LOCUS       NM_153508               4007 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus calsyntenin 3 (Clstn3), transcript variant 1, mRNA.
ACCESSION   NM_153508
VERSION     NM_153508.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4007)
  AUTHORS   Zhang,C., Ye,M., Melikov,K., Yang,D., Vale,G.D.D., McDonald,J.,
            Eckert,K., Lin,M.J. and Zeng,X.
  TITLE     CLSTN3B promotes lipid droplet maturation and lipid storage in
            mouse adipocytes
  JOURNAL   Nat Commun 15 (1), 9475 (2024)
   PUBMED   39488519
  REMARK    GeneRIF: CLSTN3B promotes lipid droplet maturation and lipid
            storage in mouse adipocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4007)
  AUTHORS   Honda,K., Takahashi,H., Hata,S., Abe,R., Saito,T., Saido,T.C.,
            Taru,H., Sobu,Y., Ando,K., Yamamoto,T. and Suzuki,T.
  TITLE     Suppression of the amyloidogenic metabolism of APP and the
            accumulation of Abeta by alcadein alpha in the brain during aging
  JOURNAL   Sci Rep 14 (1), 18471 (2024)
   PUBMED   39122814
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4007)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4007)
  AUTHORS   Qi,J., Meng,C., Mo,J., Shou,T., Ding,L. and Zhi,T.
  TITLE     CircAFF2 Promotes Neuronal Cell Injury in Intracerebral Hemorrhage
            by Regulating the miR-488/CLSTN3 Axis
  JOURNAL   Neuroscience 535, 75-87 (2023)
   PUBMED   37884088
  REMARK    GeneRIF: CircAFF2 Promotes Neuronal Cell Injury in Intracerebral
            Hemorrhage by Regulating the miR-488/CLSTN3 Axis.
REFERENCE   5  (bases 1 to 4007)
  AUTHORS   Hata,S., Saito,H., Kakiuchi,T., Fukumoto,D., Yamamoto,S.,
            Kasuga,K., Kimura,A., Moteki,K., Abe,R., Adachi,S., Kinoshita,S.,
            Yoshizawa-Kumagaye,K., Nishio,H., Saito,T., Saido,T.C.,
            Yamamoto,T., Nishimura,M., Taru,H., Sobu,Y., Ohba,H., Nishiyama,S.,
            Harada,N., Ikeuchi,T., Tsukada,H., Ouchi,Y. and Suzuki,T.
  TITLE     Brain p3-Alcbeta peptide restores neuronal viability impaired by
            Alzheimer's amyloid beta-peptide
  JOURNAL   EMBO Mol Med 15 (5), e17052 (2023)
   PUBMED   36994913
REFERENCE   6  (bases 1 to 4007)
  AUTHORS   Pettem,K.L., Yokomaku,D., Luo,L., Linhoff,M.W., Prasad,T.,
            Connor,S.A., Siddiqui,T.J., Kawabe,H., Chen,F., Zhang,L.,
            Rudenko,G., Wang,Y.T., Brose,N. and Craig,A.M.
  TITLE     The specific alpha-neurexin interactor calsyntenin-3 promotes
            excitatory and inhibitory synapse development
  JOURNAL   Neuron 80 (1), 113-128 (2013)
   PUBMED   24094106
REFERENCE   7  (bases 1 to 4007)
  AUTHORS   Uchida,Y., Gomi,F., Murayama,S. and Takahashi,H.
  TITLE     Calsyntenin-3 C-terminal fragment accumulates in dystrophic
            neurites surrounding abeta plaques in tg2576 mouse and Alzheimer
            disease brains: its neurotoxic role in mediating dystrophic neurite
            formation
  JOURNAL   Am J Pathol 182 (5), 1718-1726 (2013)
   PUBMED   23499467
  REMARK    GeneRIF: The C-terminal fragment but not full-length Cst-3
            accumulated in dystrophic neurites surrounding amyloidbeta plaques
            in Tg2576 mouse and Alzheimer disease brains.
REFERENCE   8  (bases 1 to 4007)
  AUTHORS   Railo,A., Pajunen,A., Itaranta,P., Naillat,F., Vuoristo,J.,
            Kilpelainen,P. and Vainio,S.
  TITLE     Genomic response to Wnt signalling is highly
            context-dependent--evidence from DNA microarray and chromatin
            immunoprecipitation screens of Wnt/TCF targets
  JOURNAL   Exp Cell Res 315 (16), 2690-2704 (2009)
   PUBMED   19563800
REFERENCE   9  (bases 1 to 4007)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   10 (bases 1 to 4007)
  AUTHORS   Hintsch,G., Zurlinden,A., Meskenaite,V., Steuble,M.,
            Fink-Widmer,K., Kinter,J. and Sonderegger,P.
