LOCUS       NM_019765               5877 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  Mus musculus CAP-GLY domain containing linker protein 1 (Clip1),
            transcript variant 1, mRNA.
ACCESSION   NM_019765
VERSION     NM_019765.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5877)
  AUTHORS   Barbiero,I., Zamberletti,E., Tramarin,M., Gabaglio,M., Peroni,D.,
            De Rosa,R., Baldin,S., Bianchi,M., Rubino,T. and
            Kilstrup-Nielsen,C.
  TITLE     Pregnenolone-methyl-ether enhances CLIP170 and microtubule
            functions improving spine maturation and hippocampal deficits
            related to CDKL5 deficiency
  JOURNAL   Hum Mol Genet 31 (16), 2738-2750 (2022)
   PUBMED   35348691
  REMARK    GeneRIF: Pregnenolone-methyl-ether enhances CLIP170 and microtubule
            functions improving spine maturation and hippocampal deficits
            related to CDKL5 deficiency.
REFERENCE   2  (bases 1 to 5877)
  AUTHORS   Yashirogi,S., Nagao,T., Nishida,Y., Takahashi,Y., Qaqorh,T.,
            Yazawa,I., Katayama,T., Kioka,H., Matsui,T.S., Saito,S.,
            Masumura,Y., Tsukamoto,O., Kato,H., Ueda,H., Yamaguchi,O.,
            Yashiro,K., Yamazaki,S., Takashima,S. and Shintani,Y.
  TITLE     AMPK regulates cell shape of cardiomyocytes by modulating turnover
            of microtubules through CLIP-170
  JOURNAL   EMBO Rep 22 (1), e50949 (2021)
   PUBMED   33251722
  REMARK    GeneRIF: AMPK regulates cell shape of cardiomyocytes by modulating
            turnover of microtubules through CLIP-170.
REFERENCE   3  (bases 1 to 5877)
  AUTHORS   Henrie,H., Bakhos-Douaihy,D., Cantaloube,I., Pilon,A.,
            Talantikite,M., Stoppin-Mellet,V., Baillet,A., Pous,C. and
            Benoit,B.
  TITLE     Stress-induced phosphorylation of CLIP-170 by JNK promotes
            microtubule rescue
  JOURNAL   J Cell Biol 219 (7) (2020)
   PUBMED   32491151
  REMARK    GeneRIF: Stress-induced phosphorylation of CLIP-170 by JNK promotes
            microtubule rescue.
REFERENCE   4  (bases 1 to 5877)
  AUTHORS   Timmermans,S. and Libert,C.
  TITLE     Overview of inactivating mutations in the protein-coding genome of
            the mouse reference strain C57BL/6J
  JOURNAL   JCI Insight 3 (13), 121758 (2018)
   PUBMED   29997285
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5877)
  AUTHORS   Jakka,P., Bhargavi,B., Namani,S., Murugan,S., Splitter,G. and
            Radhakrishnan,G.
  TITLE     Cytoplasmic Linker Protein CLIP170 Negatively Regulates TLR4
            Signaling by Targeting the TLR Adaptor Protein TIRAP
  JOURNAL   J Immunol 200 (2), 704-714 (2018)
   PUBMED   29222167
  REMARK    GeneRIF: we report an unexpected finding that CLIP170 negatively
            regulates TLR4 signaling by the targeted ubiquitination and
            degradation of TIRAP. Furthermore, we observed that CLIP170
            expression is modulated by LPS to maintain the cellular
            homeostasis.
REFERENCE   6  (bases 1 to 5877)
  AUTHORS   Lansbergen,G., Komarova,Y., Modesti,M., Wyman,C., Hoogenraad,C.C.,
            Goodson,H.V., Lemaitre,R.P., Drechsel,D.N., van Munster,E.,
            Gadella,T.W. Jr., Grosveld,F., Galjart,N., Borisy,G.G. and
            Akhmanova,A.
  TITLE     Conformational changes in CLIP-170 regulate its binding to
            microtubules and dynactin localization
  JOURNAL   J Cell Biol 166 (7), 1003-1014 (2004)
   PUBMED   15381688
REFERENCE   7  (bases 1 to 5877)
  AUTHORS   Cahana,A., Jin,X.L., Reiner,O., Wynshaw-Boris,A. and O'Neill,C.
