LOCUS       NM_007714               1955 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus CDC like kinase 4 (Clk4), transcript variant 1, mRNA.
ACCESSION   NM_007714
VERSION     NM_007714.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1955)
  AUTHORS   Huang,J., Wang,L., Shen,Y., Zhang,S., Zhou,Y., Du,J., Ma,X.,
            Liu,Y., Liang,D., Shi,D., Ma,H., Li,L., Zhang,Q. and Chen,Y.H.
  TITLE     CDC-like kinase 4 deficiency contributes to pathological cardiac
            hypertrophy by modulating NEXN phosphorylation
  JOURNAL   Nat Commun 13 (1), 4433 (2022)
   PUBMED   35907876
  REMARK    GeneRIF: CDC-like kinase 4 deficiency contributes to pathological
            cardiac hypertrophy by modulating NEXN phosphorylation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1955)
  AUTHORS   Jin,L., Chen,Y., Crossman,D.K., Datta,A., Vu,T., Mobley,J.A.,
            Basu,M.K., Scarduzio,M., Wang,H., Chang,C. and Datta,P.K.
  TITLE     STRAP regulates alternative splicing fidelity during lineage
            commitment of mouse embryonic stem cells
  JOURNAL   Nat Commun 11 (1), 5941 (2020)
   PUBMED   33230114
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1955)
  AUTHORS   Ninomiya,K., Kataoka,N. and Hagiwara,M.
  TITLE     Stress-responsive maturation of Clk1/4 pre-mRNAs promotes
            phosphorylation of SR splicing factor
  JOURNAL   J Cell Biol 195 (1), 27-40 (2011)
   PUBMED   21949414
  REMARK    GeneRIF: Clk1/4 expression induced by stress-responsive splicing
            serves to maintain the phosphorylation state of SR proteins.
REFERENCE   4  (bases 1 to 1955)
  AUTHORS   Katsu,R., Onogi,H., Wada,K., Kawaguchi,Y. and Hagiwara,M.
  TITLE     Novel SR-rich-related protein clasp specifically interacts with
            inactivated Clk4 and induces the exon EB inclusion of Clk
  JOURNAL   J Biol Chem 277 (46), 44220-44228 (2002)
   PUBMED   12169693
REFERENCE   5  (bases 1 to 1955)
  AUTHORS   Hartmann,A.M., Rujescu,D., Giannakouros,T., Nikolakaki,E.,
            Goedert,M., Mandelkow,E.M., Gao,Q.S., Andreadis,A. and Stamm,S.
  TITLE     Regulation of alternative splicing of human tau exon 10 by
            phosphorylation of splicing factors
  JOURNAL   Mol Cell Neurosci 18 (1), 80-90 (2001)
   PUBMED   11461155
REFERENCE   6  (bases 1 to 1955)
  AUTHORS   Watkins-Chow,D.E., Douglas,K.R., Buckwalter,M.S., Probst,F.J. and
            Camper,S.A.
  TITLE     Construction of a 3-Mb contig and partial transcript map of the
            central region of mouse chromosome 11
  JOURNAL   Genomics 45 (1), 147-157 (1997)
   PUBMED   9339371
REFERENCE   7  (bases 1 to 1955)
  AUTHORS   Nayler,O., Stamm,S. and Ullrich,A.
  TITLE     Characterization and comparison of four serine- and arginine-rich
            (SR) protein kinases
  JOURNAL   Biochem J 326 (Pt 3) (Pt 3), 693-700 (1997)
   PUBMED   9307018
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645907.9.
