LOCUS       NM_001291229            5649 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  Mus musculus CAP-GLY domain containing linker protein 1 (Clip1),
            transcript variant 2, mRNA.
ACCESSION   NM_001291229 XM_006530425
VERSION     NM_001291229.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5649)
  AUTHORS   Barbiero,I., Zamberletti,E., Tramarin,M., Gabaglio,M., Peroni,D.,
            De Rosa,R., Baldin,S., Bianchi,M., Rubino,T. and
            Kilstrup-Nielsen,C.
  TITLE     Pregnenolone-methyl-ether enhances CLIP170 and microtubule
            functions improving spine maturation and hippocampal deficits
            related to CDKL5 deficiency
  JOURNAL   Hum Mol Genet 31 (16), 2738-2750 (2022)
   PUBMED   35348691
  REMARK    GeneRIF: Pregnenolone-methyl-ether enhances CLIP170 and microtubule
            functions improving spine maturation and hippocampal deficits
            related to CDKL5 deficiency.
REFERENCE   2  (bases 1 to 5649)
  AUTHORS   Yashirogi,S., Nagao,T., Nishida,Y., Takahashi,Y., Qaqorh,T.,
            Yazawa,I., Katayama,T., Kioka,H., Matsui,T.S., Saito,S.,
            Masumura,Y., Tsukamoto,O., Kato,H., Ueda,H., Yamaguchi,O.,
            Yashiro,K., Yamazaki,S., Takashima,S. and Shintani,Y.
  TITLE     AMPK regulates cell shape of cardiomyocytes by modulating turnover
            of microtubules through CLIP-170
  JOURNAL   EMBO Rep 22 (1), e50949 (2021)
   PUBMED   33251722
  REMARK    GeneRIF: AMPK regulates cell shape of cardiomyocytes by modulating
            turnover of microtubules through CLIP-170.
REFERENCE   3  (bases 1 to 5649)
  AUTHORS   Henrie,H., Bakhos-Douaihy,D., Cantaloube,I., Pilon,A.,
            Talantikite,M., Stoppin-Mellet,V., Baillet,A., Pous,C. and
            Benoit,B.
  TITLE     Stress-induced phosphorylation of CLIP-170 by JNK promotes
            microtubule rescue
  JOURNAL   J Cell Biol 219 (7) (2020)
   PUBMED   32491151
  REMARK    GeneRIF: Stress-induced phosphorylation of CLIP-170 by JNK promotes
            microtubule rescue.
REFERENCE   4  (bases 1 to 5649)
  AUTHORS   Timmermans,S. and Libert,C.
  TITLE     Overview of inactivating mutations in the protein-coding genome of
            the mouse reference strain C57BL/6J
  JOURNAL   JCI Insight 3 (13), 121758 (2018)
   PUBMED   29997285
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5649)
  AUTHORS   Jakka,P., Bhargavi,B., Namani,S., Murugan,S., Splitter,G. and
            Radhakrishnan,G.
  TITLE     Cytoplasmic Linker Protein CLIP170 Negatively Regulates TLR4
            Signaling by Targeting the TLR Adaptor Protein TIRAP
  JOURNAL   J Immunol 200 (2), 704-714 (2018)
   PUBMED   29222167
  REMARK    GeneRIF: we report an unexpected finding that CLIP170 negatively
            regulates TLR4 signaling by the targeted ubiquitination and
            degradation of TIRAP. Furthermore, we observed that CLIP170
            expression is modulated by LPS to maintain the cellular
            homeostasis.
REFERENCE   6  (bases 1 to 5649)
  AUTHORS   Lansbergen,G., Komarova,Y., Modesti,M., Wyman,C., Hoogenraad,C.C.,
            Goodson,H.V., Lemaitre,R.P., Drechsel,D.N., van Munster,E.,
            Gadella,T.W. Jr., Grosveld,F., Galjart,N., Borisy,G.G. and
            Akhmanova,A.
  TITLE     Conformational changes in CLIP-170 regulate its binding to
            microtubules and dynactin localization
  JOURNAL   J Cell Biol 166 (7), 1003-1014 (2004)
   PUBMED   15381688
REFERENCE   7  (bases 1 to 5649)
  AUTHORS   Cahana,A., Jin,X.L., Reiner,O., Wynshaw-Boris,A. and O'Neill,C.
