LOCUS       NM_001289826            9758 bp    mRNA    linear   ROD 20-FEB-2024
DEFINITION  Mus musculus clock circadian regulator (Clock), transcript variant
            2, mRNA.
ACCESSION   NM_001289826 XM_006534743
VERSION     NM_001289826.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9758)
  AUTHORS   Xing,C., Zhai,B., Zhang,Y., Fang,Y., Zhang,M., Zhang,C., Wang,W.,
            Ding,M., Huang,X., Shen,B., Wang,R. and Song,L.
  TITLE     Sleep deprivation reduced LPS-induced IgG2b production by
            up-regulating BMAL1 and CLOCK expression
  JOURNAL   Biochem Biophys Res Commun 691, 149326 (2024)
   PUBMED   38035406
  REMARK    GeneRIF: Sleep deprivation reduced LPS-induced IgG2b production by
            up-regulating BMAL1 and CLOCK expression.
REFERENCE   2  (bases 1 to 9758)
  AUTHORS   Xie,X., Xu,H., Shu,R., Sun,L., Zhang,M., Hu,Q., Zhu,K., Li,Z. and
            Wu,F.
  TITLE     Clock gene Per3 deficiency disrupts circadian alterations of gut
            microbiota in mice
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (12), 2004-2007 (2023)
   PUBMED   37964605
  REMARK    GeneRIF: Clock gene Per3 deficiency disrupts circadian alterations
            of gut microbiota in mice.
REFERENCE   3  (bases 1 to 9758)
  AUTHORS   Kirchner,S.J., Lei,V., Kim,P.T., Patel,M., Shannon,J.L.,
            Corcoran,D., Hughes,D., Waters,D.K., Dzirasa,K., Erdmann,D.,
            Coers,J., MacLeod,A.S. and Zhang,J.Y.
  TITLE     An aging-susceptible circadian rhythm controls cutaneous antiviral
            immunity
  JOURNAL   JCI Insight 8 (20), e171548 (2023)
   PUBMED   37725438
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9758)
  AUTHORS   de Diego-Garcia,L., Brennan,G.P., Auer,T., Menendez-Mendez,A.,
            Parras,A., Martin-Gil,A., Mitra,M., Olla,I., Villalba-Benito,L.,
            Gil,B., Alves,M., Lau,K., Delanty,N., Beausang,A., Cryan,J.,
            Brett,F.M., Farrell,M.A., O'Brien,D.F., Mendez,R.,
            Carracedo-Rodriguez,G., Henshall,D.C., Lucas,J.J. and Engel,T.
  TITLE     CPEB4-CLOCK crosstalk during temporal lobe epilepsy
  JOURNAL   Epilepsia 64 (10), 2827-2840 (2023)
   PUBMED   37543852
  REMARK    GeneRIF: CPEB4-CLOCK crosstalk during temporal lobe epilepsy.
REFERENCE   5  (bases 1 to 9758)
  AUTHORS   Vyas,H., Vohra,A., Upadhyay,K., Thounaojam,M., Jadeja,R., Dalvi,N.,
            Bartoli,M. and Devkar,R.
  TITLE     miR34a-5p impedes CLOCK expression in chronodisruptive C57BL/6J
            mice and potentiates pro-atherogenic manifestations
  JOURNAL   PLoS One 18 (8), e0283591 (2023)
   PUBMED   37561715
  REMARK    GeneRIF: miR34a-5p impedes CLOCK expression in chronodisruptive
            C57BL/6J mice and potentiates pro-atherogenic manifestations.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9758)
  AUTHORS   Gekakis,N., Staknis,D., Nguyen,H.B., Davis,F.C., Wilsbacher,L.D.,
            King,D.P., Takahashi,J.S. and Weitz,C.J.
  TITLE     Role of the CLOCK protein in the mammalian circadian mechanism
  JOURNAL   Science 280 (5369), 1564-1569 (1998)
   PUBMED   9616112
REFERENCE   7  (bases 1 to 9758)
  AUTHORS   King,D.P., Vitaterna,M.H., Chang,A.M., Dove,W.F., Pinto,L.H.,
            Turek,F.W. and Takahashi,J.S.
