LOCUS       NM_025469                557 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus colipase, pancreatic (Clps), transcript variant 1,
            mRNA.
ACCESSION   NM_025469
VERSION     NM_025469.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 557)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 557)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 557)
  AUTHORS   Chang,I., Bramall,A.N., Baynash,A.G., Rattner,A., Rakheja,D.,
            Post,M., Joza,S., McKerlie,C., Stewart,D.J., McInnes,R.R. and
            Yanagisawa,M.
  TITLE     Endothelin-2 deficiency causes growth retardation, hypothermia, and
            emphysema in mice
  JOURNAL   J Clin Invest 123 (6), 2643-2653 (2013)
   PUBMED   23676500
REFERENCE   4  (bases 1 to 557)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   5  (bases 1 to 557)
  AUTHORS   Pang,W., Zhang,Y., Wang,S., Jia,A., Dong,W., Cai,C., Hua,Z. and
            Zhang,J.
  TITLE     The mPlrp2 and mClps genes are involved in the hydrolysis of
            retinyl esters in the mouse liver
  JOURNAL   J Lipid Res 52 (5), 934-941 (2011)
   PUBMED   21339507
  REMARK    GeneRIF: Data suggest that the conditional expression of mPlrp2 and
            mClps is involved in the hydrolysis of retinyl esters in the mouse
            liver.
REFERENCE   6  (bases 1 to 557)
  AUTHORS   Nicoll,D.A., Quednau,B.D., Qui,Z., Xia,Y.R., Lusis,A.J. and
            Philipson,K.D.
  TITLE     Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3
  JOURNAL   J Biol Chem 271 (40), 24914-24921 (1996)
   PUBMED   8798769
REFERENCE   7  (bases 1 to 557)
  AUTHORS   Cohen,R.D., Welch,C., Xia,Y., Lusis,A.J. and Reue,K.
  TITLE     Localization of mouse peroxisome proliferator-activated receptor
            delta (Ppard) on chromosome 17 near colipase (Clps)
  JOURNAL   Mamm Genome 7 (7), 557-558 (1996)
   PUBMED   8672143
REFERENCE   8  (bases 1 to 557)
  AUTHORS   Warden,C.H., Mehrabian,M., He,K.Y., Yoon,M.Y., Diep,A., Xia,Y.R.,
            Wen,P.Z., Svenson,K.L., Sparkes,R.S. and Lusis,A.J.
  TITLE     Linkage mapping of 40 randomly isolated liver cDNA clones in the
            mouse
  JOURNAL   Genomics 18 (2), 295-307 (1993)
   PUBMED   8288233
REFERENCE   9  (bases 1 to 557)
  AUTHORS   Warden,C.H., Davis,R.C., Yoon,M.Y., Hui,D.Y., Svenson,K., Xia,Y.R.,
            Diep,A., He,K.Y. and Lusis,A.J.
  TITLE     Chromosomal localization of lipolytic enzymes in the mouse:
            pancreatic lipase, colipase, hormone-sensitive lipase, hepatic
            lipase, and carboxyl ester lipase
  JOURNAL   J Lipid Res 34 (8), 1451-1455 (1993)
   PUBMED   8105016
REFERENCE   10 (bases 1 to 557)
  AUTHORS   Davis,R.C., Xia,Y.R., Mohandas,T., Schotz,M.C. and Lusis,A.J.
  TITLE     Assignment of the human pancreatic colipase gene to chromosome
            6p21.1 to pter
  JOURNAL   Genomics 10 (1), 262-265 (1991)
   PUBMED   2045105
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ126290.1, AK008815.1 and
            BM570078.1.
            
            On Nov 11, 2015 this sequence version replaced NM_025469.2.
            
            Summary: This gene encodes a member of the colipase family of
            coenzymes that is required for the optimal activity of pancreatic
            lipase. The encoded protein undergoes proteolytic processing to
            generate a mature polypeptide that binds to the lipase and prevents
            inhibition by bile acids. Over half of the mice lacking the encoded
            protein die within two weeks of birth while the remaining ones
            exhibit fat malabsorption and altered body weight regulation.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms that may undergo similar proteolytic
            processing. [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ128832.1, BQ128542.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BQ126290.1         1-52
            53-546              AK008815.1         2-495
            547-557             BM570078.1         1-11                c
FEATURES             Location/Qualifiers
     source          1..557
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.76 cM"
     gene            1..557
                     /gene="Clps"
                     /gene_synonym="2200003J09Rik"
                     /note="colipase, pancreatic"
                     /db_xref="GeneID:109791"
                     /db_xref="MGI:MGI:88421"
     exon            1..196
                     /gene="Clps"
                     /gene_synonym="2200003J09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..451
                     /gene="Clps"
                     /gene_synonym="2200003J09Rik"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="colipase isoform 1 preproprotein"
                     /protein_id="NP_079745.1"
                     /db_xref="CCDS:CCDS28581.1"
                     /db_xref="GeneID:109791"
                     /db_xref="MGI:MGI:88421"
                     /translation="MEKVLVLLLVSLLAVAYAAPGPRGLIINLEDGEICLNSMQCKSR
                     CCQHDTILGIARCTHKAMENSECSPKTLYGIYYRCPCERGLTCEGDRSIIGAITNTNY
                     GICLDSRRSKQ"
     exon            197..319
                     /gene="Clps"
                     /gene_synonym="2200003J09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            320..550
                     /gene="Clps"
                     /gene_synonym="2200003J09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      526..531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clps"
                     /gene_synonym="2200003J09Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      547
                     /gene="Clps"
                     /gene_synonym="2200003J09Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcgggtcatg tgtagatagg gcttctttaa aggctctctc cctcacttgg ctcttgcctt
       61 ctgctgtctg aacttccagc ttccatccac cccagcttta ccagacacca tggagaaggt
      121 ccttgttctt ctgcttgtgt ccctccttgc agtggcctat gcagctcccg gaccccgggg
      181 tcttattatc aacctggagg acggtgagat ctgtttgaac agtatgcagt gtaagagcag
      241 atgctgccaa catgacacca tcctgggcat tgcccgttgc acacacaagg ccatggagaa
      301 cagcgagtgc tccccaaaga ccctctatgg gatctactac cggtgtccct gtgagcgggg
      361 cctgacctgt gagggggaca ggagcatcat cggcgccatc accaacacca actatggcat
      421 ctgcctcgac tccaggcgct ccaagcagtg agatcacgca gttagctggg ttataccttc
      481 ttctctttct ccctctgtcc catctgagcc agccagctgt tggcaattaa aacccacttg
      541 caaccttgtc aaaaaaa
//
