LOCUS       NM_001346760            3446 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus clathrin interactor 1 (Clint1), transcript variant 2,
            mRNA.
ACCESSION   NM_001346760 XM_006532838
VERSION     NM_001346760.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3446)
  AUTHORS   Rodriguez-Fraticelli,A.E., Bagwell,J., Bosch-Fortea,M.,
            Boncompain,G., Reglero-Real,N., Garcia-Leon,M.J., Andres,G.,
            Toribio,M.L., Alonso,M.A., Millan,J., Perez,F., Bagnat,M. and
            Martin-Belmonte,F.
  TITLE     Developmental regulation of apical endocytosis controls epithelial
            patterning in vertebrate tubular organs
  JOURNAL   Nat Cell Biol 17 (3), 241-250 (2015)
   PUBMED   25706235
  REMARK    GeneRIF: PLLP recruits the clathrin adaptor EpsinR to sort the
            SNARE machinery of the endolysosomal pathway into the subapical
            compartment, which is a switch for polarized endocytosis.
REFERENCE   2  (bases 1 to 3446)
  AUTHORS   Shishido,T., Hachisuka,M., Ryuzaki,K., Miura,Y., Tanabe,A.,
            Tamura,Y., Kusayanagi,T., Takeuchi,T., Kamisuki,S., Sugawara,F. and
            Sahara,H.
  TITLE     EpsinR, a target for pyrenocine B, role in endogenous
            MHC-II-restricted antigen presentation
  JOURNAL   Eur J Immunol 44 (11), 3220-3231 (2014)
   PUBMED   25196058
  REMARK    GeneRIF: EpsinR plays a role in antigen presentation, which
            provides insight into the mechanism of presentation pathway of
            endogenous MHC class II-restricted antigen.
REFERENCE   3  (bases 1 to 3446)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   4  (bases 1 to 3446)
  AUTHORS   Wasiak,S., Denisov,A.Y., Han,Z., Leventis,P.A., de Heuvel,E.,
            Boulianne,G.L., Kay,B.K., Gehring,K. and McPherson,P.S.
  TITLE     Characterization of a gamma-adaptin ear-binding motif in
            enthoprotin
  JOURNAL   FEBS Lett 555 (3), 437-442 (2003)
   PUBMED   14675752
REFERENCE   5  (bases 1 to 3446)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   6  (bases 1 to 3446)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 3446)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
REFERENCE   8  (bases 1 to 3446)
  AUTHORS   McIntire,J.J., Umetsu,S.E., Akbari,O., Potter,M., Kuchroo,V.K.,
            Barsh,G.S., Freeman,G.J., Umetsu,D.T. and DeKruyff,R.H.
  TITLE     Identification of Tapr (an airway hyperreactivity regulatory locus)
            and the linked Tim gene family
  JOURNAL   Nat Immunol 2 (12), 1109-1116 (2001)
   PUBMED   11725301
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645948.10.
            
            On Apr 15, 2022 this sequence version replaced NM_001346760.2.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.7269.1,
                                           SRR13422590.434457.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               AL645948.10        76208-76430
            224-328             AL645948.10        107948-108052
            329-425             AL645948.10        108570-108666
            426-534             AL645948.10        110669-110777
            535-699             AL645948.10        111624-111788
            700-877             AL645948.10        114860-115037
            878-1124            AL645948.10        118109-118355
            1125-1194           AL645948.10        119298-119367
            1195-1269           AL645948.10        126449-126523
            1270-1556           AL645948.10        130419-130705
            1557-1761           AL645948.10        132078-132282
            1762-3446           AL645948.10        133179-134863
FEATURES             Location/Qualifiers
     source          1..3446
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 27.45 cM"
     gene            1..3446
                     /gene="Clint1"
                     /gene_synonym="C530049I24Rik; Enth; Epn4; F630206G17Rik"
                     /note="clathrin interactor 1"
                     /db_xref="GeneID:216705"
                     /db_xref="MGI:MGI:2144243"
     exon            1..223
                     /gene="Clint1"