  TITLE     The mouse Clock mutation behaves as an antimorph and maps within
            the W19H deletion, distal of Kit
  JOURNAL   Genetics 146 (3), 1049-1060 (1997)
   PUBMED   9215907
REFERENCE   8  (bases 1 to 9758)
  AUTHORS   Antoch,M.P., Song,E.J., Chang,A.M., Vitaterna,M.H., Zhao,Y.,
            Wilsbacher,L.D., Sangoram,A.M., King,D.P., Pinto,L.H. and
            Takahashi,J.S.
  TITLE     Functional identification of the mouse circadian Clock gene by
            transgenic BAC rescue
  JOURNAL   Cell 89 (4), 655-667 (1997)
   PUBMED   9160756
REFERENCE   9  (bases 1 to 9758)
  AUTHORS   King,D.P., Zhao,Y., Sangoram,A.M., Wilsbacher,L.D., Tanaka,M.,
            Antoch,M.P., Steeves,T.D., Vitaterna,M.H., Kornhauser,J.M.,
            Lowrey,P.L., Turek,F.W. and Takahashi,J.S.
  TITLE     Positional cloning of the mouse circadian clock gene
  JOURNAL   Cell 89 (4), 641-653 (1997)
   PUBMED   9160755
REFERENCE   10 (bases 1 to 9758)
  AUTHORS   Vitaterna,M.H., King,D.P., Chang,A.M., Kornhauser,J.M.,
            Lowrey,P.L., McDonald,J.D., Dove,W.F., Pinto,L.H., Turek,F.W. and
            Takahashi,J.S.
  TITLE     Mutagenesis and mapping of a mouse gene, Clock, essential for
            circadian behavior
  JOURNAL   Science 264 (5159), 719-725 (1994)
   PUBMED   8171325
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC147239.2, AK040337.1, AK030352.1 and BX526669.1.
            
            [WARNING] On Mar 13, 2024 this sequence was replaced by
            NM_001289826.2.
            
            On Jan 31, 2014 this sequence version replaced XM_006534743.1.
            
            Summary: The protein encoded by this gene plays a central role in
            the regulation of circadian rhythms. The protein encodes a
            transcription factor of the basic helix-loop-helix (bHLH) family
            and contains DNA binding histone acetyltransferase activity. The
            encoded protein forms a heterodimer with Arntl (Bmal1) that binds
            E-box enhancer elements upstream of Period (Per1, Per2, Per3) and
            Cryptochrome (Cry1, Cry2) genes and activates transcription of
            these genes. Per and Cry proteins heterodimerize and repress their
            own transcription by interacting in a feedback loop with
            Clock/Arntl complexes. Polymorphisms in this gene may be associated
            with behavioral changes, obesity, and metabolic syndrome. Two
            transcripts encoding the same protein have been found for this
            gene. [provided by RefSeq, Jan 2014].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129118.1, SRR10223971.5947.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC147239.2         25608-25627
            21-509              AK040337.1         2-490
            510-693             AK030352.1         475-658
            694-715             AC147239.2         75937-75958
            716-1884            AK030352.1         659-1827
            1885-2037           AC147239.2         98852-99004
            2038-2232           AC147239.2         100041-100235
            2233-2438           AC147239.2         100837-101042
            2439-2733           AC147239.2         103173-103467
