LOCUS       NM_007713               1838 bp    mRNA    linear   ROD 12-OCT-2024
DEFINITION  Mus musculus CDC-like kinase 3 (Clk3), transcript variant 1, mRNA.
ACCESSION   NM_007713
VERSION     NM_007713.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1838)
  AUTHORS   Ma,X., Gao,L., Ge,R., Yuan,T., Lin,B. and Zhen,L.
  TITLE     CDC-like kinase 3 deficiency aggravates hypoxia-induced
            cardiomyocyte apoptosis through AKT signaling pathway
  JOURNAL   In Vitro Cell Dev Biol Anim 60 (4), 333-342 (2024)
   PUBMED   38438604
  REMARK    GeneRIF: CDC-like kinase 3 deficiency aggravates hypoxia-induced
            cardiomyocyte apoptosis through AKT signaling pathway.
REFERENCE   2  (bases 1 to 1838)
  AUTHORS   Xue,M., Mi,S., Zhang,Z., Wang,H., Chen,W., Wei,W. and Lou,G.
  TITLE     MFAP2, upregulated by m1A methylation, promotes colorectal cancer
            invasiveness via CLK3
  JOURNAL   Cancer Med 12 (7), 8403-8414 (2023)
   PUBMED   36583532
  REMARK    GeneRIF: MFAP2, upregulated by m1A methylation, promotes colorectal
            cancer invasiveness via CLK3.
REFERENCE   3  (bases 1 to 1838)
  AUTHORS   Zhou,J., Wang,R., Zhang,J., Zhu,L., Liu,W., Lu,S., Chen,P., Li,H.,
            Yin,B., Yuan,J., Qiang,B., Shu,P. and Peng,X.
  TITLE     Conserved expression of ultra-conserved noncoding RNA in mammalian
            nervous system
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1860 (12), 1159-1168 (2017)
   PUBMED   29055695
REFERENCE   4  (bases 1 to 1838)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   5  (bases 1 to 1838)
  AUTHORS   Carrier,A., Nguyen,C., Victorero,G., Granjeaud,S., Rocha,D.,
            Bernard,K., Miazek,A., Ferrier,P., Malissen,M., Naquet,P.,
            Malissen,B. and Jordan,B.R.
  TITLE     Differential gene expression in CD3epsilon- and RAG1-deficient
            thymuses: definition of a set of genes potentially involved in
            thymocyte maturation
  JOURNAL   Immunogenetics 50 (5-6), 255-270 (1999)
   PUBMED   10630289
REFERENCE   6  (bases 1 to 1838)
  AUTHORS   Nayler,O., Stamm,S. and Ullrich,A.
  TITLE     Characterization and comparison of four serine- and arginine-rich
            (SR) protein kinases
  JOURNAL   Biochem J 326 (Pt 3) (Pt 3), 693-700 (1997)
   PUBMED   9307018
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122515.5.
            
            On Jun 15, 2020 this sequence version replaced NM_007713.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146942.1, BC085084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC122515.5         17605-17645
            42-193              AC122515.5         20852-21003
            194-410             AC122515.5         21679-21895
            411-507             AC122515.5         23996-24092
            508-574             AC122515.5         24369-24435
            575-691             AC122515.5         27351-27467
            692-858             AC122515.5         28051-28217
            859-953             AC122515.5         29124-29218
            954-1083            AC122515.5         29319-29448
            1084-1166           AC122515.5         29992-30074
            1167-1246           AC122515.5         30525-30604
            1247-1337           AC122515.5         30892-30982
            1338-1838           AC122515.5         31598-32098
FEATURES             Location/Qualifiers
     source          1..1838
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.47 cM"
     gene            1..1838
                     /gene="Clk3"
                     /note="CDC-like kinase 3"
                     /db_xref="GeneID:102414"
                     /db_xref="MGI:MGI:1098670"
     exon            1..41
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1514
                     /gene="Clk3"
                     /EC_number="2.7.12.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cdc2/CDC28-like protein kinase 3; dual specificity protein
                     kinase CLK3"
                     /codon_start=1
                     /product="dual specificity protein kinase CLK3 isoform 1"
                     /protein_id="NP_031739.4"
                     /db_xref="CCDS:CCDS23232.1"
                     /db_xref="GeneID:102414"
                     /db_xref="MGI:MGI:1098670"
