LOCUS       NM_023671               3395 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus chloride channel, nucleotide-sensitive, 1A (Clns1a),
            mRNA.
ACCESSION   NM_023671
VERSION     NM_023671.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3395)
  AUTHORS   Takai,H., Masuda,K., Sato,T., Sakaguchi,Y., Suzuki,T., Suzuki,T.,
            Koyama-Nasu,R., Nasu-Nishimura,Y., Katou,Y., Ogawa,H.,
            Morishita,Y., Kozuka-Hata,H., Oyama,M., Todo,T., Ino,Y., Mukasa,A.,
            Saito,N., Toyoshima,C., Shirahige,K. and Akiyama,T.
  TITLE     5-Hydroxymethylcytosine plays a critical role in
            glioblastomagenesis by recruiting the CHTOP-methylosome complex
  JOURNAL   Cell Rep 9 (1), 48-60 (2014)
   PUBMED   25284789
REFERENCE   2  (bases 1 to 3395)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   3  (bases 1 to 3395)
  AUTHORS   Fronz,K., Otto,S., Kolbel,K., Kuhn,U., Friedrich,H., Schierhorn,A.,
            Beck-Sickinger,A.G., Ostareck-Lederer,A. and Wahle,E.
  TITLE     Promiscuous modification of the nuclear poly(A)-binding protein by
            multiple protein-arginine methyltransferases does not affect the
            aggregation behavior
  JOURNAL   J Biol Chem 283 (29), 20408-20420 (2008)
   PUBMED   18495660
REFERENCE   4  (bases 1 to 3395)
  AUTHORS   Harrell,M.D., Harbi,S., Hoffman,J.F., Zavadil,J. and Coetzee,W.A.
  TITLE     Large-scale analysis of ion channel gene expression in the mouse
            heart during perinatal development
  JOURNAL   Physiol Genomics 28 (3), 273-283 (2007)
   PUBMED   16985003
REFERENCE   5  (bases 1 to 3395)
  AUTHORS   Inoue,H. and Okada,Y.
  TITLE     Roles of volume-sensitive chloride channel in excitotoxic neuronal
            injury
  JOURNAL   J Neurosci 27 (6), 1445-1455 (2007)
   PUBMED   17287519
  REMARK    GeneRIF: 1st demonstration of VSOR Cl- channel expression in
            somatosensory pyramidal neurons. It is the major anionic pathway
            for varicosity recovery after NMDA & for persistent NMDA-induced
            varicosity formation leading to necrosis in cortical neurons.
REFERENCE   6  (bases 1 to 3395)
  AUTHORS   Ritter,M., Ravasio,A., Jakab,M., Chwatal,S., Furst,J., Laich,A.,
            Gschwentner,M., Signorelli,S., Burtscher,C., Eichmuller,S. and
            Paulmichl,M.
  TITLE     Cell swelling stimulates cytosol to membrane transposition of ICln
  JOURNAL   J Biol Chem 278 (50), 50163-50174 (2003)
   PUBMED   12970357
  REMARK    GeneRIF: ICln associates with the cell membrane after cell swelling
REFERENCE   7  (bases 1 to 3395)
  AUTHORS   Friesen,W.J., Wyce,A., Paushkin,S., Abel,L., Rappsilber,J., Mann,M.
            and Dreyfuss,G.
  TITLE     A novel WD repeat protein component of the methylosome binds Sm
            proteins
  JOURNAL   J Biol Chem 277 (10), 8243-8247 (2002)
   PUBMED   11756452
REFERENCE   8  (bases 1 to 3395)
  AUTHORS   Scandella,E., Nagl,U.O., Oehl,B., Bergmann,F., Gschwentner,M.,
            Furst,J., Schmarda,A., Ritter,M., Waldegger,S., Lang,F., Deetjen,P.
            and Paulmichl,M.