            2734-9281           AC147239.2         113522-120069
            9282-9758           BX526669.1         2-478
FEATURES             Location/Qualifiers
     source          1..9758
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 40.63 cM"
     gene            1..9758
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /note="clock circadian regulator"
                     /db_xref="GeneID:12753"
                     /db_xref="MGI:MGI:99698"
     exon            1..138
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
     exon            139..217
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
     exon            218..302
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
     exon            303..392
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..2913
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /EC_number="2.3.1.48"
                     /note="isoform 1 is encoded by transcript variant 2;
                     circadian locomoter output cycles protein kaput; circadian
                     locomotor output cycles kaput"
                     /codon_start=1
                     /product="circadian locomoter output cycles protein kaput
                     isoform 1"
                     /protein_id="NP_001276755.1"
                     /db_xref="CCDS:CCDS19360.1"
                     /db_xref="GeneID:12753"
                     /db_xref="MGI:MGI:99698"
                     /translation="MVFTVSCSKMSSIVDRDDSSIFDGLVEEDDKDKAKRVSRNKSEK
                     KRRDQFNVLIKELGSMLPGNARKMDKSTVLQKSIDFLRKHKETTAQSDASEIRQDWKP
                     TFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQSIFNFIPE
                     GEHSEVYKILSTHLLESDSLTPEYLKSKNQLEFCCHMLRGTIDPKEPSTYEYVRFIGN
                     FKSLTSVSTSTHNGFEGTIQRTHRPSYEDRVCFVATVRLATPQFIKEMCTVEEPNEEF
                     TSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQYGKG
                     KSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVVSYAEVRAERRRELGIE
                     ESLPETAADKSQDSGSDNRINTVSLKEALERFDHSPTPSASSRSSRKSSHTAVSDPSS
                     TPTKIPTDTSTPPRQHLPAHEKMTQRRSSFSSQSINSQSVGPSLTQPAMSQAANLPIP
                     QGMSQFQFSAQLGAMQHLKDQLEQRTRMIEANIHRQQEELRKIQEQLQMVHGQGLQMF
                     LQQSNPGLNFGSVQLSSGNSNIQQLTPVNMQGQVVPANQVQSGHISTGQHMIQQQTLQ
                     STSTQQSQQSVMSGHSQQTSLPSQTPSTLTAPLYNTMVISQPAAGSMVQIPSSMPQNS
                     TQSATVTTFTQDRQIRFSQGQQLVTKLVTAPVACGAVMVPSTMLMGQVVTAYPTFATQ
                     QQQAQTLSVTQQQQQQQQQPPQQQQQQQQSSQEQQLPSVQQPAQAQLGQPPQQFLQTS
                     RLLHGNPSTQLILSAAFPLQQSTFPPSHHQQHQPQQQQQLPRHRTDSLTDPSKVQPQ"
     exon            393..452
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
     exon            453..601
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
     exon            602..693
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
     exon            694..783
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
     exon            784..904
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1018
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1137
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1220
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1327
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1475
