LOCUS       NM_001359224            3664 bp    mRNA    linear   ROD 08-FEB-2024
DEFINITION  Mus musculus CAP-GLY domain containing linker protein 1 (Clip1),
            transcript variant 8, mRNA.
ACCESSION   NM_001359224 XM_017321031
VERSION     NM_001359224.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3664)
  AUTHORS   Barbiero,I., Zamberletti,E., Tramarin,M., Gabaglio,M., Peroni,D.,
            De Rosa,R., Baldin,S., Bianchi,M., Rubino,T. and
            Kilstrup-Nielsen,C.
  TITLE     Pregnenolone-methyl-ether enhances CLIP170 and microtubule
            functions improving spine maturation and hippocampal deficits
            related to CDKL5 deficiency
  JOURNAL   Hum Mol Genet 31 (16), 2738-2750 (2022)
   PUBMED   35348691
  REMARK    GeneRIF: Pregnenolone-methyl-ether enhances CLIP170 and microtubule
            functions improving spine maturation and hippocampal deficits
            related to CDKL5 deficiency.
REFERENCE   2  (bases 1 to 3664)
  AUTHORS   Yashirogi,S., Nagao,T., Nishida,Y., Takahashi,Y., Qaqorh,T.,
            Yazawa,I., Katayama,T., Kioka,H., Matsui,T.S., Saito,S.,
            Masumura,Y., Tsukamoto,O., Kato,H., Ueda,H., Yamaguchi,O.,
            Yashiro,K., Yamazaki,S., Takashima,S. and Shintani,Y.
  TITLE     AMPK regulates cell shape of cardiomyocytes by modulating turnover
            of microtubules through CLIP-170
  JOURNAL   EMBO Rep 22 (1), e50949 (2021)
   PUBMED   33251722
  REMARK    GeneRIF: AMPK regulates cell shape of cardiomyocytes by modulating
            turnover of microtubules through CLIP-170.
REFERENCE   3  (bases 1 to 3664)
  AUTHORS   Henrie,H., Bakhos-Douaihy,D., Cantaloube,I., Pilon,A.,
            Talantikite,M., Stoppin-Mellet,V., Baillet,A., Pous,C. and
            Benoit,B.
  TITLE     Stress-induced phosphorylation of CLIP-170 by JNK promotes
            microtubule rescue
  JOURNAL   J Cell Biol 219 (7) (2020)
   PUBMED   32491151
  REMARK    GeneRIF: Stress-induced phosphorylation of CLIP-170 by JNK promotes
            microtubule rescue.
REFERENCE   4  (bases 1 to 3664)
  AUTHORS   Timmermans,S. and Libert,C.
  TITLE     Overview of inactivating mutations in the protein-coding genome of
            the mouse reference strain C57BL/6J
  JOURNAL   JCI Insight 3 (13), 121758 (2018)
   PUBMED   29997285
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3664)
  AUTHORS   Jakka,P., Bhargavi,B., Namani,S., Murugan,S., Splitter,G. and
            Radhakrishnan,G.
  TITLE     Cytoplasmic Linker Protein CLIP170 Negatively Regulates TLR4
            Signaling by Targeting the TLR Adaptor Protein TIRAP
  JOURNAL   J Immunol 200 (2), 704-714 (2018)
   PUBMED   29222167
  REMARK    GeneRIF: we report an unexpected finding that CLIP170 negatively
            regulates TLR4 signaling by the targeted ubiquitination and
            degradation of TIRAP. Furthermore, we observed that CLIP170
            expression is modulated by LPS to maintain the cellular
            homeostasis.
REFERENCE   6  (bases 1 to 3664)
  AUTHORS   Lansbergen,G., Komarova,Y., Modesti,M., Wyman,C., Hoogenraad,C.C.,
            Goodson,H.V., Lemaitre,R.P., Drechsel,D.N., van Munster,E.,
            Gadella,T.W. Jr., Grosveld,F., Galjart,N., Borisy,G.G. and
            Akhmanova,A.
  TITLE     Conformational changes in CLIP-170 regulate its binding to
            microtubules and dynactin localization
  JOURNAL   J Cell Biol 166 (7), 1003-1014 (2004)
   PUBMED   15381688
REFERENCE   7  (bases 1 to 3664)
  AUTHORS   Cahana,A., Jin,X.L., Reiner,O., Wynshaw-Boris,A. and O'Neill,C.
