LOCUS       NM_001163317            1349 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus clarin 2 (Clrn2), mRNA.
ACCESSION   NM_001163317 XM_888750 XM_912529
VERSION     NM_001163317.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1349)
  AUTHORS   Mendia,C., Peineau,T., Zamani,M., Felgerolle,C., Yahiaoui,N.,
            Christophersen,N., Papal,S., Maudoux,A., Maroofian,R., Patni,P.,
            Nouaille,S., Bowl,M.R., Delmaghani,S., Galehdari,H., Vona,B.,
            Dulon,D., Vitry,S. and El-Amraoui,A.
  TITLE     Clarin-2 gene supplementation durably preserves hearing in a model
            of progressive hearing loss
  JOURNAL   Mol Ther 32 (3), 800-817 (2024)
   PUBMED   38243601
  REMARK    GeneRIF: Clarin-2 gene supplementation durably preserves hearing in
            a model of progressive hearing loss.
REFERENCE   2  (bases 1 to 1349)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1349)
  AUTHORS   Vona,B., Mazaheri,N., Lin,S.J., Dunbar,L.A., Maroofian,R.,
            Azaiez,H., Booth,K.T., Vitry,S., Rad,A., Ruschendorf,F.,
            Varshney,P., Fowler,B., Beetz,C., Alagramam,K.N., Murphy,D.,
            Shariati,G., Sedaghat,A., Houlden,H., Petree,C., VijayKumar,S.,
            Smith,R.J.H., Haaf,T., El-Amraoui,A., Bowl,M.R., Varshney,G.K. and
            Galehdari,H.
  TITLE     A biallelic variant in CLRN2 causes non-syndromic hearing loss in
            humans
  JOURNAL   Hum Genet 140 (6), 915-931 (2021)
   PUBMED   33496845
REFERENCE   4  (bases 1 to 1349)
  AUTHORS   Dunbar,L.A., Patni,P., Aguilar,C., Mburu,P., Corns,L., Wells,H.R.,
            Delmaghani,S., Parker,A., Johnson,S., Williams,D., Esapa,C.T.,
            Simon,M.M., Chessum,L., Newton,S., Dorning,J., Jeyarajan,P.,
            Morse,S., Lelli,A., Codner,G.F., Peineau,T., Gopal,S.R.,
            Alagramam,K.N., Hertzano,R., Dulon,D., Wells,S., Williams,F.M.,
            Petit,C., Dawson,S.J., Brown,S.D., Marcotti,W., El-Amraoui,A. and
            Bowl,M.R.
  TITLE     Clarin-2 is essential for hearing by maintaining stereocilia
            integrity and function
  JOURNAL   EMBO Mol Med 11 (9), e10288 (2019)
   PUBMED   31448880
  REMARK    GeneRIF: In the differentiating hair bundles, lack of clarin-2
            leads to loss of mechano-electrical transduction, followed by
            selective progressive loss of the transducing stereocilia.
REFERENCE   5  (bases 1 to 1349)
  AUTHORS   Potter,P.K., Bowl,M.R., Jeyarajan,P., Wisby,L., Blease,A.,
            Goldsworthy,M.E., Simon,M.M., Greenaway,S., Michel,V., Barnard,A.,
            Aguilar,C., Agnew,T., Banks,G., Blake,A., Chessum,L., Dorning,J.,
            Falcone,S., Goosey,L., Harris,S., Haynes,A., Heise,I., Hillier,R.,
            Hough,T., Hoslin,A., Hutchison,M., King,R., Kumar,S., Lad,H.V.,
            Law,G., MacLaren,R.E., Morse,S., Nicol,T., Parker,A., Pickford,K.,
            Sethi,S., Starbuck,B., Stelma,F., Cheeseman,M., Cross,S.H.,
            Foster,R.G., Jackson,I.J., Peirson,S.N., Thakker,R.V., Vincent,T.,
            Scudamore,C., Wells,S., El-Amraoui,A., Petit,C.,
            Acevedo-Arozena,A., Nolan,P.M., Cox,R., Mallon,A.M. and Brown,S.D.
  TITLE     Novel gene function revealed by mouse mutagenesis screens for
            models of age-related disease
  JOURNAL   Nat Commun 7, 12444 (2016)
   PUBMED   27534441
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092711.14.