  TITLE     The calsyntenins--a family of postsynaptic membrane proteins with
            distinct neuronal expression patterns
  JOURNAL   Mol Cell Neurosci 21 (3), 393-409 (2002)
   PUBMED   12498782
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ152135.1, AK032336.1, AV341395.2 and CJ287099.1.
            
            On Oct 28, 2009 this sequence version replaced NM_153508.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.107147.1,
                                           SRR1660813.240960.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                CJ152135.1         2-61
            61-3479             AK032336.1         3-3421
            3480-3683           AV341395.2         182-385
            3684-3996           AK032336.1         3627-3939
            3997-4007           CJ287099.1         379-389
FEATURES             Location/Qualifiers
     source          1..4007
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.15 cM"
     gene            1..4007
                     /gene="Clstn3"
                     /gene_synonym="alc-beta; Clstn3b; Cs3; Cst-3; CSTN3"
                     /note="calsyntenin 3"
                     /db_xref="GeneID:232370"
                     /db_xref="MGI:MGI:2178323"
     exon            1..364
                     /gene="Clstn3"
                     /gene_synonym="alc-beta; Clstn3b; Cs3; Cst-3; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..3171
                     /gene="Clstn3"
                     /gene_synonym="alc-beta; Clstn3b; Cs3; Cst-3; CSTN3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; alcadein-beta; calsyntenin 3beta"
                     /codon_start=1
                     /product="calsyntenin-3 isoform 1 precursor"
                     /protein_id="NP_705728.1"
                     /db_xref="CCDS:CCDS20519.1"
                     /db_xref="GeneID:232370"
                     /db_xref="MGI:MGI:2178323"
                     /translation="MTLLLVSLLLASLLQISSGNKANKHKPWIEAEYQGIVMENDNTV
                     LLNPPLFALDKDAPLRYAGEICGFRLHGSGVPFEAVILDKATGEGLIRAKEPVDCEAQ
                     KEHTFTIQAYDCGEGPDGTNTKKSHKATVHVRVNDVNEFAPVFVERLYRAAVTEGKLY
                     DRILRVEAIDGDCSPQYSQICYYEILTPNTPFLIDNDGNIENTEKLQYSGEKLYKFTV
                     TAYDCGKKRAADDAEVEIQVKPTCKPSWQGWNKRIEYAPGAGSLALFPGIRLETCDEP
                     LWNIQATIELQTSHVAKGCDRDNYSERALRKLCGAATGEVDLLPMPGPNANWTAGLSV
                     HYSQDSSLIYWFNGTQAVQVPLGGPAGLGSGPQDGFSDHFTLSFWMKHSVTPSKGKKE
                     EETIVCNTVQNEDGYSHYSLTVHGCRIAFLYWPLLESARPVKFLWKLEQVCDDEWHHY
                     ALNLEFPTVTLYTDGISFDPALIHDNGLIHPPRREPALMIGACWTEEKNKEKKGGENS
                     TDTASGDPLLIHHYFHGYLAGFSVRSGRLESREVIECLYACREGLDYRDFESLGKGMK
                     VHVNPSQSLLTLEGDDVETFNHALQHVAYMNTLRFATPGVRPLRLTTAVKCFSEESCV
                     SIPEVEGYVVVLQPDAPQILLSGTAHFARPAVDFEGPEGVPLFPDLQITCSISHQVEA
                     KADESWQGTVTDTRMSDEIVHNLDGCEISLVGDDLDPERESLLLDMASLQQRGLELTN
                     TSAYLTIAGVETITVYEEILRQARYQLRHGAALYARKFRLSCSEMNGRYSSNEFIVEV
                     NVLHSMNRVAHPSHVLSSQQFLHRGHQPPPEMAGHSLASSHRNSMVPSAATLIIVVCV
                     GFLVLMVILGLVRIHSLHRRVSGTGGPSGASTDPKDPDLFWDDSALTIIVNPMESYQN
                     QQTCVAGVAGGQQEEEDSSDSEAADSPSSDERRIIESPPHRY"
     exon            365..487
                     /gene="Clstn3"
                     /gene_synonym="alc-beta; Clstn3b; Cs3; Cst-3; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            488..683
                     /gene="Clstn3"
                     /gene_synonym="alc-beta; Clstn3b; Cs3; Cst-3; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            684..892
                     /gene="Clstn3"
                     /gene_synonym="alc-beta; Clstn3b; Cs3; Cst-3; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1042
                     /gene="Clstn3"