  TITLE     A study of the nature of embryonic lethality in LIS1-/- mice
  JOURNAL   Mol Reprod Dev 66 (2), 134-142 (2003)
   PUBMED   12950100
REFERENCE   8  (bases 1 to 5649)
  AUTHORS   Coquelle,F.M., Caspi,M., Cordelieres,F.P., Dompierre,J.P.,
            Dujardin,D.L., Koifman,C., Martin,P., Hoogenraad,C.C.,
            Akhmanova,A., Galjart,N., De Mey,J.R. and Reiner,O.
  TITLE     LIS1, CLIP-170's key to the dynein/dynactin pathway
  JOURNAL   Mol Cell Biol 22 (9), 3089-3102 (2002)
   PUBMED   11940666
REFERENCE   9  (bases 1 to 5649)
  AUTHORS   Tarsounas,M., Pearlman,R.E. and Moens,P.B.
  TITLE     CLIP-50 immunolocalization during mouse spermiogenesis suggests a
            role in shaping the sperm nucleus
  JOURNAL   Dev Biol 236 (2), 400-410 (2001)
   PUBMED   11476580
REFERENCE   10 (bases 1 to 5649)
  AUTHORS   Akhmanova,A., Hoogenraad,C.C., Drabek,K., Stepanova,T.,
            Dortland,B., Verkerk,T., Vermeulen,W., Burgering,B.M., De
            Zeeuw,C.I., Grosveld,F. and Galjart,N.
  TITLE     Clasps are CLIP-115 and -170 associating proteins involved in the
            regional regulation of microtubule dynamics in motile fibroblasts
  JOURNAL   Cell 104 (6), 923-935 (2001)
   PUBMED   11290329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129569.17.
            
            [WARNING] On Mar 8, 2024 this sequence was replaced by
            NM_001291229.2.
            
            On Mar 29, 2014 this sequence version replaced XM_006530425.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1,
            resulting in an isoform (b) that is shorter than isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220172.1, SRR10223969.6049.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AC129569.17        35019-35128
            111-303             AC129569.17        63294-63486
            304-872             AC129569.17        65360-65928
            873-997             AC129569.17        71415-71539
            998-1220            AC129569.17        73075-73297
            1221-1418           AC129569.17        76764-76961
            1419-1522           AC129569.17        77499-77602
            1523-1583           AC129569.17        78826-78886
            1584-2300           AC129569.17        88211-88927
            2301-2417           AC129569.17        91970-92086
            2418-2475           AC129569.17        96110-96167
            2476-2559           AC129569.17        96541-96624
            2560-2716           AC129569.17        97428-97584
            2717-2882           AC129569.17        101558-101723
            2883-3098           AC129569.17        101829-102044
            3099-3215           AC129569.17        107442-107558
            3216-3322           AC129569.17        110035-110141
            3323-3443           AC129569.17        115661-115781
            3444-3496           AC129569.17        128535-128587
            3497-3614           AC129569.17        135742-135859
            3615-3765           AC129569.17        135946-136096
            3766-3815           AC129569.17        136611-136660
            3816-3940           AC129569.17        139256-139380
            3941-5649           AC129569.17        139878-141586
FEATURES             Location/Qualifiers
     source          1..5649
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 63.06 cM"
     gene            1..5649
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /note="CAP-GLY domain containing linker protein 1"
                     /db_xref="GeneID:56430"
                     /db_xref="MGI:MGI:1928401"
     exon            1..110
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            111..303
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..4166
