LOCUS       NM_022319               4383 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus calsyntenin 2 (Clstn2), transcript variant 1, mRNA.
ACCESSION   NM_022319
VERSION     NM_022319.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4383)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4383)
  AUTHORS   Xu,P., He,H., Gao,Q., Zhou,Y., Wu,Z., Zhang,X., Sun,L., Hu,G.,
            Guan,Q., You,Z., Zhang,X., Zheng,W., Xiong,M. and Chen,Y.
  TITLE     Human midbrain dopaminergic neuronal differentiation markers
            predict cell therapy outcomes in a Parkinson's disease model
  JOURNAL   J Clin Invest 132 (14) (2022)
   PUBMED   35700056
REFERENCE   3  (bases 1 to 4383)
  AUTHORS   Klenova,A.V., Volodin,I.A., Volodina,E.V., Ranneva,S.V.,
            Amstislavskaya,T.G. and Lipina,T.V.
  TITLE     Vocal and physical phenotypes of calsyntenin2 knockout mouse pups
            model early-life symptoms of the autism spectrum disorder
  JOURNAL   Behav Brain Res 412, 113430 (2021)
   PUBMED   34182007
  REMARK    GeneRIF: Vocal and physical phenotypes of calsyntenin2 knockout
            mouse pups model early-life symptoms of the autism spectrum
            disorder.
REFERENCE   4  (bases 1 to 4383)
  AUTHORS   Eltokhi,A., Santuy,A., Merchan-Perez,A. and Sprengel,R.
  TITLE     Glutamatergic Dysfunction and Synaptic Ultrastructural Alterations
            in Schizophrenia and Autism Spectrum Disorder: Evidence from Human
            and Rodent Studies
  JOURNAL   Int J Mol Sci 22 (1), 59 (2020)
   PUBMED   33374598
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4383)
  AUTHORS   Ranneva,S.V., Maksimov,V.F., Korostyshevskaja,I.M. and Lipina,T.V.
  TITLE     Lack of synaptic protein, calsyntenin-2, impairs morphology of
            synaptic complexes in mice
  JOURNAL   Synapse 74 (2), e22132 (2020)
   PUBMED   31529526
  REMARK    GeneRIF: Lack of synaptic protein, calsyntenin-2, impairs
            morphology of synaptic complexes in mice.
REFERENCE   6  (bases 1 to 4383)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   7  (bases 1 to 4383)
  AUTHORS   Garcia-Ortiz,J.E., Pelosi,E., Omari,S., Nedorezov,T., Piao,Y.,
            Karmazin,J., Uda,M., Cao,A., Cole,S.W., Forabosco,A.,
            Schlessinger,D. and Ottolenghi,C.
  TITLE     Foxl2 functions in sex determination and histogenesis throughout
            mouse ovary development
  JOURNAL   BMC Dev Biol 9, 36 (2009)
   PUBMED   19538736
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4383)
  AUTHORS   Hodge,L.K., Klassen,M.P., Han,B.X., Yiu,G., Hurrell,J., Howell,A.,
            Rousseau,G., Lemaigre,F., Tessier-Lavigne,M. and Wang,F.
  TITLE     Retrograde BMP signaling regulates trigeminal sensory neuron
            identities and the formation of precise face maps
  JOURNAL   Neuron 55 (4), 572-586 (2007)
   PUBMED   17698011
REFERENCE   9  (bases 1 to 4383)
  AUTHORS   Ishikawa,A., Kitajima,S., Takahashi,Y., Kokubo,H., Kanno,J.,
            Inoue,T. and Saga,Y.
  TITLE     Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression
            in the PSM under the control of Notch signaling
  JOURNAL   Mech Dev 121 (12), 1443-1453 (2004)
   PUBMED   15511637
REFERENCE   10 (bases 1 to 4383)
  AUTHORS   Hintsch,G., Zurlinden,A., Meskenaite,V., Steuble,M.,
            Fink-Widmer,K., Kinter,J. and Sonderegger,P.