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1551
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1693
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1794
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1884
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2037
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2232
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2438
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2733
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
     exon            2734..9744
                     /gene="Clock"
                     /gene_synonym="5330400M04Rik; KAT13D"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagccccg cgcccacgac gcatgcgccg ggaggcagcg caatcacgga ctcggctggc
       61 ggctaccggc tggagagagg aaaccccgga cggcgagagc gcgaaggaaa tctggccgcc
      121 gccgcgcacg cgctcccgtg aaagaaaagc acaagaagaa acttttacag gcgttgttga
      181 ttggactagg gcaacgattc ccaaaatcac cagcaagagt tctgatggtc agtcacacag
      241 aagacggcct tgcgtctgtg ggtgttggag actccattct aaagatataa aaagtgaaag
      301 aggagaagta caaatgtcta ccacaagacg aaaacataat gtgttatggt gtttaccgta
      361 agctgtagta aaatgagctc aattgttgac agagatgaca gtagtatttt tgatggattg
      421 gtggaagaag atgacaagga caaagcaaaa agagtatcta gaaacaaatc agaaaagaaa
      481 cgtagagatc agttcaatgt cctcattaag gagctggggt ctatgcttcc tggtaacgcg
      541 agaaagatgg acaagtctac tgttctacag aagagcattg attttttgcg caaacataaa
      601 gagaccactg cacagtcaga tgctagtgag attcgacagg actggaaacc cacattcctt
      661 agtaatgaag agtttacaca gttaatgtta gaggctcttg atggtttttt tttagcgatc
      721 atgacagatg gaagtataat atatgtatct gagagtgtaa cttcgttact tgaacattta
      781 ccatctgatc ttgtggatca aagtatattt aattttatcc cagagggaga acattcagag
      841 gtttataaga tactctctac tcatctgctg gaaagtgact cattaacccc tgagtactta
      901 aaatcaaaaa atcagttaga attctgttgt cacatgcttc gaggaacaat agacccaaag
      961 gagccatcca cctatgaata tgtgagattt ataggaaatt ttaaatcttt aaccagtgta
     1021 tcaacttcaa cacacaatgg ttttgaagga actatacaac gcacacatag gccttcttat
     1081 gaagatagag tttgttttgt agctactgtc agattagcta cacctcagtt catcaaggaa
     1141 atgtgtactg ttgaagaacc aaatgaagag tttacatcta gacacagttt agaatggaag
     1201 tttctatttt tagatcacag ggcaccacca ataataggct atttgccatt tgaagtcttg
     1261 ggaacatcag gctatgatta ctatcatgtg gatgacctag aaaatctggc aaaatgtcac
     1321 gagcacttaa tgcaatatgg aaaaggcaaa tcgtgttact atagattcct gaccaaaggc
     1381 cagcagtgga tatggcttca gactcattat tatattactt accatcagtg gaattcaagg
     1441 ccagagttca ttgtttgtac tcacactgta gtaagttatg cagaagttag ggctgaaaga
     1501 cggcgagaac ttggcattga agagtctctt cctgagacag ctgctgacaa aagccaagat
     1561 tctgggtctg acaatcgtat caacacagtg agtctcaagg aagcactgga aaggtttgat
     1621 cacagcccaa ctccttctgc ctcctctaga agctcacgaa agtcatctca caccgcagtc
     1681 tcagaccctt cctccacacc gacaaagatc cctactgata ctagcactcc tcccagacag
     1741 catttgccag ctcatgaaaa gatgacacag cggaggtcgt ccttcagcag tcagtccata
     1801 aactcccagt cagttggtcc atcattaaca cagccagcga tgtctcaagc tgcaaattta
     1861 ccaattccac aaggcatgtc acagtttcag ttttcagctc agttaggagc catgcagcat
     1921 ctaaaagacc agctagagca gcggacacgg atgatagagg caaatattca tcggcagcaa
     1981 gaagaactaa ggaaaattca agagcaactt cagatggtcc atggtcaagg gctacagatg