  TITLE     A study of the nature of embryonic lethality in LIS1-/- mice
  JOURNAL   Mol Reprod Dev 66 (2), 134-142 (2003)
   PUBMED   12950100
REFERENCE   8  (bases 1 to 3664)
  AUTHORS   Coquelle,F.M., Caspi,M., Cordelieres,F.P., Dompierre,J.P.,
            Dujardin,D.L., Koifman,C., Martin,P., Hoogenraad,C.C.,
            Akhmanova,A., Galjart,N., De Mey,J.R. and Reiner,O.
  TITLE     LIS1, CLIP-170's key to the dynein/dynactin pathway
  JOURNAL   Mol Cell Biol 22 (9), 3089-3102 (2002)
   PUBMED   11940666
REFERENCE   9  (bases 1 to 3664)
  AUTHORS   Tarsounas,M., Pearlman,R.E. and Moens,P.B.
  TITLE     CLIP-50 immunolocalization during mouse spermiogenesis suggests a
            role in shaping the sperm nucleus
  JOURNAL   Dev Biol 236 (2), 400-410 (2001)
   PUBMED   11476580
REFERENCE   10 (bases 1 to 3664)
  AUTHORS   Akhmanova,A., Hoogenraad,C.C., Drabek,K., Stepanova,T.,
            Dortland,B., Verkerk,T., Vermeulen,W., Burgering,B.M., De
            Zeeuw,C.I., Grosveld,F. and Galjart,N.
  TITLE     Clasps are CLIP-115 and -170 associating proteins involved in the
            regional regulation of microtubule dynamics in motile fibroblasts
  JOURNAL   Cell 104 (6), 923-935 (2001)
   PUBMED   11290329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129569.17.
            
            [WARNING] On Mar 8, 2024 this sequence was replaced by
            NM_001359224.2.
            
            On Dec 29, 2017 this sequence version replaced XM_017321031.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.152818.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AC129569.17        35019-35128
            111-303             AC129569.17        63294-63486
            304-872             AC129569.17        65360-65928
            873-997             AC129569.17        71415-71539
            998-1220            AC129569.17        73075-73297
            1221-1418           AC129569.17        76764-76961
            1419-1522           AC129569.17        77499-77602
            1523-1583           AC129569.17        78826-78886
            1584-2528           AC129569.17        88211-89155
            2529-2586           AC129569.17        96110-96167
            2587-2670           AC129569.17        96541-96624
            2671-2827           AC129569.17        97428-97584
            2828-2993           AC129569.17        101558-101723
            2994-3209           AC129569.17        101829-102044
            3210-3326           AC129569.17        107442-107558
            3327-3433           AC129569.17        110035-110141
            3434-3554           AC129569.17        115661-115781
            3555-3607           AC129569.17        128535-128587
            3608-3664           AC129569.17        132737-132793
FEATURES             Location/Qualifiers
     source          1..3664
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 63.06 cM"
     gene            1..3664
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /note="CAP-GLY domain containing linker protein 1"
                     /db_xref="GeneID:56430"
                     /db_xref="MGI:MGI:1928401"
     exon            1..110
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            111..303
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..3641
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /note="isoform h is encoded by transcript variant 8;
                     restin (Reed-Steinberg cell-expressed intermediate
                     filament-associated protein); cytoplasmic linker protein
                     50; Reed-Steinberg cell-espressed intermediate
                     filament-associated protein; CAP-Gly domain-containing
                     linker protein 1; Clip 170; cytoplasmic linker protein
                     170"