  TITLE     The calsyntenins--a family of postsynaptic membrane proteins with
            distinct neuronal expression patterns
  JOURNAL   Mol Cell Neurosci 21 (3), 393-409 (2002)
   PUBMED   12498782
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117219.2, AC116588.3, AC112521.4 and AC147637.3.
            
            On Nov 1, 2022 this sequence version replaced NM_022319.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063058.1, AK220500.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-339               AC117219.2         122360-122698       c
            340-462             AC116588.3         143247-143369       c
            463-658             AC112521.4         138916-139111       c
            659-867             AC112521.4         137871-138079       c
            868-1017            AC147637.3         211294-211443       c
            1018-1203           AC147637.3         182466-182651       c
            1204-1452           AC147637.3         173346-173594       c
            1453-1574           AC147637.3         167038-167159       c
            1575-1737           AC147637.3         123673-123835       c
            1738-1904           AC147637.3         110425-110591       c
            1905-2053           AC147637.3         104199-104347       c
            2054-2277           AC147637.3         102074-102297       c
            2278-2448           AC147637.3         98828-98998         c
            2449-2594           AC147637.3         98281-98426         c
            2595-2718           AC147637.3         98047-98170         c
            2719-2903           AC147637.3         97160-97344         c
            2904-3064           AC147637.3         95317-95477         c
            3065-4383           AC147637.3         85129-86447         c
FEATURES             Location/Qualifiers
     source          1..4383
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 51.06 cM"
     gene            1..4383
                     /gene="Clstn2"
                     /gene_synonym="2900042C18Rik; Cs2; Cst-2; CSTN2;
                     mKIAA4134"
                     /note="calsyntenin 2"
                     /db_xref="GeneID:64085"
                     /db_xref="MGI:MGI:1929897"
     exon            1..339
                     /gene="Clstn2"
                     /gene_synonym="2900042C18Rik; Cs2; Cst-2; CSTN2;
                     mKIAA4134"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..3125
                     /gene="Clstn2"
                     /gene_synonym="2900042C18Rik; Cs2; Cst-2; CSTN2;
                     mKIAA4134"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; alc-gamma; alcadein-gamma"
                     /codon_start=1
                     /product="calsyntenin-2 isoform 1 precursor"
                     /protein_id="NP_071714.2"
                     /db_xref="CCDS:CCDS40733.1"
                     /db_xref="GeneID:64085"
                     /db_xref="MGI:MGI:1929897"
                     /translation="MLPGRLCLVPLLLALGVGSGGGSGDGGDSRRRRLLVAKVNKHKP
                     WIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAVVLNKT
                     SGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPREAAWKKSHKAVVHIQVKDVNEFAP
                     TFKEPAYKAIVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIR
                     NTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPGS
