LOCUS       NP_598601                425 aa            linear   ROD 05-JUN-2024
DEFINITION  polyribonucleotide 5'-hydroxyl-kinase Clp1 [Mus musculus].
ACCESSION   NP_598601
VERSION     NP_598601.1
DBSOURCE    REFSEQ: accession NM_133840.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 425)
  AUTHORS   LaForce,G.R., Farr,J.S., Liu,J., Akesson,C., Gumus,E., Pinkard,O.,
            Miranda,H.C., Johnson,K., Sweet,T.J., Ji,P., Lin,A., Coller,J.,
            Philippidou,P., Wagner,E.J. and Schaffer,A.E.
  TITLE     Suppression of premature transcription termination leads to reduced
            mRNA isoform diversity and neurodegeneration
  JOURNAL   Neuron 110 (8), 1340-1357 (2022)
   PUBMED   35139363
REFERENCE   2  (residues 1 to 425)
  AUTHORS   Monaghan,C.E., Adamson,S.I., Kapur,M., Chuang,J.H. and
            Ackerman,S.L.
  TITLE     The Clp1 R140H mutation alters tRNA metabolism and mRNA 3'
            processing in mouse models of pontocerebellar hypoplasia
  JOURNAL   Proc Natl Acad Sci U S A 118 (39) (2021)
   PUBMED   34548404
  REMARK    GeneRIF: The Clp1 R140H mutation alters tRNA metabolism and mRNA 3'
            processing in mouse models of pontocerebellar hypoplasia.
REFERENCE   3  (residues 1 to 425)
  AUTHORS   Morisaki,I., Shiraishi,H., Fujinami,H., Shimizu,N., Hikida,T.,
            Arai,Y., Kobayashi,T., Hanada,R., Penninger,J.M., Fujiki,M. and
            Hanada,T.
  TITLE     Modeling a human CLP1 mutation in mouse identifies an accumulation
            of tyrosine pre-tRNA fragments causing pontocerebellar hypoplasia
            type 10
  JOURNAL   Biochem Biophys Res Commun 570, 60-66 (2021)
   PUBMED   34273619
REFERENCE   4  (residues 1 to 425)
  AUTHORS   Fujinami,H., Shiraishi,H., Hada,K., Inoue,M., Morisaki,I., Higa,R.,
            Shin,T., Kobayashi,T., Hanada,R., Penninger,J.M., Mimata,H. and
            Hanada,T.
  TITLE     CLP1 acts as the main RNA kinase in mice
  JOURNAL   Biochem Biophys Res Commun (2020) In press
   PUBMED   32081435
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   5  (residues 1 to 425)
  AUTHORS   Karaca,E., Weitzer,S., Pehlivan,D., Shiraishi,H., Gogakos,T.,
            Hanada,T., Jhangiani,S.N., Wiszniewski,W., Withers,M.,
            Campbell,I.M., Erdin,S., Isikay,S., Franco,L.M.,
            Gonzaga-Jauregui,C., Gambin,T., Gelowani,V., Hunter,J.V., Yesil,G.,
            Koparir,E., Yilmaz,S., Brown,M., Briskin,D., Hafner,M., Morozov,P.,
            Farazi,T.A., Bernreuther,C., Glatzel,M., Trattnig,S., Friske,J.,
            Kronnerwetter,C., Bainbridge,M.N., Gezdirici,A., Seven,M.,
            Muzny,D.M., Boerwinkle,E., Ozen,M., Clausen,T., Tuschl,T.,
            Yuksel,A., Hess,A., Gibbs,R.A., Martinez,J., Penninger,J.M. and
            Lupski,J.R.
  CONSRTM   Baylor Hopkins Center for Mendelian Genomics
  TITLE     Human CLP1 mutations alter tRNA biogenesis, affecting both
            peripheral and central nervous system function
  JOURNAL   Cell 157 (3), 636-650 (2014)
   PUBMED   24766809
REFERENCE   6  (residues 1 to 425)
  AUTHORS   Hanada,T., Weitzer,S., Mair,B., Bernreuther,C., Wainger,B.J.,
            Ichida,J., Hanada,R., Orthofer,M., Cronin,S.J., Komnenovic,V.,
            Minis,A., Sato,F., Mimata,H., Yoshimura,A., Tamir,I., Rainer,J.,
            Kofler,R., Yaron,A., Eggan,K.C., Woolf,C.J., Glatzel,M., Herbst,R.,
            Martinez,J. and Penninger,J.M.
  TITLE     CLP1 links tRNA metabolism to progressive motor-neuron loss
  JOURNAL   Nature 495 (7442), 474-480 (2013)
   PUBMED   23474986
  REMARK    GeneRIF: loss of CLP1 activity results in accumulation of a novel
            set of small RNA fragments derived from aberrant processing of
            tyrosine pre-transfer RNA; these tRNA fragments sensitize cells to
            oxidative-stress-induced p53 activation and p53-dependent cell
            death
REFERENCE   7  (residues 1 to 425)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928914.15.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003237.1, AK169709.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..425
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 49.45 cM"
     Protein         1..425
                     /product="polyribonucleotide 5'-hydroxyl-kinase Clp1"
                     /EC_number="2.7.1.78"
                     /note="ATP/GTP-binding protein; polynucleotide kinase
                     Clp1; pre-mRNA cleavage complex II protein Clp1"
                     /calculated_mol_wt=47607
     Region          14..423
                     /region_name="CLP1"
                     /note="Predicted GTPase subunit of the pre-mRNA cleavage
                     complex [Translation, ribosomal structure and biogenesis];
                     COG5623"
                     /db_xref="CDD:227910"
     Region          121..306
                     /region_name="CLP1_P"
                     /note="mRNA cleavage and polyadenylation factor CLP1
                     P-loop; pfam16575"
                     /db_xref="CDD:406878"
     CDS             1..425
                     /gene="Clp1"
                     /gene_synonym="Heab"
                     /coded_by="NM_133840.3:148..1425"
                     /db_xref="CCDS:CCDS16191.1"
                     /db_xref="GeneID:98985"
                     /db_xref="MGI:MGI:2138968"
ORIGIN      
        1 mseesnddkk pttkfelere telrfeveas qsvqlellag maeifgtelt rnkkftfdag
       61 akvavftwhg cslqlsgrte vayvskdtpm llylnthtal eqmrrqaeke eergprvmvv
      121 gptdvgkstv crlllnyavr lgrrptyvel dvgqgsvsip gtmgalyier padveegfsi
      181 qaplvyhfgs ttpgtnikly nkitsrladv fnqrcevnrr asvsgcvint cgwvkgygyq
      241 alvhaasafe vdvvvvldqe rlynelkrdl phfvrtvllp ksggvversk dfrrecrder
      301 ireyfygfrg cfyphafnvk fsdvkiykvg aptipdsclp lgmsqednql klvpvtpgrd
      361 mvhhllsvst aegteenlse tsvagfivvt svdvehqvft vlspaprplp knfllimdir
      421 fmdlk
//
