LOCUS       NM_009191               4509 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus ClpB caseinolytic peptidase B (Clpb), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_009191
VERSION     NM_009191.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4509)
  AUTHORS   Yoshikawa,T., Piao,Y., Zhong,J., Matoba,R., Carter,M.G., Wang,Y.,
            Goldberg,I. and Ko,M.S.
  TITLE     High-throughput screen for genes predominantly expressed in the ICM
            of mouse blastocysts by whole mount in situ hybridization
  JOURNAL   Gene Expr Patterns 6 (2), 213-224 (2006)
   PUBMED   16325481
REFERENCE   2  (bases 1 to 4509)
  AUTHORS   Perier,F., Radeke,C.M., Raab-Graham,K.F. and Vandenberg,C.A.
  TITLE     Expression of a putative ATPase suppresses the growth defect of a
            yeast potassium transport mutant: identification of a mammalian
            member of the Clp/HSP104 family
  JOURNAL   Gene 152 (2), 157-163 (1995)
   PUBMED   7835694
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129609.3, AC127586.4 and AC159005.3.
            
            On Jun 5, 2018 this sequence version replaced NM_009191.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048175.1, AK141383.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-463               AC129609.3         216143-216605
            464-515             AC129609.3         219640-219691
            516-602             AC127586.4         42220-42306         c
            603-706             AC127586.4         23008-23111         c
            707-835             AC127586.4         6761-6889           c
            836-933             AC159005.3         105646-105743       c
            934-1048            AC159005.3         93282-93396         c
            1049-1126           AC159005.3         83820-83897         c
            1127-1182           AC159005.3         82730-82785         c
            1183-1227           AC159005.3         78361-78405         c
            1228-1389           AC159005.3         77614-77775         c
            1390-1546           AC159005.3         71493-71649         c
            1547-1620           AC159005.3         70804-70877         c
            1621-1740           AC159005.3         70571-70690         c
            1741-1845           AC159005.3         70227-70331         c
            1846-4509           AC159005.3         66809-69472         c
FEATURES             Location/Qualifiers
     source          1..4509
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.63 cM"
     gene            1..4509
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /note="ClpB caseinolytic peptidase B"
                     /db_xref="GeneID:20480"
                     /db_xref="MGI:MGI:1100517"
     exon            1..463
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..2094
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /EC_number="3.6.1.3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; caseinolytic peptidase B protein homolog;
                     suppressor of potassium transport defect 3; suppressor of
                     K+ transport defect 3; ClpB caseinolytic peptidase B
                     homolog; mitochondrial disaggregase"
                     /codon_start=1
                     /product="mitochondrial disaggregase isoform 1 precursor"
                     /protein_id="NP_033217.1"
                     /db_xref="CCDS:CCDS21513.1"
                     /db_xref="GeneID:20480"
                     /db_xref="MGI:MGI:1100517"
                     /translation="MMLSAVLRRTTPAPRLFLGLIKSPSLQSRGGAYGRGVVTGDRGE
                     PQRLRAAAWVRPGASSTFVPGRGAATWGRRGERTEIPYLTAASSERGPSPEETLPGQD
                     SWNGVPNKTGLGMWALAMALVVQCYSKNPSNKDAALMEAARANNVQEVRRLLSEGADV
                     NARHKLGWTALMVASISHNESVVQVLLAAGADPNLGDEFSSVYKTANEQGVHSLEVLV
                     TREDDFNNRLNHRASFKGCTALHYAVLADDYSIVKELLDRGANPLQRNEMGHTPLDYA
                     REGEVMKLLKTSETKYMEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRK
                     ENGWYDEEHPLVFLFLGSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAK
                     FIGSPPGYIGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGK
                     GKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQMSDKITISK
                     NFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSELIQLVNKELNFWAKRAKQRHN
                     ITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVE
                     DSDKHLLKSPELPSPQAEKRPPTLRLEIIDKDSKTRKLDIQAPLHPEKVCYTI"
     exon            464..515
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            516..602
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            603..706
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            707..835
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            836..933
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1048
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1126
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1182
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1227
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1389
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1546
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1620
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1740
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1845
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..4509
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2123..2128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /note="hexamer: AATAAA"
     polyA_site      2155
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /note="major polyA site"
     polyA_site      2187
                     /gene="Clpb"
                     /gene_synonym="Skd3"
     regulatory      4244..4249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /note="hexamer: AAGAAA"
     polyA_site      4249
                     /gene="Clpb"
                     /gene_synonym="Skd3"
     polyA_site      4509
                     /gene="Clpb"
                     /gene_synonym="Skd3"
ORIGIN      
        1 agccatgttg atcgtggcta gcacaggggc cggcaccagc gggttttaga agcaggtgtc
       61 atgatgttgt ccgcggtgtt gaggagaacc acgccagcgc ctcggctctt cctagggtta
      121 atcaaatctc catctctcca aagccgggga ggtgcttacg gccgtggcgt tgtcaccgga
      181 gaccgcgggg agccgcagcg gttgagagct gccgcttggg tgcgccctgg agcatcttct
      241 accttcgtcc ccggacgggg ggcagccacc tgggggcgcc gtggagaacg caccgagatc
      301 ccatacctga ctgccgcctc gtcggaacgc ggtcctagcc ccgaagaaac actcccggga
      361 caagacagct ggaatggggt ccccaacaag acgggtctgg gcatgtgggc cttggccatg
      421 gcgctggtgg ttcagtgcta cagcaagaat ccatccaaca aggatgcagc tctaatggaa
      481 gctgcccggg ccaataacgt gcaggaagtc agaaggctgt tatcagaagg tgcagatgtc
      541 aatgcaagac acaaacttgg ctggacagca ctgatggtgg catccatcag ccacaatgag
      601 agtgtggtgc aggtcctgct tgctgctgga gctgacccaa accttgggga tgagttcagc
      661 agtgtctaca agactgccaa tgaacaggga gtccattctc tggaagtcct agtcactcga
      721 gaggatgact tcaacaaccg gctaaatcac cgtgctagct tcaaaggctg cacagccctg
      781 cactatgctg tcctggccga tgactacagc atcgtcaagg agctgctgga cagaggagcc
      841 aacccccttc agaggaatga gatgggacac acacccctgg attatgcccg ggaaggggag
      901 gttatgaagc ttctgaaaac ttctgagacc aagtacatgg agaagcagag gaagcgggag
      961 gcagaggagc ggcgccgctt cccactggag cagcgactga aggagcacat cattggccag
     1021 gagagtgcca tcgccaccgt cggtgctgcg atccggagga aggagaacgg ctggtacgat
     1081 gaggagcacc ctctagtctt cctcttcttg ggatcgtctg gaatagggaa aaccgagctg
     1141 gccaagcaga cagcaaagta tatgcacaaa gatgccaaaa agggcttcat ccggctcgac
     1201 atgtctgagt tccaggagcg acatgaggta gccaagttta tcggttctcc accaggctac
     1261 atcggccatg aagagggtgg ccagctgacc aagaaactga aacagtgccc aaatgcagta
     1321 gtcctctttg atgaggtgga caaggcccat ccagatgtgc tcaccatcat gctgcagctg