                     /gene_synonym="alc-beta; Clstn3b; Cs3; Cst-3; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1228
                     /gene="Clstn3"
                     /gene_synonym="alc-beta; Clstn3b; Cs3; Cst-3; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1510
                     /gene="Clstn3"
                     /gene_synonym="alc-beta; Clstn3b; Cs3; Cst-3; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1623
                     /gene="Clstn3"
                     /gene_synonym="alc-beta; Clstn3b; Cs3; Cst-3; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1786
                     /gene="Clstn3"
                     /gene_synonym="alc-beta; Clstn3b; Cs3; Cst-3; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1840
                     /gene="Clstn3"
                     /gene_synonym="alc-beta; Clstn3b; Cs3; Cst-3; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1998
                     /gene="Clstn3"
                     /gene_synonym="alc-beta; Clstn3b; Cs3; Cst-3; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2147
                     /gene="Clstn3"
                     /gene_synonym="alc-beta; Clstn3b; Cs3; Cst-3; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2374
                     /gene="Clstn3"
                     /gene_synonym="alc-beta; Clstn3b; Cs3; Cst-3; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2545
                     /gene="Clstn3"
                     /gene_synonym="alc-beta; Clstn3b; Cs3; Cst-3; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2691
                     /gene="Clstn3"
                     /gene_synonym="alc-beta; Clstn3b; Cs3; Cst-3; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2827
                     /gene="Clstn3"
                     /gene_synonym="alc-beta; Clstn3b; Cs3; Cst-3; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..3030
                     /gene="Clstn3"
                     /gene_synonym="alc-beta; Clstn3b; Cs3; Cst-3; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..4007
                     /gene="Clstn3"
                     /gene_synonym="alc-beta; Clstn3b; Cs3; Cst-3; CSTN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3985..3990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clstn3"
                     /gene_synonym="alc-beta; Clstn3b; Cs3; Cst-3; CSTN3"
                     /note="hexamer: AATAAA"
     polyA_site      4004
                     /gene="Clstn3"
                     /gene_synonym="alc-beta; Clstn3b; Cs3; Cst-3; CSTN3"
                     /note="major polyA site"
ORIGIN      
        1 gacgtcatcc tgcagtagcg gggatggggt gggagtgaga gagagataga gagagcaagc
       61 gagagtgagg acgctgggct ggagactgaa gagagaagct actgcaagtc ccccatctca
      121 gccacccagc gggtctgaac acatctgcta tatggactag agtggtcggc aggctccttt
      181 ccgatcttgt ccccctgccc ttccctcgta gtctctgcat ttctccccca aggtggcatt
      241 agcaggcttg aggctcccag gggataggaa cgcctggcct ggcgtgctta gcaccgcacc
      301 atgaccctcc tgctggtgtc ccttttgctg gcctctctgc ttcaaatcag ctctggcaac
      361 aaagccaaca agcacaagcc atggatcgag gcagagtacc agggcattgt catggagaat
      421 gacaacacgg tcctgttgaa cccaccactc tttgccttgg ataaagatgc tccactgcgc
      481 tatgcaggtg agatctgcgg cttccggctc catggatctg gggtaccctt cgaggctgtg
      541 atcctggaca aggcaacggg tgaagggctg atccgggcta aggagcccgt ggactgtgag
      601 gcccagaagg aacacacttt taccattcag gcttatgact gtggcgaggg acccgatggc
      661 accaatacca agaagtctca caaggcaacc gtgcatgttc gggtcaatga tgtgaatgag
      721 tttgccccgg tctttgtgga gcgtctgtac cgtgctgcag tgacggaggg gaagctgtat
      781 gatcggatct tacgtgtgga agccattgat ggcgactgct ccccgcagta cagccagatc
      841 tgctactatg agatccttac gcccaacacc cctttcctca ttgacaatga tggcaacatt
      901 gagaacacag agaagctaca gtacagtggc gagaaactct acaagttcac agtgacagcg
