LOCUS       NM_001405798            5264 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus claspin (Clspn), transcript variant 1, mRNA.
ACCESSION   NM_001405798 XM_011240540
VERSION     NM_001405798.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5264)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5264)
  AUTHORS   Madgwick,S., Luli,S., Sellier,H., Butterworth,J.A., Leslie,J.,
            Moore,A.J., Corbin,E.K., Yemm,A.I., Chiremba,R.T., Tiniakos,D.,
            Oakley,F., Perkins,N.D. and Hunter,J.E.
  TITLE     Claspin haploinsufficiency leads to defects in fertility,
            hyperplasia and an increased oncogenic potential
  JOURNAL   Biochem J 479 (19), 2115-2130 (2022)
   PUBMED   36240068
REFERENCE   3  (bases 1 to 5264)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5264)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 5264)
  AUTHORS   Yang,C.C., Suzuki,M., Yamakawa,S., Uno,S., Ishii,A., Yamazaki,S.,
            Fukatsu,R., Fujisawa,R., Sakimura,K., Tsurimoto,T. and Masai,H.
  TITLE     Claspin recruits Cdc7 kinase for initiation of DNA replication in
            human cells
  JOURNAL   Nat Commun 7, 12135 (2016)
   PUBMED   27401717
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5264)
  AUTHORS   Albino,D., Brizzolara,A., Moretti,S., Falugi,C., Mirisola,V.,
            Scaruffi,P., Di Candia,M., Truini,M., Coco,S., Bonassi,S. and
            Tonini,G.P.
  TITLE     Gene expression profiling identifies eleven DNA repair genes
            down-regulated during mouse neural crest cell migration
  JOURNAL   Int J Dev Biol 55 (1), 65-72 (2011)
   PUBMED   21425081
REFERENCE   7  (bases 1 to 5264)
  AUTHORS   Sierant,M.L., Archer,N.E. and Davey,S.K.
  TITLE     The Rad9A checkpoint protein is required for nuclear localization
            of the claspin adaptor protein
  JOURNAL   Cell Cycle 9 (3), 548-556 (2010)
   PUBMED   20081369
  REMARK    GeneRIF: Rad9A-mediated Claspin localization is a vital step during
            checkpoint activation.
REFERENCE   8  (bases 1 to 5264)
  AUTHORS   Leonard,J.M., Ye,H., Wetmore,C. and Karnitz,L.M.
  TITLE     Sonic Hedgehog signaling impairs ionizing radiation-induced
            checkpoint activation and induces genomic instability
  JOURNAL   J Cell Biol 183 (3), 385-391 (2008)
   PUBMED   18955550
REFERENCE   9  (bases 1 to 5264)
  AUTHORS   Hasthorpe,S., Tainton,K., Peart,M., Roeszler,K.N., Bell,K.M.,
            Lusby,P.E., Hutson,J.M. and Tymms,M.J.
  TITLE     G2/M checkpoint gene expression in developing germ cells
  JOURNAL   Mol Reprod Dev 74 (5), 531-538 (2007)
   PUBMED   17290426
REFERENCE   10 (bases 1 to 5264)
  AUTHORS   Gotter,A.L., Suppa,C. and Emanuel,B.S.
  TITLE     Mammalian TIMELESS and Tipin are evolutionarily conserved
            replication fork-associated factors
  JOURNAL   J Mol Biol 366 (1), 36-52 (2007)
   PUBMED   17141802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606935.8.