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /note="isoform b is encoded by transcript variant 2;
                     restin (Reed-Steinberg cell-expressed intermediate
                     filament-associated protein); cytoplasmic linker protein
                     50; Reed-Steinberg cell-espressed intermediate
                     filament-associated protein; CAP-Gly domain-containing
                     linker protein 1; Clip 170; cytoplasmic linker protein
                     170"
                     /codon_start=1
                     /product="CAP-Gly domain-containing linker protein 1
                     isoform b"
                     /protein_id="NP_001278158.1"
                     /db_xref="CCDS:CCDS71663.1"
                     /db_xref="GeneID:56430"
                     /db_xref="MGI:MGI:1928401"
                     /translation="MSMLKPSGLKAPTKILKPGSTALKTPAAAAAPVEKTIPSEKASG
                     PPSSETQEEFVDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGS
                     VAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQAAPGRTASPLSTAAATMVSSSP
                     ATPSNIPHKPSQSTAKEPSATPQISNLTKTASESISNLSEAGSVKKGERELKVGDRVL
                     VGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHK
                     VTKIGFPSTTPAKAKAAAVRRVMAATPASLKRSPSASSLSSMSSVASSVSSKPSRTGL
                     LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELA
                     LARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESIT
                     KGDLEVATVSEKSRIMELEKDLALRAQEVAELRRRLESSKPPGDVDMSLSLLQEISAL
                     QEKLEAIHTDHQGEMTSLKEHFGAREEAFQKEIKALHTATEKLSKENESLRSKLDHAN
                     KENSDVIALWKSKLETAIASHQQAMEELKVSFSKGIGTDSAEFAELKTQIERLRLDYQ
                     HEIESLQSKQDSERSAHAKEMETMQAKLMKIIKEKEDSLEAVKARLDSAEDQHLVEME
                     DTLNKLQEAEIKANSITKELQEKELVLTGLQDSLNQVNQVKETLEKELQTLKEKFAST
                     SEEAVSAQTRMQDTVNKLHQKEEQFNVLSSELEKLRENLTDMEAKFKEKDDREDQLVK
                     AKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERSVEELQLKLTKANENASFLQKSI
                     GEVTLKAEQSQQQAARKHEEEKKELEEKLLELEKKMETSYNQCQDLKAKYEKASSETK
                     TKHEEILQNLQKMLADTEDKLKAAQEANRDLMQDMEELKTQADKAKAAQTAEDAMQIM
                     EQMTKEKTETLASLEDTKQTNARLQNELDTLKENNLKTVEELNKSKELLSVENQKMEE
                     FKKEIETLKQAAAQKSQQLSALQEENVKLAEELGRTRDEVTSHQKLEEERSVLNNQLL
                     EMKKRESEFRKDADEEKASLQKSISLTSALLTEKDAELEKLRNEVTVLRGENATAKSL
                     HSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDAQAEEDERAQESQIDFLN
                     SVIVDLQRKNQDLKMKVEMMSEAALNGNGEDLNSYDSDDQEKQSKKKPRLFCDICDCF
                     DLHDTEDCPTQAQMSEDPPHSTHHGSRSEERPYCEICEMFGHWATNCNDDETF"
     exon            304..872
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            873..997
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1220
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1418
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1522
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1583
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..2300
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2417
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2475
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2559
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2716
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2882
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..3098
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3099..3215
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..3322
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..3443
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3444..3496
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3497..3614
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3615..3765