  TITLE     A study of the nature of embryonic lethality in LIS1-/- mice
  JOURNAL   Mol Reprod Dev 66 (2), 134-142 (2003)
   PUBMED   12950100
REFERENCE   8  (bases 1 to 5877)
  AUTHORS   Coquelle,F.M., Caspi,M., Cordelieres,F.P., Dompierre,J.P.,
            Dujardin,D.L., Koifman,C., Martin,P., Hoogenraad,C.C.,
            Akhmanova,A., Galjart,N., De Mey,J.R. and Reiner,O.
  TITLE     LIS1, CLIP-170's key to the dynein/dynactin pathway
  JOURNAL   Mol Cell Biol 22 (9), 3089-3102 (2002)
   PUBMED   11940666
REFERENCE   9  (bases 1 to 5877)
  AUTHORS   Tarsounas,M., Pearlman,R.E. and Moens,P.B.
  TITLE     CLIP-50 immunolocalization during mouse spermiogenesis suggests a
            role in shaping the sperm nucleus
  JOURNAL   Dev Biol 236 (2), 400-410 (2001)
   PUBMED   11476580
REFERENCE   10 (bases 1 to 5877)
  AUTHORS   Akhmanova,A., Hoogenraad,C.C., Drabek,K., Stepanova,T.,
            Dortland,B., Verkerk,T., Vermeulen,W., Burgering,B.M., De
            Zeeuw,C.I., Grosveld,F. and Galjart,N.
  TITLE     Clasps are CLIP-115 and -170 associating proteins involved in the
            regional regulation of microtubule dynamics in motile fibroblasts
  JOURNAL   Cell 104 (6), 923-935 (2001)
   PUBMED   11290329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129569.17.
            
            [WARNING] On Mar 8, 2024 this sequence was replaced by NM_019765.6.
            
            On Mar 29, 2014 this sequence version replaced NM_019765.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007191.1, SRR10223969.6047.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AC129569.17        35019-35128
            111-303             AC129569.17        63294-63486
            304-872             AC129569.17        65360-65928
            873-997             AC129569.17        71415-71539
            998-1220            AC129569.17        73075-73297
            1221-1418           AC129569.17        76764-76961
            1419-1522           AC129569.17        77499-77602
            1523-1583           AC129569.17        78826-78886
            1584-2528           AC129569.17        88211-89155
            2529-2645           AC129569.17        91970-92086
            2646-2703           AC129569.17        96110-96167
            2704-2787           AC129569.17        96541-96624
            2788-2944           AC129569.17        97428-97584
            2945-3110           AC129569.17        101558-101723
            3111-3326           AC129569.17        101829-102044
            3327-3443           AC129569.17        107442-107558
            3444-3550           AC129569.17        110035-110141
            3551-3671           AC129569.17        115661-115781
            3672-3724           AC129569.17        128535-128587
            3725-3842           AC129569.17        135742-135859
            3843-3993           AC129569.17        135946-136096
            3994-4043           AC129569.17        136611-136660
            4044-4168           AC129569.17        139256-139380
            4169-5877           AC129569.17        139878-141586
FEATURES             Location/Qualifiers
     source          1..5877
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 63.06 cM"
     gene            1..5877
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /note="CAP-GLY domain containing linker protein 1"
                     /db_xref="GeneID:56430"
                     /db_xref="MGI:MGI:1928401"
     exon            1..110
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            111..303
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..4394
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /note="isoform a is encoded by transcript variant 1;
                     restin (Reed-Steinberg cell-expressed intermediate