            
            On May 4, 2022 this sequence version replaced XM_011240540.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.86007.1,
                                           SRR13948564.5210974.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AL606935.8         106431-106590
            161-269             AL606935.8         108661-108769
            270-703             AL606935.8         109372-109805
            704-865             AL606935.8         111211-111372
            866-943             AL606935.8         113360-113437
            944-1016            AL606935.8         114386-114458
            1017-1125           AL606935.8         115143-115251
            1126-1736           AL606935.8         115424-116034
            1737-1928           AL606935.8         121732-121923
            1929-2140           AL606935.8         122589-122800
            2141-2316           AL606935.8         124094-124269
            2317-2381           AL606935.8         124548-124612
            2382-2578           AL606935.8         125299-125495
            2579-2733           AL606935.8         125795-125949
            2734-2963           AL606935.8         127066-127295
            2964-3075           AL606935.8         127776-127887
            3076-3151           AL606935.8         130413-130488
            3152-3249           AL606935.8         130885-130982
            3250-3414           AL606935.8         135291-135455
            3415-3536           AL606935.8         135558-135679
            3537-3664           AL606935.8         137011-137138
            3665-3767           AL606935.8         139993-140095
            3768-3850           AL606935.8         140637-140719
            3851-4012           AL606935.8         141048-141209
            4013-5264           AL606935.8         142105-143356
FEATURES             Location/Qualifiers
     source          1..5264
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 60.9 cM"
     gene            1..5264
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /note="claspin"
                     /db_xref="GeneID:269582"
                     /db_xref="MGI:MGI:2445153"
     exon            1..160
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..4123
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     claspin homolog"
                     /codon_start=1
                     /product="claspin isoform 1"
                     /protein_id="NP_001392727.1"
                     /db_xref="GeneID:269582"
                     /db_xref="MGI:MGI:2445153"
                     /translation="MTGEVGSEVNLEVNDLKLLSQEAADSPVDSGQGSFETLEPLSER
                     DSDEEIFVSKKPKSRKVLQDSDSEAEDRDDAPEKPTYDDSAEDTQENLHSGKSQSRSF
                     PKALADSDESDMEETPSQESPETQEAPSLEPGHQTGHSVDFTTGRKLSKTLLREGAEG
                     KAKSKRRLEKEERTMEKIRRLKKKETRCEESDADRPLNDSGCLLEDSDLFETGLEEEN
                     DSALEDEESLESIRAAVKNKVKNRKKKEPTLESEAFSLEDGNELSKGSARKERKAARL
                     SKEALKKLHSETQRLVRESALNLPYHMPESKTIHDFFKRKPRPTCQGSAMALLKSCKY
                     QSGHYKETVNPADAAGMGAEDSSRGSEQRTGAGIAAETNVLSEVSEEAGITAGSDEAC
                     GKDPVRRGELEIEETEKHSDDRPYSPGDRSMSQQESSIPRIEDNEGHQAGDLTESDPP
                     ALEGEELKTVEKTDAKEGMPEQKTQSAAAAAVAVVTAAAAPPEKVRRFTVDRLRQLGV
                     DVSSQPRLGADEDSFVILDEPKTNRELEALKQRFWRHANPAASPRACQTVNVNIIVKD
                     LGTNGKEELKAEVVPVTLAAEKLEGASHAKPGEKLQMLKAKLQEAMKLRRLEERQKRQ
                     ALFKLDNEDGFEEEEEEEEMTDESEEDGEEEVGEEEEEDQDIQETTEYLLGSEDTETK
                     DEKETDKENTDTSSDIGKSVALCVPKPLSSDSTLLLFKDSSSKMGYFPTEEKSETDEY
                     LAKQSDKLDEDDSSSLLTKESSHNSSFELIGSTIPSYQPCNRQIGRGASFLPTAGFRS
                     PSPGLFRGSLISSASKSSGKLSEPSLPVEDSQDLYTASPEPKTLFLGAGDFQFCLEDD
                     TQSQLLDADGFLNIRNHRHRYQAVKPQLPLASMDENAMDANMDELLDLCTGQFTSQPE
                     EKCQPRKNDKKENMEELLNLCSGKFPTQDASPVAPLGLRSQEKESSTEDPMEEALALC
                     SGSFPTDREEEGEEEEFGDFQLVSKENGFASDEDEHSDSNDEELALDLEDDEEELLKQ
                     SEKMKRQMRLKKYLEDEAEVSGSDVGSEDEYDGEEIDEYEEDVIDEVLPSDEELESQI
                     KKIHMKTMLDDDKRRLRLYQERYLADGDLHSDGPGRTRKFRWKHIDDTSQMDLFHRDS
                     DDDQVEEQLDETEAKWRKERIEREQWLREQAQQGKIAADEEDIGDDSQFMMLAKKVTA
