LOCUS       NM_001347512            2302 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus clathrin light chain B (Cltb), transcript variant 1,
            mRNA.
ACCESSION   NM_001347512 XM_006517418
VERSION     NM_001347512.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2302)
  AUTHORS   Chen,Y., Briant,K., Camus,M.D. and Brodsky,F.M.
  TITLE     Clathrin light chains CLCa and CLCb have non-redundant roles in
            epithelial lumen formation
  JOURNAL   Life Sci Alliance 7 (1), e202302175 (2023)
   PUBMED   37923360
  REMARK    GeneRIF: Clathrin light chains CLCa and CLCb have non-redundant
            roles in epithelial lumen formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2302)
  AUTHORS   Redlingshofer,L., McLeod,F., Chen,Y., Camus,M.D., Burden,J.J.,
            Palomer,E., Briant,K., Dannhauser,P.N., Salinas,P.C. and
            Brodsky,F.M.
  TITLE     Clathrin light chain diversity regulates membrane deformation in
            vitro and synaptic vesicle formation in vivo
  JOURNAL   Proc Natl Acad Sci U S A 117 (38), 23527-23538 (2020)
   PUBMED   32907943
REFERENCE   3  (bases 1 to 2302)
  AUTHORS   Biancospino,M., Buel,G.R., Nino,C.A., Maspero,E., Scotto di
            Perrotolo,R., Raimondi,A., Redlingshofer,L., Weber,J.,
            Brodsky,F.M., Walters,K.J. and Polo,S.
  TITLE     Clathrin light chain A drives selective myosin VI recruitment to
            clathrin-coated pits under membrane tension
  JOURNAL   Nat Commun 10 (1), 4974 (2019)
   PUBMED   31672988
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2302)
  AUTHORS   Kamiya,K., Yum,S.W., Kurebayashi,N., Muraki,M., Ogawa,K.,
            Karasawa,K., Miwa,A., Guo,X., Gotoh,S., Sugitani,Y., Yamanaka,H.,
            Ito-Kawashima,S., Iizuka,T., Sakurai,T., Noda,T., Minowa,O. and
            Ikeda,K.
  TITLE     Assembly of the cochlear gap junction macromolecular complex
            requires connexin 26
  JOURNAL   J Clin Invest 124 (4), 1598-1607 (2014)
   PUBMED   24590285
REFERENCE   5  (bases 1 to 2302)
  AUTHORS   Storbeck,M., Hupperich,K., Gaspar,J.A., Meganathan,K., Martinez
            Carrera,L., Wirth,R., Sachinidis,A. and Wirth,B.
  TITLE     Neuronal-specific deficiency of the splicing factor Tra2b causes
            apoptosis in neurogenic areas of the developing mouse brain
  JOURNAL   PLoS One 9 (2), e89020 (2014)
   PUBMED   24586484
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2302)
  AUTHORS   Chen,H., Ko,G., Zatti,A., Di Giacomo,G., Liu,L., Raiteri,E.,
            Perucco,E., Collesi,C., Min,W., Zeiss,C., De Camilli,P. and
            Cremona,O.
  TITLE     Embryonic arrest at midgestation and disruption of Notch signaling
            produced by the absence of both epsin 1 and epsin 2 in mice
  JOURNAL   Proc Natl Acad Sci U S A 106 (33), 13838-13843 (2009)
   PUBMED   19666558
REFERENCE   7  (bases 1 to 2302)
  AUTHORS   Yamauchi,T., Ishidao,T., Nomura,T., Shinagawa,T., Tanaka,Y.,
            Yonemura,S. and Ishii,S.
  TITLE     A B-Myb complex containing clathrin and filamin is required for
            mitotic spindle function
  JOURNAL   EMBO J 27 (13), 1852-1862 (2008)
   PUBMED   18548008
REFERENCE   8  (bases 1 to 2302)
  AUTHORS   Makeyev,E.V., Zhang,J., Carrasco,M.A. and Maniatis,T.