                     filament-associated protein); cytoplasmic linker protein
                     50; Reed-Steinberg cell-espressed intermediate
                     filament-associated protein; CAP-Gly domain-containing
                     linker protein 1; Clip 170; cytoplasmic linker protein
                     170"
                     /codon_start=1
                     /product="CAP-Gly domain-containing linker protein 1
                     isoform a"
                     /protein_id="NP_062739.2"
                     /db_xref="CCDS:CCDS19667.1"
                     /db_xref="GeneID:56430"
                     /db_xref="MGI:MGI:1928401"
                     /translation="MSMLKPSGLKAPTKILKPGSTALKTPAAAAAPVEKTIPSEKASG
                     PPSSETQEEFVDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGS
                     VAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQAAPGRTASPLSTAAATMVSSSP
                     ATPSNIPHKPSQSTAKEPSATPQISNLTKTASESISNLSEAGSVKKGERELKVGDRVL
                     VGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHK
                     VTKIGFPSTTPAKAKAAAVRRVMAATPASLKRSPSASSLSSMSSVASSVSSKPSRTGL
                     LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELA
                     LARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESIT
                     KGDLEVATVSEKSRIMELEKDLALRAQEVAELRRRLESSKPPGDVDMSLSLLQEISAL
                     QEKLEAIHTDHQGEMTSLKEHFGAREEAFQKEIKALHTATEKLSKENESLRSKLDHAN
                     KENSDVIALWKSKLETAIASHQQAMEELKVSFSKGIGTDSAEFAELKTQIERLRLDYQ
                     HEIESLQSKQDSERSAHAKEMETMQAKLMKIIKEKEDSLEAVKARLDSAEDQHLVEME
                     DTLNKLQEAEIKVKELEVLQAKYTEQSEVIGNFTSQLSAVKEKLLDLDALRKANSEGK
                     LELETLRQQLEGAEKQIKNLETERNAESSKANSITKELQEKELVLTGLQDSLNQVNQV
                     KETLEKELQTLKEKFASTSEEAVSAQTRMQDTVNKLHQKEEQFNVLSSELEKLRENLT
                     DMEAKFKEKDDREDQLVKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERSVEEL
                     QLKLTKANENASFLQKSIGEVTLKAEQSQQQAARKHEEEKKELEEKLLELEKKMETSY
                     NQCQDLKAKYEKASSETKTKHEEILQNLQKMLADTEDKLKAAQEANRDLMQDMEELKT
                     QADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNARLQNELDTLKENNLKTVE
                     ELNKSKELLSVENQKMEEFKKEIETLKQAAAQKSQQLSALQEENVKLAEELGRTRDEV
                     TSHQKLEEERSVLNNQLLEMKKRESEFRKDADEEKASLQKSISLTSALLTEKDAELEK
                     LRNEVTVLRGENATAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTD
                     AQAEEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGEDLNSYDSDDQ
                     EKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRSEERPYCEICEMF
                     GHWATNCNDDETF"
     exon            304..872
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            873..997
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1220
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1418
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1522
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1583
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..2528
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2645
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2703
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2787
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2944
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2945..3110
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3111..3326
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3327..3443
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3444..3550
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3551..3671
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3672..3724
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3725..3842
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3843..3993