                     KALQKNASHTVVVQESKSVLRNPFETIRPGGAHQLKTGSLLNQPKAVLQKLAALSDLN
                     PSAPRNSRNFVFHTLSPTKAEAAKDSSKPQVRRRGLSSMMSPSPKRLKTNGSSPGPKR
                     SIFRYLES"
     exon            161..269
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            270..703
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            704..865
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            866..943
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1016
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1125
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1736
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1928
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2140
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2316
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2381
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2578
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2733
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2734..2963
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3075
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..3151
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3249
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3414
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3536
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3537..3664
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3665..3767
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3768..3850
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3851..4012
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4013..5264
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5237..5242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5264
                     /gene="Clspn"
                     /gene_synonym="B130025E01; E130314M08Rik"
                     /note="major polyA site"
ORIGIN      
        1 gttgagcgtt gtaccgcgtc tgggcgcgaa agctcgaact tcgctgccga gctggagacg
       61 gcgggagctg tcgccgtcaa gttgaggtta ctgcagacac gttctcctgg agctgtgcgg
      121 aagggaggcc ggaatcatga ccggcgaggt gggttctgag gttaacctgg aagtcaacga
      181 tctaaaactt ctttcacaag aagcagcaga cagtcctgta gacagtggac agggcagctt
      241 tgaaacactc gagcccttga gtgaaagaga ttctgatgaa gagatttttg tgagcaagaa
      301 acctaagagc aggaaagtgt tacaagacag cgattctgag gctgaggaca gagacgatgc
      361 tccggagaaa cccacctacg acgacagcgc agaggacact caggagaact tacattcagg
      421 gaagagtcag agcagaagct ttcccaaagc cctggctgac agtgatgaga gtgacatgga
      481 ggaaactccg agtcaggaga gtcctgagac tcaagaggct ccttccttgg agccaggcca
      541 ccagacagga cactctgtgg acttcaccac cggcagaaag ctctccaaaa cactcctcag
      601 agaaggagct gagggaaaag caaaatccaa gagacggctg gagaaagagg agagaacaat
      661 ggagaaaatc aggagactaa aaaagaagga aacaagatgt gaggaaagtg atgcagaccg
      721 gccgcttaat gacagtggct gtctccttga agatagtgat ctttttgaga caggtttgga
      781 ggaagaaaat gactctgcac tggaggatga agagtcgtta gagtcaataa gggcggctgt
      841 aaaaaacaag gtgaaaaatc gcaagaaaaa ggaaccaact ctggagagtg aggctttttc
      901 attagaagac ggaaatgagt tatccaaagg cagtgcgagg aaggaaagaa aggcagcgag
      961 gctaagtaag gaagcattaa aaaaactgca tagtgagacc cagcgtctgg tccgagaatc
     1021 tgcacttaat cttccatatc atatgcctga gagtaaaact attcacgatt tcttcaaacg
     1081 taagccccgg cccacgtgcc agggcagtgc catggccctg ctgaagtcat gtaagtatca
     1141 gtcgggccat tacaaggaaa ccgtaaaccc tgcagatgca gctggaatgg gtgctgagga
     1201 ctccagcaga ggttctgagc agaggacagg ggctggaatt gcagcggaaa ctaatgttct
     1261 ctctgaggtc tcagaagaag ccgggatcac tgctggatca gatgaggctt gtgggaagga
     1321 tccggtaaga cgaggagagc tggaaattga ggagactgag aagcacagtg atgacagacc
     1381 ttattctcct ggggacagat ccatgtcaca gcaggaatcc tccatcccca ggatcgaaga
     1441 caatgagggg catcaggctg gagacctcac cgaatctgac cctcctgccc tggagggaga
     1501 agaactgaaa acagtagaaa aaacagacgc aaaagaggga atgcctgaac agaaaaccca
     1561 gtctgcagca gcagcggcag tggcagtagt gacggcggcg gcggcgccac ctgaaaaggt
     1621 gagacgattc accgtggacc gacttagaca gctgggagtg gatgtttcca gtcaacctcg
     1681 gctgggcgct gatgaagatt cctttgtgat acttgatgaa cctaaaacca acagagaatt
     1741 ggaagccttg aagcaacgtt tctggaggca cgctaaccca gcagccagtc ccagggcttg
     1801 tcagacggtg aacgtgaaca tcatcgtgaa ggacttgggc actaacggga aggaggagct
