LOCUS       NM_023051               4505 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus calsyntenin 1 (Clstn1), transcript variant 1, mRNA.
ACCESSION   NM_023051
VERSION     NM_023051.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4505)
  AUTHORS   Honda,K., Takahashi,H., Hata,S., Abe,R., Saito,T., Saido,T.C.,
            Taru,H., Sobu,Y., Ando,K., Yamamoto,T. and Suzuki,T.
  TITLE     Suppression of the amyloidogenic metabolism of APP and the
            accumulation of Abeta by alcadein alpha in the brain during aging
  JOURNAL   Sci Rep 14 (1), 18471 (2024)
   PUBMED   39122814
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4505)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4505)
  AUTHORS   Shiraki,Y., Mitsuma,M., Takada,R., Hata,S., Kitamura,A., Takada,S.,
            Kinjo,M., Taru,H., Muller,U.C., Yamamoto,T., Sobu,Y. and Suzuki,T.
  TITLE     Axonal transport of Frizzled5 by Alcadein alpha-containing vesicles
            is associated with kinesin-1
  JOURNAL   Mol Biol Cell 34 (11), ar110 (2023)
   PUBMED   37585286
  REMARK    GeneRIF: Axonal transport of Frizzled5 by Alcadein alpha-containing
            vesicles is associated with kinesin-1.
REFERENCE   4  (bases 1 to 4505)
  AUTHORS   Gotoh,N., Saito,Y., Hata,S., Saito,H., Ojima,D., Murayama,C.,
            Shigeta,M., Abe,T., Konno,D., Matsuzaki,F., Suzuki,T. and
            Yamamoto,T.
  TITLE     Amyloidogenic processing of amyloid beta protein precursor (APP) is
            enhanced in the brains of alcadein alpha-deficient mice
  JOURNAL   J Biol Chem 295 (28), 9650-9662 (2020)
   PUBMED   32467230
  REMARK    GeneRIF: Amyloidogenic processing of amyloid beta protein precursor
            (APP) is enhanced in the brains of alcadein alpha-deficient mice.
REFERENCE   5  (bases 1 to 4505)
  AUTHORS   Dinamarca,M.C., Raveh,A., Schneider,A., Fritzius,T., Fruh,S.,
            Rem,P.D., Stawarski,M., Lalanne,T., Turecek,R., Choo,M.,
            Besseyrias,V., Bildl,W., Bentrop,D., Staufenbiel,M., Gassmann,M.,
            Fakler,B., Schwenk,J. and Bettler,B.
  TITLE     Complex formation of APP with GABAB receptors links axonal
            trafficking to amyloidogenic processing
  JOURNAL   Nat Commun 10 (1), 1331 (2019)
   PUBMED   30902970
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4505)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 4505)
  AUTHORS   Takasato,M., Osafune,K., Matsumoto,Y., Kataoka,Y., Yoshida,N.,
            Meguro,H., Aburatani,H., Asashima,M. and Nishinakamura,R.
  TITLE     Identification of kidney mesenchymal genes by a combination of
            microarray analysis and Sall1-GFP knockin mice
  JOURNAL   Mech Dev 121 (6), 547-557 (2004)
   PUBMED   15172686
REFERENCE   8  (bases 1 to 4505)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4505)
  AUTHORS   Hintsch,G., Zurlinden,A., Meskenaite,V., Steuble,M.,
            Fink-Widmer,K., Kinter,J. and Sonderegger,P.
  TITLE     The calsyntenins--a family of postsynaptic membrane proteins with
            distinct neuronal expression patterns
  JOURNAL   Mol Cell Neurosci 21 (3), 393-409 (2002)
   PUBMED   12498782
REFERENCE   10 (bases 1 to 4505)
  AUTHORS   Vogt,L., Schrimpf,S.P., Meskenaite,V., Frischknecht,R., Kinter,J.,
            Leone,D.P., Ziegler,U. and Sonderegger,P.
  TITLE     Calsyntenin-1, a proteolytically processed postsynaptic membrane
            protein with a cytoplasmic calcium-binding domain
  JOURNAL   Mol Cell Neurosci 17 (1), 151-166 (2001)
   PUBMED   11161476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ066764.1, BY231070.1, CB525309.1, CO433558.1, AK034544.1,
            CX566257.1, BQ177451.1 and AW060392.1.