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3994..4043
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            4044..4168
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            4169..5877
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttccccg ccccgagccg aagagccggg gaggcgggag gcggcggccg cggcggctgc
       61 tgctgctgct gctgggaggc aggtgacggc gaccagcggc gtcccaggcg atttgaccga
      121 gaggctgagt tctctatagg aacacccaca tttgtatgga tgagtgggga aagatagcgg
      181 cagcagacaa ggaaaaagcg tcctgacctc ccgagaacat gagtatgcta aaacccagcg
      241 gcctgaaggc ccctaccaag atccttaagc cgggaagcac agccttgaag acgcctgctg
      301 ctgctgcagc tccagtggag aagacaatac ccagtgagaa agcctcgggc cctccatcct
      361 ccgagaccca agaggagttt gtggatgact ttcgagttgg agaacgtgtt tgggtgaacg
      421 ggaataagcc cggatttatc cagtttcttg gggaaactca gttcgcacca ggccagtggg
      481 ctgggattgt tttagatgaa cccataggga agaacgatgg ctctgtggcg ggagtgcggt
      541 atttccagtg tgaaccttta aagggcatat tcacccgacc ttcaaagcta acgaggaagg
      601 tgcaggcaga agatgaagcc aacggcctgc aggcagctcc tgggagaact gcttcacctc
      661 tgtccactgc tgcagctacc atggtgtctt cttctccagc cactccctca aatattcccc
      721 acaaaccgtc ccagtcaacg gcaaaagaac cttcggctac acctcaaatt agcaacctca
      781 caaaaactgc cagtgagtcg atctccaacc tttcagaggc tggctctgtc aagaaggggg
      841 agcgggagct caaggtcgga gacagggtgc tggttggtgg cactaaggct ggcgtagtcc
      901 gctttcttgg cgagaccgac tttgccaagg gggagtggtg tggtgtggag ttagacgagc
      961 ctttggggaa gaacgatggt gctgtggccg gaacaaggta ttttcagtgt caacccaaat
     1021 atggattgtt cgctcctgtc cacaaagtga caaagattgg cttcccgtct actaccccag
     1081 ccaaagccaa agccgccgct gtgaggcgag tgatggccgc cacgcccgcc agcctgaagc
     1141 gaagcccttc tgcctcctcc ctcagctcca tgagctccgt ggcctcctct gtgagcagca
     1201 aacccagccg gacaggacta ttgactgaaa cctcctcccg ctacgcccgc aagatctcgg
     1261 gcaccactgc cctccaggag gcgctgaagg agaagcagca gcacattgag cagctgctgg
     1321 ctgagcggga cctggagcgg gccgaggtgg ccaaggctac cagccacgtg ggggaaatag
     1381 agcaggagct agccctggcc cgagatgggc atgaccagca tgtcctggaa ctagaggcca
     1441 agatggacca gctacggacc atggtggaag ctgctgacag ggagaaagtg gagctgctca
     1501 accagctgga agaggagaag aggaaggttg aggaccttca gttccgagtt gaagaagaat
     1561 caattaccaa aggcgatctt gaggtggcta ccgtctcaga aaagtcccga ataatggaac
     1621 tagaaaagga cctagcattg agagcacagg aagtagctga gctccgaaga aggctagagt
     1681 ccagtaaacc tcctggggat gtggatatgt ctctctccct tttgcaagaa ataagtgctt
     1741 tgcaagaaaa gctagaagcc atccatactg accaccaggg cgagatgact tctttgaagg
     1801 aacacttcgg agctcgagag gaggcgtttc agaaggagat caaggctctg cacacggcca
     1861 ctgagaagct ttccaaagag aacgagtccc tgagaagcaa gctcgaccac gctaataagg
     1921 agaactccga tgtgatagct ctatggaagt ccaaactgga gaccgccata gcatcccacc
     1981 agcaggcaat ggaggagctg aaggtgtcct ttagcaaagg cattggaacg gactccgctg
     2041 aatttgctga gttaaagaca cagatagaga gactgagact agattaccag cacgaaatag
     2101 aaagtttaca gagtaaacag gactctgagc ggtctgctca tgctaaagag atggagacca
     2161 tgcaggccaa gctgatgaag atcattaaag agaaggagga cagcctggag gccgtcaaag
     2221 cgagactgga cagtgcagaa gaccagcacc tagtggaaat ggaggacacg ctaaacaaac
     2281 tgcaggaggc ggagattaag gtaaaggagc tagaggttct gcaggccaag tacactgaac
     2341 aaagcgaggt cattggtaat tttacatcgc agctcagtgc tgtcaaagaa aagctcttgg
     2401 atcttgatgc gcttcggaaa gccaattccg aaggtaaact ggagctcgag acacttagac
     2461 agcagcttga gggagctgaa aagcagatta aaaacttaga gactgaaagg aacgctgaaa
     2521 gtagcaaggc taatagcatt accaaagagc tccaggagaa agagctagtg ctcactggtc
     2581 tgcaggacag tttgaatcaa gtcaatcaag tgaaggagac tttggagaaa gaacttcaga
     2641 ctttgaaaga aaagtttgcc agtacttcag aggaggcggt ctctgctcag acaaggatgc
     2701 aagataccgt aaataaactg caccaaaagg aggaacagtt taacgtgttg tcgtctgaac
     2761 tggagaagtt gagagaaaat ttaacagaca tggaggcaaa atttaaagag aaggatgatc
