LOCUS       NM_001039162            4908 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus CAP-GLY domain containing linker protein 2 (Clip2),
            transcript variant 2, mRNA.
ACCESSION   NM_001039162 XM_895220
VERSION     NM_001039162.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4908)
  AUTHORS   Collinson,J.M., Lindstrom,N.O., Neves,C., Wallace,K., Meharg,C.,
            Charles,R.H., Ross,Z.K., Fraser,A.M., Mbogo,I., Oras,K.,
            Nakamoto,M., Barker,S., Duce,S., Miedzybrodzka,Z. and Vargesson,N.
  TITLE     The developmental and genetic basis of 'clubfoot' in the peroneal
            muscular atrophy mutant mouse
  JOURNAL   Development 145 (3) (2018)
   PUBMED   29439133
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4908)
  AUTHORS   Zhang,X., Chen,M.H., Wu,X., Kodani,A., Fan,J., Doan,R., Ozawa,M.,
            Ma,J., Yoshida,N., Reiter,J.F., Black,D.L., Kharchenko,P.V.,
            Sharp,P.A. and Walsh,C.A.
  TITLE     Cell-Type-Specific Alternative Splicing Governs Cell Fate in the
            Developing Cerebral Cortex
  JOURNAL   Cell 166 (5), 1147-1162 (2016)
   PUBMED   27565344
REFERENCE   3  (bases 1 to 4908)
  AUTHORS   Couesnon,A., Offner,N., Bernard,V., Chaverot,N., Backer,S.,
            Dimitrov,A., Perez,F., Molgo,J. and Bloch-Gallego,E.
  TITLE     CLIPR-59: a protein essential for neuromuscular junction stability
            during mouse late embryonic development
  JOURNAL   Development 140 (7), 1583-1593 (2013)
   PUBMED   23482493
  REMARK    Erratum:[Development. 2013 Jun;140(11):2444]
REFERENCE   4  (bases 1 to 4908)
  AUTHORS   Schmidt,N., Basu,S., Sladecek,S., Gatti,S., van Haren,J.,
            Treves,S., Pielage,J., Galjart,N. and Brenner,H.R.
  TITLE     Agrin regulates CLASP2-mediated capture of microtubules at the
            neuromuscular junction synaptic membrane
  JOURNAL   J Cell Biol 198 (3), 421-437 (2012)
   PUBMED   22851317
REFERENCE   5  (bases 1 to 4908)
  AUTHORS   Stepanova,T., Smal,I., van Haren,J., Akinci,U., Liu,Z., Miedema,M.,
            Limpens,R., van Ham,M., van der Reijden,M., Poot,R., Grosveld,F.,
            Mommaas,M., Meijering,E. and Galjart,N.
  TITLE     History-dependent catastrophes regulate axonal microtubule behavior
  JOURNAL   Curr Biol 20 (11), 1023-1028 (2010)
   PUBMED   20471267
REFERENCE   6  (bases 1 to 4908)
  AUTHORS   Valero,M.C., de Luis,O., Cruces,J. and Perez Jurado,L.A.
  TITLE     Fine-scale comparative mapping of the human 7q11.23 region and the
            orthologous region on mouse chromosome 5G: the low-copy repeats
            that flank the Williams-Beuren syndrome deletion arose at
            breakpoint sites of an evolutionary inversion(s)
  JOURNAL   Genomics 69 (1), 1-13 (2000)
   PUBMED   11013070
REFERENCE   7  (bases 1 to 4908)
  AUTHORS   Doyle,J.L., DeSilva,U., Miller,W. and Green,E.D.
  TITLE     Divergent human and mouse orthologs of a novel gene
            (WBSCR15/Wbscr15) reside within the genomic interval commonly
            deleted in Williams syndrome
  JOURNAL   Cytogenet Cell Genet 90 (3-4), 285-290 (2000)
   PUBMED   11124535
REFERENCE   8  (bases 1 to 4908)
  AUTHORS   DeSilva,U., Massa,H., Trask,B.J. and Green,E.D.