            
            On Mar 21, 2014 this sequence version replaced NM_023051.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.167263.1, AJ289016.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-428               CJ066764.1         2-429
            429-458             BY231070.1         215-244
            459-651             CJ066764.1         430-622
            652-1230            CB525309.1         99-677
            1231-1457           CO433558.1         204-430
            1458-2206           AK034544.1         1-749
            2207-2207           CX566257.1         277-277
            2208-3558           AK034544.1         750-2100
            3559-4124           BQ177451.1         95-660
            4125-4505           AW060392.1         1-381               c
FEATURES             Location/Qualifiers
     source          1..4505
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 79.91 cM"
     gene            1..4505
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /note="calsyntenin 1"
                     /db_xref="GeneID:65945"
                     /db_xref="MGI:MGI:1929895"
     exon            1..305
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..3154
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; alc-alpha; alcadein alpha"
                     /codon_start=1
                     /product="calsyntenin-1 isoform 1 precursor"
                     /protein_id="NP_075538.1"
                     /db_xref="CCDS:CCDS18963.1"
                     /db_xref="GeneID:65945"
                     /db_xref="MGI:MGI:1929895"
                     /translation="MLRRPAPALAPAVRLLLAGLLCGGGVWAARVNKHKPWLEPTYHG
                     IVTENDNTVLLDPPLIALDKDSPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVD
                     KSTGEGIIRSKEKLDCELQKDYTFTIQAYDCGKGPDGTGVKKSHKATVHIQVNDVNEY
                     APVFKEKSYKAAVVEGKQHSSILRVEAVDADCSPQFSQICSYEILTPDVPFTVDKDGY
                     IKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISVKPTCSPGWQGWSSRIEYEP
                     GTGALAVFPSIHLETCDEPVASVQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGT
                     SELLPSPSSSFNWTVGLPTDNGHDSDQVFEFNGTQAVRIPDGVVTLDPKEPFTISVWM
                     RHGPFGRKKETILCSSDKTDMNRHHYSLYVHGCRLVFLLRQDPSEEKKYRPAEFHWKL
                     NQVCDEDWHHFVLNVEVPSVTLYVDGIPHEPFSVTEDYPLHPTKIETQLVVGACWQEY
                     SGVESGNETEPATMASAGGDLHMTQFFRGNLAGLTVRSGKLADKKVIDCLYTCKEGLD
                     LQVPEDANRGVQIQASSSQAVLTLEGDNVGELDKAMQHISYLNSRQFPTPGIRRLKIT
                     STVKCFNEAACIEVPPVEGYVMVLQPEEPKISLSGVHHFARAASEFESAEGISLFPEL
                     RIISTITREVEPEADGSEDPTVQESLVSEEIVHDLDTCEVTVEGDELNAEQESLEVDV
                     TRLQQKGIEASHSDLGVVFTGVETMASYEEVLHLLRYRNWHTRSLLDRKFKLICSELN
                     GRYLSNEFKVEVNVIHTANPVEHANHMAAQPQFVHPEHRSFVDLSGHNLANPHPFAVV
                     PSTATVVIVVCVSFLVFMIILGVFRIRAAHQRTMRDQDTGKENEMDWDDSALTITVNP
                     METYEDQHSSEEEEEEEEEEESEDGEEEEDITSAESESSEEEEGGPGDGQNATRQLEW
                     DDSTLSY"
     exon            306..428
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            429..458
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..654
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..863
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1013
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1199