     2041 tttttgcagc aatcaaaccc tggattgaat tttggttctg ttcaactttc ctctggaaat
     2101 tctaatatcc agcaactcac acctgtaaat atgcaaggcc aggttgtccc tgctaaccag
     2161 gttcagagtg gacatatcag cacaggccag cacatgatac agcaacagac tttacaaagt
     2221 acatcaactc agcagagtca acagagtgta atgagtggac acagtcagca gacgtctctt
     2281 ccaagtcaga caccgagcac tctcacagcc ccactgtaca atacgatggt gatttcccag
     2341 cctgcagctg ggagcatggt ccagattcca tccagtatgc cacagaacag tacccagagt
     2401 gctacagtca ctacgttcac tcaggacaga cagataagat tttctcaagg tcagcaactt
     2461 gtgaccaaat tagtgactgc tcctgtagct tgtggggccg tcatggtacc aagtaccatg
     2521 cttatgggtc aggtggtgac tgcctatcct accttcgcca cacaacagca gcaggcacag
     2581 acattatcgg taacacaaca gcagcagcag cagcagcagc agccaccaca gcaacagcaa
     2641 caacaacagc agagttccca ggaacagcag cttccttcag ttcagcagcc agctcaggcc
     2701 cagctgggcc agccaccaca gcagttctta cagacatcta ggttgctcca cgggaatcct
     2761 tcgacacagc tcatcctctc tgctgccttt ccactacaac agagcacttt ccctccttcg
     2821 caccaccagc aacaccagcc tcagcagcaa cagcagcttc ctcggcacag gactgacagc
     2881 ctgactgacc cttccaaggt ccagccacag tagcacacac acttcctctc tgacatgcga
     2941 gaggaagggg atggccagaa agaatcgctc agttggcatg cggtcagaag ttgaacagtt
     3001 tcacgagggt ggtcttgagt gttcagtccc ttgatgagac ggtagggaag tgctgcccag
     3061 tgcttcagat gtccattaaa taccagccag tgggaaatgg tcatagggac acagccaatt
     3121 ctgacagttt ctttgcccag gtattttttg atagaaagag tatattgcca aatgctaaca
     3181 agctcagcta tcaaccagat ctttactgaa tccgaagagc actaacagtg ttggtagctt
     3241 tagtgggtct gtgcctgcat caaatattac agagggcaca ccactgccag gggtttgctt
     3301 agaatgccat gaagatagtc cagtagttaa tagtccccac cccaaactcc tctccctgtt
     3361 cagacaatga tggaaccgtg atgactttga gaatgttgtg caggtttgaa ttcactgtgt
     3421 acagatgctg tagtgtctct gtgtctggat ggaggagaga aagccacttt gatacagaaa
     3481 gcattatctg tccctcacag gtatgagtgc atttcattag gtttgacacc atgtacaaac
     3541 tgataacaac ctctcttttt tcattttgtt tacaacacag tagtgttctc gttacttttc
     3601 cagggcacaa gtctttttgt ccgtgctttg gctgtgatgt cacagtttgt tcagtgaggt
     3661 aacaatgtgc tgctgggaat ggattttttt taaggttaaa ttattgctac atttccactt
     3721 actcagaaat atcccttatt tcattatttt tcaattatgt ttgagagaat tgcactgctt
     3781 tattatttta gatggttggt tgagagttta atcacatatt ttgatatatt tcatagttgg
     3841 aatatttatg taaatggttt tcaacaagcc tgaaagtaat ttcaagaatg tttcagttgt
     3901 aagagtaaag tttgcacaca aaacatttta ggcacttttt taacattctc agaggtggga
     3961 attttaactt ttaggatttg ttggaatctt tttattatct ttaaaaattt caatgcttct
     4021 tttagtcaga aatgattcag ggttatttga ggggaaaaaa cccatagtgc cttgatttta
     4081 attcaggtga taactcacca tcttgaattc attgtctggt ttcagtagca gttttgaaac
     4141 cttagtacat ttttagcagc agtgtcattc tcaagtcccc atgaggactg ctgcgtctct
     4201 tgggctgcct gacagcgtca cagctgggaa tgggatccca aaatcgtttc ctgtttgcat
     4261 cttcctctaa agctaagtaa ctcttttagg aattaccagt aaatacttgc tcagagacaa
     4321 gggacaagtt gtctttaatt ttcattgcag cactagaata atgtaactca catgcttttt
     4381 aaacattaag atttcatttg gcaatatcat tctctacagg taataaactc caacaaagct
     4441 acatacattt taaaaggcat ttttttagat tttatggtac taataatgag tttttcaatt
     4501 aaagaacaaa agatcagtag gatatagaat atcaagtatt actgagaaaa gggaggataa
     4561 gtgtggcaca ttagaattga ccttaaaagg aaagtatgtg atggtgaggt gctaaactgg