                     /gene_synonym="C530049I24Rik; Enth; Epn4; F630206G17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..2108
                     /gene="Clint1"
                     /gene_synonym="C530049I24Rik; Enth; Epn4; F630206G17Rik"
                     /note="isoform 2 is encoded by transcript variant 2; ENTH
                     domain containing protein; enthoprotin; epsin 4; epsinR;
                     epsin-related protein"
                     /codon_start=1
                     /product="clathrin interactor 1 isoform 2"
                     /protein_id="NP_001333689.1"
                     /db_xref="CCDS:CCDS83796.1"
                     /db_xref="GeneID:216705"
                     /db_xref="MGI:MGI:2144243"
                     /translation="MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLM
                     GEIAKATFMYEQFPELMNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAR
                     EHIYDLRSLENYHFVDEHGKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYV
                     GVSSDSVGGFRYNERYDPEPKSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISK
                     FRRKDREDSPERCSDSDEEKKARRGRSPKGEFKDEEETVTTKHIHITQATETTTTRHK
                     RTANPSKTIDLGAAAHYTGDKASPDQNASTHTPQSSAKPSVPSSKSSGDLVDLFDGSS
                     QSAGGSADLFGGFADFGSAAASGNFPSQATSGNGDFGDWSAFNQAPSGPVASGGELFG
                     SAPQSAVELISASQPALGPPPAASNSADLFDLMGSSQATMTSSQSMNFSLMSTNTVGL
                     GLPMSRSQPLQNVSAVLQKPNPLYHQNTDMVQKSASKTLPSTWSDPSVNISLDNLLPG
                     MQPSKPQQPSLNTMIQQQNMQQPLNVMTQSFGAVNLSSPSNMLPVRPQTNPLLGGPMP
                     MNMPGVMTGTMGMAPLGNSAGMSQGMVGMNMNMGMSASGMGLSGTMGMGMPSMAMPSG
                     TVQPKQDAFANFANFSK"
     exon            224..328
                     /gene="Clint1"
                     /gene_synonym="C530049I24Rik; Enth; Epn4; F630206G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            329..425
                     /gene="Clint1"
                     /gene_synonym="C530049I24Rik; Enth; Epn4; F630206G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            426..534
                     /gene="Clint1"
                     /gene_synonym="C530049I24Rik; Enth; Epn4; F630206G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            535..699
                     /gene="Clint1"
                     /gene_synonym="C530049I24Rik; Enth; Epn4; F630206G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            700..877
                     /gene="Clint1"
                     /gene_synonym="C530049I24Rik; Enth; Epn4; F630206G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1124
                     /gene="Clint1"
                     /gene_synonym="C530049I24Rik; Enth; Epn4; F630206G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1194
                     /gene="Clint1"
                     /gene_synonym="C530049I24Rik; Enth; Epn4; F630206G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1269
                     /gene="Clint1"
                     /gene_synonym="C530049I24Rik; Enth; Epn4; F630206G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1556
                     /gene="Clint1"
                     /gene_synonym="C530049I24Rik; Enth; Epn4; F630206G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1761
                     /gene="Clint1"
                     /gene_synonym="C530049I24Rik; Enth; Epn4; F630206G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..3446
                     /gene="Clint1"
                     /gene_synonym="C530049I24Rik; Enth; Epn4; F630206G17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3424..3429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Clint1"
                     /gene_synonym="C530049I24Rik; Enth; Epn4; F630206G17Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3446
                     /gene="Clint1"
                     /gene_synonym="C530049I24Rik; Enth; Epn4; F630206G17Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcgtctcgac gtgtcactgg cggcgccgtg gctgtggccg ggagaaggag ctccggctag
       61 ggagagttcg cggcggtggg tggcggcggc gacccggacc tggaccagcc ccggcgcgga
      121 ggcgtcccgg ggtccgtgga gagtggcggc gggcggcggc gggccgggcc gcgcggggcg