  TITLE     The promoter for constitutive expression of the human ICln gene
            CLNS1A
  JOURNAL   J Biol Chem 275 (21), 15613-15620 (2000)
   PUBMED   10821842
REFERENCE   9  (bases 1 to 3395)
  AUTHORS   Pu,W.T., Wickman,K. and Clapham,D.E.
  TITLE     ICln is essential for cellular and early embryonic viability
  JOURNAL   J Biol Chem 275 (17), 12363-12366 (2000)
   PUBMED   10777517
REFERENCE   10 (bases 1 to 3395)
  AUTHORS   Wickman,K., Seldin,M.F., James,M.R., Gendler,S.J. and Clapham,D.E.
  TITLE     Partial structure, chromosome localization, and expression of the
            mouse Icln gene
  JOURNAL   Genomics 40 (3), 402-408 (1997)
   PUBMED   9073507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX236388.1, AK169259.1 and AC151477.1.
            
            On Jul 15, 2011 this sequence version replaced NM_023671.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169259.1, BC005575.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-686               CX236388.1         1-686
            687-1480            AK169259.1         651-1444
            1481-3395           AC151477.1         139420-141334
FEATURES             Location/Qualifiers
     source          1..3395
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 53.57 cM"
     gene            1..3395
                     /gene="Clns1a"
                     /gene_synonym="2610036D06Rik; 2610100O04Rik; Clci; Clcni;
                     ICLN"
                     /note="chloride channel, nucleotide-sensitive, 1A"
                     /db_xref="GeneID:12729"
                     /db_xref="MGI:MGI:109638"
     exon            1..213
                     /gene="Clns1a"
                     /gene_synonym="2610036D06Rik; 2610100O04Rik; Clci; Clcni;
                     ICLN"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..799
                     /gene="Clns1a"
                     /gene_synonym="2610036D06Rik; 2610100O04Rik; Clci; Clcni;
                     ICLN"
                     /note="chloride channel current inducer; chloride channel
                     regulator; i(Cln); chloride ion current inducer protein;
                     chloride conductance regulatory protein ICln"
                     /codon_start=1
                     /product="methylosome subunit pICln"
                     /protein_id="NP_076160.1"
                     /db_xref="CCDS:CCDS21462.1"
                     /db_xref="GeneID:12729"
                     /db_xref="MGI:MGI:109638"
                     /translation="MLSPAMSFLKSFPPPGSADGLRLQQPDTEAVLNGKGLGTGTLYI
                     AESRLSWLDGSGLGFSLEYPTISLHAVSRDPNAYPQEHLYVMVNAKLGEESKEPLSDE
                     DEEDNDDVEPISEFRFVPSDKSALEAMFTAMCECQALHPDPEDEDSDDYDGEEYDVEA
                     HEQGQGDIPTFYTYEEGLSHLTAEGQATLERLEGMLSQSVSSQYNMAGVRTEDSVRNY
                     EDGMEVETTPTVAGQFEDADVDH"
     exon            214..350
                     /gene="Clns1a"
                     /gene_synonym="2610036D06Rik; 2610100O04Rik; Clci; Clcni;
                     ICLN"
                     /inference="alignment:Splign:2.1.0"
     exon            351..449
                     /gene="Clns1a"
                     /gene_synonym="2610036D06Rik; 2610100O04Rik; Clci; Clcni;
                     ICLN"