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3766..3815
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3816..3940
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3941..5649
                     /gene="Clip1"
                     /gene_synonym="1110007I12Rik; 4631429H07Rik; CLIP-170;
                     CLIP170; Clip50; CYLN1; mKIAA4046; restin; Rsn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttccccg ccccgagccg aagagccggg gaggcgggag gcggcggccg cggcggctgc
       61 tgctgctgct gctgggaggc aggtgacggc gaccagcggc gtcccaggcg atttgaccga
      121 gaggctgagt tctctatagg aacacccaca tttgtatgga tgagtgggga aagatagcgg
      181 cagcagacaa ggaaaaagcg tcctgacctc ccgagaacat gagtatgcta aaacccagcg
      241 gcctgaaggc ccctaccaag atccttaagc cgggaagcac agccttgaag acgcctgctg
      301 ctgctgcagc tccagtggag aagacaatac ccagtgagaa agcctcgggc cctccatcct
      361 ccgagaccca agaggagttt gtggatgact ttcgagttgg agaacgtgtt tgggtgaacg
      421 ggaataagcc cggatttatc cagtttcttg gggaaactca gttcgcacca ggccagtggg
      481 ctgggattgt tttagatgaa cccataggga agaacgatgg ctctgtggcg ggagtgcggt
      541 atttccagtg tgaaccttta aagggcatat tcacccgacc ttcaaagcta acgaggaagg
      601 tgcaggcaga agatgaagcc aacggcctgc aggcagctcc tgggagaact gcttcacctc
      661 tgtccactgc tgcagctacc atggtgtctt cttctccagc cactccctca aatattcccc
      721 acaaaccgtc ccagtcaacg gcaaaagaac cttcggctac acctcaaatt agcaacctca
      781 caaaaactgc cagtgagtcg atctccaacc tttcagaggc tggctctgtc aagaaggggg
      841 agcgggagct caaggtcgga gacagggtgc tggttggtgg cactaaggct ggcgtagtcc
      901 gctttcttgg cgagaccgac tttgccaagg gggagtggtg tggtgtggag ttagacgagc
      961 ctttggggaa gaacgatggt gctgtggccg gaacaaggta ttttcagtgt caacccaaat
     1021 atggattgtt cgctcctgtc cacaaagtga caaagattgg cttcccgtct actaccccag
     1081 ccaaagccaa agccgccgct gtgaggcgag tgatggccgc cacgcccgcc agcctgaagc
     1141 gaagcccttc tgcctcctcc ctcagctcca tgagctccgt ggcctcctct gtgagcagca
     1201 aacccagccg gacaggacta ttgactgaaa cctcctcccg ctacgcccgc aagatctcgg
     1261 gcaccactgc cctccaggag gcgctgaagg agaagcagca gcacattgag cagctgctgg
     1321 ctgagcggga cctggagcgg gccgaggtgg ccaaggctac cagccacgtg ggggaaatag
     1381 agcaggagct agccctggcc cgagatgggc atgaccagca tgtcctggaa ctagaggcca
     1441 agatggacca gctacggacc atggtggaag ctgctgacag ggagaaagtg gagctgctca
     1501 accagctgga agaggagaag aggaaggttg aggaccttca gttccgagtt gaagaagaat
     1561 caattaccaa aggcgatctt gaggtggcta ccgtctcaga aaagtcccga ataatggaac
     1621 tagaaaagga cctagcattg agagcacagg aagtagctga gctccgaaga aggctagagt
     1681 ccagtaaacc tcctggggat gtggatatgt ctctctccct tttgcaagaa ataagtgctt
     1741 tgcaagaaaa gctagaagcc atccatactg accaccaggg cgagatgact tctttgaagg
     1801 aacacttcgg agctcgagag gaggcgtttc agaaggagat caaggctctg cacacggcca
     1861 ctgagaagct ttccaaagag aacgagtccc tgagaagcaa gctcgaccac gctaataagg
     1921 agaactccga tgtgatagct ctatggaagt ccaaactgga gaccgccata gcatcccacc
     1981 agcaggcaat ggaggagctg aaggtgtcct ttagcaaagg cattggaacg gactccgctg
     2041 aatttgctga gttaaagaca cagatagaga gactgagact agattaccag cacgaaatag
     2101 aaagtttaca gagtaaacag gactctgagc ggtctgctca tgctaaagag atggagacca
     2161 tgcaggccaa gctgatgaag atcattaaag agaaggagga cagcctggag gccgtcaaag
     2221 cgagactgga cagtgcagaa gaccagcacc tagtggaaat ggaggacacg ctaaacaaac
     2281 tgcaggaggc ggagattaag gctaatagca ttaccaaaga gctccaggag aaagagctag
     2341 tgctcactgg tctgcaggac agtttgaatc aagtcaatca agtgaaggag actttggaga
     2401 aagaacttca gactttgaaa gaaaagtttg ccagtacttc agaggaggcg gtctctgctc
     2461 agacaaggat gcaagatacc gtaaataaac tgcaccaaaa ggaggaacag tttaacgtgt
     2521 tgtcgtctga actggagaag ttgagagaaa atttaacaga catggaggca aaatttaaag
     2581 agaaggatga tcgagaagat cagctggtaa aggcaaagga aaaattagaa aacgacattg