  TITLE     Comparative mapping of the region of human chromosome 7 deleted in
            williams syndrome
  JOURNAL   Genome Res 9 (5), 428-436 (1999)
   PUBMED   10330122
REFERENCE   9  (bases 1 to 4908)
  AUTHORS   Hoogenraad,C.C., Eussen,B.H., Langeveld,A., van Haperen,R.,
            Winterberg,S., Wouters,C.H., Grosveld,F., De Zeeuw,C.I. and
            Galjart,N.
  TITLE     The murine CYLN2 gene: genomic organization, chromosome
            localization, and comparison to the human gene that is located
            within the 7q11.23 Williams syndrome critical region
  JOURNAL   Genomics 53 (3), 348-358 (1998)
   PUBMED   9799601
REFERENCE   10 (bases 1 to 4908)
  AUTHORS   De Zeeuw,C.I., Hoogenraad,C.C., Goedknegt,E., Hertzberg,E.,
            Neubauer,A., Grosveld,F. and Galjart,N.
  TITLE     CLIP-115, a novel brain-specific cytoplasmic linker protein,
            mediates the localization of dendritic lamellar bodies
  JOURNAL   Neuron 19 (6), 1187-1199 (1997)
   PUBMED   9427243
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC053048.1 and BC121191.1.
            
            On Oct 23, 2013 this sequence version replaced NM_001039162.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. It encodes
            isoform b, which lacks an internal segment and is shorter, compared
            to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053048.1, BC039162.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3993              BC053048.1         1-3993
            3994-4908           BC121191.1         3638-4552
FEATURES             Location/Qualifiers
     source          1..4908
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 74.63 cM"
     gene            1..4908
                     /gene="Clip2"
                     /gene_synonym="B230327O20; CLIP-115; Clip1; Cyln2;
                     mKIAA0291; wbscr4; WSCR4"
                     /note="CAP-GLY domain containing linker protein 2"
                     /db_xref="GeneID:269713"
                     /db_xref="MGI:MGI:1313136"
     exon            1..389
                     /gene="Clip2"
                     /gene_synonym="B230327O20; CLIP-115; Clip1; Cyln2;
                     mKIAA0291; wbscr4; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            390..580
                     /gene="Clip2"
                     /gene_synonym="B230327O20; CLIP-115; Clip1; Cyln2;
                     mKIAA0291; wbscr4; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..3495
                     /gene="Clip2"
                     /gene_synonym="B230327O20; CLIP-115; Clip1; Cyln2;
                     mKIAA0291; wbscr4; WSCR4"
                     /note="isoform b is encoded by transcript variant 2;
                     CAP-Gly domain-containing linker protein 2; cytoplasmic
                     linker protein 2; cytoplasmic linker protein 1, 115 kDa"
                     /codon_start=1
                     /product="CAP-Gly domain-containing linker protein 2
                     isoform b"
                     /protein_id="NP_001034251.1"
                     /db_xref="CCDS:CCDS39309.1"
                     /db_xref="GeneID:269713"
                     /db_xref="MGI:MGI:1313136"
                     /translation="MQKPSGLKPPGRGGKHSSPVGRPSVGSASSSVVASTSGSKEGSP
                     LHKQASGPSSSGAATTVSEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGET
                     QFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDTH
                     SVESLTAQNLSLHSGTATPPLTGRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGDK
                     DLHLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPK
                     FGLFAPIHKVIRIGFPSTSPAKAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGR
                     PSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICE
                     VEKEIALLKAQHEQYVAEAEEKLQRARLLVENVRKEKVDLSNQLEEERRKVEDLQFRV
                     EEESITKGDLELTTVAEKSRVLQLEEELSLRRGEIEELQHCLLQSGPPPADHPEAAET
                     LRLRERLLSASKEHQRDSTLLQDKYEHMLKTYQTEVDKLRAANEKYAQEVADLKAKVQ
                     QATTENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKALVEGIKM
                     EHQLELGNLQAKHDLETAMHGKEKEGLRQKLQEVQEELAGLQQHWREQLEEQASQHRL
                     ELQEAQDQCRDAQLRAQELEGLDVEYRGQAQAIEFLKEQISLAEKKMLDYEMLQRAEA
                     QSRQEAERLREKLLVAENRLQAAESLCSAQHSHVIESSDLSEETIRMKETVEGLQDKL
                     NKRDKEVTALTSQMDMLRAQVSALENKCKSGEKKIDSLLKEKRRLEAELEAVSRKTHD
                     ASGQLVHISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKD
                     DIRGLREKLTGLDKEKSLSEQRRYSLIDPASPPELLKLQHQLVSTEDALRDALNQAQQ
                     VERLVEALRGCSDRTQTISNSGSANGIHQPDKAHKQEDKH"
     exon            581..1137
                     /gene="Clip2"
                     /gene_synonym="B230327O20; CLIP-115; Clip1; Cyln2;
                     mKIAA0291; wbscr4; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1262
                     /gene="Clip2"
                     /gene_synonym="B230327O20; CLIP-115; Clip1; Cyln2;
                     mKIAA0291; wbscr4; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1476
                     /gene="Clip2"
                     /gene_synonym="B230327O20; CLIP-115; Clip1; Cyln2;
                     mKIAA0291; wbscr4; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1674
                     /gene="Clip2"
                     /gene_synonym="B230327O20; CLIP-115; Clip1; Cyln2;
                     mKIAA0291; wbscr4; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1778
                     /gene="Clip2"
                     /gene_synonym="B230327O20; CLIP-115; Clip1; Cyln2;
                     mKIAA0291; wbscr4; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1839
                     /gene="Clip2"
                     /gene_synonym="B230327O20; CLIP-115; Clip1; Cyln2;
                     mKIAA0291; wbscr4; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..2775
                     /gene="Clip2"
                     /gene_synonym="B230327O20; CLIP-115; Clip1; Cyln2;
                     mKIAA0291; wbscr4; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2833
                     /gene="Clip2"
                     /gene_synonym="B230327O20; CLIP-115; Clip1; Cyln2;
                     mKIAA0291; wbscr4; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..2917
                     /gene="Clip2"
                     /gene_synonym="B230327O20; CLIP-115; Clip1; Cyln2;
                     mKIAA0291; wbscr4; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3074
                     /gene="Clip2"
                     /gene_synonym="B230327O20; CLIP-115; Clip1; Cyln2;
                     mKIAA0291; wbscr4; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3234
                     /gene="Clip2"
                     /gene_synonym="B230327O20; CLIP-115; Clip1; Cyln2;
                     mKIAA0291; wbscr4; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3235..3420
                     /gene="Clip2"
                     /gene_synonym="B230327O20; CLIP-115; Clip1; Cyln2;
                     mKIAA0291; wbscr4; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3421..3483