      961 tatgactgtg ggaagaagcg agcggcagat gatgctgagg tggagattca ggtgaagccc
     1021 acctgcaaac ccagctggca aggctggaac aaaaggattg aatatgcccc aggagccggg
     1081 agcttggctt tgttccctgg catccgtctg gagacctgtg atgagccact gtggaacatt
     1141 caggccacca tagagctgca gaccagccat gtggccaagg gctgcgaccg agacaactat
     1201 tcagagaggg ctctgcggaa gctctgtggt gctgctactg gggaggtgga cctgttgccc
     1261 atgcccggcc ccaatgccaa ctggacagcg gggctgtcgg tgcactacag ccaggacagc
     1321 agcctcatct actggttcaa tggcacacaa gctgtgcaag ttcccctggg tggtccagca
     1381 gggctgggct ctgggccgca ggatggcttc agcgaccact ttaccctgtc cttctggatg
     1441 aagcatagtg tgactcccag caaggggaag aaggaggagg agaccattgt gtgtaacaca
     1501 gtccagaatg aggacggcta ctctcactac tcactgactg tccatggctg cagaattgcc
     1561 tttctctact ggccgttgct tgagagtgct cgtcctgtca agttcctctg gaagctggag
     1621 caggtgtgtg atgatgaatg gcatcactac gccctgaacc tggagttccc cacggtcaca
     1681 ctgtatactg acggtatctc cttcgacccg gctctcatcc acgacaatgg tctcatccac
     1741 ccacccagga gggaacctgc actcatgatt ggggcctgct ggactgaaga gaagaacaaa
     1801 gagaagaagg ggggagagaa cagtacagac acagcctcag gagacccctt gctgatccac
     1861 cactactttc atggctacct agctggtttc agcgtgcgct caggtcgcct ggagagccgt
     1921 gaggtcatcg agtgcctcta tgcatgtcgg gaggggctgg actataggga tttcgagagc
     1981 ctgggcaaag gcatgaaggt ccacgtgaac ccctcgcagt ccctgctcac cctggagggg
     2041 gatgatgtgg agaccttcaa ccatgccctg cagcatgtgg cttacatgaa cactctgcgc
     2101 tttgccacac ccggcgtcag gcccctgcgc ctcaccaccg ctgtcaagtg ctttagtgaa
     2161 gagtcctgtg tctccatccc tgaagtggag ggctatgtgg tggttcttca gcccgacgcc
     2221 ccccagatcc ttctgagtgg cacagctcat tttgcccgcc cagctgtgga ctttgaggga
     2281 cccgagggag tccccttgtt ccccgatctt cagatcacct gctccatttc tcaccaggtg
     2341 gaggccaaag cagatgagag ttggcagggc acagtgacag acacacgcat gtcagatgag
     2401 attgtacaca acttggacgg ctgtgagatt tctctggtgg gggatgacct agaccctgaa
     2461 cgagagagcc tgctcttgga catggcttcc ctgcagcagc gaggcctgga actcaccaac
     2521 acatctgcct acctcaccat tgctggggtg gagaccatca ctgtgtatga agagatcctg
     2581 aggcaggctc gttatcagct tcggcatgga gctgcccttt atgccaggaa attccggctt
     2641 tcttgctcgg agatgaacgg ccgatactcc agcaacgaat tcattgtgga ggtcaacgtc
     2701 ctgcatagca tgaaccgggt ggcccatccc agtcatgtgc tcagttcaca gcagttcctg
     2761 caccggggtc accagcctcc tcctgagatg gctggacaca gcctggccag ctcccaccgg
     2821 aactccatgg tccccagtgc tgcgactctc atcattgtgg tatgcgtggg ctttctggtg
     2881 cttatggtta tcctcggcct cgttcggatc cactcccttc atcgccgcgt ctcaggaact
     2941 ggcggacctt caggggcttc cactgacccg aaggaccctg acctcttctg ggatgactct
     3001 gctctcacca ttattgtcaa tcctatggag tcctaccaga accagcagac ctgtgtggca
     3061 ggggtggctg gtggccagca agaggaagag gacagcagtg actcggaagc agccgactcc
     3121 cccagcagtg atgagagacg catcattgag agccccccac accgctattg aggcgccaac
     3181 cctgccaaga gagagaggcc tgccctgggg agacaggcac tcaggaaaaa aaagggagaa
     3241 cggcattttg agagaagaga gaccgagggg ggagaaagag ctcttcattt ggagcagtcc
     3301 ttcaatctca gaaccccagg aggccccaca ggagttgccc tcctccttca gcctgcccct
     3361 gccttgggct gcccttcccc tggtgtactc ctgaggtgtc tgccccagct ggctgccctg
     3421 ggagagtggc tggatggctt tggctgccct gtagcctacc tgtggcagca tactgtgcca
     3481 gccatgcact gtattaggga gggggatgtc aacagccttg gttgaggtgg gaatgcaatt
     3541 gatgggagcc tgctgctgtg tccttctcta ctctgttctg tccgtgaggg ctttccttct
     3601 gttgcccctc cccctcccgc ttcccctagg atcccctcgc ctctatttcc atttcactct
     3661 ggggatccct gctcctccct cttctcagcc tcctccctct tttgtcctct tttcctctcc
     3721 tgcctgagca gtaccaaggt cttactgtct ctattccttt ctccatggcc tgctttgcct
     3781 gggttgtggg gaaggaggag gagggggacc ctgggggtgt attatatata gtgtatattt
     3841 tttcaatgtt gtcgtgagcg cagctcctgt gtttctgtgt gcagctcaca gccttgtatg
     3901 tgtgcgtgtg cgtggcattg tcatgtcctg ggatgagggt agggggtggg tgtggtaaag
     3961 gagggccgca ccctagggtt ttcaaataaa acaactagaa aaaagtt
//
