and is developmentally regulated in
            embryonic kidneys
  JOURNAL   J Biol Chem 276 (20), 17132-17139 (2001)
   PUBMED   11278314
REFERENCE   10 (bases 1 to 1019)
  AUTHORS   Zhang,H., Wada,J., Kanwar,Y.S., Tsuchiyama,Y., Hiragushi,K.,
            Hida,K., Shikata,K. and Makino,H.
  TITLE     Screening for genes up-regulated in 5/6 nephrectomized mouse kidney
  JOURNAL   Kidney Int 56 (2), 549-558 (1999)
   PUBMED   10432394
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732294.18 and AK148534.1.
            
            Transcript Variant: This variant (2) contains an alternate exon in
            place of the first two exons and lacks an alternate internal
            in-frame exon compared to variant 1. The resulting isoform (2) is
            shorter at the N-terminus and lacks an alternate internal segment
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY042134.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849385 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               AL732294.18        84032-84186
            156-355             AK148534.1         201-400
            356-458             AK148534.1         596-698
            459-459             AL732294.18        110142-110142
            460-1019            AK148534.1         700-1259
FEATURES             Location/Qualifiers
     source          1..1019
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 76.12 cM"
     gene            1..1019
                     /gene="Cltrn"
                     /gene_synonym="0610008J07Rik; NX-17; NX17; Tmem27"
                     /note="collectrin, amino acid transport regulator"
                     /db_xref="GeneID:57394"
                     /db_xref="MGI:MGI:1926234"
     exon            1..155
                     /gene="Cltrn"
                     /gene_synonym="0610008J07Rik; NX-17; NX17; Tmem27"
                     /inference="alignment:Splign:2.1.0"
     exon            156..241
                     /gene="Cltrn"
                     /gene_synonym="0610008J07Rik; NX-17; NX17; Tmem27"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..512
                     /gene="Cltrn"
                     /gene_synonym="0610008J07Rik; NX-17; NX17; Tmem27"
                     /note="isoform 2 is encoded by transcript variant 2;
                     kidney-specific membrane protein; collectrin;
                     transmembrane protein 27"
                     /codon_start=1
                     /product="collectrin isoform 2"
                     /protein_id="NP_001300648.1"
                     /db_xref="GeneID:57394"
                     /db_xref="MGI:MGI:1926234"
                     /translation="MVAFSMRKVPNREATEISHVLLCNITQRVSFWFVVTDPSNNYTL
                     PAAEVQSAIRNNKGPPGVEDAEDKCENIITIENGIPCDPLDMKGGHINDGFLTEDERL
                     TPL"
     exon            242..355
                     /gene="Cltrn"
                     /gene_synonym="0610008J07Rik; NX-17; NX17; Tmem27"
                     /inference="alignment:Splign:2.1.0"
     exon            356..1019
                     /gene="Cltrn"
                     /gene_synonym="0610008J07Rik; NX-17; NX17; Tmem27"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggttgttt caagacaaag gaactgttta aaccatcaaa tgctggtgag aggccaagat
       61 cattctgtga aggctgagga ggttagcagg agctgttttt gcaaagatgg agaaggaaaa
      121 agtcagatat tggagagggg gataaaataa gcaggtatgt ctgggacacg gatcaagaat
      181 acctcttcag agcaatggtg gcattctcca tgagaaaagt tcccaacaga gaagcaacag
      241 aaatttccca tgtcctgctt tgcaacataa cccagagggt gtcgttctgg tttgtggtca
      301 cggacccttc caacaattat actcttcctg cagctgaagt acagtcggcc ataaggaaca
      361 acaaaggacc acctggagtg gaagatgcag aagacaagtg tgaaaacatc atcacaatag
      421 aaaatggcat cccttgtgat cccttggaca tgaagggagg gcacattaat gatggcttct
      481 tgacagagga tgagcgcctc acccctctct gagagtgaca gtcttgtaag aaaattttaa
      541 gatgcttgaa tgtgattgac aacaaattat atccacaaag accaatgaaa tcataaggtg
      601 ttagcttctc aaaatattct agaattttct ttttgataac tgattatgta ggtatagtgt
      661 gtgtttgtag ttactgattt gagcatttct agaaataaag tcagggctgt aactatattt
      721 catattttga agacctaaga aaaaaatttt cactggagaa tggctataac atggcataga
      781 aatcattaaa aatggatctt tttgaatact gtttatatta ctctgtatat gatgcatcga
      841 gtaaaattaa acaagagatg gataaaaatg gcaagggaat tttattctgt tatcacacca
      901 acagttgctt gtatagtttc tgcatattag tctttagtag ggcaagcaga tctatttgtt
      961 gttgcctgca atttgtacac atcctaccta tgctgattta ataaagtagt gatcatctc
//