     1861 gaaggcagaa gtggtacccg tcactttggc agcagagaag ctggagggag caagccacgc
     1921 aaagccaggt gaaaaactgc agatgttgaa agctaagttg caggaggcaa tgaaactccg
     1981 aaggcttgag gagcggcaga agcgccaagc attatttaaa ttagataatg aagatggatt
     2041 tgaagaggag gaggaagagg aagaaatgac agatgagtct gaggaagatg gagaagagga
     2101 ggtgggagag gaggaggagg aggatcaaga cattcaggag actacagaat atcttcttgg
     2161 tagtgaagat acagaaacca aagatgaaaa agaaacagat aaagaaaata cagacaccag
     2221 tagtgacatt ggcaagtctg ttgccctctg tgtccccaag cctctctctt cagactccac
     2281 cttacttctg tttaaggaca gctcttctaa gatgggttac tttcctactg aagaaaagtc
     2341 agaaacagat gaatacttgg ccaagcagtc tgacaaactg gatgaggatg actcgagttc
     2401 actgctaaca aaggagagca gtcacaatag cagctttgag ctgattggtt ccacaattcc
     2461 atcctatcag ccttgcaaca gacagatagg ccgtggggca agttttctcc ctacagcagg
     2521 attcagatcg ccgtcccctg ggctgttccg agggagtttg atcagctcgg cttctaagag
     2581 ttcaggaaaa ctgtctgagc cttcacttcc cgtagaggat tcccaggatc tgtacaccgc
     2641 ctccccagag cctaagacac ttttcctagg agcaggagac ttccagttct gtttggaaga
     2701 tgacactcag agccaactgt tggatgcaga tggattttta aacattagaa atcaccgcca
     2761 tcgatatcag gctgtgaagc cccagttgcc actggccagc atggacgaga atgccatgga
     2821 cgccaacatg gacgagctgc tggatttgtg cactggacag tttacatctc agcctgagga
     2881 gaaatgtcaa ccaaggaaga atgacaaaaa agaaaacatg gaggaacttt tgaatctctg
     2941 ctcgggcaaa tttcctactc aagatgcctc cccggtggcc ccactggggc tgaggagtca
     3001 ggagaaggag agcagcacag aagatccgat ggaagaggca cttgctcttt gctccggctc
     3061 tttcccaaca gacagggagg aagagggtga agaggaggaa tttggagact tccagcttgt
     3121 ttcaaaggag aatggatttg ctagtgacga ggatgaacac agtgactcca atgatgaaga
     3181 gctggccctg gacctggagg atgatgaaga agagctcctg aagcagtctg agaagatgaa
     3241 gcgccaaatg agactgaaga aatacttgga agatgaggca gaggtgtcag gcagtgacgt
     3301 gggaagtgag gacgagtacg atggggagga gattgatgaa tacgaagagg acgtcattga
     3361 tgaggtgctt ccgtctgatg aggagctgga gagtcagatc aagaagatac acatgaaaac
     3421 catgttggat gatgataagc ggcgactacg gttatatcaa gagaggtacc ttgctgatgg
     3481 ggatctacac agcgacgggc ctggacgaac aagaaaattc cgatggaaac acatagatga
     3541 tacctcccag atggatctat ttcacagaga ctccgatgac gatcaggttg aagaacagct
     3601 tgacgagacc gaagccaagt ggaggaagga acggattgag cgagagcagt ggcttcggga
     3661 acaggctcaa caggggaaaa ttgctgctga cgaagaggac attggggacg acagtcagtt
     3721 tatgatgcta gccaagaaag tcacagccaa agcactgcag aagaatgcca gtcatactgt
     3781 ggttgttcag gaatcaaagt ctgtgctcag aaaccctttt gaaaccatca gaccaggagg
     3841 tgctcaccag ctgaagacag gctccctgct aaaccagccc aaagctgtgc tccaaaaact
     3901 tgctgccctg tctgacctca accccagcgc tccccgaaac tcaaggaact ttgtctttca
     3961 tacactttct cccaccaagg cagaggcagc aaaggactca tctaagcctc aggtcagaag
     4021 aaggggactg tcgtcaatga tgtcaccgtc tcctaagcgg ctaaagacaa acggaagcag
     4081 tccagggcca aagcgaagca tcttcagata cttggaaagc taacgccatc caggatgcca
     4141 gtgtctgtgg aaagtactca gagtaggtct ggcggggagg gtgggactgc tgtttccgcc
     4201 gatgacctcc ccttccctca gaatcaactc gtaatgagcc gagcttccct tctccccaca
     4261 cagctctcag cagcactctt ctctcctagt gttatttttc agtttggcca ccaatctcag
     4321 cacaacagag tgcccagcat cgacttacag aataattgaa gtctcacttc ttccgttaag
     4381 cacttgacat tttttcctag cagtttcctg ggttgacacc actttcaagt caaggtgttc
     4441 agaggaagaa gaaagtgtgg cattatagaa aattgcagaa agcactgaaa gccagcctgg
     4501 gatgaggctc ccacagccac acggccctta acacagtacc aggccgagaa gcacgcaccc
     4561 agctgttgca tcgtcctgtt ccttctgtgt catgtaaact tctagtcttg atctctgatt
     4621 aaccttcatc gcctttgaca taaggactca agctggtacc tagttgagaa agaggttatc
     4681 cctccctttc tgcaccttcc ccaggactag agtttcaact taaagcattt gttccagagc
     4741 ctccctccct tctgcagaaa cctgaccact atttattgct gctttggggc cgagtttctt
     4801 gccctgacca tcagaggaca ttttaatatt tcatcactaa tattgagagc agaccagtag
     4861 aatttaataa aaacgttgaa gagaactgct attagtcgct ttctttggct ttcagaaaca
     4921 taggccagtt ctcttctatc agagcagaat tcagtgctgc tttgcaaaaa ccatggcagg
     4981 tgaacgttgg cttcagtgtc gaaagctgag cgtgagaagt tggatgaggt tgtgtccgtc
     5041 ctttattgag agacataaag cagcctgttc gactgatgag attaagatgt aggttttctg
     5101 ttaggtgctg gggcttttgg tttgggtttt tctaatactc aggatgctga cttggacaga
     5161 acatacattt gtatatttgt aatcttgtaa tgggagaaat gtgtacaaag ctgttttaat
     5221 atgtatgtag gttttcaata aatctcattg ccttgtgggc agga
//