                     /gene="Clip2"
                     /gene_synonym="B230327O20; CLIP-115; Clip1; Cyln2;
                     mKIAA0291; wbscr4; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3484..4893
                     /gene="Clip2"
                     /gene_synonym="B230327O20; CLIP-115; Clip1; Cyln2;
                     mKIAA0291; wbscr4; WSCR4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4867..4872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clip2"
                     /gene_synonym="B230327O20; CLIP-115; Clip1; Cyln2;
                     mKIAA0291; wbscr4; WSCR4"
                     /note="hexamer: AATAAA"
     polyA_site      4893
                     /gene="Clip2"
                     /gene_synonym="B230327O20; CLIP-115; Clip1; Cyln2;
                     mKIAA0291; wbscr4; WSCR4"
                     /note="major polyA site"
ORIGIN      
        1 tttgttcgct ctctggccgc tgagctctcc tggcgctcgg cttctctcgg ctgggctcgg
       61 ctcaccttgg cagggctcca ccgggctccg ctctgctcgg tttctctcgc ctccgccccg
      121 tttggctcgg atcttcccgg ctcggccccg ctcggctcga ctcagctcgg ctccgcctcg
      181 gggcgcgcag gcagcggccg ggcttactgg atcggcccct ccctctatcc ccttctggac
      241 gtagatcctg tgcgaggccc ggactccgag cgcggagacc cggttagtgt atcggcgtga
      301 ggagaccggc gcagcatcct cgttcccggg acgcgcggac caagaggagg cgaggggtgt
      361 cgggtcctgg tcgctgctgg agctccaagg tgaccgagga tggcagagag gatgtgacca
      421 ttgtctgcct tggtctgccc ttctagtggc accgccatgc agaagcccag tggcctgaag
      481 ccccctggcc gaggggggaa gcactccagc cccgtgggca ggccgtccgt tgggtctgct
      541 tcatcttccg tggtggcctc gaccagtggc tccaaagaag ggtctcccct gcacaaacag
      601 gcatcgggcc cctcctcgtc tggagccgcc accaccgtct ctgagaagcc aggtccaaag
      661 gcggctgaag tgggtgatga cttcctggga gactttgtgg tgggcgagag ggtgtgggtg
      721 aatggcgtga agccaggcgt ggtgcagtac ctgggtgaga cacagtttgc gccaggccag
      781 tgggccggcg tggtcttgga cgacccggtg ggcaagaacg atggagctgt gggtggcgtg
      841 cgctacttcg agtgcccggc tctacagggc atcttcacgc ggccctccaa gctgacccgc
      901 cagcccaccg ctgagggctc gggcagtgat acgcactcgg tggaatccct cacggcccag
      961 aacctgtccc tgcattctgg cacggccacg cccccactca caggccgagt catccccctg
     1021 cgggagagtg ttcttaacag ctcagtgaag acgggcaatg agtctggttc caacctctcc
     1081 gacagtggtt ctgtgaagcg cggtgacaag gacctccacc tgggagaccg tgtgctggtt
     1141 ggtgggacga agaccggtgt ggtgcgatat gttggggaga cggactttgc caaaggcgag
     1201 tggtgtggtg tggagctgga tgagcccctc gggaagaacg acggggcggt ggcaggaacc
     1261 aggtacttcc agtgcccacc caagttcggt ctctttgcac caatccacaa ggtcatccga
     1321 attggcttcc catccaccag tccagccaag gccaagaaga ccaaacgcat ggccatgggt
     1381 gtctccgctt tgacccacag ccccagcagc tcttccatta gctctgtcag ctctgtggcc
     1441 tcctctgttg gtggccggcc cagccgcagt ggcctgctca cagagacctc ttcgcgctat
     1501 gcccggaaga tctcaggcac cacagctctg caggaggccc tgaaggagaa gcagcagcac
     1561 attgaacagc tgctggctga gcgcgacttg gagagagccg aagtagccaa ggctaccagc
     1621 catatctgtg aggtggagaa ggagatcgcc ctgctgaagg cacagcatga gcagtatgtt
     1681 gcagaagccg aggagaagct gcagcgggca cggttgctgg tggaaaacgt gaggaaagag
     1741 aaggtggatc tgtccaatca gctggaggag gagaggagga aggtggagga cctgcagttc
     1801 cgggtggaag aagaatccat caccaaagga gacttggagc tgaccacagt ggctgagaag
     1861 tctcgggtgc tgcagctgga agaagagttg agcctgcggc gtggtgagat cgaagagctg
     1921 caacactgtc tcctccagtc aggcccgcca cccgcagacc acccagaggc cgctgagact
     1981 ttgcggctgc gagagcggct gctgtcggct agcaaggagc accagcgaga cagtaccttg
     2041 ctccaggaca aatatgagca catgctaaag acctaccaga ccgaggtgga caagctccgg