     4621 tttcagcagt gcagataacc taaggcagag ttgctagatc agggcttggg gaactcggag
     4681 tcagctatct gtctctagct ttgctctcat catcagtaag tgtgtctttg ttttcctgtt
     4741 tacctgactg caattaagtt agcaagttag tgataaaaag aaaacaacca aagaaaattg
     4801 gtacctactc ttctgcataa gaagtgtgtc tagataccag tcagtaactc acatatcaca
     4861 gagttcttct agctgacatt catacgaata ccagaaatag ttgtgagaat acacatttat
     4921 gcaagtttgt gcacacgtga cgaaatcaat gtaagtcgag cacccacatt gcttttctcc
     4981 cttccacatt gccttcttct ctttggccat tccatgtcct cggagtcgga gctgtgcctc
     5041 gtttatcttt ttgcatcaca tagcgataag aatttagcta caggagatac aacatgctag
     5101 ttatgtaatg cctgctgttc ttcacagttc atctccctgc ttaaaagtag cagttgataa
     5161 gaaactctag ctgctaaggc tgctgtccac acggagatgc atgctgggca acagttgtca
     5221 gcactagctg cctcttagct ccttaattct tggttccttt ggatggcaaa ctgtctttgt
     5281 ctgctcccca cacgactcca gtattctgaa gaaagttcat cttttgcctg ttcatttctg
     5341 tagccaaagc tgactgaaac cccaaatcta aatcatgaaa agataccaaa aagaaacact
     5401 tctcagcttc ttagaaacct taacttctct tgctgtattt catggatttg attttctttg
     5461 aaatttttga ttctgggcag cgccttttaa ttaagaaatt gttaggatga aggtcaaaca
     5521 ggttctcatt gccctgcagg taccttgctc tggactgctt ctgtatgggg tgacttgggg
     5581 ttgctgaaca cacaggatta gaacagtaaa cacaaagctg cccttgaggc tggcgttaaa
     5641 ccagagcctc aatattgaaa atatcaagtc ctctttcctt ccttagagac gagactgtga
     5701 gaggaaagca actgtggtag gtgggcttgc ttgcacatga gcaccaagac cattccccaa
     5761 gctctatcct cagggtagca tttagagtgc tgtgttctgc tgtcacatag acatggctta
     5821 gggatgtagc actaataaaa gaatgcccgt gcttttgaat agttgtgata gcaaactcta
     5881 ggctaactag caagtgtttg aattctgtgt gctgtatagt agttggtcat tgccttaaag
     5941 cagtctcttg gaagttggga gcactgaagc agtccaacca tatatgggca tcacgttgag
     6001 ggagatgagc cttgttcaag ccttagaaag gacccttagt ctacacaggt agattctttt
     6061 cacttggata ttactgtgtt taaaatgttt ccactatgtt gaggcagttt tttaaagtgg
     6121 aacacagata ggatttttag tatttctttt tttgtttctt tggtgattaa aggtttgttg
     6181 gtagacattt gtgtaaaagt tgttcaagcc tatcatcttt ccagtacttg tggtcctgtt
     6241 cttagtacca gagtccacaa tggaaagtgt aaacactgga tattaatatt gctgagggtg
     6301 catagccagg tgtgagctga ctggaacttc tcagtggtga agaaacagca caacggcact
     6361 tgccattttc atagtgattg cataaagaga ccttctaagt ttgtctggat tgagtgaaca
     6421 ctcttctaag aggagcttct caagtaaatg caaaggaaaa gagttgacta tttttatagc
     6481 atatttaata tatttgtata taactatgag tgtagtagga accctccaca tgcctcccac
     6541 ttttctaatt ccctcccctt ctgccgtagc cctagtccag cctcatccgc atgggtaatg
     6601 tgcctactgt cagcctacct accaaaagat agtgctgctg ctttctgaga caggtgagat
     6661 cagactctca tgcctgggga tccttatggg aggaatagca cacacttaga acaacatacc
     6721 acagtttaag agcatcattt tgaaaggtaa taagcacttt attgcaatta ttcatttaga
     6781 taaagtttgt atcttaggca ttaaccgttt ttaaaggatc cctaatcatc acttaggtga
     6841 aatgataaac gacacatttc tgagaaatgt tcaggtccag tgaaccgtag caggtttatg
     6901 ggaatgattt caaggtagcc aaataaactc tgacttttgt tttgaatgtg gtggagtcag
     6961 gagattgtag atgtgtagtt tgatttaaac actattgtaa acctatcttg cctattgtgt
     7021 ggacaccaaa agagaccaat gagcctgttt attttcagag gtctaggaat atgcatctgt
     7081 ctgagtagat atacagaact aatctataaa cggttggtag taatatttta ggatacagta
     7141 acttcaagaa ttattgagtg ttttaaatgt gccctgaaat gttggcatgt catttcagcg
