LOCUS       NM_001360763            3345 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus CAP-GLY domain containing linker protein 3 (Clip3),
            transcript variant 2, mRNA.
ACCESSION   NM_001360763 XM_006540410
VERSION     NM_001360763.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3345)
  AUTHORS   Sun,Y., Ren,W., Cote,J.F., Hinds,P.W., Hu,X. and Du,K.
  TITLE     ClipR-59 interacts with Elmo2 and modulates myoblast fusion
  JOURNAL   J Biol Chem 290 (10), 6130-6140 (2015)
   PUBMED   25572395
  REMARK    GeneRIF: Collectively, our studies demonstrate that formation of an
            Elmo2.ClipR-59 complex plays an important role in myoblast fusion.
REFERENCE   2  (bases 1 to 3345)
  AUTHORS   Ren,W., Sun,Y. and Du,K.
  TITLE     DHHC17 palmitoylates ClipR-59 and modulates ClipR-59 association
            with the plasma membrane
  JOURNAL   Mol Cell Biol 33 (21), 4255-4265 (2013)
   PUBMED   24001771
REFERENCE   3  (bases 1 to 3345)
  AUTHORS   Couesnon,A., Offner,N., Bernard,V., Chaverot,N., Backer,S.,
            Dimitrov,A., Perez,F., Molgo,J. and Bloch-Gallego,E.
  TITLE     CLIPR-59: a protein essential for neuromuscular junction stability
            during mouse late embryonic development
  JOURNAL   Development 140 (7), 1583-1593 (2013)
   PUBMED   23482493
  REMARK    GeneRIF: CLIPR-59 is involved in the stabilization of specific
            motor axons at the neuromuscular junction during mouse late
            embryogenesis and its role is crucial for mouse perinatal
            development.
            Erratum:[Development. 2013 Jun;140(11):2444]
REFERENCE   4  (bases 1 to 3345)
  AUTHORS   Ren,W., Cheema,S. and Du,K.
  TITLE     The association of ClipR-59 protein with AS160 modulates AS160
            protein phosphorylation and adipocyte Glut4 protein membrane
            translocation
  JOURNAL   J Biol Chem 287 (32), 26890-26900 (2012)
   PUBMED   22689584
  REMARK    GeneRIF: Because ClipR-59 also interacts with Akt and enhances the
            interaction between Akt and AS160, we suggest that ClipR-59
            functions as a scaffold protein to facilitate Akt-mediated AS160
            phosphorylation, thereby regulating glucose transport
REFERENCE   5  (bases 1 to 3345)
  AUTHORS   Ding,J. and Du,K.
  TITLE     ClipR-59 interacts with Akt and regulates Akt cellular
            compartmentalization
  JOURNAL   Mol Cell Biol 29 (6), 1459-1471 (2009)
   PUBMED   19139280
  REMARK    GeneRIF: ClipR-59 functions as a scaffold protein that interacts
            with phospho-Akt and recruits active Akt on the membrane and may
            play an important role in adipocyte glucose transport.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149067.3.
            
            On Feb 13, 2018 this sequence version replaced XM_006540410.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.101628.1,
                                           SRR1660817.47547.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AC149067.3         100394-100541
            149-360             AC149067.3         100854-101065
            361-500             AC149067.3         105547-105686
            501-594             AC149067.3         105772-105865
            595-756             AC149067.3         106054-106215
            757-875             AC149067.3         106619-106737
            876-1112            AC149067.3         107511-107747
            1113-1248           AC149067.3         110545-110680
            1249-1377           AC149067.3         110835-110963
            1378-1521           AC149067.3         112069-112212
            1522-1645           AC149067.3         112307-112430
            1646-1710           AC149067.3         112611-112675
            1711-1783           AC149067.3         114458-114530
            1784-3345           AC149067.3         115505-117066
FEATURES             Location/Qualifiers
     source          1..3345
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 17.37 cM"
     gene            1..3345
                     /gene="Clip3"
                     /gene_synonym="1500005P14Rik; Clipr-59"
                     /note="CAP-GLY domain containing linker protein 3"