     2821 gagaagatca gctggtaaag gcaaaggaaa aattagaaaa cgacattgca gaaataatga
     2881 agatgtcagg agataactct tctcagctga caaagatgaa tgatgaatta cgtctgaagg
     2941 aaagatccgt ggaagaactc cagctcaagc ttacaaaggc caatgaaaac gccagttttc
     3001 tgcagaagag tattggcgaa gtgactctta aagctgagca gagtcagcag caagcagcca
     3061 gaaaacatga agaagaaaag aaagagttgg aggaaaaact gttggaactg gaaaagaaga
     3121 tggaaacaag ctacaaccag tgtcaggacc tgaaagctaa gtatgaaaaa gccagttctg
     3181 agactaaaac aaagcatgaa gaaatcctgc agaacctcca gaagatgctg gcggacacag
     3241 aggataagct gaaggctgct caggaggcga acagagatct gatgcaggac atggaggagc
     3301 tgaaaacaca ggccgacaaa gccaaagctg ctcagactgc agaagacgcc atgcagatca
     3361 tggaacagat gaccaaagag aaaacagaaa cgctggcctc cttggaggac accaagcaaa
     3421 caaatgcaag actacagaat gaattggaca cacttaagga aaacaacttg aaaactgtgg
     3481 aagagctgaa caagtcaaaa gaactgctga gtgtagagaa ccaaaaaatg gaagaattca
     3541 agaaagaaat agaaacccta aagcaggcag cagctcagaa gtcccagcag ctttcagcac
     3601 tgcaggaaga gaacgtcaaa cttgccgagg agctggggag aacccgggac gaagtcacaa
     3661 gtcaccagaa gctggaagaa gaacgatctg tactcaataa tcagttgtta gaaatgaaaa
     3721 agagagaatc tgagttcaga aaagacgccg atgaagagaa agcctccttg cagaagtcga
     3781 tcagcctcac cagtgccttg ctcacagaga aggacgcgga gctggagaag ctgaggaatg
     3841 aggtcacagt gctcagggga gagaatgcca ccgccaagtc cctgcactca gttgtgcaga
     3901 cactggagtc tgataaggtg aagcttgagc tcaaggtcaa aaacttggaa cttcaactca
     3961 aggagaacaa gaggcagctc agcagctcct caggtaacac tgatgctcag gcggaagagg
     4021 atgagagagc ccaggagagt cagattgatt tcctcaactc ggtaatagtg gatcttcaaa
     4081 gaaagaacca agacctcaag atgaaggtgg agatgatgtc tgaagctgca ctcaatggca
     4141 acggggaaga cctgaacagt tatgacagtg atgaccagga aaagcagtcc aagaagaaac
     4201 cccgcctctt ctgtgacatc tgtgactgct ttgacctcca cgatacagag gactgtccca
     4261 cccaggcaca gatgtcggaa gatcctcccc attccactca ccatggcagc cggagcgagg
     4321 agcggccata ctgtgagatc tgtgagatgt ttgggcactg ggcaaccaac tgcaatgacg
     4381 acgagacctt ctgaggaagc cgggagggca ggaagggctt ccccgacaaa cgccggctcc
     4441 tcagcagctc ccgccagcat tggtgtgcaa cttcagaaga gctccttatt ttttgacccc
     4501 tgtcaacaaa tctgagaaaa tattttgatc ttcaacaagt ttccctttca tttcccctcg
     4561 taagttaaaa taataataaa tatttggtag gtgggcttgc acttccgtcc ttgttttctg
     4621 gatttttaag gtttaagaca ttgtaccagg cacagttcct gtttgttcct agagaaaccc
     4681 tctgggacaa gtgggaccct ggcagtatct tatttaggaa acttcaaatg atgccgttga
     4741 ctctcatgtt tgcactaaaa tgtttcctgg ctacatctgt atatttaggt tgttgttgtt
     4801 gttgttatgc tttgacactg gaatgagttg caaaaaaacc ctgtgccact ttgtgatttc
     4861 ctgcctcatt taaatactct catctctaaa ccccaagctc ttctcttcgc actccctgct
     4921 ctcaggaggg cctttttcca ggcttgacaa tacttaggtg tgactataaa tcatgaaaac
     4981 aggtaaaagg gaggggaaag cccgaactgc tgtggggaca ttttctaatc tatatgctgc
     5041 acccatggac cgacagtggt gttttcttta ctggttttac ataatttcaa cgtctatata
     5101 ttatatgtgt atatattttt aaaagaatct atattttggg aaaaagtcta tacaatgtgt
     5161 cttcttttca gattttttta cctttatgaa aaagaaaaca tctaaaggct caccagcatg
     5221 tgactgactg ggcccaagat gggctctgcg gtggtctctg ctgtgaggtt ccagctatcg
     5281 tctttgtctc catgatgttt cttagccaga tcggagtagc tggaagaaca gtctccggct
     5341 ccttgcttgt gtttcccttc cttagcagat aaccccagca gcaaactaag ccactcttca
     5401 gagagctaag ctaactgatc tacaaccctc ctttatacat ttgtggggtg tgtttgtttg
     5461 tttgtttttt actgtatttt taaatgaatg tatgatgaga aattcaacat gaataatttt
     5521 ggattttctt atcacaaaaa agataaaaca aaggacctca accaactgaa gagttgaccc
     5581 cgccagtctg cgtctctctg tcttcacttg aatgtctttg agaatatgta aaaaggagcc
     5641 acatgcacct ccacgcagtg tgcaggacga gaacttccgt cattgtatat aggcctctgc
     5701 cccgtctccc cttaaggtta tccactgtgc ttgatgagtg agcagtcaat acatctgctg
     5761 cccgtcggca ttctgggtta ataaaactat aggaattatt tcacaaacaa actatggaaa
     5821 gcagtattaa aatctgagtt ctgtatctac tttaataaat gttttgggtc tctttgg
//