            
            On Oct 4, 2022 this sequence version replaced NM_001163317.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC147731.1, SRR14995045.610420.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-385               AC092711.14        102854-103238
            386-565             AC092711.14        109217-109396
            566-1349            AC092711.14        112874-113657
FEATURES             Location/Qualifiers
     source          1..1349
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     gene            1..1349
                     /gene="Clrn2"
                     /gene_synonym="EG624224; mpc169H"
                     /note="clarin 2"
                     /db_xref="GeneID:624224"
                     /db_xref="MGI:MGI:3646230"
     exon            1..385
                     /gene="Clrn2"
                     /gene_synonym="EG624224; mpc169H"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..831
                     /gene="Clrn2"
                     /gene_synonym="EG624224; mpc169H"
                     /codon_start=1
                     /product="clarin-2"
                     /protein_id="NP_001156789.1"
                     /db_xref="CCDS:CCDS51497.1"
                     /db_xref="GeneID:624224"
                     /db_xref="MGI:MGI:3646230"
                     /translation="MPGWFKKVWYGLASLLSFSSFLLIIVALSLPHWLSGKILCQTGV
                     DLVNATDPELVKFIGDIYYGLFRGCKVRQCGLGGRQSQFTIFPHLVKELNAGLHVTIL
                     LLLFLALALALVSMGFAILNIIQVPYRAVNGPGGICLWNVLAGGVVALAIGSFMAAVK
                     FHDLTERIANFQERLFQFVVVEEQYEESFWICVASASAHAANLVVVAISQIPLPEIKT
                     KMEEATVTPEDILY"
     exon            386..565
                     /gene="Clrn2"
                     /gene_synonym="EG624224; mpc169H"
                     /inference="alignment:Splign:2.1.0"
     exon            566..1349
                     /gene="Clrn2"
                     /gene_synonym="EG624224; mpc169H"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagctgag gaggcaggca ctgagggagg atgaactagc gtgtatggag caggctatta
       61 tggactgtct gaaagatgtc cacttgccca acggttgccc agagtgctgg gggatgactt
      121 gcactcatta gtatgcctgg atggttcaaa aaggtgtggt acgggctggc atctctactc
      181 agtttctcat ccttccttct gatcatcgtc gctttgtctc tgcctcattg gctgagtggg
      241 aaaatcttgt gtcagactgg agtggatttg gtcaatgcca cagacccaga actggtcaaa
      301 ttcatcgggg acatttacta cgggctcttc cgaggatgca aggtgcggca atgcggactt
      361 gggggacgcc agtcccaatt tacaatcttc ccgcatctgg tgaaggagct caatgcaggc
      421 ctccacgtca caattctctt gctcctcttc ctggcgttgg ccctggctct ggtcagcatg
      481 ggttttgcta ttctcaacat cattcaggtc ccctacagag cagtcaatgg ccctggtggc
      541 atctgccttt ggaatgtcct cgcaggtgga gtcgtggcac tagccatcgg cagcttcatg
      601 gctgcggtga aatttcacga cctgacagaa aggatcgcca acttccagga gaggctcttt
      661 cagtttgtag tggtggaaga acagtatgaa gaatcatttt ggatatgcgt ggcgagcgcc
      721 tcagcccacg cagcaaactt ggttgtggtg gcaatcagtc aaattcccct tccagaaatc
      781 aagactaaaa tggaagaggc cacagttacc ccggaggaca ttttatactg ataactgact
      841 cctgcgtaca ccttgtgacg tcaatgggaa acaggtttgc attttccagc tttctcgttc
      901 cacagtgtcc ccattcttgg tagtggacta aaggggtggt tgggccagaa aggaaaaaaa
      961 ctctcctgat gaccagggtt cttgtgcttc cttttgatgc ccttggagat gaactggaga
     1021 ctcctgaact tgtcagctgt gtctgacact ggacaactca ctcactaatt ctcggttccc
     1081 tcgtctgtca aaagtggggg tagtaacaac gttgcatgct ctgttgttcc agcggtgctg
     1141 caggcggtgc cgcaagcatg gctctctgca aataagttat atatactcca ttaagattca
     1201 gtagaacctt gctctgttct ctatagtatt ggaggtgtgc aaagaaaacc gtgatgatcg
     1261 tgtctctgcc cttgaaaagt aataatgtat tcacatgaca cagaaatcaa gcatcaaaga
     1321 acagaataag tgtgagtttc tatgcggcc
//