                     GSMPLFPSIHLETCDGAVSSLQVTAELQTNYIGKGCDRETYSEKSLQKLCGASSGIID
                     LLPSPSAATNWTAGLLVDSSEMIFKFDGRQGAKIPDGIVPKNLTDQFTITMWMKHGPS
                     PGVRAEKETILCNSDKTEMNRHHYALYVHNCRLVFLLRKDFDQADTFRPAEFHWKLDQ
                     ICDKEWHYYVINVEFPVVTLYMDGATYEPYLVTNDWPIHPSHIAMQLTVGACWQGGEV
                     AKPRFAQFFHGSLASLTIRPGKMESQKVISCLQACKEGLDINSLESLGRGIKYHFNPS
                     QSILVMEGDDIGNINRALQKVSYINSRQFPTAGVRRLRLSSKVQCFGEDVCISIPDVD
                     AYIMVLQAIEPQITLQGTERFWRPAAQFESARGVTLFPDIKIVSTFAKTEASGDMRAT
                     GTAPKSAVLEEMLHNLDFCDILVLGGDLDPRQECLELNHSELHQRHLDATNSTAGYSI
                     YGVGSMNRYEQVLHHLRYRNWHPTSLETRRFRIKCSELNGRYTSNEFNLEVSVLHEVR
                     VSDKEHVNHLIVQPPFLQSVHHPETRSSIQRSSVVPSIATVVIIISVCMLVFVVAMGV
                     YRVRIAHQHFIQETEAAKEAEMDWDDSALTITVNPMEKHEGPGNGEDETTEVEEEEEA
                     EEGSSSSSSGSDDSEEEEEEGMGRVRHGQSGTSSQSPERSTWNTAGVINIWK"
     exon            340..462
                     /gene="Clstn2"
                     /gene_synonym="2900042C18Rik; Cs2; Cst-2; CSTN2;
                     mKIAA4134"
                     /inference="alignment:Splign:2.1.0"
     exon            463..658
                     /gene="Clstn2"
                     /gene_synonym="2900042C18Rik; Cs2; Cst-2; CSTN2;
                     mKIAA4134"
                     /inference="alignment:Splign:2.1.0"
     exon            659..867
                     /gene="Clstn2"
                     /gene_synonym="2900042C18Rik; Cs2; Cst-2; CSTN2;
                     mKIAA4134"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1017
                     /gene="Clstn2"
                     /gene_synonym="2900042C18Rik; Cs2; Cst-2; CSTN2;
                     mKIAA4134"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1203
                     /gene="Clstn2"
                     /gene_synonym="2900042C18Rik; Cs2; Cst-2; CSTN2;
                     mKIAA4134"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1452
                     /gene="Clstn2"
                     /gene_synonym="2900042C18Rik; Cs2; Cst-2; CSTN2;
                     mKIAA4134"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1574
                     /gene="Clstn2"
                     /gene_synonym="2900042C18Rik; Cs2; Cst-2; CSTN2;
                     mKIAA4134"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1737
                     /gene="Clstn2"
                     /gene_synonym="2900042C18Rik; Cs2; Cst-2; CSTN2;
                     mKIAA4134"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1904
                     /gene="Clstn2"
                     /gene_synonym="2900042C18Rik; Cs2; Cst-2; CSTN2;
                     mKIAA4134"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2053
                     /gene="Clstn2"
                     /gene_synonym="2900042C18Rik; Cs2; Cst-2; CSTN2;
                     mKIAA4134"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2277
                     /gene="Clstn2"
                     /gene_synonym="2900042C18Rik; Cs2; Cst-2; CSTN2;
                     mKIAA4134"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2448
                     /gene="Clstn2"
                     /gene_synonym="2900042C18Rik; Cs2; Cst-2; CSTN2;
                     mKIAA4134"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2594
                     /gene="Clstn2"
                     /gene_synonym="2900042C18Rik; Cs2; Cst-2; CSTN2;