  TITLE     The MicroRNA miR-124 promotes neuronal differentiation by
            triggering brain-specific alternative pre-mRNA splicing
  JOURNAL   Mol Cell 27 (3), 435-448 (2007)
   PUBMED   17679093
REFERENCE   9  (bases 1 to 2302)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 2302)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY256386.1, BY075785.1, BC070404.1, AK167531.1, BQ173953.1 and
            BE991851.1.
            
            On Nov 30, 2016 this sequence version replaced XM_006517418.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070404.1, BQ177244.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BY256386.1         1-15
            16-99               BY075785.1         1-84
            100-1085            BC070404.1         1-986
            1086-1968           AK167531.1         1004-1886
            1969-2244           BQ173953.1         18-293              c
            2245-2302           BE991851.1         287-344
FEATURES             Location/Qualifiers
     source          1..2302
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 28.84 cM"
     gene            1..2302
                     /gene="Cltb"
                     /gene_synonym="2310046E19Rik; lcb"
                     /note="clathrin light chain B"
                     /db_xref="GeneID:74325"
                     /db_xref="MGI:MGI:1921575"
     exon            1..296
                     /gene="Cltb"
                     /gene_synonym="2310046E19Rik; lcb"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..799
                     /gene="Cltb"
                     /gene_synonym="2310046E19Rik; lcb"
                     /note="isoform a is encoded by transcript variant 1;
                     clathrin, light polypeptide (Lcb)"
                     /codon_start=1
                     /product="clathrin light chain B isoform a"
                     /protein_id="NP_001334441.1"
                     /db_xref="CCDS:CCDS84024.1"
                     /db_xref="GeneID:74325"
                     /db_xref="MGI:MGI:1921575"
                     /translation="MAEDFGFFSSSESGAPEAAEEDPAAAFLAQQESEIAGIENDPGF
                     GAPAASQVASAQPGLASGAGSEDMSTTVNGDVFQEANGPADGYAAIAQADRLTQEPES
                     IRKWREEQKKRLQELDAASKVTEQEWREKAKKDLEEWNQRQSEQVEKNKINNRIADKA
                     FYQQPDADTIGYVASEEAFVKESKEETPGTEWEKVAQLCDFNPKSSKQCKDVSRLRSV
                     LMSLKQTPLSR"
     exon            297..343
                     /gene="Cltb"
                     /gene_synonym="2310046E19Rik; lcb"
                     /inference="alignment:Splign:2.1.0"
     exon            344..461
                     /gene="Cltb"
                     /gene_synonym="2310046E19Rik; lcb"
                     /inference="alignment:Splign:2.1.0"
     exon            462..573
                     /gene="Cltb"
                     /gene_synonym="2310046E19Rik; lcb"
                     /inference="alignment:Splign:2.1.0"
     exon            574..627
                     /gene="Cltb"
                     /gene_synonym="2310046E19Rik; lcb"
                     /inference="alignment:Splign:2.1.0"
     exon            628..2284
                     /gene="Cltb"
                     /gene_synonym="2310046E19Rik; lcb"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1085
                     /gene="Cltb"
                     /gene_synonym="2310046E19Rik; lcb"
                     /note="major polyA site"
     regulatory      1707..1712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cltb"
                     /gene_synonym="2310046E19Rik; lcb"
                     /note="hexamer: ATTAAA"
     polyA_site      1725
                     /gene="Cltb"
