LOCUS       NM_001080384            1719 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus clathrin light chain A (Clta), transcript variant 1,
            mRNA.
ACCESSION   NM_001080384 XM_006537590
VERSION     NM_001080384.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1719)
  AUTHORS   Wang,L., Yang,Z., Satoshi,F., Prasanna,X., Yan,Z., Vihinen,H.,
            Chen,Y., Zhao,Y., He,X., Bu,Q., Li,H., Zhao,Y., Jiang,L., Qin,F.,
            Dai,Y., Zhang,N., Qin,M., Kuang,W., Zhao,Y., Jokitalo,E.,
            Vattulainen,I., Kajander,T., Zhao,H. and Cen,X.
  TITLE     Membrane remodeling by FAM92A1 during brain development regulates
            neuronal morphology, synaptic function, and cognition
  JOURNAL   Nat Commun 15 (1), 6209 (2024)
   PUBMED   39043703
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1719)
  AUTHORS   Chen,Y., Briant,K., Camus,M.D. and Brodsky,F.M.
  TITLE     Clathrin light chains CLCa and CLCb have non-redundant roles in
            epithelial lumen formation
  JOURNAL   Life Sci Alliance 7 (1), e202302175 (2023)
   PUBMED   37923360
  REMARK    GeneRIF: Clathrin light chains CLCa and CLCb have non-redundant
            roles in epithelial lumen formation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1719)
  AUTHORS   Redlingshofer,L., McLeod,F., Chen,Y., Camus,M.D., Burden,J.J.,
            Palomer,E., Briant,K., Dannhauser,P.N., Salinas,P.C. and
            Brodsky,F.M.
  TITLE     Clathrin light chain diversity regulates membrane deformation in
            vitro and synaptic vesicle formation in vivo
  JOURNAL   Proc Natl Acad Sci U S A 117 (38), 23527-23538 (2020)
   PUBMED   32907943
REFERENCE   4  (bases 1 to 1719)
  AUTHORS   de Groot,N.E., van den Hoogenhof,M.M.G., Najafi,A., van der
            Made,I., van der Velden,J., Beqqali,A., Pinto,Y.M. and
            Creemers,E.E.
  TITLE     Heterozygous loss of Rbm24 in the adult mouse heart increases
            sarcomere slack length but does not affect function
  JOURNAL   Sci Rep 10 (1), 7687 (2020)
   PUBMED   32376900
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1719)
  AUTHORS   Biancospino,M., Buel,G.R., Nino,C.A., Maspero,E., Scotto di
            Perrotolo,R., Raimondi,A., Redlingshofer,L., Weber,J.,
            Brodsky,F.M., Walters,K.J. and Polo,S.
  TITLE     Clathrin light chain A drives selective myosin VI recruitment to
            clathrin-coated pits under membrane tension
  JOURNAL   Nat Commun 10 (1), 4974 (2019)
   PUBMED   31672988
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1719)
  AUTHORS   Lu,J., Helton,T.D., Blanpied,T.A., Racz,B., Newpher,T.M.,
            Weinberg,R.J. and Ehlers,M.D.
  TITLE     Postsynaptic positioning of endocytic zones and AMPA receptor
            cycling by physical coupling of dynamin-3 to Homer
  JOURNAL   Neuron 55 (6), 874-889 (2007)
   PUBMED   17880892
REFERENCE   7  (bases 1 to 1719)
  AUTHORS   Kessels,M.M., Engqvist-Goldstein,A.E. and Drubin,D.G.
  TITLE     Association of mouse actin-binding protein 1 (mAbp1/SH3P7), an Src
            kinase target, with dynamic regions of the cortical actin
            cytoskeleton in response to Rac1 activation
  JOURNAL   Mol Biol Cell 11 (1), 393-412 (2000)
   PUBMED   10637315
REFERENCE   8  (bases 1 to 1719)
  AUTHORS   Smith,C.J. and Pearse,B.M.
  TITLE     Clathrin: anatomy of a coat protein
  JOURNAL   Trends Cell Biol 9 (9), 335-338 (1999)
   PUBMED   10461185
  REMARK    Review article
REFERENCE   9  (bases 1 to 1719)
  AUTHORS   Scott,L.M., Mueller,L. and Collins,S.J.
  TITLE     E3, a hematopoietic-specific transcript directly regulated by the
            retinoic acid receptor alpha
  JOURNAL   Blood 88 (7), 2517-2530 (1996)
   PUBMED   8839844
REFERENCE   10 (bases 1 to 1719)
  AUTHORS   Wong,D.H., Ignatius,M.J., Parosky,G., Parham,P., Trojanowski,J.Q.
            and Brodsky,F.M.
  TITLE     Neuron-specific expression of high-molecular-weight clathrin light
            chain
  JOURNAL   J Neurosci 10 (9), 3025-3031 (1990)
   PUBMED   2204686
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL732563.5.
            
            On Mar 20, 2019 this sequence version replaced NM_001080384.2.