                     mKIAA4134"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2718
                     /gene="Clstn2"
                     /gene_synonym="2900042C18Rik; Cs2; Cst-2; CSTN2;
                     mKIAA4134"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2903
                     /gene="Clstn2"
                     /gene_synonym="2900042C18Rik; Cs2; Cst-2; CSTN2;
                     mKIAA4134"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..3064
                     /gene="Clstn2"
                     /gene_synonym="2900042C18Rik; Cs2; Cst-2; CSTN2;
                     mKIAA4134"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..4383
                     /gene="Clstn2"
                     /gene_synonym="2900042C18Rik; Cs2; Cst-2; CSTN2;
                     mKIAA4134"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4354..4359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clstn2"
                     /gene_synonym="2900042C18Rik; Cs2; Cst-2; CSTN2;
                     mKIAA4134"
                     /note="hexamer: AATAAA"
     polyA_site      4383
                     /gene="Clstn2"
                     /gene_synonym="2900042C18Rik; Cs2; Cst-2; CSTN2;
                     mKIAA4134"
                     /note="major polyA site"
ORIGIN      
        1 agtgagtgct gctgttgcgg gagagcgagc gacgcggcga agggcagcgg aggcggtgag
       61 tgagggcggc ggcggcggct ccagaagcgc acccggcagc tccagggagg cggcgcggca
      121 ggcaccggcg gacaccagcg gacgccagcg gacaccggca ggcgaggccg gcgcgagcgg
      181 taggaggcgg cggctgcagc tcggtggcgg ctcaggcggc gaggatgctg ccggggaggc
      241 tgtgcttggt gccgctcctg ctggcgctgg gcgtagggag cggcggcggc agtggagacg
      301 gcggagacag ccggcggcgc cgcctcctcg tggcgaaagt caataaacac aagccatgga
      361 tcgagacatc gtatcacgga gtcataactg agaacaatga cacagtcatc ttggaccctc
      421 cactggttgc cctggataaa gatgccccag tgccttttgc aggggaaatc tgtgcattca
      481 agatccatgg acaggagctg ccctttgagg ctgtggtgct caataagaca tctggagagg
      541 gccggctccg cgccaagagt cccatcgact gtgagctgca gaaggagtac acgttcatca
      601 tccaggccta tgactgtggt gcggggcctc gggaagcagc ctggaagaag tcacacaagg
      661 ctgtggtcca catccaggtg aaggatgtca atgagtttgc acccaccttc aaagagccag
      721 cctacaaggc catcgtcacg gagggcaaga tctatgacag catcctgcag gtagaagcca
      781 ttgatgagga ctgctccccg cagtacagcc agatttgcaa ctatgaaatt gtcacaacgg
      841 atgtgccttt tgccattgac agaaatggca acatcaggaa cactgagaag ctgagctatg
      901 acaagcaaca ccagtatgag atcctggtaa ccgcttatga ctgtggacag aaacccgccg
      961 ctcaggacac cctggtgcag gtggacgtga aaccagtgtg caagcccggc tggcaagatt
     1021 ggaccaaaag gattgagtac cagcctggct cggggagtat gcccttgttc cccagcatcc
     1081 acctggagac atgcgatgga gctgtgtcct ccctccaggt cactgcggag ctgcagacta
     1141 attacatcgg caagggctgt gaccgagaga cctactctga gaaatccctt cagaaattat
     1201 gtggcgcatc ctcgggtatc atcgatctct tgccgtcccc tagcgcagct accaactgga
     1261 ctgcggggct gctggtggac agcagtgaga tgatcttcaa gtttgacggc aggcagggtg
     1321 ccaagatccc tgatgggatc gtgcccaaga acctgacgga ccagttcacc atcaccatgt
     1381 ggatgaaaca tggccccagc cccggcgtga gagccgagaa ggaaactatc ctctgtaact
     1441 cagataaaac tgaaatgaac cggcatcact atgccctgta tgtgcacaac tgccgcctcg
     1501 tcttcctcct gcggaaggac tttgaccagg cagacacctt tcgccctgca gagtttcact
     1561 ggaagctgga ccagatttgt gacaaagagt ggcattacta tgtcatcaat gtggagttcc
     1621 ctgtggttac cctgtacatg gatggagcaa catatgaacc atacctggtg actaatgact