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1448
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1570
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1733
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1790
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1948
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2097
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2324
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2495
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2641
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2777
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2778..2962
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..4489
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4466..4471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /note="hexamer: AATAAA"
     polyA_site      4489
                     /gene="Clstn1"
                     /gene_synonym="1810034E21Rik; Cst-1; Cstn1"
                     /note="major polyA site"
ORIGIN      
        1 gccgccgcca tcttagccgc cgccgcctcc agcgcagcgc tgccgacgag gggagggcgc
       61 gcgcggccca gcagcacggc ggctgccgtt cccatcccgg tgctcgccgc gccgcccagc
      121 cgccggcccc cggctgcccg cgcccctctc ggcgtcccgc gcgactccct gctgcttccg
      181 cgtcgggccg gccgtggcgc cccgagcccg agcgatgctg cgccgccctg cgcccgcgct
      241 ggccccggcc gtccggctgc tgctggcggg gctgctgtgc ggcggcgggg tctgggccgc
      301 gcgagttaac aagcacaagc catggctcga gcccacctac catgggatag tcaccgagaa
      361 cgataacacg gtgctgctcg accctcccct catcgccctg gataaagatt caccgctccg
      421 ctttgcagag agttttgagg tgacagtcac caaagaaggt gagatttgtg gctttaaaat
      481 tcacgggcag aatgtcccct ttgatgccgt ggtagtggat aagtccacgg gtgagggaat
      541 aatccggtca aaagagaaac tggactgtga actacagaaa gactacacat tcaccatcca
      601 ggcctacgac tgcgggaagg gccccgatgg caccggtgtg aaaaagtctc acaaagcgac
      661 cgtgcacatc caggtgaacg acgtgaacga gtacgccccc gtgttcaagg agaagtcgta
      721 caaggcggcc gtggtggagg gcaagcagca cagcagcatc ctcagggtgg aggctgtgga
      781 cgcagactgc tccccgcagt tcagccagat ctgcagctac gagattctca ccccagacgt
      841 gccgttcact gtggacaaag acggttatat taagaacaca gagaagctaa actatggcaa
      901 agagcatcag tataagctca cagtcacagc ctacgactgt gggaagaaaa gagccaccga
      961 ggacgtccta gtgaagataa gcgtcaagcc cacctgcagc cccgggtggc aaggctggag
     1021 cagcagaatt gagtatgagc ccggcacggg tgctttggct gtcttcccga gcatccactt
     1081 ggagacctgt gacgagcctg tcgcctctgt gcaggccacg gtggagctgg agaccagcca
     1141 catagggaaa ggctgcgacc gagataccta ctctgagaag tcccttcacc ggctctgtgg
     1201 ggctgctgcc ggcacctcag agctgctccc gtcccccagt agctccttca actggactgt
     1261 gggcctcccc accgacaacg gccatgacag tgaccaggtc tttgagttca acggcacgca
     1321 ggccgtgagg attccagacg gcgttgtgac ccttgaccct aaagaaccct ttacaatctc
     1381 cgtgtggatg cggcatgggc cgtttggccg gaagaaggag acaattctct gcagttcgga
     1441 taagacagat atgaaccgac accattattc gctctacgtc cacgggtgca ggctagtttt
     1501 cctcctccgt caggacccgt ctgaggagaa gaaatacagg cctgcggagt tccactggaa
     1561 gctgaaccaa gtctgtgatg aggactggca ccactttgtc ctcaatgtgg aagttccaag
     1621 tgtgactctc tacgtggacg gcatccctca tgagcccttc tctgtgacag aggactaccc
     1681 gcttcatcca accaaaatag agactcagct tgtggtcgga gcttgctggc aagagtattc
     1741 aggagtggag agtggcaatg agactgagcc tgcgacgatg gcctctgcag gtggcgacct
     1801 gcacatgaca cagtttttcc gaggtaacct ggctggcctc acagtccgtt ctgggaaact