     7201 ttcccatttg agttgctctt gtaatatttt tgcacaaaaa ggactgagaa aagactgctt
     7261 tggttgaaga aaactataat ttggtcttat tttaatgtct cctgtggaaa cactggaggt
     7321 aaatttgttg gcatagttac taattcagga tatttaaaac agtgttgaac agctcatcag
     7381 aaattaagca aacttatata tttaaaaatt aaaaatcttt ttttccatgt gactgttttg
     7441 catatttttt ccgttgtcat accacactac attccttggt tttttttctg aaataataat
     7501 ttgtgaaaga tttgagtatt caacaatatt ttttaagacg cctgggtttt cccaggaaaa
     7561 tgtcctagtg aagtaagtta tagctatata tagtttgtgg agactattga gattccatca
     7621 acaccaccag caaacactga ggtgctgaac caagagacaa tcataatagt aagtatttac
     7681 aggacttagg agaggctgca aggaacactt gttcccaaag cagttctctg ggtctcctaa
     7741 ataaaatggc tgtgtattta gatttctaca ttgtgtagtt ggtgatttat ttaatttatt
     7801 gcatcatttt cttgtcgttg gagaacttgc tcttgtttgg ggcagtcact accctaccct
     7861 ctagtgactc cccactgaca gatcattggg atccattgtg catcacgatg gtgatggagg
     7921 gtgaacctga atgtccctgc acttccctcc tgctctgaat tcatttaaga aaagaacatt
     7981 aaaagctaac tccttttagc tctggtcaca tagtgtcact tgttgccttc tctgattcat
     8041 gggcactttt tatacattcg tttccccaac acagtcaaaa aggccagtaa gacagaacca
     8101 agggcacatg ttgcctctgt tgcccatttg gggaaatgct agcaaagtaa tatctattaa
     8161 tgactgtcgt cactacatcc atatatagaa gtccttctat atagttgaac agtgtatgca
     8221 cactgaaaac tttgaaaagt tggctgtctt ttagatcctc catagtccag taaagtggtg
     8281 cttgaacata gggagtctag ttgtgtgagg atccttcctg ctcacgtgac caaagtgggc
     8341 tatggtcctc ctttagcacg gttgcggctc tggagtccca cagtcagggt ctaacacaca
     8401 tagggatccc ctggagagca gttattaaaa tactgtcaga cacaaactgg gtttattact
     8461 taagaggcat ctaactctga ggggcataaa ttcaaaatat accattttta gatgtttgct
     8521 tttaaatcag tgaaaacaaa ctgtgacatc gctttaagaa atgacttttc aaatgttttg
     8581 agttggcctg tactggttca catttattgc tgacaatggt ttgaagagta ctacaaagct
     8641 tatttaaaaa aaaaaaaaaa aaagaaagaa ggaaagaaag aaagaaagaa aaagttaagt
     8701 tgatttcaag caaagacatt gccttcaaaa agtcccttac taataagcaa ggggtatgtc
     8761 agccagaact ggaatttaca ccattctaaa attattttga aatctatttt actgtggttt
     8821 aagttgggaa aagctccagt atagcacttt catattcacc ctgtgtaaag attaaagccc
     8881 aaagacaaat taatgctgta ttaaaaccag ttagtgcaaa aactataaat ataagtttta
     8941 tctttgtaaa ctctgttaaa tcagttggta gttgtacaaa catgcaccag atttctctta
     9001 agttccgtgt ggtcttgctg tgctgttcct gacattgctg tccttactgc ttggttctgg
     9061 gtttaaacta aaacaagaat aagcagagcg catcccttgc agctccaaaa gaggggcacg
     9121 atatggctgt gtatctccag atgagaattc ctcccctcct aaagcaaaca ttgaattgag
     9181 acttacactc tttcaggtgt ttaccccttt gccaaaacta gaaatatgaa ggattatgag
     9241 tgatttcaat ggtgctatat taggttccct ggttttcata agctatgttt ggaaatacag
     9301 cactgaataa aatgcagact cttgctacca gctgcatatt gccgttgtaa ttgggtccag
     9361 tacaattgga tatacttgtt tatcaaagtt accctttgaa gaagtaaaac tggtacacca
     9421 gcatgccttc actcaggcct cctgctgtat gacatgcaca gctttaacgt aaaatcacaa
     9481 caaaccatca taatgctctt ttctctagac ccttgtaatg tattcagaac ctaaaactac
     9541 agcaaaagag ccaagcagta gcaatgtttg tttttttttt tttttgtaaa tgtaaaaata
     9601 attagctcta gacctgtttc ctttgattta aaaataaaga atgcctcagt gctgctctca
     9661 gtgtcacctg cttatgtggc acatatgtgt aagagtccca ttttggattt atagaacaac
     9721 tattaaatgt ttttaaatct gtcaaaaaaa aaaaaaaa
//