                     /db_xref="GeneID:76686"
                     /db_xref="MGI:MGI:1923936"
     exon            1..148
                     /gene="Clip3"
                     /gene_synonym="1500005P14Rik; Clipr-59"
                     /inference="alignment:Splign:2.1.0"
     exon            149..360
                     /gene="Clip3"
                     /gene_synonym="1500005P14Rik; Clipr-59"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1838
                     /gene="Clip3"
                     /gene_synonym="1500005P14Rik; Clipr-59"
                     /note="clip-170 related protein 59 kDa; CLIP-170-related
                     59 kDa protein; cytoplasmic linker protein 170-related 59
                     kDa protein"
                     /codon_start=1
                     /product="CAP-Gly domain-containing linker protein 3"
                     /protein_id="NP_001347692.1"
                     /db_xref="CCDS:CCDS39880.1"
                     /db_xref="GeneID:76686"
                     /db_xref="MGI:MGI:1923936"
                     /translation="MTKTDPAPMAPPPRGEEEEEEEEDEPVPEAPSPTQERRQKPVVH
                     PSAPAPLPKDYAFTFFDPNDPACQEILFDPKTTIPELFAIVRQWVPQVQHKIDVIGNE
                     ILRRGCHVNDRDGLTDMTLLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRWT
                     NMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFNHGSALHIAASNLCLGAAKCLL
                     EHGANPALRNRKGQVPAEVVPDPMDMSLDKAEAALVAKELRTLLEEAVPLSCTLPKVT
                     LPNYDNVPGNLMLSALGLRLGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGK
                     NDGSVGGVRYFICPPKQGLFASVSKVSKAVDAPPSSVTSTPRTPRMDFSRVTGKGRRE
                     HKGKKKSPSSPSLGSLQQREGAKAEVGDQVLVAGQKQGIVRFYGKTDFAPGYWYGIEL
                     DQPTGKHDGSVFGVRYFTCAPRHGVFAPASRIQRIGGSTDPPGDSVGAKKVHQVTMTQ
                     PKRTFTTVRTPKDIASENSISRLLFCCWFPWMLRAEMQS"
     exon            361..500
                     /gene="Clip3"
                     /gene_synonym="1500005P14Rik; Clipr-59"
                     /inference="alignment:Splign:2.1.0"
     exon            501..594
                     /gene="Clip3"
                     /gene_synonym="1500005P14Rik; Clipr-59"
                     /inference="alignment:Splign:2.1.0"
     exon            595..756
                     /gene="Clip3"
                     /gene_synonym="1500005P14Rik; Clipr-59"
                     /inference="alignment:Splign:2.1.0"
     exon            757..875
                     /gene="Clip3"
                     /gene_synonym="1500005P14Rik; Clipr-59"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1112
                     /gene="Clip3"
                     /gene_synonym="1500005P14Rik; Clipr-59"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1248
                     /gene="Clip3"
                     /gene_synonym="1500005P14Rik; Clipr-59"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1377
                     /gene="Clip3"
                     /gene_synonym="1500005P14Rik; Clipr-59"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1521
                     /gene="Clip3"
                     /gene_synonym="1500005P14Rik; Clipr-59"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1645
                     /gene="Clip3"
                     /gene_synonym="1500005P14Rik; Clipr-59"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1710
                     /gene="Clip3"
                     /gene_synonym="1500005P14Rik; Clipr-59"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1783
                     /gene="Clip3"
                     /gene_synonym="1500005P14Rik; Clipr-59"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..3345
                     /gene="Clip3"
                     /gene_synonym="1500005P14Rik; Clipr-59"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3325..3330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clip3"
                     /gene_synonym="1500005P14Rik; Clipr-59"
                     /note="hexamer: AATAAA"
     polyA_site      3345
                     /gene="Clip3"
                     /gene_synonym="1500005P14Rik; Clipr-59"
                     /note="major polyA site"
ORIGIN      