     1681 ggcccattca tccatctcac atagccatgc aacttactgt cggcgcctgt tggcaaggag
     1741 gcgaagtggc caaaccacgg tttgcacaat ttttccatgg cagccttgcc agtctcacaa
     1801 tccgtcctgg caaaatggaa agccagaagg tgatttcttg tttgcaggcc tgcaaagaag
     1861 ggctggatat taattccttg gaaagccttg ggcgagggat aaagtatcac ttcaaccctt
     1921 cacagtccat cctcgtgatg gaaggcgatg acattgggaa catcaaccga gccctccaga
     1981 aagtctccta tatcaactcc cggcaattcc caacagcagg ggtccggcgc ctcagactct
     2041 cttccaaagt ccagtgcttt ggagaagatg tgtgcatcag catcccagat gtggatgcct
     2101 acatcatggt cttacaggcc attgagcccc agatcaccct ccagggaaca gagcgtttct
     2161 ggagacctgc tgcccagttt gaaagtgcca gaggagtgac tctcttccct gacatcaaga
     2221 ttgtgagcac ctttgccaag actgaggcct ccggggacat gagagccaca ggtacagccc
     2281 ccaaatcagc agtcttggaa gaaatgctac acaatttgga tttctgtgac attttggtgc
     2341 ttggagggga cttggatcca aggcaagagt gcttggagct caaccacagt gagctccacc
     2401 aacgacacct tgatgccacc aactcaactg ctggctactc catctatggt gtgggctcca
     2461 tgaaccgcta tgagcaggtg ctgcatcacc tccgttaccg caactggcac cccacgtccc
     2521 ttgagacccg gaggttccgg atcaagtgct cagaactcaa cgggcgttac actagcaatg
     2581 agttcaactt ggaggtcagt gtcctccatg aagtgagagt ctctgacaag gaacatgtca
     2641 accaccttat tgtgcagcca ccctttctcc agtctgtcca tcaccctgag acccggagta
     2701 gtatccagcg cagttcagtg gtcccgagca tcgccactgt cgtcatcatt atctctgtgt
     2761 gcatgctagt gtttgttgtg gccatgggtg tgtaccgagt ccgaattgcc caccagcatt
     2821 ttatccaaga gactgaggct gccaaggaag ctgagatgga ctgggatgac tctgcactga
     2881 ctatcactgt caaccctatg gagaaacatg aaggcccagg gaacggggaa gatgaaacca
     2941 ccgaagtaga ggaagaggag gaagcagagg aaggctcgag ctccagcagc agtggttccg
     3001 atgacagcga agaggaagaa gaggaaggga tgggcagagt cagacatggg cagagcggca
     3061 ccagctctca aagccctgaa agaagtacct ggaacactgc aggagtcata aacatttgga
     3121 agtgaagcat ctagcttgtc cttacttggt gaagacccag tatatcagta aactccatat
     3181 tgactgaacc atatagaagc aggccaacca cgcagatctc ctagcttaca gaagcctccg
     3241 tgaatcttca tattctgtgc agtagtcaga cagtggcaga cactggccat gaacagtgac
     3301 agtgctgcac atcgttgctt gcacacattt agaacatacc tgaataacat ccccaatgct
     3361 gtttctacag agcagaggct gcccaaccta ccattgtctc tgcctttccc taagtacttg
     3421 ctaaatattg ttcactctat catcttctgt cattgatgct gggactaaat ataaaggttc
     3481 tgggttcggc caatctcaga cccttccctc ccatctctgg agatgatgtc accattttta
     3541 aagccttgtg tgagaagcct gtttgttccc agctcaatgc atgggaaagg cctgagatgg
     3601 acagactatt ttatctactg gagtctcttt ggggttcact ctgcagagag aaagagcagt
     3661 ctcattgtaa gcaatcaccc tccacctgca cctgacttca tggtggccga atggtcagtg
     3721 cagcttgagt gtctttcacg ggagccagct gcacttgggg tttgtgtgtt cttggaacac
     3781 agtagacttc tgagcctctg gagctgcctc caagaatgaa tctctttagt ctacaaaatg
     3841 tatttatttg gtaactatgc tattgtgtgt gtatgagtct gatacaatgc aaaccttgaa
     3901 atgtcttact aaaaggaatt atgaattcat agaaaattga atccaacttc agaacagcgc
     3961 attatgttgc cggtcaataa ggttgcccag ccacggggga ccagagaaaa gccttcccct
     4021 cccacccctt tccttagtac cctctccctc cctaattgcc ctactaggtt ctaactgatg
     4081 cagagtgaag ggtaccgaga aagtacatgt acataaagat ttaagaggga cataacccct
     4141 gggggaatca gttgagtttc ttcccatggc tgtgatctta tcatgcctga attccaaact
     4201 ttaaatttct aacaatttcg attcttgaag tttctgagta atttgttaaa tgcctattca
     4261 acacagacag atatttattt tcagcgttgg cttgtaaatg cctacaaact gattcatgtt
     4321 ggtggtcatt acgacacttc tgtgaattgg ttgaataaat atgattttag aatttcacag
     4381 taa
//