     1861 ggcggataag aaggtgattg actgtctcta cacctgcaag gaggggctgg acctgcaggt
     1921 ccctgaagat gccaacagag gcgtgcagat ccaagcaagc tccagccagg cggtcttgac
     1981 cttggaggga gacaacgttg gagagctgga taaggctatg cagcacattt cctaccttaa
     2041 ctcaaggcag ttccccacac caggcatccg caggctcaaa atcaccagca ccgtcaagtg
     2101 tttcaacgag gcggcttgca tcgaggtgcc cccggtggaa ggctacgtga tggttttgca
     2161 gccggaggag cctaagatca gcctgagtgg cgtccaccac tttgcccgcg cagcttctga
     2221 gtttgagagc gcggagggta tttccctctt ccctgagctg agaatcatca gcaccatcac
     2281 cagagaggtg gagcccgagg cagatgggtc cgaggacccc acagtgcaag aatccctggt
     2341 gtcagaggaa attgtgcatg acctggacac ctgtgaggtc acagtggaag gggatgagct
     2401 gaacgcagag caggagagcc tggaggtaga cgtgacccgc ctccagcaga agggcatcga
     2461 agcaagccac tctgacctgg gtgtggtctt cacaggcgtg gagaccatgg caagctacga
     2521 ggaggttttg cacctccttc gctatcggaa ttggcacacc aggtccctgc tggatcgcaa
     2581 gttcaagctc atttgctcag aactaaatgg tcgctacctc agcaatgagt tcaaggtgga
     2641 ggtgaatgtg atccacacag ccaaccccgt ggaacatgcc aaccacatgg ctgcccagcc
     2701 acagttcgtc caccctgaac atcgatcctt tgtggacctg tctggtcaca acctggccaa
     2761 tcctcacccg tttgcagttg tccccagcac ggcgacagtg gtgattgtgg tgtgtgtcag
     2821 cttcctggtt ttcatgatca tcctgggggt gtttcggatc cgggctgcac atcagcgaac
     2881 gatgcgggac caggacacgg ggaaggagaa tgagatggac tgggatgact ctgccttgac
     2941 catcaccgtc aaccccatgg agacatatga ggaccagcac agcagtgagg aggaggaaga
     3001 ggaggaggag gaggaggaga gcgaagatgg ggaggaagag gaagacatca ccagtgccga
     3061 gtctgagagc agtgaggagg aggaaggagg ccccggagac ggccagaatg ccacccgaca
     3121 gctggaatgg gatgactcca cactcagcta ctaaacccgc actcagcgcc tgctctccag
     3181 actctctccc agccccacgg gtccacgatg tacaaaatca ttttgaccag caggtctgca
     3241 gacccttccc ccactgctca aagtcctccc gtgcttggtg tgtgggacca ccggctccac
     3301 cctccccgcc catcaccatt gcagttttgc tagaagctgg cgcttcctcc ccagggcagg
     3361 ggccccacag cacctcagac cccaagtgtg tctggagttc cctgtcggcc agggagagga
     3421 caccagcacc tgggacctcc agagaagccg cactgagcgg acttgtcgac agagggtgaa
     3481 aaattactcc cacgcagtca gtaaccattt ctcttatttt taaaagtttt tttatttttt
     3541 tttcccaaac tagtgcatgt ataaagtggg agagcagagg gggttaatat gtagatggcc
     3601 aaccgacttt ttaatatttt gtaaataaat tgggattctg tgtgtcctct gtgctagtag
     3661 tccaggacag gaatgtaaag tcagaatgcg gggccaggag ggcctcttcc tccctcttcc
     3721 ctcccaagaa accaggttgg agaggcccaa gtcactgggg cccacccttg ctagggtttc
     3781 cgtacagcca cgtggccggg gccatggctt tcaagtgctg tctggggggg ccagccccac
     3841 gagcctccaa ccacattaga ggctgggaac agccaggatg ttgccaaagc ccctggcctt
     3901 tcctgtacac gcctgtgact ggcagccaca tggtttctgc ttattaacgt gagcctccct
     3961 gttggtgaaa tggtgtagct gggaacggac agcaaaggtg caggcggtca ggctcctcgc
     4021 ttggaagacc acggttctga gcaagtctgc acaacagcac caaaaggaga ccccgaggcc
     4081 caaagataaa ctgctacaat gctccagaac aatcttttct ctcctcccca gaggccccat
     4141 gggatgccgc gtgctgttgg gtttgggcta agatctaaga cccagcagat aggagacagc
     4201 aggtaccacc cacacagcac agctcttcat tcacagtcaa gagtttagac tgctccagct
     4261 gggacatcca gtcctcgctg ctgttgctgc tagttcgaag gatgccgccg tgctgtctgt
     4321 ggccgccctc ccatgtcctg tcccctgtag ctgctttctt agatggaaac aggctaacga
     4381 agagagggac actgtcgtgt cagtagccgc agggtcccct ttaagatgtg tatatcgaca
     4441 ctaggtcaga aagtgtatgc gttataataa agttctggtt ctaactccaa aaaaaaaaaa
     4501 aaaaa
//