     2641 cagaaataat gaagatgtca ggagataact cttctcagct gacaaagatg aatgatgaat
     2701 tacgtctgaa ggaaagatcc gtggaagaac tccagctcaa gcttacaaag gccaatgaaa
     2761 acgccagttt tctgcagaag agtattggcg aagtgactct taaagctgag cagagtcagc
     2821 agcaagcagc cagaaaacat gaagaagaaa agaaagagtt ggaggaaaaa ctgttggaac
     2881 tggaaaagaa gatggaaaca agctacaacc agtgtcagga cctgaaagct aagtatgaaa
     2941 aagccagttc tgagactaaa acaaagcatg aagaaatcct gcagaacctc cagaagatgc
     3001 tggcggacac agaggataag ctgaaggctg ctcaggaggc gaacagagat ctgatgcagg
     3061 acatggagga gctgaaaaca caggccgaca aagccaaagc tgctcagact gcagaagacg
     3121 ccatgcagat catggaacag atgaccaaag agaaaacaga aacgctggcc tccttggagg
     3181 acaccaagca aacaaatgca agactacaga atgaattgga cacacttaag gaaaacaact
     3241 tgaaaactgt ggaagagctg aacaagtcaa aagaactgct gagtgtagag aaccaaaaaa
     3301 tggaagaatt caagaaagaa atagaaaccc taaagcaggc agcagctcag aagtcccagc
     3361 agctttcagc actgcaggaa gagaacgtca aacttgccga ggagctgggg agaacccggg
     3421 acgaagtcac aagtcaccag aagctggaag aagaacgatc tgtactcaat aatcagttgt
     3481 tagaaatgaa aaagagagaa tctgagttca gaaaagacgc cgatgaagag aaagcctcct
     3541 tgcagaagtc gatcagcctc accagtgcct tgctcacaga gaaggacgcg gagctggaga
     3601 agctgaggaa tgaggtcaca gtgctcaggg gagagaatgc caccgccaag tccctgcact
     3661 cagttgtgca gacactggag tctgataagg tgaagcttga gctcaaggtc aaaaacttgg
     3721 aacttcaact caaggagaac aagaggcagc tcagcagctc ctcaggtaac actgatgctc
     3781 aggcggaaga ggatgagaga gcccaggaga gtcagattga tttcctcaac tcggtaatag
     3841 tggatcttca aagaaagaac caagacctca agatgaaggt ggagatgatg tctgaagctg
     3901 cactcaatgg caacggggaa gacctgaaca gttatgacag tgatgaccag gaaaagcagt
     3961 ccaagaagaa accccgcctc ttctgtgaca tctgtgactg ctttgacctc cacgatacag
     4021 aggactgtcc cacccaggca cagatgtcgg aagatcctcc ccattccact caccatggca
     4081 gccggagcga ggagcggcca tactgtgaga tctgtgagat gtttgggcac tgggcaacca
     4141 actgcaatga cgacgagacc ttctgaggaa gccgggaggg caggaagggc ttccccgaca
     4201 aacgccggct cctcagcagc tcccgccagc attggtgtgc aacttcagaa gagctcctta
     4261 ttttttgacc cctgtcaaca aatctgagaa aatattttga tcttcaacaa gtttcccttt
     4321 catttcccct cgtaagttaa aataataata aatatttggt aggtgggctt gcacttccgt
     4381 ccttgttttc tggattttta aggtttaaga cattgtacca ggcacagttc ctgtttgttc
     4441 ctagagaaac cctctgggac aagtgggacc ctggcagtat cttatttagg aaacttcaaa
     4501 tgatgccgtt gactctcatg tttgcactaa aatgtttcct ggctacatct gtatatttag
     4561 gttgttgttg ttgttgttat gctttgacac tggaatgagt tgcaaaaaaa ccctgtgcca
     4621 ctttgtgatt tcctgcctca tttaaatact ctcatctcta aaccccaagc tcttctcttc
     4681 gcactccctg ctctcaggag ggcctttttc caggcttgac aatacttagg tgtgactata
     4741 aatcatgaaa acaggtaaaa gggaggggaa agcccgaact gctgtgggga cattttctaa
     4801 tctatatgct gcacccatgg accgacagtg gtgttttctt tactggtttt acataatttc
     4861 aacgtctata tattatatgt gtatatattt ttaaaagaat ctatattttg ggaaaaagtc
     4921 tatacaatgt gtcttctttt cagatttttt tacctttatg aaaaagaaaa catctaaagg
     4981 ctcaccagca tgtgactgac tgggcccaag atgggctctg cggtggtctc tgctgtgagg
     5041 ttccagctat cgtctttgtc tccatgatgt ttcttagcca gatcggagta gctggaagaa
     5101 cagtctccgg ctccttgctt gtgtttccct tccttagcag ataaccccag cagcaaacta
     5161 agccactctt cagagagcta agctaactga tctacaaccc tcctttatac atttgtgggg
     5221 tgtgtttgtt tgtttgtttt ttactgtatt tttaaatgaa tgtatgatga gaaattcaac
     5281 atgaataatt ttggattttc ttatcacaaa aaagataaaa caaaggacct caaccaactg
     5341 aagagttgac cccgccagtc tgcgtctctc tgtcttcact tgaatgtctt tgagaatatg
     5401 taaaaaggag ccacatgcac ctccacgcag tgtgcaggac gagaacttcc gtcattgtat
     5461 ataggcctct gccccgtctc cccttaaggt tatccactgt gcttgatgag tgagcagtca
     5521 atacatctgc tgcccgtcgg cattctgggt taataaaact ataggaatta tttcacaaac
     5581 aaactatgga aagcagtatt aaaatctgag ttctgtatct actttaataa atgttttggg
     5641 tctctttgg
//