        1 ctccatcccc atcccccgcc agcgtctggg cctcgtcccc ttctctctgt ctccctctcg
       61 tcccccatct cgtcccccga cactgacacc ccgatactcc tgaactctct tcagtcccag
      121 ccttgctctc caatcggcgc catctgaggc caccccccca actttgcaca ggcccccaag
      181 ggctacagag gaccatgact aagacggatc ctgccccaat ggcccctccg ccccgagggg
      241 aggaggaaga ggaggaggaa gaagacgaac cagttccaga agcccccagc cccacccagg
      301 agcgccggca gaagccagtt gtgcacccct cagcacctgc tccgctcccc aaagactacg
      361 cttttacctt cttcgatccc aatgaccctg cgtgccagga aattctgttt gacccgaaga
      421 ccaccatccc agagctgttc gccattgtac gccagtgggt cccccaagtc cagcacaaga
      481 ttgatgtcat tggcaacgag attcttcgtc gtggctgcca cgtgaatgat cgtgatgggc
      541 tcacagatat gacactgctc cattatgcgt gcaaagctgg ggctcatgga gttggagacc
      601 ctgcggccgc tgtgcgtctc tcacagcagc tgctggcgct aggcgcagat gtgaccctgc
      661 gcagccgctg gaccaacatg aacgcccttc actatgccgc ctattttgat gtgccagacc
      721 ttgttcgcgt gctgctgaag ggggcgaggc ccagggtggt gaactccacc tgcagtgact
      781 tcaaccatgg ctcggctctg cacatcgctg cctcgaatct gtgcctgggc gctgccaaat
      841 gtttactgga gcatggtgcc aacccagcac tgaggaaccg aaagggacag gtgccagcgg
      901 aagtggtccc agaccccatg gacatgtccc ttgacaaggc agaggcggcc ctggtggcca
      961 aggaactgcg gacactccta gaagaggctg tgccactgtc ctgcaccctg cccaaagtta
     1021 cactccccaa ctatgacaac gtcccaggca atctcatgct cagcgcgctg ggcctgcgcc
     1081 taggagacag agtgctcctt gatgggcaga agacgggcac gctgaggttc tgtgggacca
     1141 ctgagttcgc cagcggccag tgggtgggcg tggagctaga tgaaccagaa ggcaagaacg
     1201 atggcagcgt tgggggtgtc cggtacttca tctgccctcc caagcaaggt ctctttgcct
     1261 ctgtgtccaa agtctccaag gcagtggatg cacccccctc atctgttacc tccacgcccc
     1321 ggactccccg gatggacttc tcccgtgtaa ctggcaaggg ccgaagagaa cacaaaggga
     1381 agaagaagtc cccatcttcc ccatctctgg gcagtctgca gcagcgtgaa ggggccaaag
     1441 ctgaagttgg agaccaagtc cttgtggcag gccagaagca ggggattgtg cgcttctatg
     1501 ggaagactga ctttgctcca ggttactggt atggcatcga gctggaccag cccacaggca
     1561 aacatgacgg ctctgtgttc ggcgtccggt actttacctg tgccccgagg catggggtct
     1621 ttgcaccagc atctcgtatc cagaggattg gtggatccac tgatcccccc ggagacagtg
     1681 ttggagccaa aaaagtgcat caagtgacaa tgacacagcc caaacgcacc tttacgacag
     1741 tccggacccc aaaggacatt gcgtcagaga actctatctc caggttactc ttctgctgct
     1801 ggtttccttg gatgctgagg gcagagatgc agtcttagag gccctggata cctaacacag
     1861 agacagagtc ccctctagca tctcctaaca caaggagccc ccccagccat cccaagatag
     1921 agattcccag tgacttcaga atagaaaccc cgttagccag ccctcgatta ctgaggtccc
     1981 attattaaca gatctcccac cacgacgact ccctaaatac agacctcatg tttcccaaaa
     2041 gagattccct gagtagcacc ttcaggctag tccctgtccc ctactcctca gagcagattc
     2101 cccccaataa acattttcca cttcacccaa gggatgctga ccctctccac aacaggacgt
     2161 tcttgagtta ccagtgaatt agagtcccat gaatgaagac cccccaccct ggttctcctt
     2221 aagcataggt catacttcca gaatagccag ccacatcact gtccccattt aacatcagtc
     2281 tcctcaaaat gttgtgaccc caaggtcacc agaaagccct tatattctac tctccttatc
     2341 agagatgccc cccattcact taagtccctg ttctcacccc tgaacaagac acccacttag
     2401 tcggcccact caccccaatt tacaaacacc aaaaccgtcc tggaagcatg aattacagga
     2461 cagcaagtct tcctgccctc tgtaccctga gaaaccccca gtgccttgta tgaagcccac
     2521 cccacatggc ccacagtccc tgtgctggcc aaggctccca gaaaattctc tattttttaa
     2581 agtgataact tccccccttt ggggggaaat ccccaaattt ggaggcccca ttctagaact
     2641 ctggggagtt caaattccag agagaatata tattatatat gtccccaaat ttcccatccc
     2701 tccaagcccc acgatctcta gaagacccca aatttctaat tcccaggact tccctaccca
     2761 agtaacagaa tcttcaaatc cccagggaat cccaaactta agaccccaat cccaagccct
     2821 caggaaaccc caactacaag gtcctaagga ctgggaggaa ggaccctgtt gccaggctct
     2881 cagggcatct caaacctgac tcccaggcac caggagaccc caaacaggaa gtcccatctt
     2941 tggaacaagg atagaggact ctaatactct tagtccatgg atcatctaat ctctcaacct
     3001 ccaaattcca tgggccccag cttcaaggga acccccaagt cccaaatctc tgattactaa
     3061 tatgtgcagg gccccagggc tctaacagga ccccaagtca tggagtccct acttcaatct
     3121 accttccggt cacaggtcca agacactaaa tctgagtcat tggccccaaa ggacttcaca
     3181 gctcctgggc cagaccaaca gcctgcggga gaacctgagg gccccatagg tccagagcag
     3241 acctggggcc ctgaccacca aggacagctc acgactgccc cttcactgca tgtccctaaa
     3301 atcagcatga ctcctgtcct cttcaataaa gacgtttcta tggcc
//