            
            On Feb 7, 2015 this sequence version replaced NM_007714.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012675.1, AF033566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AL645907.9         62018-62173
            157-317             AL645907.9         66075-66235
            318-540             AL645907.9         70704-70926
            541-631             AL645907.9         71982-72072
            632-698             AL645907.9         72464-72530
            699-815             AL645907.9         74115-74231
            816-982             AL645907.9         74316-74482
            983-1077            AL645907.9         74674-74768
            1078-1207           AL645907.9         75022-75151
            1208-1290           AL645907.9         76757-76839
            1291-1370           AL645907.9         79262-79341
            1371-1461           AL645907.9         80013-80103
            1462-1955           AL645907.9         80181-80674
FEATURES             Location/Qualifiers
     source          1..1955
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.02 cM"
     gene            1..1955
                     /gene="Clk4"
                     /note="CDC like kinase 4"
                     /db_xref="GeneID:12750"
                     /db_xref="MGI:MGI:1098551"
     exon            1..156
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1602
                     /gene="Clk4"
                     /EC_number="2.7.12.1"
                     /note="isoform 1 is encoded by transcript variant 1; dual
                     specificity protein kinase CLK4"
                     /codon_start=1
                     /product="dual specificity protein kinase CLK4 isoform 1"
                     /protein_id="NP_031740.1"
                     /db_xref="CCDS:CCDS24651.1"
                     /db_xref="GeneID:12750"
                     /db_xref="MGI:MGI:1098551"
                     /translation="MRHSKRTHCPDWDSRESWGHESYSGSHKRKRRSHSSTQENRHCK
                     PHHQFKDSDCHYLEARCLNERDYRDRRYIDEYRNDYCEGYVPRHYHRDVESTYRIHCS
                     KSSVRSRRSSPKRKRNRPCASHQSHSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYE
                     IVDTLGEGAFGKVVECIDHGMDGLHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNS
                     VFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINF
                     LHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHH
                     STLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERI
                     LGPIPAHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFD
                     LVRRMLEYDPARRITLDEALQHPFFDLLKRK"
     exon            157..317
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     exon            318..540
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     exon            541..631
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     exon            632..698
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     exon            699..815
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     exon            816..982
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1077
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1207
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1290
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1370
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1461
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1955
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1932..1937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clk4"
                     /note="hexamer: AGTAAA"
     polyA_site      1949
                     /gene="Clk4"
                     /note="major polyA site"
ORIGIN      
        1 cgcgctggct cggcgtaggt ggcgctggag ccacctgagg aggttgtagg gtgacggcgc
       61 ggacgccatt ttgtcggtgt ctgtcgcagc ggctggagag gaacgacggc ggtttggcga
      121 catttctcgg ccaaaaggcc gcttgctttt gcggagatgc ggcattccaa acgaactcac
      181 tgtcctgatt gggatagtag agaaagctgg ggccatgaaa gctacagtgg aagtcacaaa
      241 cgcaagagaa ggtctcacag cagtactcag gagaacaggc actgtaaacc acatcatcag
      301 tttaaagact cggattgtca ctatttagaa gcaagatgct tgaatgagag agattatcgg
      361 gaccggagat acattgatga atacagaaat gactactgcg aaggatatgt tccaagacat
      421 taccatagag acgttgaaag cacttaccgg atccattgca gtaaatcctc agtcaggagc
      481 aggagaagca gccctaagag aaagcgtaat agaccctgtg caagtcatca gtcgcattcg
      541 aagagccacc gaaggaaaag atccaggagt atagaggatg atgaggaggg tcacctgatc
      601 tgtcaaagtg gagacgttct aagagcaaga tatgaaatcg tggacacttt aggtgaagga
      661 gcctttggca aagttgtaga gtgcattgat cacggcatgg atggcttaca tgtagcagtg
      721 aaaattgtaa aaaatgtagg ccgttaccgg gaggcagctc gttctgaaat ccaagtattg
      781 gagcacttga acagcactga ccccaacagt gtcttccgat gcgtccagat gctagagtgg
      841 tttgatcatc atggtcatgt ttgtattgtg tttgagctgc tgggacttag tacctatgat
      901 tttattaaag aaaatagttt tctgccattt caaattgatc acatcaggca aatggcttat
      961 cagatctgcc agtctataaa ttttttacat cataataaat taacacacac ggacctaaaa
     1021 cctgaaaata ttttatttgt gaagtctgac tatgtagtca aatacaattc taaaatgaaa
     1081 cgagatgagc gcacattgaa aaacacagat atcaaagttg ttgattttgg aagtgcaaca
     1141 tatgacgacg aacatcatag tactttggtg tccacaaggc actacagggc tccagaggtc
     1201 attttggctc taggttggtc tcagccttgt gatgtttgga gcataggctg cattcttatt
     1261 gagtactacc ttgggttcac agtctttcag acccacgata gtaaagagca cctggcaatg
     1321 atggagcgga tcttaggacc catcccagca catatgatcc agaagacaag gaaacgcaag
     1381 tatttccacc ataaccagct agattgggac gagcatagtt cagctgggag atatgttagg
     1441 agacgctgca agccgttaaa ggaatttatg ctgtgtcatg acgaagagca tgagaagctg
     1501 tttgacctgg ttcgaagaat gttggagtat gacccagcga gaaggatcac cttggatgaa
     1561 gcattgcagc accctttctt tgacttatta aaaaggaaat gagtgggagt caggggtctt
     1621 ctgtgtactt ctctaggagc agttacttcc agactgtgtc agtcaactaa accttctaat
     1681 atttttgtaa acattaaatt attttgtaca gttaagtgta aatactgtat gttttgtatc
     1741 aatagcataa ctaccttgtt aagtatggtg ttgataatga atgcaataca agagttacaa
     1801 tgaattttcc ttttgatgtt aattgccact ttaaaggctt ttagaatgcc ctttgtgtcc
     1861 agtgataaac gtgattggtc ccatcttttg tacatgaagg ttgactctga agtgattttt
     1921 ttttttcctc aagtaaaagg aaatcttgac cactt
//