                     /codon_start=1
                     /product="CAP-Gly domain-containing linker protein 1
                     isoform h"
                     /protein_id="NP_001346153.1"
                     /db_xref="GeneID:56430"
                     /db_xref="MGI:MGI:1928401"
                     /translation="MSMLKPSGLKAPTKILKPGSTALKTPAAAAAPVEKTIPSEKASG
                     PPSSETQEEFVDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGS
                     VAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQAAPGRTASPLSTAAATMVSSSP
                     ATPSNIPHKPSQSTAKEPSATPQISNLTKTASESISNLSEAGSVKKGERELKVGDRVL
                     VGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHK
                     VTKIGFPSTTPAKAKAAAVRRVMAATPASLKRSPSASSLSSMSSVASSVSSKPSRTGL
                     LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELA
                     LARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESIT
                     KGDLEVATVSEKSRIMELEKDLALRAQEVAELRRRLESSKPPGDVDMSLSLLQEISAL
                     QEKLEAIHTDHQGEMTSLKEHFGAREEAFQKEIKALHTATEKLSKENESLRSKLDHAN
                     KENSDVIALWKSKLETAIASHQQAMEELKVSFSKGIGTDSAEFAELKTQIERLRLDYQ
                     HEIESLQSKQDSERSAHAKEMETMQAKLMKIIKEKEDSLEAVKARLDSAEDQHLVEME
                     DTLNKLQEAEIKVKELEVLQAKYTEQSEVIGNFTSQLSAVKEKLLDLDALRKANSEGK
                     LELETLRQQLEGAEKQIKNLETERNAESSKKEKFASTSEEAVSAQTRMQDTVNKLHQK
                     EEQFNVLSSELEKLRENLTDMEAKFKEKDDREDQLVKAKEKLENDIAEIMKMSGDNSS
                     QLTKMNDELRLKERSVEELQLKLTKANENASFLQKSIGEVTLKAEQSQQQAARKHEEE
                     KKELEEKLLELEKKMETSYNQCQDLKAKYEKASSETKTKHEEILQNLQKMLADTEDKL
                     KAAQEANRDLMQDMEELKTQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTN
                     ARLQNELDTLKENNLKTVEELNKSKELLSVENQKMEEFKKEIETLKQAAAQKSQQLSA
                     LQEENVKLAEELGRTRDEVTSHQKLEEERSVLNNQLLEMKKRLKKVYPRYNK"
     exon            304..872
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            873..997
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1220
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1418
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1522
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1583
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..2528
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2586
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2670
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2827
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..2993
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3209
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3326
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3327..3433
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3434..3554
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3555..3607
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3608..3664
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttccccg ccccgagccg aagagccggg gaggcgggag gcggcggccg cggcggctgc
       61 tgctgctgct gctgggaggc aggtgacggc gaccagcggc gtcccaggcg atttgaccga
      121 gaggctgagt tctctatagg aacacccaca tttgtatgga tgagtgggga aagatagcgg
      181 cagcagacaa ggaaaaagcg tcctgacctc ccgagaacat gagtatgcta aaacccagcg
      241 gcctgaaggc ccctaccaag atccttaagc cgggaagcac agccttgaag acgcctgctg
      301 ctgctgcagc tccagtggag aagacaatac ccagtgagaa agcctcgggc cctccatcct
      361 ccgagaccca agaggagttt gtggatgact ttcgagttgg agaacgtgtt tgggtgaacg
      421 ggaataagcc cggatttatc cagtttcttg gggaaactca gttcgcacca ggccagtggg
      481 ctgggattgt tttagatgaa cccataggga agaacgatgg ctctgtggcg ggagtgcggt
      541 atttccagtg tgaaccttta aagggcatat tcacccgacc ttcaaagcta acgaggaagg
      601 tgcaggcaga agatgaagcc aacggcctgc aggcagctcc tgggagaact gcttcacctc