                     /gene_synonym="2310046E19Rik; lcb"
                     /note="major polyA site"
     regulatory      2224..2229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cltb"
                     /gene_synonym="2310046E19Rik; lcb"
                     /note="hexamer: AATAAA"
     polyA_site      2244
                     /gene="Cltb"
                     /gene_synonym="2310046E19Rik; lcb"
     regulatory      2260..2265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cltb"
                     /gene_synonym="2310046E19Rik; lcb"
                     /note="hexamer: ATTAAA"
     polyA_site      2284
                     /gene="Cltb"
                     /gene_synonym="2310046E19Rik; lcb"
ORIGIN      
        1 gcgactcctc ccgccgccgc tgcagccgca gtgacaggca agccgggcgg gtgacgggaa
       61 gtgcgggccg cgggcgcggg cgggaggtga cagcagccac gcggggaaga tggctgagga
      121 cttcggcttc ttctcatcgt cggagagcgg ggccccggag gccgccgagg aggacccagc
      181 ggccgccttc ctggcccagc aggaaagcga gattgctggc atcgagaatg acccgggttt
      241 cggggcacct gccgccagcc aggtggcctc tgcgcagccg ggactcgcga gcggggctgg
      301 ttcagaggac atgagtacta cagtcaatgg agatgtgttt caggaggcta acgggcctgc
      361 cgatggctac gctgcgattg cccaggcgga caggttgact caggagcccg agagcatccg
      421 gaagtggaga gaggagcaga agaaaaggct gcaggagtta gacgctgcct cgaaggtgac
      481 cgaacaggag tggcgggaga aggccaagaa agacctggag gagtggaacc agcgccaaag
      541 tgaacaggtt gagaagaaca agatcaacaa caggatcgct gacaaagcgt tctaccagca
      601 gccagatgct gataccattg gctatgtggc atcggaagag gcttttgtga aagaatccaa
      661 ggaggagacc ccgggcacag agtgggagaa ggtagcccag ctgtgtgact tcaatcccaa
      721 gagcagcaag cagtgtaaag atgtgtcccg cctgcgctcg gtgctcatgt ccctgaagca
      781 aacaccactg tcccgctagg tgcccgtcac gagaacggcc gcgaagcaca tgggccttgc
      841 tggggcagag gagcagctgc ttccgccaga gtggaacttc ctctggcagc tgccacacac
      901 agcctgttct gttcctctga atctctggga gctaggaagt gggaccctta cccctttcac
      961 cccacaactc cttcctggtc ccctggccca gcccctcatg actcctgtca gcccactcaa
     1021 ttgtgactgt ccctcctgat gtatttttct tggcttaaag ggtgtgttaa ctctttttac
     1081 acttatttat tagtatcctc atttctctgg aagccgcaac tggtgtcagc gctcagtttg
     1141 tgcatagaat tttcctagct ccgtgtcctt aaaaggtgag gatgtagtct tagaaaccca
     1201 gagctcgcag ctggaagcag gaaccccaac ctgtctgtgt ctgctgtctg ccctccaaga
     1261 agaaaggcaa attttcacga gacagggtct gcaaccttgc tctctgtgat tctttaacaa
     1321 gtctgaaggt agggactctg ctgtcctcat gtatagctga gaaaactaag actccccaaa
     1381 cagaattggc ttttgtgtag aaaggaagtg aggccagcgt gctctaaggc tgtgtctagg
     1441 cctgagtaag ggtggcaaat acagcatccg cccaaccttc ttcctcgaga gtgaccaaga
     1501 ccctcttaag acatgcaggc ctgctgcagt acagatgtgc ctccctcttc agctattccc
     1561 ccctgtggac ttaggataag caacagtgac cacaccttct tccccttcag cagaggccgt
     1621 ataacaggac tttaagccat tacgatctac atggtgtttg aaaagatttg ggtaattgct
     1681 aacagtatta gttccctaag attgccatta aagaatacca aaaaacctgg ctgccttaga
     1741 gcatcagaaa tctgttgtct caattccgga ggctaaaagt cccaaatttg ggaacgacca
     1801 agccacgccc cccagagatg ctaaggcagg acctgtgcct ctcgtagctt ctagtagctc
     1861 aggtatcctt tggtttgcag atataggtct ccagttttgc ttacaccctc acatggctgt
     1921 ctgtgttcat cattttccca tgtataattt gtgtgtccaa ttttttttct ttttttggtt
     1981 tttttgagac agggtttctc tgtatagctc tggctgtcaa tctttttttt taaatatgga
     2041 tacgaggggc tagatatatg gttcagtggt taagagcact ggctgctctt ccagaggttc
     2101 tgagatcaat gcccagcaac taactacatg gaaacttaaa accatctgta atgggatctg
     2161 ataccctctt ctggcatgcg tgtgtacatg cagagagaga gaggggagtg gggagaactc
     2221 ctaaataaat tttaaaacaa tggataccag tattactgga ttaaagccca ccttaaagac
     2281 tgtaaaaaaa aaaaaaaaaa aa
//