                     /translation="MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPP
                     RRSRSRSHDRIPYQRRYREHRDSDTYRCEERSPSFGEDCYGSSRSRHRRRSRERAPYR
                     TRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVG
                     NLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFL
                     CVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHE
                     NQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTI
                     VATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGP
                     IPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMR
                     RMLEFDPAQRITLAEALLHPFFAGLTPEERSFHSSRNPSR"
     exon            42..193
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            194..410
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            411..507
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            508..574
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            575..691
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            692..858
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            859..953
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1083
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1166
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1246
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1337
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1838
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1725..1730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clk3"
                     /note="hexamer: AATAAA"
     polyA_site      1750
                     /gene="Clk3"
                     /note="major polyA site"
     regulatory      1815..1820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clk3"
                     /note="hexamer: AATAAA"
     polyA_site      1838
                     /gene="Clk3"
ORIGIN      
        1 gtggggagtg gggcctagcc gcagccggag cctgggagac gatgcatcac tgtaagcgat
       61 accgttcccc agagccagac ccatacctga gctaccgctg gaagaggagg cggtcttaca
      121 gtcgggagca tgaaggtcga ctacgatacc catcccgaag ggagcctccc ccacggagat
      181 cacggtccag aagccatgat cgtataccct accagcggag gtaccgggaa caccgtgaca
      241 gtgatacgta tcggtgtgaa gagcggagcc catcttttgg agaggactgc tatgggtctt
      301 cacgttctcg acatcggaga cggtcacgag agagggcgcc gtaccgtacc cgcaagcatg
      361 cccaccactg tcacaaacgc cgtaccaggt cttgtagcag tgcttcctcg agaagccaac
      421 agagcagtaa gcgcagcagc cggagtgtgg aagatgacaa ggagggccac ctggtgtgcc
      481 ggatcggcga ttggctccaa gagcgatatg agatcgtggg gaacctgggt gaaggcacct
      541 ttggcaaggt ggtggagtgc ttggaccatg ccagagggaa gtcacaggtt gccctgaaga
      601 tcatccgtaa tgtgggcaag tatcgggaag ctgctcgtct agaaattaat gttctcaaga
      661 aaatcaagga gaaagacaag gaaaataagt tcctttgtgt cctgatgtct gactggttca
      721 acttccatgg tcatatgtgc atcgcctttg agctcctggg caagaacacc tttgagttcc
      781 tgaaggagaa caacttccag ccttaccccc taccacatgt ccggcacatg gcctaccagc
      841 tctgtcatgc ccttagattt ctacacgaga accagctgac ccacacagac ttgaagccag
      901 agaacatctt gtttgtgaat tctgagtttg aaaccctcta caatgagcac aagagctgcg
      961 aggagaagtc agtgaagaac accagcatcc gagtggcaga ctttggcagt gccacgtttg
     1021 accatgaaca tcacaccacc attgtggcca cccgtcacta ccgcccacct gaggtgatcc
     1081 ttgagctggg ctgggcacag ccctgtgatg tctggagtat cggctgcatt ctctttgagt
     1141 actaccgtgg ctttacactc ttccagaccc atgaaaatag agaacacttg gttatgatgg
     1201 agaagattct aggacccatc ccatcacaca tgatccaccg taccaggaag cagaaatatt
     1261 tctacaaagg gggcctggtt tgggatgaga acagctctga tgggcggtat gtgaaggaga
     1321 actgcaaacc tctgaagagt tacatgctgc aggactccct ggagcatgtg cagctgtttg
     1381 acctgatgag gaggatgtta gagttcgacc ctgctcagcg catcacattg gcagaagcct
     1441 tgctgcaccc cttctttgct ggcctgaccc ctgaggagcg gtccttccac agcagccgta
     1501 accccagcag atgacaggtg caggccagca cacgaagagt tggagagctg gactgggctg
     1561 ctggcccctt ttctccagcc tctcccactg gcctcagagc cagagccacc gatgaacagt
     1621 gcaatgtgaa ggaaggcagg agcctgcaag ggaaggggga atgtggtgcc cggctgccag
     1681 aaagcacaga ttggacccaa gctatttata tgttgtaaag ttataataaa gtgtttctta
     1741 ctgtttgtaa ccccctggta ccagtgtgtc catctccagg ctccttgccc tctccctacg
     1801 ctgactgact tattaataaa gtctttctta gcagctca
//