      661 tgtccactgc tgcagctacc atggtgtctt cttctccagc cactccctca aatattcccc
      721 acaaaccgtc ccagtcaacg gcaaaagaac cttcggctac acctcaaatt agcaacctca
      781 caaaaactgc cagtgagtcg atctccaacc tttcagaggc tggctctgtc aagaaggggg
      841 agcgggagct caaggtcgga gacagggtgc tggttggtgg cactaaggct ggcgtagtcc
      901 gctttcttgg cgagaccgac tttgccaagg gggagtggtg tggtgtggag ttagacgagc
      961 ctttggggaa gaacgatggt gctgtggccg gaacaaggta ttttcagtgt caacccaaat
     1021 atggattgtt cgctcctgtc cacaaagtga caaagattgg cttcccgtct actaccccag
     1081 ccaaagccaa agccgccgct gtgaggcgag tgatggccgc cacgcccgcc agcctgaagc
     1141 gaagcccttc tgcctcctcc ctcagctcca tgagctccgt ggcctcctct gtgagcagca
     1201 aacccagccg gacaggacta ttgactgaaa cctcctcccg ctacgcccgc aagatctcgg
     1261 gcaccactgc cctccaggag gcgctgaagg agaagcagca gcacattgag cagctgctgg
     1321 ctgagcggga cctggagcgg gccgaggtgg ccaaggctac cagccacgtg ggggaaatag
     1381 agcaggagct agccctggcc cgagatgggc atgaccagca tgtcctggaa ctagaggcca
     1441 agatggacca gctacggacc atggtggaag ctgctgacag ggagaaagtg gagctgctca
     1501 accagctgga agaggagaag aggaaggttg aggaccttca gttccgagtt gaagaagaat
     1561 caattaccaa aggcgatctt gaggtggcta ccgtctcaga aaagtcccga ataatggaac
     1621 tagaaaagga cctagcattg agagcacagg aagtagctga gctccgaaga aggctagagt
     1681 ccagtaaacc tcctggggat gtggatatgt ctctctccct tttgcaagaa ataagtgctt
     1741 tgcaagaaaa gctagaagcc atccatactg accaccaggg cgagatgact tctttgaagg
     1801 aacacttcgg agctcgagag gaggcgtttc agaaggagat caaggctctg cacacggcca
     1861 ctgagaagct ttccaaagag aacgagtccc tgagaagcaa gctcgaccac gctaataagg
     1921 agaactccga tgtgatagct ctatggaagt ccaaactgga gaccgccata gcatcccacc
     1981 agcaggcaat ggaggagctg aaggtgtcct ttagcaaagg cattggaacg gactccgctg
     2041 aatttgctga gttaaagaca cagatagaga gactgagact agattaccag cacgaaatag
     2101 aaagtttaca gagtaaacag gactctgagc ggtctgctca tgctaaagag atggagacca
     2161 tgcaggccaa gctgatgaag atcattaaag agaaggagga cagcctggag gccgtcaaag
     2221 cgagactgga cagtgcagaa gaccagcacc tagtggaaat ggaggacacg ctaaacaaac
     2281 tgcaggaggc ggagattaag gtaaaggagc tagaggttct gcaggccaag tacactgaac
     2341 aaagcgaggt cattggtaat tttacatcgc agctcagtgc tgtcaaagaa aagctcttgg
     2401 atcttgatgc gcttcggaaa gccaattccg aaggtaaact ggagctcgag acacttagac
     2461 agcagcttga gggagctgaa aagcagatta aaaacttaga gactgaaagg aacgctgaaa
     2521 gtagcaagaa agaaaagttt gccagtactt cagaggaggc ggtctctgct cagacaagga
     2581 tgcaagatac cgtaaataaa ctgcaccaaa aggaggaaca gtttaacgtg ttgtcgtctg
     2641 aactggagaa gttgagagaa aatttaacag acatggaggc aaaatttaaa gagaaggatg
     2701 atcgagaaga tcagctggta aaggcaaagg aaaaattaga aaacgacatt gcagaaataa
     2761 tgaagatgtc aggagataac tcttctcagc tgacaaagat gaatgatgaa ttacgtctga
     2821 aggaaagatc cgtggaagaa ctccagctca agcttacaaa ggccaatgaa aacgccagtt
     2881 ttctgcagaa gagtattggc gaagtgactc ttaaagctga gcagagtcag cagcaagcag
     2941 ccagaaaaca tgaagaagaa aagaaagagt tggaggaaaa actgttggaa ctggaaaaga
     3001 agatggaaac aagctacaac cagtgtcagg acctgaaagc taagtatgaa aaagccagtt
     3061 ctgagactaa aacaaagcat gaagaaatcc tgcagaacct ccagaagatg ctggcggaca
     3121 cagaggataa gctgaaggct gctcaggagg cgaacagaga tctgatgcag gacatggagg
     3181 agctgaaaac acaggccgac aaagccaaag ctgctcagac tgcagaagac gccatgcaga
     3241 tcatggaaca gatgaccaaa gagaaaacag aaacgctggc ctccttggag gacaccaagc
     3301 aaacaaatgc aagactacag aatgaattgg acacacttaa ggaaaacaac ttgaaaactg
     3361 tggaagagct gaacaagtca aaagaactgc tgagtgtaga gaaccaaaaa atggaagaat
     3421 tcaagaaaga aatagaaacc ctaaagcagg cagcagctca gaagtcccag cagctttcag
     3481 cactgcagga agagaacgtc aaacttgccg aggagctggg gagaacccgg gacgaagtca
     3541 caagtcacca gaagctggaa gaagaacgat ctgtactcaa taatcagttg ttagaaatga
     3601 aaaagagact aaagaaagtc tatccacgtt ataataaata aacctcatat atttttagta
     3661 aacc
//