     1381 tttgatgagg gccgcctgac agatggcaaa gggaagacca ttgactgcaa ggatgccatc
     1441 ttcatcatga cttccaatgt agccagtgat gagatcgccc agcatgcatt gcagctcaga
     1501 caggaagctt tggagatgag ccgaaatcga atcgctgaaa accttgggga tgtccagatg
     1561 agtgacaaga tcaccatctc caagaacttt aaagagaatg tgatccgacc catcttgaaa
     1621 gctcacttcc ggagagacga gtttctggga cggatcaatg agatcgtcta cttcctccct
     1681 ttctgccact cagagctcat ccagctggtc aacaaggaac tgaacttctg ggccaagaga
     1741 gccaagcaga ggcacaacat cacactactg tgggaccgcg aggtggcaga tgtgttggtt
     1801 gatggctaca acgtccacta tggtgcccgc tccattaagc atgaggtaga gcggcgtgtg
     1861 gtaaaccaac tggcggcagc ctatgagcag gacctgctac cagggggttg caccctgcgt
     1921 atcactgtgg aggattcgga caagcacctc ctcaagagcc ctgagctgcc ctcaccccag
     1981 gctgagaagc gtccacctac attgcgactg gagatcattg ataaggacag caagacccgc
     2041 aaactggaca tccaggcacc actccaccct gagaaggtgt gctacaccat ctagcatcca
     2101 cctgtctgtg ccctgaacat ctaataaagg ccccttgctg tggcatggca accaatccac
     2161 cttgccctca tgcctttcca aggcctagca ccctctcctg cctttcttgg ttgtgaggtt
     2221 catagtctgt tatgatctcc aaggcaagga acaggaagcc tggtctgcac ttcagtgtgc
     2281 actccactcc atgtcctcac tagagcattg acgtgtggcc agaagctcag aaacatgcag
     2341 cggagaacaa gtctggctga agaagatagg actcaggcag tggtgcacca cctctgcttg
     2401 tgctgatgcg gctcatcctc aggatggccc cgtggcagtg gggggaagcc aggagcccca
     2461 agcacaggta gctctgtagt ttattctaca gctacctctt tcccatgccc tacaactgtc
     2521 agagtcaagg cttgtgactg agccagtgta gagcacccat aggtctgact ggtccctctt
     2581 cctgccttcc tctggggtgg gaccatggtc ccaggtgaac acctcagctc tgagatgggg
     2641 ctcattcagc aggctggcag tctagataac agaaggtgct gtgggagcaa ggctggagtc
     2701 aggctccaca caggtgggca cgggtctgcc ttagccctgt ctcttaactg ccgtcccagc
     2761 caggtagcaa ttccatgggc ctagcatacc cataaaggac agcaggacac agcagggcct
     2821 ggcaagtcac tctgcatcat ctgcagaagc catcaccact acaggactga gtagagccct
     2881 cctgtgtgtt agccagcctc tgtcaagatg tttagacagg gctgaagtca gtgccatgac
     2941 tcatagattg tcatgacaag atgctcacag ctctgagtga caccacctca cccctaagag
     3001 gctgcctgct ccttactacc tcaaaactgt atcctctttt tactttgaaa ttctctaggc
     3061 ttacagaaaa ttatgaagaa aaaaaaaagt aaacctctta tacctttaac tcagcctctc
     3121 ctgtcacaca gcatagacgc atggggagtg acaggaccag gaaagtagca ttgccacaca
     3181 ctcctgcccc atctgcaggc tgtggctttc accagcctgg acatcccaca gtgcattcta
     3241 ctttccatcg ccttcccctg tgtcgcccaa ggcagtttct gtgtcttccc tgctcttcgg
     3301 tgatcgtgac acttttgaag agtccaggcc agttcttttg tagaatatcc ttcagccgag
     3361 ctctatctaa tgctctcact gatgagtctg ggggtctgcg tttttggcaa ggtgaccaca
     3421 gagaccaatg ccctgctgcc tccctcacag cacgtggcag taaccccaaa gctcgaattg
     3481 tctggaaaaa ggtcccctac tgtaaaattg aaagtttcac gctggggtgt agtattagac
     3541 cttggctagc atgcacagag gcccgggttg attcccagtg ccacaaaaat aaataagtgt
     3601 ataaatataa ttttttccta gaactaaaat caagccagac tacttactgg tttgtgcctg
     3661 gactcccagc aattgggagg ttgaggtagg attgtcacaa gtttgaggct actttgtgct
     3721 gcatactaag ttccaggcca gcctaggcta catagtaaaa cccaatctcc aagagtcaag
     3781 tggatacatc tctataaagt cgagactggc ctggtctgca gagagagctg cgggccagcc
     3841 aggactgcag agtgagacct tgtcttaaaa aacagcaatc ctttaccatg gcccagcagg
     3901 ttatggcact ttttacccag cctgatgact tgagttaatt ccttgaaccc atataaaaat
     3961 gaaggtagag aacggacctc aaaaaaaaaa atggttctct gaccacacac gtggtgacat
     4021 gacttcctgc cccacacaga catatacatg acagtaataa tacttttaaa gtaatgataa
     4081 tgttctggga agatacttaa agctgtgtaa atgccacgtg cttatatttt ttagagtaag
     4141 tgtccatctc agctgagaca ttttactgtt gaatttcctg ttttacttgt gcagatttgt
     4201 tgttccttat ccatctgtgt ttaataattg gtgttctgtt ccaaagaaac ctttcacctc
     4261 attcatttac tcagaatgta tgcccatgta ttctgtggtt atgatgtagt aggaagtgtg
     4321 ttgctccgtg cagccacgtg gggcctatgt gagctccttc atgctttggc gttgcttgca
     4381 cctccatgtt ctgccactgt agactgtcct gggccaactc acagcctcca caccacagct
     4441 cccatttctc caaggccttc ctgtttcctg ttattgtgtg aaccaatggc ttcttgatgc
     4501 tctaaagaa
//