            
            Summary: Clathrin is a large, soluble protein composed of heavy and
            light chains. It functions as the main structural component of the
            lattice-type cytoplasmic face of coated pits and vesicles which
            entrap specific macromolecules during receptor-mediated
            endocytosis. This gene encodes one of two clathrin light chain
            proteins which are believed to function as regulatory elements.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) differs in the 5' UTR and
            lacks alternate in-frame exons, compared to variant 2, resulting in
            a shorter protein (isoform a), compared to isoform b.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146965.1, SRR13422597.1088569.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               AL732563.5         37299-37556
            259-1005            AL732563.5         45118-45864
            1006-1043           AL732563.5         51669-51706
            1044-1161           AL732563.5         52730-52847
            1162-1273           AL732563.5         58305-58416
            1274-1719           AL732563.5         65257-65702
FEATURES             Location/Qualifiers
     source          1..1719
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 23.09 cM"
     gene            1..1719
                     /gene="Clta"
                     /gene_synonym="Lca"
                     /note="clathrin light chain A"
                     /db_xref="GeneID:12757"
                     /db_xref="MGI:MGI:894297"
     exon            1..258
                     /gene="Clta"
                     /gene_synonym="Lca"
                     /inference="alignment:Splign:2.1.0"
     exon            259..1005
                     /gene="Clta"
                     /gene_synonym="Lca"
                     /inference="alignment:Splign:2.1.0"
     CDS             789..1445
                     /gene="Clta"
                     /gene_synonym="Lca"
                     /note="isoform a is encoded by transcript variant 1;
                     clathryn light chain (LCA2); clathrin, light polypeptide
                     (Lca)"
                     /codon_start=1
                     /product="clathrin light chain A isoform a"
                     /protein_id="NP_001073853.1"
                     /db_xref="CCDS:CCDS38748.1"
                     /db_xref="GeneID:12757"
                     /db_xref="MGI:MGI:894297"
                     /translation="MAELDPFGAPAGAPGGPALGNGVAGAGEEDPAAAFLAQQESEIA
                     GIENDEAFAILDGGAPGPQPHGEPPGGPDAVDGVMNGEYYQESNGPTDSYAAISEVDR
                     LQSEPESIRKWREEQTERLEALDANSRKQEAEWKEKAIKELEEWYARQDEQLQKTKAN
                     NRAAEEAFVNDIDESSPGTEWERVARLCDFNPKSSKQAKDVSRMRSVLISLKQAPLVH
                     "
     exon            1006..1043
                     /gene="Clta"
                     /gene_synonym="Lca"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1161
                     /gene="Clta"
                     /gene_synonym="Lca"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1273
                     /gene="Clta"
                     /gene_synonym="Lca"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1719
                     /gene="Clta"
                     /gene_synonym="Lca"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1694..1699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clta"
                     /gene_synonym="Lca"
                     /note="hexamer: AATAAA"
     polyA_site      1719
                     /gene="Clta"
                     /gene_synonym="Lca"
                     /note="major polyA site"
ORIGIN      
        1 ggtctttgct ctatgacctg aagcaaagtc agctggatgg ccttgagctg ttccactgta
       61 caggtgaaat ggtttggccc ccactgactt ggcttggagt caccaccacc accatgtccg
      121 tgactctgct cagcctggcc agggtgtaag gaggagctag agacttcttt tatagcaatg
      181 gacctttgag agagctctgc tcacttggac ttttgggctc tctctctttt tggcttggct
      241 tcatagaagg agatccaggg tggtaacatt aaatggtaac tgcacttctc ttggtctatg
      301 cacccataaa atttttcaat catccaggag ggaggcaatg caagattctt ctaccagctt
      361 tccaagcgag gacactgagg ttcagaaaca cccagtggtt gtgtgttgag tagtcgggaa
      421 gagctcacgt ccctgatgcc cacaaatggc tgttcctgat cactccagct cccgatgctc
      481 ggcgactccc agcttcccct agggtggcac ttccgctggc tcttccttct gctcccagtc
      541 acgagttgtc cccagggctc ctcccctttg ccagctgatt gggcagctcc cgtcttctga
      601 ttggctgttc tttttgtggc tcaccaaccc aaccggatat agaagcaggg tttccgcttc
      661 caccttctcc ctcttctcgc tcgtcctccg gtagcagccg ccagcacagt gtcggctgct
      721 gggcggggtg tcggcggatc ggtcggttgg tttcggcttc ggcgtctctg cggttgagtt
      781 gggctgtcat ggccgagttg gatccattcg gcgctcccgc cggtgcgccc ggtggccccg
      841 ctctaggaaa cggggtggcg ggcgccggcg aagaagaccc ggccgcggcc ttcttggcgc
      901 agcaagagag tgagattgcg ggcatcgaga acgatgaggc cttcgccatc ctggacggcg
      961 gcgcccccgg gccgcagcca cacggcgagc cgccgggagg tccggatgct gttgacggag
     1021 tgatgaatgg tgaatactac caggagagca atggtccaac agacagttac gcagccattt
     1081 cagaagtgga tcgattgcag tcagagcctg aaagtatccg taagtggaga gaagagcaga
     1141 cagagcgcct ggaagccctc gatgccaatt ctcggaagca agaagcggag tggaaagaaa
     1201 aggcgataaa ggagctggaa gagtggtatg cgaggcagga cgagcagcta cagaagacaa
     1261 aggcaaacaa cagggcagca gaagaagcct ttgtaaacga cattgacgag tcatccccag
     1321 gcactgagtg ggagcgggtg gcccgcctgt gtgactttaa ccccaagtcc agcaaacagg
     1381 ccaaagatgt ctctcgcatg cgctcagtcc tcatctccct gaagcaggcc cccctggtgc
     1441 actgaagagc caccctgtgg aaacactacg tctacaatat cttaatccta ctcagtgaag
     1501 ctgttcacgt aattggatta attatgttga gttcttttgg accaaacctt ttgtctttag
     1561 agttgatcat tgtttgtgat tgcatgtttc cttcaactgt gttctccctg gcattcagag
     1621 acgagagagg aagaggaagg gagaggagct cccgacagta gcctcaacct gtgcttttgt
     1681 gcattattct gagaataaat ttctgtttca aacaatgta
//