                     /inference="alignment:Splign:2.1.0"
     exon            450..557
                     /gene="Clns1a"
                     /gene_synonym="2610036D06Rik; 2610100O04Rik; Clci; Clcni;
                     ICLN"
                     /inference="alignment:Splign:2.1.0"
     exon            558..731
                     /gene="Clns1a"
                     /gene_synonym="2610036D06Rik; 2610100O04Rik; Clci; Clcni;
                     ICLN"
                     /inference="alignment:Splign:2.1.0"
     exon            732..820
                     /gene="Clns1a"
                     /gene_synonym="2610036D06Rik; 2610100O04Rik; Clci; Clcni;
                     ICLN"
                     /inference="alignment:Splign:2.1.0"
     exon            821..3395
                     /gene="Clns1a"
                     /gene_synonym="2610036D06Rik; 2610100O04Rik; Clci; Clcni;
                     ICLN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1393..1398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clns1a"
                     /gene_synonym="2610036D06Rik; 2610100O04Rik; Clci; Clcni;
                     ICLN"
                     /note="hexamer: AATAAA"
     polyA_site      1412
                     /gene="Clns1a"
                     /gene_synonym="2610036D06Rik; 2610100O04Rik; Clci; Clcni;
                     ICLN"
                     /note="major polyA site"
     regulatory      1460..1465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clns1a"
                     /gene_synonym="2610036D06Rik; 2610100O04Rik; Clci; Clcni;
                     ICLN"
                     /note="hexamer: AATAAA"
     polyA_site      1481
                     /gene="Clns1a"
                     /gene_synonym="2610036D06Rik; 2610100O04Rik; Clci; Clcni;
                     ICLN"
                     /note="major polyA site"
     regulatory      1504..1509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clns1a"
                     /gene_synonym="2610036D06Rik; 2610100O04Rik; Clci; Clcni;
                     ICLN"
                     /note="hexamer: AGTAAA"
     polyA_site      1527
                     /gene="Clns1a"
                     /gene_synonym="2610036D06Rik; 2610100O04Rik; Clci; Clcni;
                     ICLN"
ORIGIN      
        1 cgactactgc ttccggggca gctccgtgcg agccgcgatt gcggtactcg cctctctcgg
       61 ttcgcgtgga gcgatgcttt ccccggcaat gagcttcctc aaaagcttcc cgccgcctgg
      121 gtcggccgac gggctccggc tgcagcagcc agacaccgag gctgtgctga acgggaaggg
      181 gctcggcacc ggcacgcttt acatcgcgga gagccgcctg tcctggttag atggttcggg
      241 attaggattc tcactggaat accccaccat tagtttacat gcggtgtcca gggatccaaa
      301 cgcttaccct caagagcatt tgtatgttat ggtgaatgcc aagcttggag aagaatcaaa
      361 agaacctctc tctgatgaag atgaggaaga caatgatgat gttgaaccca tttctgaatt
      421 tcgatttgtg cccagtgata agtcagcatt ggaggcgatg ttcacagcaa tgtgtgagtg
      481 ccaggccttg catccagacc ctgaggatga agactcggac gactatgatg gagaggagta
      541 tgatgtggag gcacatgaac aaggacaagg ggacatccct acattttata cctatgaaga
      601 aggactatcc catttaacag cggaagggca agccacgttg gagagattag aagggatgct
      661 ttctcagtct gtgagcagcc aatataatat ggcaggcgtc cgaacagaag actcagtaag
      721 aaattatgaa gatggcatgg aggtggaaac cacaccaact gttgccggac agtttgagga