      181 cgatgctgaa catgtggaag gtgcgggagc tggtggacaa agccaccaat gtggttatga
      241 attactcaga gattgagtct aaggttcgag aagcaacgaa tgatgatccc tggggacctt
      301 ctgggcagct catgggagag attgccaagg ctacctttat gtatgagcag ttcccagaac
      361 tcatgaacat gctttggtcc cggatgctaa aagacaacaa aaagaactgg agaagagttt
      421 ataagtcgtt gctgctccta gcttacctca taagaaatgg atcggagcga gttgttacaa
      481 gtgccagaga acacatttat gatttgcgat ccctggaaaa ttaccacttt gtagatgagc
      541 atggcaagga tcaaggtata aacattcgac agaaagtaaa ggaactggtt gagtttgcac
      601 aggatgatga caggcttcga gaagagcgaa agaaagcaaa gaagaacaaa gacaagtatg
      661 tcggggtctc ttcagacagc gttggtggat tccgatacaa tgagcggtac gatcctgagc
      721 ccaagtccaa atgggacgaa gagtgggata agaacaagag cgcgtttccg ttcagtgaca
      781 agctgggcga gctgagcgac aagatcggga gcacgatcga cgacaccatc agcaagttcc
      841 ggaggaaaga ccgggaggac tctccggaaa ggtgcagcga cagtgatgag gaaaagaaag
      901 caagaagagg tagatctccc aaaggtgaat tcaaagatga agaggaaacg gtgacgacga
      961 agcatatcca catcacacag gccacagaga ccaccacaac ccggcacaag cgcacagcaa
     1021 acccttccaa aaccattgat cttggagcag cagcacatta cacgggggac aaagccagcc
     1081 cagatcagaa tgcttcaacc cacacgcctc agtcgtcagc caagccatcg gtgccgagca
     1141 gcaagtcctc gggggacctc gttgacctgt ttgatggcag tagccagtca gcaggtggat
     1201 cagctgattt atttggggga tttgctgact ttggctcagc tgctgcatca ggcaatttcc
     1261 cttcccaagc aacaagtggg aatggtgact ttggtgactg gagtgccttc aaccaagccc
     1321 catcaggccc tgtggcttct ggtggtgagc tcttcggcag tgccccacag tcggctgtgg
     1381 agcttatcag tgcttcacag ccagctttag gcccaccgcc tgctgcctca aactcggcag
     1441 acctgtttga tcttatgggc tcatcccagg caaccatgac gtcttcccag agcatgaatt
     1501 tctctctcat gagcactaac accgtgggac ttggtttgcc catgtccaga tcacagcctc
     1561 tgcagaatgt tagtgcagtg ctgcagaagc ctaaccctct ctatcatcag aatacagata
     1621 tggtccagaa gtcggccagc aaaaccctgc cctctacttg gtctgacccc agtgtcaaca
     1681 tcagcctaga caacttacta cctggtatgc agccttccaa gccccagcag ccatcgctta
     1741 atacaatgat tcaacaacag aatatgcaac agcctctgaa tgtgatgaca caaagctttg
     1801 gagctgtgaa cctcagttct ccatcaaaca tgcttcctgt ccggcctcaa actaaccctc
     1861 tcctgggggg acccatgcct atgaacatgc ccggtgtaat gacgggcacc atgggaatgg
     1921 cccctctggg gaacagcgca gggatgagcc agggcatggt gggcatgaac atgaacatgg
     1981 ggatgtcggc ctcggggatg ggcttgtcgg gcaccatggg aatgggcatg cccagcatgg
     2041 ccatgccttc tggaactgtg caacccaagc aagatgcctt tgcaaacttt gccaacttta
     2101 gcaaataaaa ggttgtaacg gagcgagtgg aagaagactc tgtaactgca ataggtgatg
     2161 ttgggatgga agatgctaag cagttccctt ttcttttatc agttaattaa ataacccaca
     2221 taaagaacca aaaaggctgg tgtttcagaa gcgatgcaag agcacttcag atgaggcagt
     2281 caggatcggt ttccccagtg aagatacgct ccaaatgggg tgagggtcac gagagcctct
     2341 ctgggtcaga gagcccatgt cacagcgtag tctgtgggag gactggcacg gatggggctg
     2401 agtgtgtgtg cttcactctc taactttata cttctttctc cctgaggaac ttgatttttc
     2461 tgtccctcaa tcgccttgtc atgattgggt ctgttccttt actaccactc tcaagtccat
     2521 agatgaaatc attaaagttg gatgatcagt tttttataaa aatatatatt tttgtccaaa
     2581 aaaaaggcat acatatgtga ttatggctaa atcagaggta actggatgtg tgtgcttttg
     2641 ccaagactcc agcagtgctg ctaactacca tctgagtttc catggatttg acccctcttc
     2701 cgcaggcagc tggcagtagc tgtgagactt cgcccgtgtc tcctgcagtt accctgtgca
     2761 gaactgggaa gcctttcttg ggactgctcg gcggtttcct ttaacagtcg gagaaggaag
     2821 actcgtgtgt tgtctgtctg tagcggttgt tcactgcctt tgcagtgact gacttggcaa
     2881 agctgtttcc tgtgcgtagc cttgtagcca tcattcaagt cagaaacagt caaaagagaa
     2941 aaatatttat ttttatcttt tttggtgtct tttcaaaaaa ttgaaaggta aaactacatt
     3001 aaaaccttaa gttaaatgta catgttagga ctcagcaatt tcacatttag attttatact
     3061 gtattcattt tgtttgcgtt ttgagtgtgt aataccgcat tagcaatatg gttccaatag
     3121 aagttcgata tatattatta aaggagacct gtagcagtca gagattttat tgatttaatg
     3181 acaaataaag gaaattaatt aatttttttt cctgctgtga tactgcatta agctcacatg
     3241 aaaatcatga tgctagagtt tggaatgcaa aattaaatgt ttcaacctca agctgggaat
     3301 attttttaaa ataaatacta taagtatcaa attattacct cccctacttt atgttgaaat
     3361 tttttttatt gaattgatac aactttgttt ccattgtatt catgatgttc tgttctatat
     3421 aacattaaaa cattcattaa aaccaa
//