     2101 gcggccaatg agaagtacgc tcaggaggtg gcagacctca aggccaaggt ccagcaggcc
     2161 accacggaaa acatggggct catggacaac tggaaatcca agctggactc gctggcctcc
     2221 gatcaccaga aatccctgga ggacctgaag gccacgctga actctggccc aggcgcccag
     2281 cagaaggaga tcggagagtt gaaggccctg gtagagggca tcaagatgga gcaccagctg
     2341 gagttaggta acctgcaggc caagcacgac ttggagacgg ccatgcatgg gaaggagaag
     2401 gagggcctgc ggcagaagct gcaagaggtc caggaggagc tggccgggct gcagcagcac
     2461 tggagggagc agctggagga gcaggccagc cagcatcggc tggagctcca agaagcccag
     2521 gaccaatgtc gcgacgccca gctgcgcgcg caggagctag agggactgga tgtggagtac
     2581 cgtggccagg ctcaagccat cgagttcctc aaagagcaga tctcactggc tgaaaagaag
     2641 atgctagatt acgagatgct gcagagggcc gaagcccaga gcaggcagga ggccgagcgg
     2701 ctgcgggaaa agcttctggt ggctgagaat agactccagg ctgccgagtc cctgtgctca
     2761 gcccagcaca gccatgtgat cgaatccagt gacctttctg aggagacaat tcggatgaag
     2821 gagactgtag agggcctgca ggacaagctg aacaagaggg acaaagaggt gacagccttg
     2881 acatcccaga tggacatgct cagggcccaa gtaagtgctc tagaaaacaa gtgcaaatca
     2941 ggagagaaga agatagattc tctcctgaag gagaagaggc gcctagaggc agagctggag
     3001 gctgtgtctc ggaagaccca cgatgcctcc ggccagctgg tccacatcag ccaggagttg
     3061 ctgcggaaag agaggagtct gaacgagctg agggtgttgc tgttagaagc caatcgccac
     3121 tccccagggc ccgagagaga cctgagccgt gaagtacaca aagctgaatg gcggataaag
     3181 gaacagaaac tgaaggatga catccggggc ctgcgtgaga agctgaccgg gctggacaag
     3241 gagaagtccc tatcagagca gagacgctac tccctcattg acccagcttc accacccgag
     3301 ctgctgaaac tgcagcatca gttggtgagc acggaagacg ccctgcggga tgcgctgaac
     3361 caggcccagc aggtggagag gctggtggag gccctgaggg gctgctcaga caggactcag
     3421 accatcagca attccggttc tgccaacggt attcaccagc cagacaaggc ccacaaacag
     3481 gaggacaaac actgaccgca agggacacca aggaccgacc ctactcacac cagaagccct
     3541 accaggcttc ccagcagcgc caccttcagg caggagtcag aactgtcccc ttggagatgt
     3601 gactgtgttt gtaacaatat tgtcctcact gccgtggaca cgtggacacg tcccacctga
     3661 accccctgcc ggaccaggag gctcccacag acacggcctt ccacagagcg cggtacagct
     3721 gggcccagcc ctggagaacc tctcttgtcc caaggagctt cgtgaactgg cagaggctga
     3781 agcgatccag ttgggcctct cttgactata gcaggctgct gctgcggctt gtctggacac
     3841 ctggggactt ccccgcctcc cttcccttct gtgtccccag gtcccccgca ggcccctgag
     3901 ggatggagca gggcccctgc ttggacacag aacacaccaa gaagggcttc agaaactagg
     3961 gagggaatgc ttgactccac gcattgagcc cctcctacac attggtacaa ggtcgcttag
     4021 gcccctctag tcagggaaga tttgggggtg acaggctcct tagtcctcga caccaagcta
     4081 gtatgcgtta cccacctccc atctgctgcc cggaaggcac tgagcagaca gcttcagtat
     4141 tcagcgagca cgcgaaccca cgcttcttac ctttaccttg agctgggact ggcttggggc
     4201 ttagaaccaa gaacaggtag aaaattcctt aaacaaagca ttcctacagc gttttgctgg
     4261 gtgagaggaa tcaaactggt tccctttctt tctgggaacc cctgccatgt tactctaaag
     4321 accccagcaa cccagagaga gccctgcttc catcttccca gggcaggacc acagtggtaa
     4381 atcctaagga tggcccaggt ggcctgtgtg agcgccacta ggcaccagaa ggtggcgctc
     4441 acgctctcgt ccttagggag gagctgactt agcagcccct cagcccaacc ccctgcttcc
     4501 tgttggcttt tgggtagcac ttgccattaa caacagcagc ctagaactga cgctttagtg
     4561 gcccgtctgc agagccaaat cttgctcttt ccagcacaat cgggcagctc acggattagg
     4621 aattaacagc caaaggctcc cacggaaggg accagaaggg gctgagcccc accctggagt
     4681 gggcttgcac ctggtaggtg tgcaagaagc catttcccca taagcactgg cctttgatgg
     4741 ccccctcagc ctacctggtg tggccaccca gctgtggctc agccatcccc gccctccctc
     4801 cgctccccct ccccctccct ctccccccag tggaattgtg gaagtgtggc aagtccatgt
     4861 tcggacaata aagcttgtga ttgaggttca ggaaaaaaaa aaaaaaaa
//