      781 tgcagatgtg gatcactgag gatggctgac ctactataca attctgctca taactgtagg
      841 caagaacgtg gtgcctcttc actccagaat ggggctggtg aaaggcattt ttcttctcca
      901 aaactcattt ctcaagtcaa actataatga gacagcaagc tgtcaccagc agaagagact
      961 atgtatgacc tctattaaca aaggtgaatt aactgaacgg gtatttgtag tttctcattt
     1021 cccccaagct tcctgtgtat gttctgagaa ggcctctgag tcctgccttt gctgtgtgcg
     1081 tctgtcagct gcaagattcg cctatgtggt gaaatgcaca gagctcacac tgggcggaag
     1141 ggacgtgcgg aagcttagat gtctctggga ttcaggagaa ctcttatccc tgagattaaa
     1201 aagcagaggc ctcagaggga gcagccgcta gcattttcca cagaggcatg ggtcctctac
     1261 ttggggctca gccacatctc gcaatacttg tgtgctagct tctgttattc ttcatgtacc
     1321 atcagctctg ttatgttctc ctaggttagg tccttgactg tccaccctct taacgttcgc
     1381 tttctgtcac agaataaata atctgaaatg aagtctgcaa agtactctca atgatatttt
     1441 gtctttgtaa tagttaacaa ataaatctgg gtttttttct atatcgctgt gattttgctc
     1501 ttgagtaaaa ccattaatga gaaaagacta agatatttaa attgtacatg tatgtgtgtt
     1561 ttgcctgcgt acatcatgtg cgtgcctggt gcccatggag gtctgaagaa ggtgttggaa
     1621 ccacaggaac tggagttcca gttgtttatg aacggccgtg aggatgctgg aaactgacgc
     1681 taggtcctct gcaagagcag caagtattct taactgctga gccctctctc cagcccagca
     1741 cttgctgctc ttttagagga gctggattca gttcctctgc ttctgtgttg ggcagctcac
     1801 agctgctata tgctgctggc ttccagggat ctcaatagcc tcttctggtt tcctcagcta
     1861 cacatgcaaa tgcagacaga cgcccataca cataacaata gtaacgtttt aaagtcctgc
     1921 gggggcgagg ggtgtgaatt agttggtgga gctggtctag ctgcatgaag ccctgggttt
     1981 agtccctacc actttataag cttggcctgg ttgcatatgc ctataaattc cagtactcag
     2041 gaggtggagg caggaggatc agaaattcga ggtcatcctc agctaagtag cacatgagca
     2101 cagaaacaaa atactagtac tgaggggagc tttggtggag gagaccgtct ctgtgtggag
     2161 cccatgctgg cctggagttt acagaaatct gcctggctct gctctcctac tgctggactt
     2221 gaaggcatgt gccaccatgc tcatttttac ttttaattat atatatgcgt gtgggtctgt
     2281 gcacatgagt gcaggtgcct acgggatcac agagggtcca gatcccctgg gcctgggcta
     2341 tttgatgttt tggggaactg aacttgggtc ctcttaatac tcttagcggt ttaacactga
     2401 gccccatctg ccttatttct tgctatgagg ttaactcact gaacctggac tggctgacca
     2461 gcaagctcca ggcatcttct gtcttccagg ccctccgttg acactactcc tctcaacatt
     2521 gaaagtatag acactgcccc actattgctt gagtggtagg agccaaactc aggtccttac
     2581 atttgcaagg aaggcaatct ataaactaaa ccagtgcccc agctcaattt tagttccatt
     2641 tgttgggatg tgtatgcttc tagcaagtct ttcttttttt ttttttaaag atttatttaa
     2701 agattttatg tgagtccact gtagctgtac agatggttgt gagccttcat gtggttgttg
     2761 gggattgaat ttttaggacc tctgcttgct ccagtctact ccactcgctc agtccctgct
     2821 tgctccagcc aagtacttac tatgcatagg tacactgtag ctgacttcta acgcaccaga
     2881 agagggcgtc agatctcatt ccgggaggtt gtgagccacc atgtgattga actcaggacc
     2941 tatggaagat cagccagtgc tcttacacgc tgagccatct cactagcccc tagcaagtct
     3001 ttcataaggg gagtcttaaa acataaagac cttgctgatg ctgcctggat tgggagtagt
     3061 ttttaagttc atcagccctc actatagagt ttccataggc acctgggtat tcataaggct
     3121 gaatttcgta gttctagact taggcccttt tttgttattg tttttgagac attatgtatc
     3181 tctgactggt ctagaactca cagagatcta cctgccttgg tctcccaagt cttgggatta
     3241 aaggtgtgta cctggacttt ctgtggcctt tgaaagaagg ttctatgcac aatttggagc
     3301 tgtcagcctg attagctgct aggtcctgct gacagcctca ggcccgtggt tgttgtagca
     3361 gtttttcatt gagtttctca tcttgcagaa taagt
//
